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World Journal of Gastroenterology 2025年第3期31卷 1-10页

作者： ming-hua zheng Amedeo Lonardo Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Internal Medicine Azienda Ospedaliero-Universitaria of Modena(2023)Modena 41126Italy

Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical *** paper published by Dallio et al reports on red cell distribution width(RDW)/platelet ratio(RPR)as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease(MASLD)-related *** from other biomarkers and algorithms,RPR is inexpensive and widely available,based on parameters which are included in a complete blood *** is computed on the grounds of two different items,one of which,RDW,mirrors the host’s response to a variety of disease stimuli and is *** second parameter involved in RPR,platelet count,is more specific and has been used in the hepatological clinic to discriminate cirrhotic from non-cirrhotic chronic liver disease for *** disease is the primary cause of mortality among MASLD subjects,followed by extra-hepatic cancers and liver-related ***,MASLD biomarkers should be validated not only in terms of liver-related events but also in the prediction of major adverse cardiovascular events and cardiovascular mortality and extra-hepatic *** sized multi-ethnic confirmatory investigation is required to define the role and significance of RPR in the stratification of MASLD-cACLD.

关键词： Cirrhosis Liver fibrosis Natural course Prognostication Stratification

Metabolic-associated Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 793-794页

作者： ming-hua zheng NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Key Laboratory of Diag-nosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiangChina

A panel of experts from 22 countries recently proposed a name change from nonalcoholic fatty liver disease(NAFLD)to metabolic-associated fatty liver disease,or MAFLD.1 Sub-sequently,new criteria for diagnosing MAFLD were provided to help guide clinicians in their clinical practice.2 The criteria are based on evidence of hepatic steatosis in the presence of one or more of overweight/obesity,type 2 diabetes,or metabolic dysregulation.3 The proposed novel diagnostic criteria represent a landmark in hepatology that combines our current understanding of obesity,metabolic syndrome and system biology into a single focus.

关键词： obesity hepatic clinical

The uprising of metabolic dysfunction-associated fatty liver disease(MAFLD)in acute-on-chronic liver failure(ACLF)

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 857-859页

作者： Kenneth I.zheng ming-hua zheng NAFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)(1)is currently the leading cause of chronic liver disease in the United States(US)and Europe,and the second leading cause for liver transplantation(2).Despite advancements in knowledge over the past decade,MAFLD-related cirrhosis is the most rapidly growing etiology for acute-on-chronic liver failure(ACLF)in the US(3-5).ACLF is a syndrome characterized by acute deterioration of cirrhosis and extrahepatic failure of 1 or more *** represents a significant healthcare burden,and is associated with high short-term ***,an epidemiology study showed a 3-fold increase in MAFLD-related ACLF waitlisted patients in the United Network for Organ Sharing(UNOS)database from 2005 to 2017(4),and a similar trend was observed in the European Liver Transplant Registry(ELTR)database(5).This is particularly concerning,as the quick rise in MAFLD-related ACLF has created a major gap between the number of patients requiring a liver transplant and the number of available liver donors.

关键词： acute epidemiology organs

LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 452-459页

作者： Zhong-hua Wang Kenneth I zheng Xiao-Dong Wang Jin Qiao Yang-Yang Li Li Zhang ming-hua zheng Jian Wu Department of Medical Microbiology and Parasitology MOE/NHC/CAMS Key Laboratory of Medical Molecular VirologySchool of Basic Medical SciencesFudan University Shanghai Medical CollegeShanghai 200032China NAFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Institute of Hepatology Wenzhou Medical UniversityWenzhou 325000China The Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province Wenzhou 325000China Department of General Practice Huaihai Middle Road Community Health Service Center of Huangpu DistrictShanghai 200025China Department of Pathology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Gastroenterology and Hepatology Zhongshan Hospital of Fudan UniversityShanghai 200032China Laboratory of Fatty Liver and Metabolic Diseases Shanghai Institute of Liver DiseasesFudan University Shanghai Medical CollegeShanghai 200032China

Background: Nonalcoholic fatty liver disease(NAFLD) is one of the main liver diseases, and its pathologic profile includes nonalcoholic fatty liver(NAFL) and nonalcoholic steatohepatitis(NASH). However, there is no reliable non-invasive parameter in distinguishing NASH from NAFL in clinical practice. The present study was to find a non-invasive way to differentiate these two categories of NAFLD via lipidomic analysis. Methods: Lipidomic analysis was used to determine the changes of lipid moieties in blood from 20 NAFL and 10 NASH patients with liver biopsy. Liver histology was evaluated after hematoxylin and eosin staining and Masson’s trichrome staining. The profile of lipid metabolites in correlation with steatosis, inflammation, hepatocellular necroptosis, fibrosis, and NAFLD activity score(NAS) was analyzed. Results: Compared with NAFL patients, NASH patients had higher degree of steatosis, ballooning degeneration, lobular inflammation. A total of 434 different lipid molecules were identified, which were mainly composed of various phospholipids and triacylglycerols. Many lipids, such as phosphatidylcholine(PC)(P-22:0/18:1), sphingomyelin(SM)(d14:0/18:0), SM(d14:0/24:0), SM(d14:0/22:0), phosphatidylethanolamine(PE)(18:0/22:5), PC(O-22:2/12:0), and PC(26:1/11:0) were elevated in the NASH group compared to those in the NAFL group. Specific analysis revealed an overall lipidomic profile shift from NAFL to NASH, and identified valuable lipid moieties, such as PCs [PC(14:0/18:2), PE(18:0/22:5) and PC(26:1/11:0)] or plasmalogens [PC(O-22:0/0:0), PC(O-18:0/0:0), PC(O-16:0/0:0)], which were significantly altered in NASH patients. In addition, PC(14:0/18:2), phosphatidic acid(18:2/24:4) were positively correlated with NAS;whereas PC(18:0/0:0) was correlated positively with fibrosis score. Conclusions: The present study revealed overall lipidomic profile shift from NAFL to NASH, identified valuable lipid moieties which may be non-invasive biomarkers in the categorization o

关键词： Lipidomics Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Biomarker Nonalcoholic activity score Hepatic fibrosis

Manipulation of multi-transparency windows and fast-slow light transitions in a hybrid cavity optomechanical system

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Science China(Physics,Mechanics & Astronomy) 2019年第5期62卷 75-83页

作者： ming-hua zheng Tie Wang Dong-Yang Wang Cheng-hua Bai Shou Zhang Cheng-Shou An Hong-Fu Wang Department of Physics College of Science Yanbian University Department of Physics Harbin Institute of Technology

We study the generation of quadruple-transparency windows and the implementation of a conversion between slow and fast light in a hybrid optomechanical system. By demonstrating the generation of these transparency windows one by one, we analyze the physical mechanism through which each transparency window forms in detail. Additionally, we discuss how the system parameters affect the formation of transparency windows and conclude that the location, width, and absorption of each transparency window can be arbitrarily manipulated by varying the appropriate parameters. Moreover, when the pump field is changed from red to blue detuning, conversions between slow and fast light occur in the output field. These interesting properties of the output field can be applied to achieve the coherent control and manipulation of light pulses using cavity optomechanical system.

关键词： hybrid cavity optomechanical system optomechanical induced transparency fast-slow light

Metabolic(dysfunction)associated fatty liver disease:more evidence and a bright future

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 849-852页

作者： Ting-Yao Wang Jacob George ming-hua zheng Department of Nephrology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia NAFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChina

Recently,metabolic(dysfunction)associated fatty liver disease(MAFLD)has been proposed as a name to replace non-alcoholic fatty liver disease(NAFLD)(1).Controversy over the name is in full swing and evidence-based debate will determine the ***-based medicine is predicated on rigorous scientific data,clinical experience and patient *** how does MAFLD stack up?We briefly summarize the existing evidence and find that MAFLD does hold up to its promise as an advance in the terminology for the disease we all treat.

关键词： NAFLD replace terminology

Recommendations and Clinical Guidance for Children with Metabolic-associated Liver Disease duringthe COVID-19 Pandemic0

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 1-2页

作者： Yong-Hai Zhou Rafael S.Rios Kenneth I.zheng ming-hua zheng Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina MAFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiangChina

The outbreak of coronavirus disease-2019(COVID-19),a new disease caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in December 2019 affected most countries in the world within just a few *** March 11,2020,the Director-General at the World Health Organization(WHO)declared that COVID-19 can be considered a pandemic,and as of January 11,2021,there were over 88.8 million cases of COVID-19 worldwide and 1.9 million deaths reported by *** order to prevent the further spread of this epidemic outbreak,measures such as social distancing,stay-at-home orders,and school closure were executed in many ***,these measures also greatly reduced the opportunities for physical activity among *** on past experience,there are indications that an increased rate of weight gain occurs during summer school vacation for overweight ***,it is reasonable to speculate that under the influence of the COVID-19 epidemic,long-term school closures may significantly increase the risk of weight gain in obese *** children with metabolic-associated fatty liver disease(MAFLD),formerly known as nonalcoholic fatty liver disease,weight reduction through lifestyle changes(caloric restriction and physical activity)is considered as the first step in reversing disease progression,which makes managing MAFLD in children quite difficult during the ongoing COVID-19 *** addition,several studies found a significant correlation between a higher risk of severe illness from COVID-19 and metabolic disorders(***,obesity,MAFLD).

关键词： COVID-19 MAFLD Children

When a new definition overhauls perceptions of MAFLD related cirrhosis care

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 801-804页

作者： Kenneth I.zheng Mohammed Eslam Jacob George ming-hua zheng MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouChina

Metabolic-associated fatty liver disease(MAFLD)(1),formerly known as non-alcoholic fatty liver disease,is a major causes of liver cirrhosis(2).MAFLD represents a growing global health and economic burden since approximately one in four people have the disease(3).As a consequence,MAFLD-related cirrhosis is expected to become the leading cause for liver failure and liver cancer,and the major indication for liver transplantation this century(3).

关键词： cirrhosis MAF Metabolic

Metabolic Acidosis in Critically Ill Cirrhotic Patients with Acute Kidney Injury

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 112-121页

作者： Dan-Qin Sun Lai Zhang Chen-Fei zheng Wen-Yue Liu Kenneth I.zheng Xiao-ming Chen ming-hua zheng Wei-Jie Yuan Department of Nephrology The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiChina Department of Nephrology Shanghai General Hospital of Nanjing Medical UniversityShanghaiChina Department of Nephrology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Zhejiang Engineering Research Center of Intelligent Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province WenzhouChina

Background and Aims:The metabolic acid-base disorders have a high incidence of acute kidney injury(AKI)in critically ill cirrhotic patients(CICPs).The aims of our study were to ascertain the composition of metabolic acidosis of CICPs with AKI and explore its relationship with hospital ***:Three-hundred and eighty consecutive CICPs with AKI were eligible for the cohort ***,clinical and laboratory parameters were recorded and arterial acid-base state was analyzed by the Stewart and Gilfix ***:Net metabolic acidosis,lactic acidosis,acidosis owing to unmeasured anions,acidemia,and dilutional acidosis were less frequent in the non-survival group compared to the survival group of *** presence of acidemia,acidosis owing to unmeasured anions,and lactic acidosis were independently associated with increased risk of intensive care unit 30-day mortality,with hazard ratios of 2.11(95%confidence interval(CI):1.43–3.12),3.38(95%CI:2.36–4.84),and 2.16(95%CI:1.47–3.35),*** full adjustment for confounders,the relationship between acidosis owing to unmeasured anions with hospital mortality was still significant,with hazard ratio of 2.29(95%CI:1.22–4.30).Furthermore,arterial lactate concentration in combination with chronic liver failure-sequential organ failure assessment and BEUMA had the strongest ability to differentiate 30-day mortality(area under the receiver operating characteristic curve:0.79,95%CI:0.74–0.83).

关键词： Metabolic acidosis Critically ill cirrhotic patients Acute kidney injury Hospital morality

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： Chen-Xiao huang Xiao-Dong Zhou Calvin Q Pan ming-hua zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores