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甲状腺激素水平与司法精神医学鉴定中交通事故所致颅脑外伤患者的关系

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重庆医学 2024年第S1期53卷 1-5页

作者：蔡政忠 tsai Cheng-chung 韶关学院心理学系广东韶关512005 广东药科大学中药学院广州511400 泰国格乐大学泰国曼谷10220

目的探讨甲状腺激素水平与司法精神医学鉴定中交通事故所致颅脑外伤患者的关系。方法选取2022年5月至2023年5月司法鉴定所进行司法精神医学鉴定为交通事故所致颅脑损伤且存在一定的精神障碍的92例被鉴定人为研究对象,根据其病情将其分... 详细信息

目的探讨甲状腺激素水平与司法精神医学鉴定中交通事故所致颅脑外伤患者的关系。方法选取2022年5月至2023年5月司法鉴定所进行司法精神医学鉴定为交通事故所致颅脑损伤且存在一定的精神障碍的92例被鉴定人为研究对象,根据其病情将其分为边缘精神障碍组(n=41)、轻度精神障碍组(n=35)、中度精神障碍组(n=10)、重度精神障碍组(n=6),另选取就诊的50例非颅脑损伤和精神障碍患者,分别分析不同程度颅脑损伤、精神障碍患者和非精神障碍患者、精神障碍不同等级患者及重度精神障碍患者存活与死亡的甲状腺激素水平、伤残鉴定结果及其与甲状腺激素、精神障碍分级的关系。结果中、重型颅脑损伤组T_(3)、FT_(3)水平均低于轻型颅脑损伤组,且3组T_(3)、FT_(3)水平均随着颅脑损伤程度的加重而呈现出明显下降趋势(P0.05),与精神障碍分级之间有相关性(P<0.05)。结论甲状腺激素T_(3)、FT_(3)水平与颅脑损伤合并精神障碍、精神伤残鉴定结果存在相关性。

关键词：甲状腺激素水平司法精神医学鉴定精神障碍分级交通事故颅脑外伤

Diffusion characteristics of HTO and 99TcO_4^- in compacted Gaomiaozi(GMZ) bentonite

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Nuclear Science and Techniques 2017年第5期28卷 60-67页

作者： Tsuey-Lin tsai Shih-Chin tsai Yu-hung Shih Liang-Cheng Chen Chuan-Pin Lee Te-Yen Su Chemistry Division Institute of Nuclear Energy ResearchNo. 1000 Wenhua Rd. Jiaan Village Longtan DistrictTaoyuan China Nuclear Science and Technology Development Center National Tsing Hua University Hsinchu China Department of Earth Sciences National Cheng Kung University No. 1 University Road Tainan China

The characteristics of diffusion are essential to the transport of radionuclides through buffer/backfill materials, such as bentonite, which are commonly found in waste repositories. This study used through-diffusion techniques to investigate the diffusion behavior of HTO and ^(99)TcO_4^- on GMZ bentonite of various densities. Diffusion rates were calculated by measuring the diffusion coefficients(De, Da), plotting breakthrough curves and interpreting experiment data. The apparent and effective diffusion coefficients of HTO ranged from(1.68 ± 0.40) 9 × 10^(-11) to(2.80 ± 0.62) 9 × 10^(-11) m^2/s and from(4.61 ±1.28) 9 × 10^(-12) to (16.2 ± 2.50) 9 × 10^(-12) m^2/s, *** apparent and effective diffusion coefficients of^(99)TcO_4^-ranged from(5.26 ± 0.16) 9 × 10^-12to(7.78 ± 0.43) 9× 10^-12m^2/s and from(1.49 ± 0.002) 9 × 10^(-12) to(4.16 ±0.07) 9 × 10^(-12) m^2/s, respectively. The distribution coefficients of HTO and^(99)TcO_4^-ranged from(0.70 ± 0.12) 9× 10^(-2) to(1.36 ± 0.53) 9 × 10^(-2) mL/g and from(1.12 ±0.06) 9 × 10^(-2) to(5.79 ± 2.22) 9 × 10^(-2) mL/g, *** Deand Kdvalues were shown to decrease with an increase in the bulk dry density of compacted bentonite. Our results show that HTO and ^(99)Tc could be considered nonsorbent radionuclides. The data obtained in this studyprovide a valuable reference for the safety assessment of waste repositories.

关键词： Distribution coefficient Apparent diffusion coefficient Effective diffusion coefficient Compacted bentonite Through-diffusion

Adaptive PID controller based on Q-learning algorithm

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CAAI Transactions on Intelligence Technology 2018年第4期3卷 235-244页

作者： Qian Shi Hak-Keung Lam Bo Xiao Shun-hung tsai Department of Informatics King’s College LondonBush HouseStrand Campus30 AldwychLondon WC2B 4BGUK Hamlyn Centre for Robotic Surgery Imperial College LondonLondon SW7 2AZUK Graduate Institute of Automation Technology National Taipei University of TechnologyTaipei 10608Taiwan

An adaptive proportional–integral–derivative(PID)controller based on Q-learning algorithm is proposed to balance the cart–pole system in simulation *** controller was trained using Q-learning algorithm and implemented the learned Q-tables to change the gains of linear PID controllers according to the state of the system during the control *** adaptive PID controller based on Q-learning algorithm was trained from a set of fixed initial positions and was able to balance the system starting from a series of initial positions that are different from the ones used in the training session,which achieved equivalent or even better performances in comparison with the conventional PID controller and the controller only uses Q-learning *** indicates the advantage of the adaptive PID controller based on Q-learning algorithm both in the generality of balancing the cart–pole system from a relatively wide range of initial positions and in the stabilisability of achieving smaller steady-state error.

关键词： Adaptive PID the controller

Sub-micron-structure machining on silicon by femtosecond laser

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中国有色金属学会会刊：英文版 2009年第B9期19卷 171-177页

作者： hung-Yin tsai Shao-Wei LUO Chih-Wei WU Shing-Hoa WANG Department of Power Mechanical Engineering National Tsing Hua University Department of Mechanical and Mechatronic Engineering National Taiwan Ocean University

Sub-micron-structure machining on silicon substrate was studied by direct writing system of femtosecond laser with the central wavelength of 800 nm, pulse duration of 120 fs and repetition rate of 1 kHz. Three kinds of experiments were conducted: 1) the effect of photoresist on silicon; 2) machinability of different orientations of silicon; and 3) the size of micro-structure and the cross-section shape. Photoresist SU8 was coated onto silicon substrates in thicknesses of 100 μm. SU8 remained on the silicon substrate while the silicon under the machined SU8 was removed after laser machining. Orientations of (100), (110), and (111) silicon substrates were machined with the laser power of 60 μW and the scanning speed of 3 mm/min. Spike morphologies were observed on all three orientations of silicon substrates without obvious directional difference of these spikes on different silicon substrates. In addition, the ablation threshold energies were also similar. In the consideration of ablation energy, one numerical model of the machining parameters has been proposed to simulate the cross-section of the micro-structure. The predicted shape by simulation can fit the profile of the cross-section shape well.

关键词：亚微米结构激光加工硅基底飞秒激光直接写入断面形状微观结构模拟预测

Targeted tumor coating with antigenic, CTL-recognizable peptides via Annexin A5 chimeric constructs following chemotherapy redirects adaptive CD8+ T cell immunity for tumor clearance

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Cellular & Molecular Immunology 2021年第6期18卷 1578-1580页

作者： Tae Heung Kang Andrew Yang Yachea tsai Louise Ferrall Chien-Fu hung Institute of Biomedical Science and Technology Konkuk UniversitySeoulSouth Korea Genetics and Genomics Graduate Program Baylor College of MedicineHoustonTXUSA Medical Scientist Training Program Baylor College of MedicineHoustonTXUSA Department of Pathology Johns Hopkins UniversityBaltimoreMDUSA Department of Oncology Johns Hopkins UniversityBaltimoreMDUSA

A common drawback of many cancer immunotherapies,including immune checkpoint blockade,is their reliance on the expression of immunogenic tumor antigens by cancer cells for immune recognition and clearance,which limits their efficacy against cancers with weak antigenicity.1 To overcome this obstacle,we and others have explored strategies to harness the immune responses against nontumor antigens and redirect those immune responses to target tumor cells.2,3,4,5 In particular,we have pioneered a therapeutic strategy fusing tumor-targeting proteins with known antigenic peptide epitopes not naturally expressed by tumor cells,which are flanked by peptide sequences that can be recognized and cleaved by proteases overexpressed in most cancers.2,3 This strategy facilitates the targeted delivery of immunogenic peptides into tumor foci,the release of immunogenic peptides into the tumor microenvironment(TME)via tumor protease cleavage,and subsequent loading of these peptides onto major histocompatibility complex class 1(MHC-I)on the tumor cell surface,allowing the recognition of coated tumor cells by the respective peptide-specific cytotoxic CD8+T lymphocytes(CTLs)for elimination.

关键词： immunity overcome coating

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黄明昊青春蒙太奇

大众电影 2024年第7期 66-75,2,3页

作者：李拾齐 Tina tsai(摄影) 不详

上海国际电影节开幕式当晚,夜上海灯火阑珊,群星云集,又是一年盛夏,又有一个个新故事联袂登场。酒店中,我们与黄明昊相见,他刚刚从开幕式现场返回,一身黑西服,英气逼人。采访之前,我们先进行了平面拍摄,记者不小心碰到了手机的音乐播放... 详细信息

上海国际电影节开幕式当晚,夜上海灯火阑珊,群星云集,又是一年盛夏,又有一个个新故事联袂登场。酒店中,我们与黄明昊相见,他刚刚从开幕式现场返回,一身黑西服,英气逼人。采访之前,我们先进行了平面拍摄,记者不小心碰到了手机的音乐播放键,一首韦礼安的《慢慢等》响起,正在拍摄的黄明昊在椅子上忽然抬起手:“这也是我歌单里的歌!”

关键词：上海国际电影节音乐播放蒙太奇相见开幕式

Potential prognostic,diagnostic and therapeutic markers for human gastric cancer

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World Journal of Gastroenterology 2014年第38期20卷 13791-13803页

作者： ming-ming tsai Chia-Siu Wang Chung-Ying tsai Hsiang-Cheng Chi Yi-Hsin Tseng Kwang-Huei Lin Department of Nursing Chang-Gung University of Science and Technology Department of General Surgery Chang Gung Memorial Hospital at Chiayi Department of Biochemistry College of MedicineChang-Gung University

The high incidence of gastric cancer (GC) and its consequent mortality rate severely threaten human health. GC is frequently not diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus, early screening and diagnosis are critical for improving prognoses in patients with GC. Gastroscopy with biopsy is an appropriate method capable of aiding the diagnosis of specific early GC tumor types; however, the stress caused by this method together with it being excessively expensive makes it difficult to use it as a routine method for screening for GC on a population basis. The currently used tumor marker assays for detecting GC are simple and rapid, but their use is limited by their low sensitivity and specificity. In recent years, several markers have been identiﬁed and tested for their clinical relevance in the management of GC. Here, we review the serum-based tumor markers for GC and their clinical significance, focusing on discoveries from microarray/proteomics research. We also review tissue-based GC tumor markers and their clinical application, focusing on discoveries from immunohistochemical research. This review provides a brief description of various tumor markers for the purposes of diagnosis, prognosis and therapeutics, and we include markers already in clinical practice and various forthcoming biomarkers.

关键词： Tumor marker Prognosis Gastric cancer Serum-based Tissue-based

Reduced risk of dementia in patients with type 2 diabetes mellitus using Chinese herbal medicine:A nested case-control study

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World Journal of Diabetes 2023年第11期14卷 1632-1642页

作者： Hou-Hsun Liao Hanoch Livneh Hua-Lung Huang Jui-Yu hung ming-Chi Lu How-Ran Guo Tzung-Yi tsai Department of Chinese Medicine Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi 62247TaiwanChina Graduate Institute of Chinese Medicine School of Chinese MedicineCollege of Chinese MedicineChina Medical UniversityTaichung 404333TaiwanChina Department of Nursing Tzu Chi University of Science and TechnologyHualien 62247TaiwanChina Department of Special and Counselor Education Portland State UniversityPortlandOR 97207United States Department of Rehabilitation Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi 62247TaiwanChina Department of Nursing Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi 62247TaiwanChina Division of Allergy Immunology and RheumatologyDalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi 62247TaiwanChina Department of Environmental and Occupational Health College of MedicineNational Cheng Kung UniversityTainan 70428TaiwanChina Department of Occupational and Environmental Medicine National Cheng Kung University HospitalTainan 70428TaiwanChina Occupational Safety Healthand Medicine Research CenterNational Cheng Kung UniversityTainan 70428TaiwanChina Department of Medical Research Dalin Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationChiayi 62247TaiwanChina

BACKGROUND Dementia is a prevalent condition in type 2 diabetes mellitus(T2DM)*** Chinese herbal medicine(CHM)is often employed as complementary therapy for glycemic control,its effect in controlling likelihood of dementia has not yet been fully *** To compare the risk of dementia between T2DM patients with and without CHM *** We undertook a nested case-control study and obtained data on patients 20-70 years of age who received medical care for T2DM between 2001 and 2010 from the National Health Insurance Research database in ***,defined as those with dementia that occurred at least one year after the diagnosis of T2DM,were randomly matched to controls without dementia from the study cohort at a 1:1 *** applied conditional logistic regression to explore the associations between CHM treatment and *** A total of 11699 dementia cases were matched to 11699 non-dementia *** found that adding CHM to conventional care was related to a lower risk of dementia[adjusted odds ratio(OR)=0.51],and high-intensity CHM treatment was associated with an adjusted OR of *** This study shows that the cumulative CHM exposure was inversely associated with dementia risk in an exposureresponse manner,implying that CHM treatment may be embraced as a disease management approach for diabetic patients to prevent dementia.

关键词： Type 2 diabetes mellitus Dementia Chinese herbal medicine Nested case-control study Odds ratio

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

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World Journal of Stem Cells 2022年第1期14卷 76-91页

作者： Hsi-Lung Hsieh ming-Chin Yu Li-Ching Cheng Ta-Sen Yeh ming-ming tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333Taiwan Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Neurology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of General Surgery Chang Gung Memorial Hospital at LinkouTaoyuan 333Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236Taiwan Department of General Surgery Chang Gung Memorial HospitalChiayi 613Taiwan

Gastric cancer(GC)is a primary cause of cancer-related mortality worldwide,and even after therapeutic gastrectomy,survival rates remain *** presence of gastric cancer stem cells(GCSCs)is thought to be the major reason for resistance to anticancer treatment(chemotherapy or radiotherapy),and for the development of tumor recurrence,epithelial–mesenchymal transition,and ***,GCSCs have the capacity for self-renewal,differentiation,and tumor *** also synthesize antiapoptotic factors,demonstrate higher performance of drug efflux pumps,and display cell plasticity ***,the tumor microenvironment(TME;tumor niche)that surrounds GCSCs contains secreted growth factors and supports angiogenesis and is thus responsible for the maintenance of the growing ***,the genesis of GCSCs is unclear and exploration of the source of GCSCs is *** this review,we provide up-todate information about GCSC-surface/intracellular markers and GCSC-mediated pathways and their role in tumor *** information will support improved diagnosis,novel therapeutic approaches,and better prognosis using GCSC-targeting agents as a potentially effective treatment choice following surgical resection or in combination with chemotherapy and *** date,most anti-GCSC blockers when used alone have been reported as unsatisfactory anticancer ***,when used in combination with adjuvant therapy,treatment can *** providing insights into the molecular mechanisms of GCSCs associated with tumors in GC,the aim is to optimize anti-GCSCs molecular approaches for GC therapy in combination with chemotherapy,radiotherapy,or other adjuvant treatment.

关键词： Gastric cancer stem cells Stem cell-surface markers Tumor niche Tumor microenvironment