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Detection of Stage I nasopharyngeal carcinoma by serologicscreening and clinical examination

Chinese Journal of Cancer 2011年第2期30卷 120-123页

作者： ming-fang ji Yuan-Long Yu Wei-ming Cheng Yong-Sheng Zong Park Sze-Park Ng Daniel Tsin-Tien Chua Mun-Hon Ng Cancer Research Institute of Zhongshan City Zhongshan Guangdong 528403 P R China Department of Pathology Sun Yat-sen Medical College Sun Yat-sen University Guangzhou Guangdong 510080 P. R. China Department of Microbiology Faculty of Medicine The University of Hong Kong Hong Kong SAR P. R. China Department of Clinical Oncology Faculty of Medicine The University of Hong Kong Hong Kong SAR P. R. China

In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed nasopharyngeal carcinoma (NPC). Although Epstein-Barr virus (EBV) antibody levels of the cohort fluctuated, the antibody levels of 93% of the patients with NPC were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor tumor progression during the preclinical stage of NPC development, facilitating early NPC detection. We reviewed the clinical records of the 171 patients with NPC in the prospective study to assess the efficacy of early NPC detection by serologic screening and clinical examination. Of the 171 patients, 51 had Stage I tumor (44 were among the 73 patients detected by clinical examination and 7 were among the 98 patients presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 patients detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I tumor. The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I tumors among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop.

关键词：血清学检测临床检查鼻咽癌筛查一阶全国人民代表大会抗体水平 EB病毒

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Incidence and mortality of liver cancer in China, 2010

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Chinese Journal of Cancer 2014年第8期33卷 388-394页

作者： Kuang-Rong Wei Xia Yu Rong-Shou Zheng Xia-Biao Peng Si-Wei Zhang ming-fang ji Zhi-Heng Liang Zhi-Xiong Ou Wan-Qing Chen Cancer Institute Zhongshan Municipal People’s HospitalZhongshan Guangdong National Central Cancer Registry National Cancer CenterBeijing Digestive Internal Department Zhongshan Municipal People’s HospitalZhongshan Guangdong

Liver cancer is a common malignant tumor in China and a major health concern. We aimed to estimate the liver cancer incidence and mortality in China in 2010 using liver cancer data from some Chinese cancer registries and provide reference for liver cancer prevention and treatment. We collected and evaluated the incidence and mortality data of liver cancer in 2010 from 145 cancer registries, which were included in the 2013 Chinese Cancer Registry Annual Report, calculated crude, standardized, and truncated incidences and mortalities, and estimated new liver cancer cases and deaths from liver cancer throughout China and in different regions in 2010 from Chinese practical population. The estimates of new liver cancer cases and deaths were 358,840 and 312,432, respectively, in China in 2010. The crude incidence, age-standardized rate by Chinese standard population(ASR China), and age-standardized rate by world standard population(ASR world) were 27.29/100,000, 21.35/100,000, and 20.87/100,000, respectively; the crude, ASR China, and ASR world mortalities were 23.76/100,000, 18.43/100,000, and 18.04/100,000, respectively. The incidence and mortality were the highest in western regions, higher in rural areas than in urban areas, and higher in males than in females. The age-specific incidence and mortality of liver cancer showed a rapid increase from age 30 and peaked at age 80-84 or 85+. Our results indicated that the 2010 incidence and mortality of liver cancer in China, especially in undeveloped rural areas and western regions, were among high levels worldwide. The strategy for liver cancer prevention and treatment should be strengthened.

关键词：中国标准死亡率肝癌世界人口死亡病例恶性肿瘤西部地区农村地区

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Inhibitory effect of IGF-Ⅱ antisense RNA on malignant phenotype of hepatocellular carcinoma

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World Journal of Gastroenterology 2000年第2期6卷 266-267页

作者： Dong Hua Yang ming Qing Zhang jiang Du Chong Xu Oiao ming Liang ji fang Mao Han Rong Qin Zi Rong Fan Department of Gastroenterology,Zhujiang Hospital,the First Military Medical University,Guangzhou 510282,China Laboratory of Molecular Biology,Zhujiang Hospital,the First Military Medical University,Guangzhou,China Departrnent of Biochemistry,the Second Military Medical University,Shanghai,China 第一军医大学广东广州

INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression *** constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱ*** biological behavior changes ofhepatoma cells were *** these

关键词： carcinoma hepatocellular insulin-like growth factor Ⅱ genes suppressor tumor RNA antisense liver neoplasms

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型钢混凝土中高剪力墙的抗震性能

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深圳大学学报（理工版） 2012年第1期29卷 38-44页

作者：方明霁李国强李一松上海师范大学建筑工程学院上海200043 同济大学土木工程学院上海200092 同济大学建筑设计研究院上海200092

在单调和低周反复荷载作用下进行4榀1/3～1/4缩尺模型的中高混凝土剪力墙的对比试验,包括1榀普通钢筋、1榀内置型钢框架和2榀内置型钢桁架.结果表明,带型钢内置框架剪力墙的耗能能力远优于纯钢筋混凝土剪力墙,斜向支撑使试件的抗震能力... 详细信息

在单调和低周反复荷载作用下进行4榀1/3～1/4缩尺模型的中高混凝土剪力墙的对比试验,包括1榀普通钢筋、1榀内置型钢框架和2榀内置型钢桁架.结果表明,带型钢内置框架剪力墙的耗能能力远优于纯钢筋混凝土剪力墙,斜向支撑使试件的抗震能力进一步提高;与纯钢筋混凝土相比,型钢支撑框架混凝土剪力墙的极限荷载提高约25%,极限位移提高约29%,耗能提高约36%;内置型钢框架和型钢桁架可不同程度地提高普通剪力墙的后期刚度,减小墙体的层间位移,改善墙体的破坏形态.

关键词：结构工程高层建筑结构设计型钢混凝土中高剪力墙桁架抗震性能

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基于多弹簧模型的空间梁柱单元(II):参数分析

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计算力学学报 2008年第1期25卷 134-138页

作者：李国强方明霁孙飞飞张强同济大学土木工程学院上海200092 上海师范大学建筑工程学院上海201418

为模拟地震作用时杆件在变动轴力和双向弯曲的耦合特点,基于简化纤维模型的多弹簧单元模型近年被广泛应用。本文作者在相关论文中提出了考虑剪切变形弹塑性刚度影响的多弹簧模型空间梁柱单元,杆件的计算模拟精度除了取决于单元模型之外... 详细信息

为模拟地震作用时杆件在变动轴力和双向弯曲的耦合特点,基于简化纤维模型的多弹簧单元模型近年被广泛应用。本文作者在相关论文中提出了考虑剪切变形弹塑性刚度影响的多弹簧模型空间梁柱单元,杆件的计算模拟精度除了取决于单元模型之外,还决定于两个重要参数:弹簧位置及个数布置、塑性区长度,本文将针对其进行参数分析并提出合理建议取值。本文最后还提出了模拟杆件残余应力的合理弹簧布置方式。

关键词：多弹簧模型剪切变形塑性区长度弹簧布置

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大跨度钢桁架拱桥的极限承载力研究

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世界桥梁 2010年第4期38卷 35-38页

作者：方明霁孙海涛同济大学上海200092 上海市政工程设计研究总院上海200092

在强地震设防区或桥梁承受铁路荷载且地质条件良好时,钢桁架拱桥是理想的大跨度桥梁选择方案。以朝天门大桥和大宁河大桥为背景,从边界条件、初始状态、荷载要素等几个关键影响参数着手,对大跨度钢桁架拱桥的极限承载能力进行参数研究,... 详细信息

在强地震设防区或桥梁承受铁路荷载且地质条件良好时,钢桁架拱桥是理想的大跨度桥梁选择方案。以朝天门大桥和大宁河大桥为背景,从边界条件、初始状态、荷载要素等几个关键影响参数着手,对大跨度钢桁架拱桥的极限承载能力进行参数研究,指出活载的布置形式、侧向风荷载及不同的约束条件对钢桁架拱桥的极限承载力有较大影响。

关键词：大跨度桥梁钢桁架拱桥极限承载力 Arch Span Long Ultimate Carrying Capacity 极限承载能力铁路荷载朝天门大桥约束条件影响参数选择方案地质条件初始状态参数研究布置形式边界条件强地震风荷载

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen ji Yu Chen Zheng Shan Huang ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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干旱胁迫对结缕草叶绿素荧光和光合关键酶活性的影响

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草地学报 2016年第6期24卷 1304-1308页

作者：胡化广张振铭季芳芳刘建秀盐城师范学院海洋与生物工程学院江苏盐城224051 江苏省中国科学院植物研究所(南京中山植物园) 江苏南京210014

在对中国结缕草属(Zoysia Willd.)植物53份种源水分利用效率评价的基础上,以高水分利用效率种源Z110和低水分利用效率种源Z132作为试验材料,对其干旱胁迫过程中叶绿素荧光特征、光合关键酶核酮糖二磷酸(RuBP)羧化酶和磷酸烯醇式丙酮酸(P... 详细信息

在对中国结缕草属(Zoysia Willd.)植物53份种源水分利用效率评价的基础上,以高水分利用效率种源Z110和低水分利用效率种源Z132作为试验材料,对其干旱胁迫过程中叶绿素荧光特征、光合关键酶核酮糖二磷酸(RuBP)羧化酶和磷酸烯醇式丙酮酸(PEP)羧化酶的活性进行了研究。结果表明,在干旱胁迫过程中,两份结缕草种源的叶绿素初始荧光(Fo)、非光化学猝灭系数(qN)逐渐增加;叶绿素最大荧光(Fm),PSⅡ实际光化学效率Yield,叶片表观光合电子传递速率ETR,PSⅡ光化学猝灭系数(qP),RuBP羧化酶和PEP羧化酶活性逐渐降低。在干旱胁迫过程中,除种源Z110叶绿素Fo小于Z132的叶绿素Fo外,其他参数均大于Z132,说明干旱胁迫对Z132的光合作用影响较大,Z110对干旱胁迫表现出较强的的适应能力。

关键词：干旱胁迫结缕草叶绿素荧光光合关键酶

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离子交换树脂膜吸附土壤养分的动力学研究

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土壤肥料 2002年第4期 15-18页

作者：程明芳金继运中国农业科学院土壤肥料研究所北京100081

采用从英国进口的离子交换树脂膜和室内埋置法研究了取自河北玉田县的 4个土壤吸附土壤磷、钾、钙、镁和锰的动力学。结果表明 ,在 0 .5～ 2 4h的吸附时间内 ,随着提取时间的延长 ,树脂膜吸附的土壤磷、钙量和锰量显著增加 ,而吸附的钾... 详细信息

采用从英国进口的离子交换树脂膜和室内埋置法研究了取自河北玉田县的 4个土壤吸附土壤磷、钾、钙、镁和锰的动力学。结果表明 ,在 0 .5～ 2 4h的吸附时间内 ,随着提取时间的延长 ,树脂膜吸附的土壤磷、钙量和锰量显著增加 ,而吸附的钾量减少。

关键词：离子交换树脂膜土壤养分吸附动力学室内埋置法

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan fang Li-Hui Li ming-Qian He Yue ji Dong-Yan Lu Li-Bing Zhang jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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