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Complications and Costs Associated with Initiation of Anti-coagulation Therapy Using Warfarin--An Observation Study

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Journal of Pharmacy and Pharmacology 2015年第6期3卷 262-267页

作者： Jasmine Chiat Ling Ong Seng Han lim Chai Ling Ong Liping Chen Elicia Purnata Edmund Joo Sheng See Joel Cho-Lun Chiang Vivian Shi Yin Wong Loke Khee Siow Jin Shing Hon ming Chai Kong Chi Keong Ching Department of Pharmacy Singapore General Hospital Outram Road Singapore 169608 Singapore Department of Pharmacy National Heart Centre Singapore 5 Hospital Drive Singapore 16960 Singapore Department of Cardiology National Heart Centre Singapore 5 Hospital Drive Singapore 169609 Singapore

To evaluate the safety and cost of anticoagulation therapy in patients newly initiated on warfarin in two institutions in Singapore. All patients newly started on warfarin between December 2011 and May 2012 were recruited and followed up for a period of 6 months. All hospitalization attributed to complications of warfarin therapy, number of INR （international normalized ratio） greater than 4 and total cost of warfarin therapy were collected and analysed. A total of 321 patients were newly initiated on warfarin for standard indications were recruited. At the end of 6 month period, 8.4% of patients were hospitalized for complication related to warfarin therapy. For patients who had stable INR while on warfarin, this rate was almost 2 times lower （3.8% vs 8.4%）. In our study group, patients started on warfarin as inpatients had higher rates of bleeding （15.1% vs 6.7%） and more 1NRs greater than 4 （0.7 per patient vs 0.11 per patient）. The cost of initating warfarin was USD660 over the first 6 months of therapy. Patients newly initiated on warfarin were at a heightened risk of bleeding complications as compared to patients already stable on warfarin therapy. This also translates to considerable costs of warfarin initiation.

关键词： Anticoagulation warfarin initiation complications cost.

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从人间到冥世:宋代冥契文化述论

湖南师范大学社会科学学报 2010年第2期39卷 132-136页

作者：董春林上海师范大学人文与传播学院上海200234

冥契作为中国传统文化里别具特色的现象,以其神秘的文化特质融通于中国人的生存空间。无论是实物冥契,还是口头冥契,在宋代,不仅普遍盛行于民间社会,并且取得官方的认同,其中实物冥契的规范形式一直延续到了晚清。他们在人间与冥世之间... 详细信息

冥契作为中国传统文化里别具特色的现象,以其神秘的文化特质融通于中国人的生存空间。无论是实物冥契,还是口头冥契,在宋代,不仅普遍盛行于民间社会,并且取得官方的认同,其中实物冥契的规范形式一直延续到了晚清。他们在人间与冥世之间建构起一座沟通的虚拟桥梁,对后世造成深远的影响。特别是在其与儒家传统契合的过程中,平衡了宋人各阶层的心态,从而造就了宋代社会相对的稳定。

关键词：宋代人间冥世冥契文化

Electroacupuncture alleviates ciliary muscle cell apoptosis in lens-induced myopic guinea pigs through inhibiting the mitochondrial signaling pathway

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 1942-1951页

作者： Zhao-Hui Yang Jia-Wen Hao Jin-Peng Liu Bo Bao Tu-Ling Li Qiu-Xin Wu ming-Guang He Hong-Sheng Bi Da-Dong Guo Shandong University of Traditional Chinese Medicine Jinan 250014Shandong ProvinceChina Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine Shandong Provincial Clinical Medical Research Center of Optometry and Adolescent Low Vision Prevention and ControlJinan 250002Shandong ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases Shandong Academy of Eye Disease Prevention and TherapyMedical College of Optometry and OphthalmologyShandong University of Traditional Chinese MedicineJinan 250002Shandong ProvinceChina

AIM:To investigate the effect of electroacupuncture(EA)on the mitochondria-dependent apoptotic signaling pathway in the ciliary muscle of guinea pigs with negative lensinduced myopia(lim).METHODS:Guinea pigs were randomly divided into normal control(NC)group,lim group,lim+SHAM acupoint(lim+SHAM)group,and lim+EA *** in the NC group received no intervention,while those in other three groups were covered with-6.0 diopter(D)lenses on right ***,animals in the lim+EA group received EA at Hegu(LI4)combined with Taiyang(EX-HN5)acupoints,while those in the lim+SHAM group were treated at sham *** treatments for 1,2,and 4wk,morphological changes in ciliary muscles were observed with hematoxylin and eosin(H&E)staining and nick end labeling(TUNEL),and the expression of the mitochondrial apoptotic signaling pathway-related molecules in ciliary muscles was measured by real-time quantitative polymerase chain reaction(qPCR)and Western ***,the adenosine triphosphate(ATP)contents were also determined in ciliary ***:Axial length increased significantly in the lim and lim+SHAM groups and decreased in the lim+EA *** ciliary muscle fibers were broken and destroyed in both lim and lim+SHAM groups,whereas those in the lim+EA group improved *** assay showed the number of apoptotic cells increased in the lim and lim+SHAM groups,whereas reduced in the lim+EA *** contents showed a significant decrease in the lim and lim+SHAM groups,whereas increased after EA *** with the NC group,the dynamin-related protein 1(DRP1),Caspase3,and apoptotic protease activator 1(APAF1)levels were significantly increased in the lim group and decreased in the lim+EA ***:The results provide evidence of EA inhibiting the development of myopia by regulating the mitochondrial apoptotic signaling pathway.

关键词： myopia electroacupuncture ciliary muscle apoptosis mitochondrial signaling pathway guinea pigs

不同排列方式和间隙比下双圆柱流致振动特性研究

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海洋工程 2018年第4期36卷 105-113页

作者：刘巨保杨明岳欠杯丁宇奇姚利明东北石油大学机械科学与工程学院黑龙江大庆163318

采用基于ALE的流固耦合分析方法,将圆柱体振动模型简化为平面双自由度质量-弹簧-阻尼系统,进行了计算参数无关性分析。对不同θ角和间隙比T下的双圆柱流致振动进行数值模拟,并与单圆柱振动计算结果进行比较,得到了不同θ角和间隙比T下... 详细信息

采用基于ALE的流固耦合分析方法,将圆柱体振动模型简化为平面双自由度质量-弹簧-阻尼系统,进行了计算参数无关性分析。对不同θ角和间隙比T下的双圆柱流致振动进行数值模拟,并与单圆柱振动计算结果进行比较,得到了不同θ角和间隙比T下中心圆柱的升阻力系数、流场分布和运动轨迹变化情况。通过分析发现小间隙比下由于两圆柱间的相互干扰,改变了中心圆柱的尾涡结构,导致了升力和阻力系数随不同θ角而发生变化;小间隙比下由于两圆柱间的相互干扰影响,均使中心圆柱的轨迹在不同θ角下发生了较大的变化,顺流向的振动频率与单圆柱振动时相比出现了多倍频,导致其运动轨迹发生了变化。

关键词：流致振动双圆柱不同排列间隙比升阻力系数

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三能级原子系统中量子态相干保持的控制策略

控制与决策 2009年第3期24卷 451-454页

作者：李明陈宗海中国科学技术大学自动化系合肥230027

研究光与物质的相互作用并利用其性质设计新型的量子器件,以实现光信息存储及其消相干抑制.分析了以单色激光场为控制场的Λ型三能级原子系统的主方程模型,借助于无消相干子空间的构造方法,通过改变耦合激光场Rabi频率的方式,设计了实... 详细信息

研究光与物质的相互作用并利用其性质设计新型的量子器件,以实现光信息存储及其消相干抑制.分析了以单色激光场为控制场的Λ型三能级原子系统的主方程模型,借助于无消相干子空间的构造方法,通过改变耦合激光场Rabi频率的方式,设计了实现系统中量子态相干保持的控制策略.

关键词：三能级原子系统量子调控相干保持相干控制无消相干子空间

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PEM燃料电池膜电极中的水传输行为

湖南大学学报（自然科学版） 2016年第12期43卷 50-55页

作者：叶东浩詹明潘牧武汉理工大学材料复合新技术国家重点实验室湖北武汉430070 武汉船用电力推进装置研究所湖北武汉430064

为避免电池“水淹”，PEM燃料电池发生电化学反应产生的多余水必须及时排出．基于阴极催化层（CL）与气体扩散层（GDL）之间极易发生的“水淹”特点，建立实验模型，分析阴极催化层产生的水穿透碳纸气体扩散层材料到达气体流道的路径与... 详细信息

为避免电池“水淹”，PEM燃料电池发生电化学反应产生的多余水必须及时排出．基于阴极催化层（CL）与气体扩散层（GDL）之间极易发生的“水淹”特点，建立实验模型，分析阴极催化层产生的水穿透碳纸气体扩散层材料到达气体流道的路径与阻力．在纵向传输过程中，GDL中最大孔中的最小孔径是限制水渗透的主要阻力．只有IV 水头压力足够大时，水才能进入并且穿过这些限制孔径的孔到达GDL材料表面．对于碳纸GDL材料，水在这些孔中流动时所需压力（～1kPa）显著小于水初始穿透这些孔所需压力（～6kPa）．增加微孔层（MPL）会明显增加液态水的穿透阻力，MPL层中不同Teflon含量对水渗透压力影响不大．对碳纸GDL材料设置引导孔能显著降低液态水的渗透压力，有助于提升燃料电池中的水管理能力．

关键词：燃料电池水传输气体扩散层限制孔渗透压力

多棘海盘车诱导排卵最佳KCl剂量以及水温和盐度对胚胎和幼虫发育的影响(英文)

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中国水产科学 2008年第4期15卷 677-682页

作者：康庆浩张志峰邵明瑜林相民金在敏中国海洋大学海洋生命学院山东青岛266003 全南国立大学校海洋技术学部韩国丽水550-749

海星的大量繁殖与入侵可对滩涂养殖贝类造成极大威胁。对海星繁殖生物学的研究可为有效控制海星过度增殖提供信息,同时也可为其胚胎和幼虫培育以及发育生物学的深入研究奠定基础。本研究以韩国和中国沿海常见的多棘海盘车（Asterias amu... 详细信息

海星的大量繁殖与入侵可对滩涂养殖贝类造成极大威胁。对海星繁殖生物学的研究可为有效控制海星过度增殖提供信息,同时也可为其胚胎和幼虫培育以及发育生物学的深入研究奠定基础。本研究以韩国和中国沿海常见的多棘海盘车（Asterias amurensis）为材料,研究KCl诱导海盘车排放生殖细胞的最佳剂量,以及水温和盐度对胚胎和幼虫发育的影响。采用不同剂量（1.0mL、3.0mL、5.0mL和7.0mL）0.5mol/LKCl注入性成熟海盘车体腔,皆可诱导生殖细胞的排放,3mL注射组的排放个体比例最高（80%）,雌性个体排卵量最大（536.5×10^4个/ind）,同时用诱导获得的精/卵进行人工授精后也获得了较高的受精率（92.7±2.9）%。水温和盐度对多棘海盘车胚胎和幼虫的存活率具有显著的影响。在盐度为35时,20℃时多棘海盘车羽腕幼虫的存活率最高（90.1±2.1）%,15℃时次之（84.4±5.2）%。在温度为15℃时,盐度为35时幼虫培养60h后存活率最高（87.6±4.1）%,盐度为30时次之（85.4±4.0）%。多棘海盘车各期胚胎和幼虫的发育速度（1/t,h^-1）随水温升高而加快,在一定温度范围内有明显的正相关性,其关系式为：至2-细胞：1/t=0.1108Tw-0.5997（r^2=0.9465）;至8-细胞：1/t=0.0454Tw-0.2334（r^2=0.9477）;至桑椹胚：1/t=0.0179Tw-0.0679（r^2=0.8687）;至囊胚：1/t=0.0042Tw（r^2=0.89）;至羽腕幼虫：1/t=0.0006Tw-0.0087（r^2=0.8784）。盐度为35时,胚胎和幼虫的发育速度最快,发育至羽腕幼虫需55.4h。根据不同水温和盐度条件下,胚胎和幼虫的存活率和发育速率,确定15-20℃是多棘海盘车发育的适宜温度,最适温度为20℃;适宜盐度为30-35,最适盐度为35。

关键词：多棘海盘车排卵诱导胚胎和幼虫发育 KCl 水温盐度

Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience

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World Journal of Clinical Oncology 2020年第5期11卷 283-293页

作者： Ga-Jing Kee Ryan Ying-Cong Tan Sultana Rehena Joycelyn Jie-Xin Lee Ma Wai-Wai Zaw Wei-Xiang Lian Joe Yeong Su-ming Tan Swee-Ho lim Benita Kiat-Tee Tan Yoon-Sim Yap Rebecca Alexandra Dent Fuh-Yong Wong Guek-Eng Lee Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Division of Medical Oncology National Cancer CentreSingapore 169610Singapore Centre for Quantitative Medicine Duke-NUS Medical SchoolSingapore 169857Singapore Department of Anaesthesiology Singapore General HospitalSingapore 169608Singapore Division of Radiation Oncology National Cancer CentreSingapore 169610Singapore Division of Pathology Singapore General HospitalSingapore 169608Singapore Division of Breast Surgery Changi General HospitalSingapore529889Singapore SingHealth Duke-NUS Breast Centre Singapore 169610Singapore Kandang Kerbau Breast Centre Kandang Kerbau Women’s and Children’s HospitalSingapore 229899Singapore Department of Breast Surgery Singapore General HospitalSingapore 169608Singapore

BACKGROUND Invasive lobular carcinomas(ILC)form 5%-10%of breast cancer and rarely show overexpression of human epidermal growth factor receptor 2(HER2).AIM To describe the prevalence and prognostic factors of HER2 positive(HER2+)ILC in an Asian *** A retrospective review of patients with ILC seen between January 1985 and March 2018 at various SingHealth medical institutions was *** and clinical data were collected from medical *** examined clinicopathological characteristics and survival in relation to HER2 *** A total of 864 patients were *** of HER2 positivity was 10.1%(87 patients).Compared with HER2 negative(HER2-)ILC,HER2+ILC was associated with a higher proportion of estrogen receptor negative(24.4%vs 5.9%,P<0.001),progesterone receptor negative(PR-)(40.2%vs 24%,P=0.002)and grade 3 tumours(Grade 3,29.0%vs 10.2%,P<0.001).Overall survival rate was poorer in patients with HER2+compared to HER2-ILC(56.7%vs 72.9%alive at 10 years;hazard ratio 1.87,95%confidence interval:1.21-2.90,P=0.004).Based on multivariate analysis,negative prognostic factors for overall survival included HER2 positivity,PR negativity,older age,Indian ethnicity and higher tumour *** Prevalence of HER2+ILC was 10.1%.HER2+ILC was more likely to have poorer prognostic features such as estrogen receptor negative,PR-and higher tumour grade,and have a poorer survival.

关键词： Lobular breast cancer Invasive breast cancer Human epidermal growth factor receptor 2 positive Singapore Clinicopathological characteristics Prognostic value

分段供电直线电机切换开关的关断故障在线诊断方法

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电机与控制学报 2018年第12期22卷 1-10页

作者：徐兴华马伟明崔小鹏张明元腾腾海军工程大学舰船综合电力技术国防科技重点实验室武汉430011

针对分段供电直线电机开关的关断故障诊断问题,提出一种在线诊断方法。对分段供电网络的拓扑结构进行了分层,分析关断故障的产生特点,利用电流过零信号占空比与ABC三相电流的局部积分作为故障特征,利用统计分析对正常运行的特征进行了归... 详细信息

针对分段供电直线电机开关的关断故障诊断问题,提出一种在线诊断方法。对分段供电网络的拓扑结构进行了分层,分析关断故障的产生特点,利用电流过零信号占空比与ABC三相电流的局部积分作为故障特征,利用统计分析对正常运行的特征进行了归纳,从而给出异常的判据,通过分析供电频率对故障特征持续时间误差的影响,给出故障定位的方法。最后通过实验对方法进行了验证,实验结果表明:该方法可有效识别分段供电直线电机切换开关的直通故障。

关键词：分段供电切换开关过零信号占空比供电频率