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Rare Metals 2022年第5期41卷 1434-1455页

作者： Chang-Min Li Liang Huang Cheng-Lin Li Song-Xiao Hui Yang Yu ming-jie zhao Shi-Qi Guo Jian-Jun Li State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430074China State Key Laboratory of Nonferrous Metals and Processes General Research Institute for Nonferrous MetalsBeijing 100049China

High-strength β titanium alloys represented by near β titanium alloy and metastable β titanium alloy are preferred materials for large-scale load-carrying *** order to achieve the precise regulation of microstructure in the deformation process, massive efforts have been made to study the flow behavior and microstructure evolution of βtitanium alloy in the hot deformation process. This paper reviews the flow behavior of high-strength titanium alloy,including the effects of initial microstructure, deformation process parameters, work hardening, and dynamic softening on flow stress. Furthermore, the effects of deformation process parameters on the apparent activation energy for deformation and strain rate sensitivity coefficient are analyzed. The discontinuous yield phenomenon is discussed,and the constitutive models of flow stress are ***, some microstructural evolution models are reviewed. Finally, the development direction and difficulties of the flow behavior and constitutive model are pointed out.

关键词： High-strengthβtitanium alloy Hot deformation Flow behavior Constitutive model

Investigation and Modeling of Austenite Grain Evolution for a Typical High-strength Low-alloy Steel during Soaking and Deformation Process

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Acta Metallurgica Sinica(English Letters) 2022年第6期35卷 996-1010页

作者： ming-jie zhao Liang Huang Chang-Min Li Jia-Hui Xu Xu-Yang Li Jian-Jun Li Peng-Chuan Li Chao-Yuan Sun State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China China National Erzhong Group Deyang Wanhang Die Forging Co.LTD Deyang 618000China

The final mechanical properties of components greatly depend on their grain size. It is necessary to study the grain evolution during different thermomechanical processes. In the study, the real-time austenite grain evolution of a high-strength low-alloy(HSLA) steel during the soaking process is investigated by in situ experiments. The effects of different deformation parameters on the dynamic recrystallization(DRX) kinetic behaviors are investigated by hot compression experiments. Based on the observations and statistics of the microstructures at different thermomechanical processes, a unified grain size model is established to evaluate the effects of soaking parameters and deformation parameters on the austenite grain evolution. Also, the DRX kinetic model and critical strain model are established, which can describe the effects of the soaking process on the DRX kinetics process well. The established grain size model and DRX kinetic model are compiled into the numerical simulation software using Fortran language. The austenite grain evolution of the material under different deformation conditions is simulated, which is consistent with the experimental results. It indicates that the established model is reliable, and can be used to simulate and predict the grain size during different thermomechanical processes accurately.

关键词： High-strength steel Grain growth Dynamic recrystallization Grain size model Numerical simulation

Soil quality and sustainable land use in urban-rural marginal area: a case study of Kaifeng

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Journal of Geographical Sciences 2001年第3期11卷 356-365页

作者： QIN ming-zhou, zhao jie (College of Environment and Planning, Henan University, Kaifeng 475001, China) College of Environment and Planning Henan University Kaifeng China

By using the basic theories of physical geography, land resources and ecology, this article analyzes the soil quality of the rural-urban marginal area in Kaifeng. Computer techniques, based on soil samples analysis, are used to study soil quality changes in the Kaifeng’s rural-urban marginal area. While focusing on nutrient circle key links of input and output in soil, relying on numerous practical survey data, this article reveals clearly the impact of land use change on soil quality.

关键词： urban-rural marginal area land use change soil quality soil nutriment balance

Mechanisms of hydraulic fracturing in cohesive soil

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Water Science and Engineering 2009年第4期2卷 95-102页

作者： Jun-jie WANG Hui-ping ZHANG ming-jie zhao Xin LIN School of River and Ocean Engineering Chongqing Jiaotong University Chongqing 400074 P. R. China Key Laboratory of Hydraulic and Waterway Engineering of Ministry of Education Chongqing Jiaotong University Chongqing 400074 P. R. China

Hydraulic fracturing in the soil core of earth-rockfill dams is a common problem affecting the safety of the dams. Based on fracture tests, a new criterion for hydraulic fracturing in cohesive soil was suggested. Using this criterion, the mechanisms of hydraulic fracturing in cubic soil specimens were investigated. The results indicate that the propagation of the crack in a cubic specimen under water pressure occurs in a mixed mode I-II if the crack face is not perpendicular to any of the principal stresses, and the crack most likely to propagate is the one that is perpendicular to the minor principal stress and propagates in mode I.

关键词： hydraulic fracturing cohesive soil crack propagation mixed mode I-II

Research progress on microstructure evolution and hot processing maps of high strength β titanium alloys during hot deformation

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Transactions of Nonferrous Metals Society of China 2022年第12期32卷 3835-3859页

作者： Liang HUANG Chang-min LI Cheng-lin LI Song-xiao HUI Yang YU ming-jie zhao Shi-qi GUO Jian-jun LI National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China State Key Laboratory of Nonferrous Metals&Processes GRIMAT Engineering Institute Co.Ltd.Beijing 100086China

High strength β titanium alloys are widely used in large load bearing components in the aerospace field. At present, large parts are generally formed by die forging. Different initial microstructures and deformation process parameters will significantly affect the flow behavior. To precisely control the microstructures, researchers have conducted many studies to analyze the microstructure evolution law and deformation mechanism during hot compression. This review focuses on the microstructure evolution of high strength β titanium alloys during hot deformation, including dynamic recrystallization and dynamic recovery in the single-phase region and the dynamic evolution of the α phase in the two-phase region. Furthermore, the optimal hot processing regions, instability regions,and the relationship between the efficiency of power dissipation and the deformation mechanism in the hot processing map are summarized. Finally, the problems and development direction of using hot processing maps to optimize process parameters are also emphasized.

关键词： high strengthβtitanium alloy hot deformation microstructure evolution hot processing map

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新闻出版行业标准碎片化标引的研究与实现

计算机工程与设计 2017年第8期38卷 2281-2286页

作者：吴洁明赵文丽北方工业大学计算机学院北京100144

当前新闻出版行业对标准文献的标引工作都是采集标准的结构化信息进行标引,不对标准的具体内容部分标引,导致用户查询时无法快速定位到标准内容,为此提出针对标准的"碎片化"标引方案。根据标准的特点存储标准的结构及内容,建立新闻出版... 详细信息

当前新闻出版行业对标准文献的标引工作都是采集标准的结构化信息进行标引,不对标准的具体内容部分标引,导致用户查询时无法快速定位到标准内容,为此提出针对标准的"碎片化"标引方案。根据标准的特点存储标准的结构及内容,建立新闻出版行业词库,以此为基础进行分词,采用统计加权算法,考虑词频、词性、词长、位置加权因子进行自动标引。实验结果表明,该方案实现了新闻出版行业标准的碎片化标引,提高了检索的效率和质量。

关键词：新闻出版标准碎片化自动标引词库

Synthesis of New Amino Sugar Nucleoside Compounds

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Synthesis of New Amino Sugar Nucleoside Compounds

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

2011年全国药物化学学术会议——药物的源头创新

作者： zhao Zhang,ming-Li zhao,jie Gao,Wen Qu,Peng-Yun Li,Hong-Min Liu~* School of Pharmaceutical Sciences,New Drug Research & Development Center, Zhengzhou University,Zhengzhou 450001

＜正＞The synthesis of novel nucleoside analogues is gaining importance because of their applications as key intermediates in the development of antisense and/or antigene oligonucleotides to regulate targeted gene expression,and for their direct utilization as anti-tumor or antiviral *** years it has seen the emergence of sugar modified

关键词：

来源： cnki会议评论

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang zhao mingkai Zhang Qimeng Li Xuemin Wang jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

血管内皮生长因子靶向抗体对大鼠角膜碱烧伤后新生血管抑制作用的研究

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眼科新进展 2017年第11期37卷 1010-1014页

作者：王群姜严明赵杰侯宝杰吕明黄一飞武警总医院眼科北京市100039 火箭军总医院眼科北京市100088 军事医学科学院北京市100086 解放军总医院眼科北京市100053

目的通过对角膜碱烧伤大鼠模型结膜下注射VEGF靶向抗体MIL60,观察其对角膜新生血管(corneal neovascularization,CoNV)生长的影响,初步探讨MIL60抑制大鼠CoNV生长的基本作用机制。方法建立碱烧伤诱导的SD大鼠CoNV模型(右眼造模),根据碱... 详细信息

目的通过对角膜碱烧伤大鼠模型结膜下注射VEGF靶向抗体MIL60,观察其对角膜新生血管(corneal neovascularization,CoNV)生长的影响,初步探讨MIL60抑制大鼠CoNV生长的基本作用机制。方法建立碱烧伤诱导的SD大鼠CoNV模型(右眼造模),根据碱烧伤后第1天结膜下注射的药物不同将72只大鼠随机分为:25 mg·m L^(-1) MIL60组、地塞米松组、MIL60溶剂组和NaCl组。观察并记录CoNV生长情况及角膜的形态变化,通过软件分析Co NV的长度及累及面积。碱烧伤后第3天、第7天、第14天、第21天和第28天分别处死动物,取角膜组织行HE染色和免疫组织化学染色,同时检测角膜中血管内皮生长因子(vascular endothelial growth factor,VEGF)、VEGF受体-1(VEGF receptor-1,VEGFR-1)、VEGFR-2和基质金属蛋白酶-9(matrix metallopeptidase-9,MMP-9)蛋白的表达。结果在各个时间点,与MIL60溶剂组和NaCl组比较,地塞米松组、25 mg·m L^(-1) MIL60组CoNV面积和长度显著减少,差异均具有统计学意义(均为P0.05)。同时,MIL60还能有效降低角膜组织中VEGF、VEGFR-1、VEGFR-2以及MMP-9蛋白的表达。结论 MIL60能显著抑制角膜碱烧伤后CoNV的生长,并且还能减轻碱烧伤引起的炎症反应。

关键词：血管内皮生长因子 MIL60 角膜新生血管碱烧伤

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response