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FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma

World Journal of Gastroenterology 2015年第1期21卷 196-213页

作者： Fan-Di Meng Ji-Chao Wei Kai Qu Zhi-Xin Wang Qi-Fei Wu ming-hui tai Hao-Chen Liu Rui-Yao Zhang Chang Liu Department of Hepatobiliary Surgery the First Affiliated HospitalSchool of MedicineXi’an Jiaotong University Department of Thoracic Surgery the First Affiliated Hospital of Xi’an Jiaotong University

AIM: To investigate the expression of forkhead box protein M1(Fox M1) in the process of epithelial mesenchymal transition in hepatocellular carcinoma(HCC) and its role in ***: Fox M1 and E-cadherin expression in HCC tissue microarray specimens was evaluated by immunohistochemical staining,and statistical methods were applied to analyze the correlation between FoxM 1 and epithelial-mesenchymal transition(EMT).KaplanMeier analysis of the correlation between the Fox M1 expression level and recurrence or overall survival of HCC patients was *** expression of FoxM 1,E-cadherin and snail homologue 1(SNAI1) in HCC cell lines was evaluated by real-time reverse transcriptionpolymerase chain reaction and Western *** growth factor(HGF) was used to induce EMT and stimulate cell migration in HCC *** expression of Fox M1 and SNAI1 was regulated by transfection with plasmids pc DNA3.1 and si RNAs in *** occurrence of EMT was evaluated by Transwell assay,morphologic analysis and detection of the expression of EMT markers(E-cadherin and vimentin).Luciferase and chromatin immunoprecipitation assays were used to evaluate whether SNAI1 is a direct transcriptional target of FoxM ***: FoxM 1 expression was increased significantly in HCC compared with para-carcinoma(10.7 ± 0.9 vs 8.2 ± 0.7,P < 0.05) and normal hepatic(10.7 ± 0.9 vs 2.7 ± 0.4,P < 0.05) *** of Fox M1 was correlated with HCC tumor size,tumor number,macrovascular invasion and higher TNM stage,but was negatively correlated with E-cadherin expression in microarray specimens and in cell *** M1 overexpression was correlated significantly with HCC metastasis and *** vitro,we found that FoxM 1 plays a key role in HGF-induced EMT,and overexpression of Fox M1 could suppress E-cadherin expression and induce EMT changes,which were associated with increased HCC cell ***,we confirmed that FOXM1 directly binds to and activates the SNAI1 promot

关键词： Forkhead box protein M1 Hepatocellular carcinoma E

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Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats

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World Journal of Gastroenterology 2014年第6期20卷 1614-1622页

作者： Jing-Yao Zhang Qi-Fei Wu Yong Wan Si-Dong Song Jia Xu Xin-Sen Xu Hu-Lin Chang ming-hui tai Ya-Feng Dong Chang Liu Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center Department of Thoracic Surgery The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center Department of Obstetrics and Gynecology University of Kansas School of Medicine

AIM: To investigate the role of the hydrogen-rich water (HRW) in the prevention of aspirin-induced gastric mucosal injury in rats.

关键词： Hydrogen Aspirin Gastric lesion Oxidative stress Cytokines Cyclooxygenase 2

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Pyogenic liver abscesses associated with nonmetastatic colorectal cancers: An increasing problem in Eastern Asia

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World Journal of Gastroenterology 2012年第23期18卷 2948-2955页

作者： Kai Qu Chang Liu Zhi-Xin Wang Feng Tian Ji-Chao Wei ming-hui tai Lei Zhou Fan-Di Meng Rui-Tao Wang Xin-Sen Xu Department of Hepatobiliary Surgery First AfTfiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To elaborate the clinicopathologic features of colorectal cancer-related pyogenic liver abscess (PLA). METHODS: Reported cases of colorectal cancer-related PLAs were collected from the literature published up to October 2011 and evaluated for their clinicopathologic features. Data of collected cases included demographics, clinical presentation, microbial findings and treatment. Categorical variables were compared by 2 analysis and continuous variables were evaluated using Student's t test. RESULTS: A total 96 cases of colorectal cancer-related PLA were collected from the previous literature. Most patients (60%) were male and 40% cases occurred in the age group of 61-70 years. Apart from some special types of PLA, there were significant differences in the microbiological spectrum between Eastern Asia and non-Eastern Asian countries, which implied different risk factors and courses of the disease. Gram negative bacteria especially Klebsiella pneumoniae (K. pneu- moniae ) PLA was predominant in Eastern Asia (80.0%) in contrast to non-Eastern Asian countries (P < 0.01). Meanwhile, most of the Eastern Asian patients exhibited smaller size of liver abscess and atypical presentation. Sigmoid colon and rectum (72.73%) were the main sites of tumor in Eastern Asian patients, whereas tumor sites were uneven among most of the non-Easter Asian PLA patients. CONCLUSION:K. pneumoniae PLA was strongly associated with colorectal cancer, especially those occurring in sigmoid colon and rectum, in elderly Eastern Asian male patients.

关键词： Colorectal cancer Pyogenic liver abscess Etiology Microbiology Treatment

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Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第25期21卷 7895-7906页

作者： Qing Pang Kai Qu Jian-Bin Bi Su-Shun Liu Jing-Yao Zhang Si-Dong Song Ting Lin Xin-Sen Xu Yong Wan ming-hui tai Hao-Chen Liu Ya-Feng Dong Chang Liu Department of Hepatobiliary Surgery the First Affiliated Hospital of Medical College Xi’an Jiaotong University Department of Obstetrics and Gynecology University of Kansas School of Medicine

AIM: To investigate the association between thrombocytopenia and relapse after treatment for hepatocellular carcinoma(HCC).METHODS: We searched the Pub Med, EMBASE, and Web of Science databases to obtain eligible studies. The hazard ratios(HRs) values and 95% confidence intervals(CIs) were pooled by random effects model. Subsequently, we estimated the heterogeneity, performed a sensitivity analysis, determined the publication bias, and performed subgroup and meta-regression analyses. Study quality was assessed by using the Oxford Center for Evidence Based Medicine ***: We identified 18 eligible studies by retrieval(published during 2000-2014). Out of the 4163 patients with HCC who were recruited, 2746(66.0%) experienced recurrence. In general, our meta-analysis suggested that low platelet count(PLT) before therapy significantly increased the probability of postoperative recurrence(HR = 1.53, 95%CI: 1.29-1.81). PLT was also valuable in the prediction of intrahepatic distant recurrence(HR = 1.49, 95%CI: 1.25-1.77). Subgroupand meta-regression analyses identified various therapeutic modalities as the source of a high degree of heterogeneity. The pooled HR values showed no obvious change when a single study was removed, but otherwise, an opposite-effects model was used. In addition, no significant publication bias was ***: Thrombocytopenia before treatment might be an inexpensive and useful predictor of postoperative recurrence in patients with HCC.

关键词： Hepatocellular carcinoma Blood platelets Thrombocytopenia Recurrence Prognosis

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu ming-hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Machine learning method to predict dynamic compressive response of concrete-like material at high strain rates

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Defence Technology（防务技术） 2023年第5期23卷 100-111页

作者： Xu Long ming-hui Mao Tian-xiong Su Yu-tai Su Meng-ke Tian School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'anChina School of Civil Engineering Liaoning Petrochemical UniversityFushunChina Beijing Microelectronics Technology Institute BeijingChina

Machine learning(ML)methods with good applicability to complex and highly nonlinear sequences have been attracting much attention in recent years for predictions of complicated mechanical properties of various *** one of the widely known ML methods,back-propagation(BP)neural networks with and without optimization by genetic algorithm(GA)are also established for comparisons of time cost and prediction *** the aim to further increase the prediction accuracy and efficiency,this paper proposes a long short-term memory(LSTM)networks model to predict the dynamic compressive performance of concrete-like materials at high strain *** explicit analysis is performed in the finite element(FE)software ABAQUS to simulate various waveforms in the split Hopkinson pressure bar(SHPB)experiments by applying different stress waves in the incident *** FE simulation accuracy is validated against SHPB experimental results from the viewpoint of dynamic increase *** order to cover more extensive loading scenarios,60 sets of FE simulations are conducted in this paper to generate three kinds of waveforms in the incident and transmission bars of SHPB *** training the proposed three networks,the nonlinear mapping relations can be reasonably established between incident,reflect,and transmission *** measures are used to quantify the network prediction accuracy,confirming that the predicted stress-strain curves of concrete-like materials at high strain rates by the proposed networks agree sufficiently with those by FE *** is found that compared with BP network,the GA-BP network can effectively stabilize the network structure,indicating that the GA optimization improves the prediction accuracy of the SHPB dynamic responses by performing the crossover and mutation operations of weights and thresholds in the original BP *** eliminating the long-time dependencies,the proposed LSTM network achieves better results than the BP

关键词： Deep learning LSTM network GA-BP network Dynamic behaviour Concrete-like materials

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Properties of Mechanically Milled Nanocrystalline and Amorphous Mg–Y–Ni Electrode Alloys for Ni–MH Batteries

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Acta Metallurgica Sinica(English Letters) 2015年第7期28卷 826-836页

作者： Yang-Huan Zhang Ze-ming Yuan tai Yang Zhong-hui Hou Dong-Liang Zhao Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and Technology Department of Functional Material Research Central Iron and Steel Research Institute

Nanocrystalline and amorphous Mg2Ni-type Mg20-xYxNi10（x = 0,1,2,3 and 4） electrode alloys were fabricated using mechanical *** effects of the Y content and milling time on the microstructures and electrochemical performances of the alloys were investigated in detail.X-ray diffraction and transmission electron microscopy analyses revealed that the substitution of Y for Mg yields an obvious change in the phase composition and micro morphology of the *** the Y content x ≤ 1,the substitution of Y for Mg does not change the major phase Mg2 Ni,but with a further increase in the Y content,the major phase of the alloys transforms into the YMg Ni4 YMg3 phase.A nanocrystalline and amorphous structure can be obtained by mechanical milling,and the amorphisation degree of the alloy visibly increases with increased milling *** measurements indicate that the discharge capacity of the alloys first increases and then decreases with increasing Y content and milling *** substitution of Y for Mg dramatically ameliorates the cycle stability of the as-milled alloys,and the mechanical milling more or less impairs the cycle stability of the ***,the high rate discharge ability,electrochemical impedance spectrum,Tafel polarisation curves and potential step measurements indicate that the electrochemical kinetic properties of the as-milled alloys first increase and then decrease with increasing Y content and milling time.

关键词： Mg2Ni-type alloy Y substitution for Mg Milling time Electrochemical performance

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IMAGE SEGMENTATION BY PIECEWISE CONSTANT MUMFORD-SHAH MODEL WITHOUT ESTIMATING THE CONSTANTS

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Journal of Computational Mathematics 2006年第3期24卷 435-443页

作者： Xue-cheng tai Chang-hui Yao CIPR Department of Mathematics University of Bergen Norway Department of Mathematics University of Bergen Norway

In this work, we try to use the so-called Piecewise Constant Level Set Method （PCLSM） for the Mumford-Shah segmentation model. For image segmentation, the Mumford-Shah model needs to find the regions and the constant values inside the regions for the segmen- tation. In order to use PCLSM for this purpose, we need to solve a minimization problem using the level set function and the constant values as minimization variables. In this work, we test on a model such that we only need to minimize with respect to the level set function, i.e., we do not need to minimize with respect to the constant values. Gradient descent method and Newton method are used to solve the Euler-Lagrange equation for the minimization problem. Numerical experiments are given to show the efficiency and advantages of the new model and algorithms.

关键词： PCLSM Image Segmentation Mumford-Shah model.

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Densification of MXene films by sequential bridging

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National Science Review 2022年第1期9卷 10-11页

作者： hui-ming Cheng Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

Voids are an essential scientific issue when it comes to traditional composite materials, because they greatly degrade the laer’s properties and usually cause catastrophic failure [1].

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Brainin A,a novel flavanol from Brainea insignis

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Chinese Chemical Letters 2011年第4期22卷 455-457页

作者： ming hui Yang Le Cai Zhi Gang tai Xue Qiong Yang Zhong Tao Ding Key Laboratory of Medicinal Chemistry for Nature Resource Ministry of Education School of Chemical Science and Technology Yunnan University Kunming 650091 China School of Pharmaceutical Sciences and Chemistry Dali University Dali 671000 China

A novel flavanol bearing phenylpropionic acid moiety at C-4 through a C-C bonding,named brainin A（1）,was isolated from the rhizomes of Brainea *** structure was elucidated on the basis of spectral data including 2D ... 详细信息

关键词： Fern Flavanol Brainea insignis Brainin A

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