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Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases:From the oral cavity to rectum

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 55-74页

作者： Yang-Che Kuo Lo-Yip Yu Horng-Yuan Wang ming-jen chen ming-Shiang Wu Chun-jen Liu Ying-Chun Lin Shou-Chuan Shih Kuang-Chun Hu Division of Gastroenterology Department of Internal MedicineMacKay Memorial HospitalTaipei 10449TaiwanChina Department of Internal Medicine Healthy Evaluation CenterMackay Memorial HospitalTaipei 10449TaiwanChina Department of Internal Medicine National Taiwan University HospitalTaipei 10051TaiwanChina Department of Internal Medicine Institute of Clinical MedicineNational Taiwan University College of MedicineTaipei 10051TaiwanChina Department of Anesthesia MacKay Memorial HospitalTaipei 10449TaiwanChina Division of Gastroenterology Department of Internal MedicineHealth Evaluate CenterMackay Memorial HospitalTaipei 10449TaiwanChina Department of Internal Medicine Healthy Evaluation CenterMackay Memorial HospitalMacKay Junior College of MedicineNursingand ManagementTaipei 10038TaiwanChina

Helicobacter pylori(***)has infected approximately fifty percent of humans for a long period of ***,improvements in the public health environment have led to a decreased chance of *** ***,a high infection rate is noted in populations with a high incidence rate of gastric cancer(GC).The worldwide fraction of GC attributable to *** is greater than 85%,and a high *** prevalence is noted in gastric mucosa-associated lymphoid tissue lymphoma *** results indicate that the majority of GC cases can be prevented if *** infection is *** *** exhibits oral-oral or fecal-oral transmission,the relationship between this microorganism and other digestive tract malignant diseases has also attracted *** review article provides an overview of *** and the condition of the whole gastrointestinal tract environment to further understand the correlation between the pathogen and the host,thus allowing improved realization of disease presentation.

关键词： Helicobacter pylori Gastrointestinal tract Malignant disease

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A Blade Altering Toolbox for Automating Rotor Design Optimization

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Communications on Applied Mathematics and Computation 2024年第1期6卷 688-704页

作者： Akiva Wernick jen-Ping chen Mechanical and Aerospace Engineering The Ohio State University201 W.19th Ave.ColumbusOH43210USA

The Blade Altering Toolbox(BAT)described in this paper is a tool designed for fast reconstruction of an altered blade geometry for design optimization *** BAT algorithm is capable of twisting a given rotor’s angle of attack and stretching the chord length along the span of the *** test cases were run using the BAT’s *** BAT code’s twisting,stretching,and mesh reconstruction capabilities proved to be able to handle reasonably large geometric alterations to a provided input rotor *** test examples showed that the toolbox’s algorithm could handle any stretching of the blade’s chord as long as the blade remained within the original bounds of the unaltered *** algorithm appears to fail when the net twist angle applied the geometry exceeds approximately 30 degrees,however this limitation is dependent on the initial geometry and other input ***,the algorithm is a very powerful tool for automating a design optimization procedure.

关键词： Mesh reconstruction Mesh alteration Rotor alteration Design optimization

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Impact of COVID-19 on liver

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World Journal of Clinical Cases 2021年第27期9卷 7998-8007页

作者： Yu-Jang Su chen-Wang Chang ming-jen chen Yen-Chun Lai Department of Emergency Medicine MacKay Memorial HospitalTaipei City 10449Taiwan Poison Center Department of Emergency MedicineMacKay Memorial HospitalTaipei City 10449Taiwan Yuanpei University of Medical Technology HsinChu 30015Taiwan MacKay Junior College of Medicine Nursing and ManagementTaipei City 25245Taiwan Department of Medicine MacKay Medical CollegeNew Taipei City 25245Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineMacKay Memorial HospitalTaipei City 10449Taiwan Department of Anesthesiology Taipei Medical University HospitalTaipei City 110301Taiwan Heroic Faith Medical Science Company Taipei 11493Taiwan

The incidence of liver injury after coronavirus disease 2019(COVID-19)infection ranged from 15%-53%.The mechanism includes direct viral cytopathic effect,cytokinesis,and treatment drug-induced liver *** symptoms include nausea,vomiting,diarrhea,and loss of *** laboratory results include increased liver enzyme levels,decreased monocyte count,and longer prothrombin *** most common imaging findings are hepatomegaly on ultrasound,ground-glass opacity on chest computed tomography(CT),and liver hypodensity and pericholecystic fat stranding on abdominal *** may also have different presentations and poor outcomes of different liver diseases concomitant with COVID-19 *** function test(LFT)results should be monitored,and all factors known to cause or predispose liver injury should be investigated while managing the *** risks of transfer to an intensive care unit,need for mechanical ventilator support,and acute kidney injury is higher in COVID-19 patients with than without abnormal *** mortality and length of hospital stay are both observed.

关键词： COVID-19 Fatty liver Liver cirrhosis Hepatitis Hypoalbuminemia Hepatic injury

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Sutured scleral fixation of existing subluxated/dislocated acrylic one-piece intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 665-669页

作者： Wei-Yu Huang Yung-jen chen Department of Ophthalmology Chi Mei Medical CenterTainan City 710TaiwanChina Department of Ophthalmology Chang Gung Memorial HospitalKaohsiung City 833TaiwanChina

AIM:To evaluate the visual and refractive outcomes in cases after sutured scleral fixation of existing subluxated or dislocated acrylic one-piece intraocular lenses(IOLs).METHODS:This study retrospectively enrolled a consecutive series of patients who underwent a surgery of sutured existing subluxated or dislocated IOLs from October 2018 to June *** patients underwent comprehensive preoperative and postoperative ophthalmologic examination,and data were collected including age,sex,surgical indications,best-corrected visual acuity,refractive error,intraocular *** of intraoperative and postoperative surgical complications was ***:A total of 20 consecutive cases were enrolled for analysis with mean final follow-up period 9.8±*** acuity improved from a mean of 0.35(0.46±0.32 logMAR)preoperatively to 0.61(0.21±0.18 logMAR)at the 3-month follow-up(P=0.002).The mean amount of preoperative keratometric astigmatism and total postoperative refractive astigmatism was-1.24±0.80 diopters(D)and-1.42±0.97 D,*** was no statistically significant difference between preoperative and postoperative astigmatism(P=0.156).The mean IOL-induced astigmatism was-0.23±0.53 *** mean spherical equivalent at the 3-month follow-up was-0.1±0.94 *** major complications were noted during the follow-up ***:Surgical techniques using sutured scleral fixation of existing subluxated or dislocated acrylic one-piece IOLs result in favorable visual and refractive outcomes without major complications.

关键词： intraocular lens dislocation intraocular lens subluxation lens dislocation lens subluxation scleral fixation

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Swelling of Spherical Polyelectrolyte Gels

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Chinese Journal of Polymer Science 2024年第9期42卷 1386-1392,I0009页

作者： ming-Yu Duan Jia-Dong chen Yi-ming Liu Zhao-Feng Peng Guang chen Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

Polyelectrolyte(PE)gels,distinguished by their unique stimuli-responsive swelling behavior,serve as the basis of broad applications,such as artificial muscles and drug *** this work,we present a theoretical model to analyze the electrostatics and its contribution to the swelling behavior of PE gels in salt *** minimizing the free energy of PE gels,we obtain two distinct scaling regimes for the swelling ratio at equilibrium with respect to the salt *** compare our predictions for the swelling ratio with experimental measurements,which show excellent *** addition,we employ a finite element method to assess the applicability range of our theoretical model and *** anticipate that our model will also provide valuable insights into drug adsorption and release,deformation of red blood cells,4D printing and soft robotics,where the underlying mechanism of swelling remains enigmatic.

关键词： Gels Polyelectrolytes Swelling Stimuli-responsive Electrostatic interaction Cell model

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Fe-N_(x) sites coupled with core-shell FeS@C nanoparticles to boost the oxygen catalysis for rechargeable Zn-air batteries

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Journal of Energy Chemistry 2024年第3期90卷 565-577,I0013页

作者： Katam Srinivas Zhuo chen Anran chen Fei Ma ming-qiang Zhu Yuanfu chen School of Integrated Circuit Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina

The development of efficient single-atom catalysts(SACs) for the oxygen reduction reaction(ORR)remains a formidable challenge,primarily due to the symmetric charge distribution of metal singleatom sites(M-N_(4)).To address such issue,herein,Fe-N_(x) sites coupled synergistic catalysts fabrication strategy is presented to break the uniform electronic distribution,thus enhancing the intrinsic catalytic ***,atomically dispersed Fe-N_(x) sites supported on N/S-doped mesoporous carbon(NSC)coupled with FeS@C core-shell nanoparticles(FAS-NSC@950) is synthesized by a facile hydrothermal reaction and subsequent *** to the presence of an in situ-grown conductive graphitic layer(shell),the FeS nanoparticles(core) effectively adjust the electronic structure of single-atom Fe sites and facilitate the ORR kinetics via short/long-range coupling ***,FAS-NSC@950displays a more positive half-wave potential(E_(1/2)) of 0.871 V with a significantly boosted ORR kinetics(Tafel slope=52.2 mV dec^(-1)),outpacing the commercial Pt/C(E_(1/2)=0.84 V and Tafel slope=54.6 mV dec^(-1)).As a bifunctional electrocatalyst,it displays a smaller bifunctional activity parameter(ΔE) of 0.673 V,surpassing the Pt/C-RuO_(2) combination(ΔE=0.724 V).Besides,the FAS-NSC@950-based zincair battery(ZAB) displays superior power density,specific capacity,and long-term cycling performance to the Pt/C-Ir/C-based *** work significantly contributes to the field by offering a promising strategy to enhance the catalytic activity of SACs for ORR,with potential implications for energy conversion and storage technologies.

关键词： Fe-N_(x)sites Core-shell FeS@C Synergistic interactions Oxygen reduction reaction Zn-air battery

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Training gastroenterology fellows to perform gastric polypectomy using a novel ex vivo model

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World Journal of Gastroenterology 2011年第41期17卷 4619-4624页

作者： ming-jen chen Ching-Chung Lin Chia-Yuan Liu Chih-jen chen chen-Wang Chang Ching-Wei Chang Chien-Wei Lee Shou-Chuan Shih Horng-Yuan Wang Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Mackay Medicine Nursing and Management College Clinical Skills Training Center Department of Medical EducationMackay Memorial Hospital Mackay Medical College

AIM:To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo ***:Eight gastroenterology fellows at Mackay Memorial Hospital,Taipei were evaluated in gastricpolypectomy techniques using a pig stomach with artificial polyps created by a rubber band ligation *** performance of four second year(year-2)fellows who had undergone one year of clinical training was compared with that of four f irst year(year-1)fellows both before and after a 4-h workshop using the ex vivo *** workshop allowed for hands-on train-ing in the removal of multiple artif icial polyps and the placement of hemoclips at the excision *** included observation of technical skills,procedure time,and the fellows' conf idence ***:One week after the workshop,the year-1 fellows were re-evaluated and had significantly im-proved mean performance scores(from 17.9 ± 1.8 to 22.5 ± 0.7),conf idence scale(from 4.5 ± 1.0 to 7.8 ± 0.5)and procedure time(from 615.0 ± 57.4 s to 357.5 ± 85.0 s)compared with their baseline *** 4 h of training using the ex vivo simulator,the skills of the year-1 fellows were statistically similar to those of the year-2 ***:Use of this ex vivo simulator significantly improved the endoscopic gastric polypectomy skills of gastroenterology fellows who had not had previous clinical training in gastric polypectomy.

关键词：胃肠病学体外模拟技能培训研究员肉模型评估方法模拟器

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QAAS:quick accurate auto-scaling for streaming processing

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Frontiers of Computer Science 2024年第1期18卷 5-15页

作者： Shiyuan LIU Yunchun LI Hailong YANG ming DUN chen chen Huaitao ZHANG Wei LI State Key Laboratory of Software Development Environment Beijing 100191China School of Computer Science and Engineering Beihang UniversityBeijing 100191China School of Cyber Science and Technology Beihang UniversityBeijing 100191China School of Computer Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

In recent years,the demand for real-time data processing has been increasing,and various stream processing systems have *** the amount of data input to the stream processing system fluctuates,the computing resources required by the stream processing job will also *** resources used by stream processing jobs need to be adjusted according to load changes,avoiding the waste of computing *** present,existing works adjust stream processing jobs based on the assumption that there is a linear relationship between the operator parallelism and operator resource consumption(e.g.,throughput),which makes a significant deviation when the operator parallelism *** paper proposes a nonlinear model to represent operator *** divide the operator performance into three stages,the Non-competition stage,the Non-full competition stage,and the Full competition *** our proposed performance model,given the parallelism of the operator,we can accurately predict the CPU utilization and operator *** with actual experiments,the prediction error of our model is below 5%.We also propose a quick accurate auto-scaling(QAAS)method that uses the operator performance model to implement the auto-scaling of the operator parallelism of the Flink *** to previous work,QAAS is able to maintain stable job performance under load changes,minimizing the number of job adjustments and reducing data backlogs by 50%.

关键词： stream processing performance model auto-scaling

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Fault Diagnosis Scheme for Railway Switch Machine Using Multi-Sensor Fusion Tensor Machine

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Computers, Materials & Continua 2024年第6期79卷 4533-4549页

作者： chen chen Zhongwei Xu Meng Mei Kai Huang Siu ming Lo School of Electronic and Information Engineering Tongji UniversityShanghai201804China Department of Architecture and Civil Engineering City University of Hong KongHong KongChina School of Computer Engineering Jimei UniversityXiamen361021China

Railway switch machine is essential for maintaining the safety and punctuality of train operations.A data-driven fault diagnosis scheme for railway switch machine using tensor machine and multi-representation monitoring data is developed *** existing methods,this approach takes into account the spatial information of the time series monitoring data,aligning with the domain expertise of on-site manual ***,a multi-sensor fusion tensor machine is designed to improve single signal data’s limitations in insufficient ***,one-dimensional signal data is preprocessed and transformed into two-dimensional ***,the fusion feature tensor is created by utilizing the images of the three-phase current and employing the CANDE-COMP/PARAFAC(CP)decomposition ***,the tensor learning-based model is built using the extracted fusion feature *** developed fault diagnosis scheme is valid with the field three-phase current *** experiment indicates an enhanced performance of the developed fault diagnosis scheme over the current approach,particularly in terms of recall,precision,and F1-score.

关键词： Railway switch machine tensor machine fault diagnosis

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Data-driven Anomaly Detection Method Based on Similarities of Multiple Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 803-818页

作者： Xiangjun Zeng ming Yang chen Feng mingqiang Wang Lingqin Xia the College of Electrical Engineering&New Energy China Three Gorges UniversityYichang 443002China the Key Laboratory of Power System Intelligent Dispatch and Control Shandong UniversityJinan 250061China

The operating conditions of wind turbines(WTs)in the same wind farm(WF)may share similarities due to their shared manufacturing process,control strategy,and operating ***,the similarities of WTs are seldom considered in WT anomaly detection,resulting in the disregard of useful *** paper proposes a method to improve the reliability and accuracy of WT anomaly detection using the supervisory control and data acquisition(SCADA)data of multiple WTs in the same ***,a similarity assessment method based on a comparison of different observation time series is proposed,which objectively quantifies the similarities of WT operating ***,the SCADA data of the target WT and selected WTs that are similar are used to establish several estimation models through a long short-term memory(LSTM)*** models that exhibit good estimation performance are used to construct a combined estimation model that estimates the variations in the monitored variables of the target ***,an anomaly detection method that jointly compares the effective value and information entropy of the residuals is proposed to identify *** effectiveness and accuracy of the proposed method are verified using the data of two actual WFs.

关键词： Anomaly detection information entropy long short-term memory similarity assessment wind farm wind turbines

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