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反馈型TM01主模同轴虚阴极振荡器

物理学报 2019年第20期68卷 103-109页

作者：张运俭丁恩燕高功率微波技术重点实验室绵阳621900 复杂电磁环境科学与技术重点实验室绵阳621900 中国工程物理研究院应用电子学研究所绵阳621900

作为一种空间电荷高功率微波器件,同轴虚阴极振荡器微波输出模式一般为TM01与TE11模式的混合模式.本文通过数值模拟及实验分析,对同轴虚阴极振荡器进行了结构调整,提出了一种同轴反馈式虚阴极振荡器.通过对阳极网的结构设计,器件内阳极... 详细信息

作为一种空间电荷高功率微波器件,同轴虚阴极振荡器微波输出模式一般为TM01与TE11模式的混合模式.本文通过数值模拟及实验分析,对同轴虚阴极振荡器进行了结构调整,提出了一种同轴反馈式虚阴极振荡器.通过对阳极网的结构设计,器件内阳极网的反馈结构改变了阳极网内虚阴极反射电子束的分布,实现了同轴虚阴极振荡器以TM01模式为主要模式输出的高功率微波.同轴虚阴极振荡器在工作电压400 kV下微波输出850 MW,微波脉宽半高宽约30 ns,频率为4.1 GHz.

关键词：同轴虚阴极高功率微波模式控制

Lowering the threshold of alanine aminotransferase for enhanced identification of significant hepatic injury in chronic hepatitis B patients

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世界胃肠病学杂志:英文版 2023年第35期29卷 5166-5177页

作者： Hong-Sheng Yu Hao jiang ming-Kai Li Bi-Lan Yang Abdukyamu Smayi jian-Ning Chen Bin Wu Yi-Dong Yang Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Liver Disease Guangdong Provincial Key Laboratory of Liver Disease ResearchGuangzhou 510630Guangdong ProvinceChina Department of Pathology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND The clinical and histological features of chronic hepatitis B(CHB)patients who fall into the"grey zone(GZ)"and do not fit into conventional natural phases are *** To explore the impact of varying the threshold of alanine aminotransferase(ALT)levels in identifying significant liver injury among GZ *** This retrospective analysis involved a cohort of 1617 adult patients diagnosed with CHB who underwent liver *** clinical phases of CHB patients were determined based on the European Association for the Study of the Liver 2017 Clinical Practice *** CHB patients were classified into four groups:GZ-A(HBeAg positive,normal ALT levels,and HBV DNA≤10^(7) IU/mL),GZ-B(HBeAg positive,elevated ALT levels,and HBV DNA10^(7) IU/mL),GZC(HBeAg negative,normal ALT levels,and HBV DNA≥2000 IU/mL),and GZ-D(HBeAg negative,elevated ALT levels,and HBV DNA≤2000 IU/mL).Significant hepatic injury(SHI)was defined as the presence of notable liver inflammation(≥G2)and/or significant fibrosis(≥S2).RESULTS The results showed that 50.22%of patients were classified as GZ,and 63.7%of GZ patients developed *** study also found that lowering the ALT treatment thresholds to the American Association for the Study of Liver Diseases 2018 treatment criteria(35 U/L for men and 25 U/L for women)can more accurately identify patients with significant liver damage in the GZ *** total,the proportion of patients with ALT≤40 U/L who required antiviral therapy was 64.86%[(221+294)/794].When we lowered the ALT treatment threshold to the new criteria(30 U/L for men and 19 U/L for women),the same outcome was revealed,and the proportion of patients with ALT≤40 U/L who required antiviral therapy was 75.44%[(401+198)/794].Additionally,the proportion of SHI was 49.1%in patients under 30 years old and increased to 55.3%in patients over 30 years old(P=0.136).CONCLUSION These findings suggest the importance of redefining the natural phases of CHB and using ne

关键词： Chronic hepatitis B Grey zone Indeterminate phase Alanine aminotransferase Antiviral therapy

Highly efficient twin-field quantum key distribution with neural networks

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Science China(Information Sciences) 2023年第8期66卷 281-282页

作者： Jingyang LIU Qingqing jianG Huajian ding Xiao MA mingshuo SUN Jiaxin XU Chun-Hui ZHANG Shipeng XIE jian LI Guigen ZENG Xingyu ZHOU Qin WANG Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications Key Lab of Broadband Wireless Communication and Sensor Network Technology Ministry of Education Telecommunication and Networks National Engineering Research Center Nanjing University of Posts and Telecommunications

Quantum key distribution(QKD) allows two legitimate parties, Alice and Bob, to share a series of random bits that are secured by the laws of quantum mechanics. As a remarkable theoretical progress towards longer distances, the proposal of twin-field QKD(TF-QKD) [1] shows the capability to break a repeaterless bound and provides a key rate in the square-root scale of channel transmittance(i.e.,

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某品牌灵芝破壁孢子粉的安全性评价

江苏预防医学 2024年第1期35卷 84-87页

作者：武新月张颖徐捡俞萍张薇施伟庆陆罗定梁婕江苏省疾病预防控制中心江苏南京210009

目的研究某品牌灵芝破壁孢子粉的安全性。方法采用急性毒性试验、3项遗传毒性试验和30 d喂养试验评价灵芝破壁孢子粉的安全性。结果该品牌灵芝破壁孢子粉对小鼠急性经口MTD值>15000 mg/kg ***,属无毒级;3项遗传毒性试验均为阴性结果;30 ... 详细信息

目的研究某品牌灵芝破壁孢子粉的安全性。方法采用急性毒性试验、3项遗传毒性试验和30 d喂养试验评价灵芝破壁孢子粉的安全性。结果该品牌灵芝破壁孢子粉对小鼠急性经口MTD值>15000 mg/kg ***,属无毒级;3项遗传毒性试验均为阴性结果;30 d喂养期间,不同剂量的灵芝破壁孢子粉对大鼠的体重、食物利用率、主要脏体、血液学和血生化指标均产生显著影响(P值均<0.05);试验动物组织病理学均未见显著改变。结论试验条件下,该品牌灵芝破壁孢子粉的安全性良好。

关键词：灵芝破壁孢子粉安全性评价毒理学

论中国养老保障制度与服务整合——基于“四力协调”的分析框架

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西北大学学报（哲学社会科学版） 2019年第2期49卷 102-108页

作者：丁建定华中科技大学社会学院湖北武汉430074

养老保障体系既应该包括养老保障制度,也应该包括相关的养老服务体系。中国现行养老保障制度与服务的割裂和碎片化导致资源利用效果不佳。养老保障制度与服务的实际效果取决于资源配置力,这种配置力受到老年人自理状况所决定的需求力,... 详细信息

养老保障体系既应该包括养老保障制度,也应该包括相关的养老服务体系。中国现行养老保障制度与服务的割裂和碎片化导致资源利用效果不佳。养老保障制度与服务的实际效果取决于资源配置力,这种配置力受到老年人自理状况所决定的需求力,收入状况所决定的承受力,满足状况所决定的获得力的影响。必须对现行养老保障制度与服务加以整合,通过准确把握和合理满足老年人养老保障与服务的需求力,增强老年人养老保障与服务的承受力,强化养老保障制度与服务资源的配置力,提升老年人养老保障与服务的获得力。进而提升老年人养老保障的获得感、幸福感、安全感。

关键词：养老保障体系需求力承受力配置力获得力

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不同连通性含水层溶质运移模拟尺度提升研究

地下水 2024年第2期46卷 1-4页

作者：丛帆陈涛孙明远高宗军冯建国王敏山东科技大学地球科学与工程学院山东青岛266590 山东省地矿工程集团有限公司山东济南250000

含水层溶质运移数值模拟是预测地下水污染物演化特征的重要方法。考虑到模型计算时间和精度,如何将小尺度实测获得的水文地质参数换算到模型网格尺度,即尺度提升,是数值模拟过程中的关键问题。本文针对不同连通性含水层,考虑不同尺度提... 详细信息

含水层溶质运移数值模拟是预测地下水污染物演化特征的重要方法。考虑到模型计算时间和精度,如何将小尺度实测获得的水文地质参数换算到模型网格尺度,即尺度提升,是数值模拟过程中的关键问题。本文针对不同连通性含水层,考虑不同尺度提升方法和网格尺度的大小等因素,探究尺度提升对溶质运移模拟精度和效率的影响。结果表明:对具有不同连通性的含水层,能够获得相对误差小于5%的升尺度模型,然而网格大小或尺度提升方法选取不当会使误差增大;简单拉普拉斯方法是较优的尺度提升方法,尤其对于中连通性含水层;网格大小是影响升尺度模型精度的主要因素,对于高连通性含水层更加明显。

关键词：渗透系数尺度提升含水层连通性溶质运移数值模拟

Use of a compact high-definition two-dimensional exoscope in surgical treatment of large vestibular schwannoma

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Chinese Medical Journal 2020年第11期133卷 1292-1297页

作者： Xin Chen Xiang-Liang Gao Yan Chai ming-ming Shi jian-Ning Zhang Shu-Yuan Yue Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin 300052China

Background::Extra-corporeal video telescope operating monitor system provides a necessary instrument to perform high-precision neurosurgical procedures that could substitute or supplement the traditional surgical *** present study was designed to evaluate a compact high-definition two-dimensional exoscope system for assisting in surgical removal of large vestibular schwannoma(VS),as an alternative to a binocular surgical ***::Patients with Koos grade 3 and grade 4 VS undergoing surgery were enrolled in this prospective cohort study between January 2013 and June *** demographics and tumor characteristics(size,Koos grade,composition[cystic or solid mass])were matched between the two groups of *** following outcome measurements were compared between the two groups:duration of surgery,volume of blood loss,extent of tumor resection,number of operating field adjustments,pre-and post-operative facial and cochlear nerve function evaluated at 3 months post-surgery,complications and surgeons’***::A total of 81 patients received tumor resection through the retrosigmoid approach under either an exoscope(cases,n=39)or a surgical microscope(control,n=42).Patients in the two groups had comparable tumor location(P=0.439),Koos grading(P=0.867),and composition(P=0.891).While no significant differences in the duration of surgery(P=0.172),extent of tumor resection(P=0.858),facial function(P=0.838),and hearing ability(P=1.000),patients operated on under an exoscope had less blood loss(P=0.036)and a fewer field adjustments(P<0.001).Both primary and assistant surgeons reported a high level of comfort operating under the exoscope(P=0.001 and P<0.001,respectively).Conclusions::The compact high-definition two-dimensional exoscope system provides a safe and efficient means to assist in removing large VSs,as compared to a surgical *** the acquaintance with a visual perception through a dynamic hint and stereoscopically vie

关键词： Vestibular schwannoma Exoscope Telescope video monitor Operating microscope

Genome-wide association study reveals novel loci for adult type 1 diabetes in a 5-year nested case-control study

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World Journal of Diabetes 2021年第12期12卷 2073-2086页

作者： Yan Gao Shi Chen Wen-Yong Gu Chen Fang Yi-Ting Huang Yue Gao Yan Lu jian Su ming Wu Jun Zhang ming Xu Zeng-Li Zhang Department of Occupational and Environmental Health School of Public HealthMedical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Institute of Suzhou Biobank Suzhou Center for Disease Prevention and ControlSuzhou 215004Jiangsu ProvinceChina Department of Public Health Sciences University of North Carolina CharlotteNC 28223United States School of Data Science University of North Carolina CharlotteNC 28223United States Department of Ultrasound The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Endocrinology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Clinical Nutrition The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Clinical Nutrition Department The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Occupational Disease Prevention Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009Jiangsu ProvinceChina Public Health Research Institute of jiangsu Province Nanjing 210009Jiangsu ProvinceChina Department of Chronic Disease Prevention and Control Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009Jiangsu ProvinceChina

BACKGROUND Type 1 diabetes(T1D)is a severe and prevalent metabolic *** to its high heredity,an increasing number of genome-wide association studies have been performed,most of which were from hospital-based case-control studies with a relatively small sample *** association of single nucleotide polymorphisms(SNPs)and T1D has been less studied and is less understood in natural *** To investigate the significant variants of T1D,which could be potential biomarkers for T1D prediction or even *** A genome-wide association study(GWAS)of adult T1D was performed in a nested case-control study(785 cases vs 804 controls)from a larger 5-year cohort study in Suzhou,*** harmful or protective SNPs were evaluated for *** expression and splicing quantitative trait loci(eQTL and sQTL)analyses were carried out to identify target genes modulated by these *** A harmful SNP for T1D,rs3117017[odds ratio(OR)=3.202,95%confidence interval(CI):2.296-4.466,P=9.33×10-4]and three protective SNPs rs55846421(0.113,0.081-0.156,1.76×10-9),rs75836320(0.283,0.205-0.392,1.07×10-4),rs362071(0.568,0.495-0.651,1.66×10-4)were ***-two genes were further identified as potential candidates for T1D *** We identified a potential genetic basis of T1D,both protective and harmful,using a GWAS in a larger nested case-control study of a Chinese population.

关键词： Type 1 diabetes Genome-wide association study Nested case-control study Polymorphism

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中国特色社会主义政治发展道路简析

理论前沿 2008年第14期527卷 26-27页

作者：丁剑贵州警官职业学院政治理论部

在改革开放的实践中,在总结经验教训的基础上,我们已经探索出了一条初步具备成功基础的中国特色政治发展道路。确立了中国特色民主制度模式和中国特色民主发展模式,中国特色政治发展道路已经成为时代的基本共识,具备了自我推进的动力机制。

关键词：中国特色民主制度发展模式