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Dapagliflozin in heart failure and type 2 diabetes:Efficacy,cardiac and renal effects,safety

World Journal of Diabetes 2024年第7期15卷 1518-1530页

作者： Pei-Ling Yu You Yu Shuang Li Bai-Chen Mu ming-hua nan Min Pang The Second Department of Cardiology The Second Affiliated Hospital of Liaoning Hospital of Traditional Chinese MedicineShenyang 110034Liaoning ProvinceChina Department of Outpatient The Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110034Liaoning ProvinceChina

BACKGROUND Heart failure(HF),especially HF with reduced ejection fraction(HFrEF),presents complex challenges,particularly in the aging population where it often coexists with type 2 diabetes mellitus(T2DM).AIM To analyze the effect of dapagliflozin treatment on cardiac,renal function,and safety in patients with HFrEF combined with *** Patients with T2DM complicated with HFrEF who underwent treatment in our hospital from February 2018 to March 2023 were retrospectively analyzed as the subjects of this *** propensity score matching method was used,and a total of 102 eligible samples were *** clinical efficacy of the two groups was evaluated at the end of the treatment,comparing the results of blood glucose,insulin,cardiac function,markers of myocardial injury,renal function indexes,and 6-min walk test(6MWT)before and after the *** compared the occurrence of adverse effects on the treatment process of the two groups of *** incidence of adverse outcomes in patients within six months of treatment was *** The overall clinical efficacy rate of patients in the study group was significantly higher than that of patients in the control group(P=0.013).After treatment,the pancreatic beta-cell function index,left ventricular ejection fraction,and glomerular filtration rate of patients in the study group were significantly higher than control group(P<0.001),while their fasting plasma glucose,2-h postprandial glucose,glycosylated hemoglobin,insulin resistance index,left ventricular end-systolic diameter,left ventricular end-diastolic diameter,cardiac troponin I,creatine kinase-MB,N-terminal pro b-type natriuretic peptide,serum creatinine,and blood urea nitrogen were significantly lower than those of the control *** treatment,patients in the study group had a significantly higher 6MWT than those in the control group(P<0.001).Hypoglycemic reaction(P=0.647),urinary tract infection(P=0.558),gastrointestinal adverse effect(P=0.

关键词： Heart failure Type 2 diabetes mellitus Heart failure with preserved ejection fraction Myocardial infarction markers Cardiac function

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin nan Wang Huiqi Sun Luqian Feng hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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参龙煎剂对博来霉素致肺纤维化大鼠肺组织基质金属蛋白酶2与金属蛋白酶组织抑制剂1表达的影响(英文)

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中西医结合学报 2010年第10期8卷 961-967页

作者：吕晓东庞立健王琳琳南明花马智辽宁中医药大学附属第二医院呼吸科辽宁沈阳110034 辽宁中医药大学附属医院呼吸科辽宁沈阳110032

目的:观察博来霉素致肺纤维化大鼠肺组织中基质金属蛋白酶2(matrixmetalloproteinase-2,MMP-2)和金属蛋白酶组织抑制剂1(tissue inhibitor of metallo proteinase-1,TIMP-1)mRNA的表达,探讨中药复方参龙煎剂防治大鼠肺纤维化的作用机制... 详细信息

目的:观察博来霉素致肺纤维化大鼠肺组织中基质金属蛋白酶2(matrixmetalloproteinase-2,MMP-2)和金属蛋白酶组织抑制剂1(tissue inhibitor of metallo proteinase-1,TIMP-1)mRNA的表达,探讨中药复方参龙煎剂防治大鼠肺纤维化的作用机制。方法:230只健康雄性Wistar大鼠随机分为正常对照组、模型组、泼尼松组和参龙煎剂低、中、高剂量组,采用气管内注入博来霉素的方法建立Wistar大鼠肺纤维化模型。正常对照组和模型组大鼠第2日起每日予生理盐水灌胃,其余各组大鼠按配好的参龙煎剂以等容药品灌胃。苏木素-伊红染色和Masson染色观察不同时间点大鼠肺组织病理变化,以评价模型是否成功。逆转录聚合酶链反应检测大鼠肺组织MMP-2和TIMP-1mRNA的表达水平。结果:各组大鼠肺组织在各个时间点均有MMP-2和TIMP-1mRNA表达。与正常对照组大鼠比较,模型组大鼠在第7天时MMP-2和TIMP-1mRNA基因转录水平均显著增高,尤以MMP-2mRNA增加明显,差异均有统计学意义(P<0.05或P<0.01);在第14天时,MMP-2和TIMP-1mRNA的基因转录表达继续增高,但TIMP-1mRNA增加更显著,差异均有统计学意义(P<0.05或P<0.01);第28天时,MMP-2已有所下降,但TIMP-1mRNA表达仍持续性增高,差异均有统计学意义(P<0.05或P<0.01)。与模型组大鼠比较,治疗组大鼠第7天MMP-2和TIMP-1mRNA基因转录水平降低,尤其是MMP-2的表达降低更明显,第28天时这种降低作用仍持续存在,以参龙煎剂中剂量组大鼠表现最明显,差异均有统计学意义(P<0.05或P<0.01)。结论:参龙煎剂可能是通过上调TIMP-1mRNA的表达来抑制MMP-2mRNA表达水平,从而起到延缓肺纤维化的作用。

关键词：肺纤维化博来霉素基质金属蛋白酶2 金属蛋白酶组织抑制剂1 大鼠

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西山岛游客构成与行为分析

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铁道师院学报 2000年第2期17卷 21-29页

作者：黄明华伍燕南苏州铁道师范学院地理系苏州215009

西山岛游客主要源于周边地区 ,具明显的季节性和空间分布规律。调查显示 ,西山旅游资源丰富 ,但旅游服务等满意率较低。今后西山岛应加强促销 ,强化政府调控力度 ,保护自然环境 ;同时 ,提高产品与旅游服务的质量 ;发展农业旅游、生态旅... 详细信息

西山岛游客主要源于周边地区 ,具明显的季节性和空间分布规律。调查显示 ,西山旅游资源丰富 ,但旅游服务等满意率较低。今后西山岛应加强促销 ,强化政府调控力度 ,保护自然环境 ;同时 ,提高产品与旅游服务的质量 ;发展农业旅游、生态旅游、观光度假旅游等 ,满足旅游者的需求。

关键词：西山岛游客构成游客行为分析旅游业苏州市

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Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

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World Journal of Gastroenterology 2007年第8期13卷 1214-1220页

作者： ming-Fu Yin Li-hua Lian Dong-ming Piao Ji-Xing nan Key Laboratory of Organism Functional Factors of the Changbai Mountain (Yanbian University) Ministry of Education and College of Pharmacy Yanbian University Yanji 133002 Jilin Province China College of Pharmacy Yanbian University Yanji 133002 Jilin Province China Department of Pathology the Affiliated Hospital Medical College Yanbian University Yanji 133002 Jilin Province China

AIM： To investigate the therapeutic effect of tetrandrine on liver fibrosis induced by thioacetamide in rats in vivo and in vitro. METHODS： In vitro study： we investigated the effect of tetrandrine on the apoptosis of rat hepatic stellate cells transformed by simian virus 40 （T-HSC/CI-6）, which retains the features of activated cells. In vivo study： hepatic fibrosis was induced in rats by thioacetamide. Tetrandrine was given orally to rats at doses of 5, 10 or 20 mg/kg for 4 wk compared with intraperitoneal injection of interferon-r. RESULTS： In vitro study： 5, 10 or 25 μg/mL of tetrandrine-induced activation of caspase-3 in t-HSC/CI-6 cells occurred dose-dependently. In vivo study： tetrandrine treatment as well as interferon-r significantly ameliorated the development of fibrosis as determined by lowered serum levels of aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, total bilirubin （T-Bil） and the levels of liver hydroxyproline （Hyp）, hyaluronic acid （HA）, laminin （LN） and also improved histological findings. The effects of tetrandrine at the concentration of 20 mg/kg were better than the other concentration groups. CONCLUSION： Tetrandrine promotes the apoptosis of activated HSCs in vitro. Tetrandrine administration can prevent liver fibrosis and liver damage induced by thioacetamide in rats in vivo, indicating that it might exert a direct effect on rat HSCs.

关键词： Tetrandrine Apoptosis Caspase-3 Liver fibrosis Thioacetamide

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高校学生基层党建品牌建设的探索与研究——以大连海洋大学“红·绿·蓝——海洋先锋工程”为例

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大连大学学报 2017年第4期38卷 136-139页

作者：王磊田鸽张铭化孙艳楠季洪宇大连海洋大学海洋科技与环境学院辽宁大连116023

高校基层党建工作质量决定高校育人质量。培育特色鲜明、具有长效性和影响力的党建项目品牌,用品牌项目凝聚、感染青年学生,创新党建工作模式,可提升高校党建工作的影响力与实效性。大连海洋大学海洋科技与环境学院自2012年起启动了"红... 详细信息

高校基层党建工作质量决定高校育人质量。培育特色鲜明、具有长效性和影响力的党建项目品牌,用品牌项目凝聚、感染青年学生,创新党建工作模式,可提升高校党建工作的影响力与实效性。大连海洋大学海洋科技与环境学院自2012年起启动了"红绿蓝——海洋先锋工程",致力于学生党建工作的品牌建设,目前成效初显,已荣获2015-2016年度辽宁省高校党的基层组织建设创新成果一等奖;2013-2015年大连市高校优秀基层党建品牌荣誉称号等多项荣誉。本文以学生党建品牌项目"红绿蓝——海洋先锋工程"建设情况的实践为例,探讨高校学生党建工作品牌项目建设的探索与实践。

关键词：高校党建工作品牌建设探索实践

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Application of Helical Strakes for Suppressing the Flow-Induced Vibration of Two Side-by-Side Long Flexible Cylinders

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China Ocean Engineering 2020年第2期34卷 172-184页

作者： XU Wan-hai YANG Meng AI hua-nan HE ming LI Mu-han State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Hydro Science&Engineering Taiyuan University of TechnologyTaiyuan 030024China

Helical strakes have been widely applied for suppressing the vibration of flexible cylinders undergoing vortexshedding in offshore ***,most research works have concerned on the application of helical strakes for the isolated flexible cylinder subjected to vortex-induced vibration(VIV).The effectiveness of helical strakes attached to side-by-side flexible cylinders in vibration reduction is still *** this paper,the response characteristics of two side-by-side flexible cylinders with and without helical strakes were experimentally investigated in a towing *** configuration of the helical strakes used in the experiment had a pitch of 17.5D and a height of 0.25D(where D is the cylinder diameter),which is usually considered the most effective for VIV suppression of isolated marine risers and *** center-to-center distance of the two cylinders was *** uniform flow with a velocity ranging from 0.05 m/s to 1.0 m/s was generated by towing the cylinder models along the *** results,including the displacement amplitude,the dominant frequency,the dominant mode,and the mean drag force coefficient,were summarized and *** the case where only one cylinder in the two-cylinder system had helical strakes,the experimental results indicated that helical strakes can remarkably reduce the flow-induced vibration(FIV)of the staked *** the case of two straked cylinders in a side-by-side arrangement,it was found that the performance of helical strakes in suppressing the FIV is as good as that for the isolated cylinder.

关键词： side-by-side FIV reduction helical strakes flexible cylinder center-to-center distance

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Theoretical design of new bridge-ring insensitive high energy compounds by selected normal Diels-Alder reactions between NH_(2)-substituted oxazoles and NO_(2)/NF_(2)/NHNO_(2)-substituted ethylenes/acetylenes

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Defence Technology（防务技术） 2021年第5期17卷 1731-1739页

作者： Qiong Wu Qin-nan Hu ming-quan Li Ze-wu Zhang Wei-hua Zhu Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology1 Hongjing RoadNanjing211167China Institute for Computation in Molecular and Materials Science and Department of Chemistry Nanjing University of Science and TechnologyNanjing210094China

In this work,NH_(2)-substituted oxazoles and NO_(2)/NF_(2)/NHNO_(2)-substituted ethylenes/acetylenes were designed and used as dienes and dienophiles,respectively,in order to develop new bridge-ring insensitive high energy compounds through the Diels-Alder reaction between *** reaction type,reaction feasibility and performance of reaction products were investigated in detail *** results showed that dienes most possibly react with dienophiles through the HOMO-diene controlled normal Diels-Alder reaction at relatively low energy *** could react with the designed dienes much more easily than other dienophiles,and was employed to further design 29 new bridge-ring energetic *** to high heat of formation,density and oxygen balance,all designed bridge-ring energetic compounds have outstanding detonation performance,16 of them have higher energy than HMX(1,3,5,7-tetranitro-1,3,5,7-tetrazocine)and 2 others even possess comparative energy with the representative of high energy compounds CL-20(2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane).The predicted average h50 value of these bridge-ring energetic compounds is 83 cm,showing their low impact *** NH2 groups could obviously impel the proceeding of Diels-Alder reactions,but would slightly decrease the energy and sensitivity *** all,the new designed bridge-ring compounds have both high energy and low sensitivity,and may be produced through Diels-Alder reactions at relatively low energy *** paper may be helpful for the theoretical design and experiment synthesis of new advanced insensitive high energy compounds.

关键词： Diels-Alder Energetic compounds Oxazole High energy Insensitive

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Organic Nonlinear Optical Crystal MHBA for Compact Blue-Violet Laser

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Chinese Physics Letters 1996年第11期13卷 841-843页

作者： YUAN Duo-rong XU Dong ZHANG nan LIU ming-guo JIANG Min-hua Institute of Crystal materials and National Laboratory of Crystal MaterialsShandong UniversityJi’nan 250100

By using a 3-methoxy-4-hydroxy-benzaldehyde(MHBA)crystal as frequency doubler at room temperature,an efficient blue light output for near IR automatic tunable picosecond parametric laser is obtained,and blue-violet light output by frequency doubling of GaAlAs laser diode is also realized.A 404.5nm light,with output power of 3μW is generated from the 1W input power of a 809 nm GaAlAs laser diode on a MHBA crystal device which is 3 mm thick at the phase matching angles ofθ=90°,ψ=15°.

关键词： tunable Crystal MHBA

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Tunable perpendicular anisotropic magnetoresistance in CoO/Co/Pt heterostructures

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Rare Metals 2023年第2期42卷 579-584页

作者： Qian-Qian Liu Guang Yang Jing-Yan Zhang Guo-nan Feng Chun Feng Qian Zhan ming-hua Li Guang-hua Yu Department of Materials Physics and Chemistry University of Science and Technology BeijingBeijing100083China

Transport properties of magnetron-sputtered CoO/Co/Pt heterostructures were investigated by physical property measurement *** types of magnetoresistance are observed in the heterostructures,including isotropic anisotropic magnetoresistance(AMR),AMR with geometric size effect,and interfacial effect.A reversal in sign of perpendicular AMR is found in the film CoO(3 nm)/Co(3 nm)/Pt(3 nm)compared to the film CoO(3 nm)/Co(3 nm)/CoO(3 nm),which is associated with ***,perpendicular AMR is tunable in the films CoO(3 nm)/Co(3 nm)/CoO(t)/Pt(3 nm)and CoO(3 nm)/Co(3 nm)/Pt(t)/CoO(3 nm)at will,with either positive or negative value,by varying the inserting layer *** electronic structure information of the samples was measured by X-ray photoelectron spectroscopy(XPS).The spin-related transport and XPS results manifest that magnetic proximity effect,surface scattering,together with oxygen migration contribute to the tunable function of Pt.

关键词： Perpendicular anisotropic magnetoresistance Magnetic proximity effect Surface scattering X-ray photoelectron spectroscopy

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