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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui li Nai-Kui liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

骨髓增生异常综合征患者淋巴细胞绝对值计数与地西他滨治疗反应的关系

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解放军医学杂志 2018年第3期43卷 239-243页

作者：庞艳彬赵松颖薛华郭慧敏化罗明范丽霞罗建民杜欣河北大学附属医院血液内科河北保定071000 河北医科大学第二医院血液内科石家庄050000 广东省人民医院/广东省医学科学院华南理工大学医学院第一临床医院血液内科广州510080

目的探计第1疗程地西他滨(DAC)治疗后骨髓增生异常综合征(MDS)患者淋巴细胞计数与患者对DAC治疗反应的关系。方法研究对象为2014年1月-2016年12月在河北大学附属医院血液科接受过DAC治疗的MDS和MDS继发的急性髓系白血病(AML)患者35例。... 详细信息

目的探计第1疗程地西他滨(DAC)治疗后骨髓增生异常综合征(MDS)患者淋巴细胞计数与患者对DAC治疗反应的关系。方法研究对象为2014年1月-2016年12月在河北大学附属医院血液科接受过DAC治疗的MDS和MDS继发的急性髓系白血病(AML)患者35例。根据第1个疗程DAC治疗后28~35d血常规中的淋巴细胞计数,将患者分为高淋巴细胞组(H-Lym组,淋巴细胞计数≥1.2×10~9/L)和低淋巴细胞组(L-Lym组,淋巴细胞计数0.05),两组基线资料中仅骨髓原始细胞≥10%的患者比例的差异有统计学意义(P0.05),而L-Lym组则明显低于诊断时的水平(P<0.05)。H-Lym组总反应率(80.0%)明显高于L-Lym组(40.0%),差异有统计学意义(P<0.05)。H-Lym组的中位PFS为10个月,L-Lym组为7.6个月,两组差异有统计学意义(P<0.05)。单因素分析结果显示,淋巴细胞计数绝对值低是MDS疾病进展的预后因素(P<0.05)。结论第1疗程DAC治疗后淋巴细胞计数≥1.2×10~9/L的患者具有较高的总反应率和较长的无进展生存期。

关键词：地西他滨骨髓增生异常综合征淋巴细胞无进展生存期

Magnesium based degradable biomaterials： A review

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Frontiers of Materials Science 2014年第3期8卷 200-218页

作者： Xue-Nan GU Shuang-Shuang li Xiao-ming li Yu-Bo fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

Magnesium has been suggested as a revolutionary biodegradable metal for biomedical applications. The corrosion of magnesium, however, is too rapid to match the rates of tissue healing and, additionally, exhibits the localized corrosion mechanism. Thus it is necessary to control the corrosion behaviors of magnesium for their practical use. This paper comprehensively reviews the research progress on the development of representative magnesium based alloys, including Mg-Ca, Mg-Sr, Mg-Zn and Mg-REE alloy systems as well as the bulk metallic glass. The influence of alloying element on their microstructures, mechanical properties and corrosion behaviors is summarized. The mechanical and corrosion properties of wrought magnesium alloys are also discussed in comparison with those of cast alloys. Furthermore, this review also covers research carried out in the field of the degradable coatings on magnesium alloys for biomedical applications. Calcium phosphate and biodegradable polymer coatings are discussed based on different preparation techniques used. We also compare the effect of different coatings on the corrosion behaviors of magnesium alloys substrate.

关键词： magnesium alloy degradable biomaterial coating degradation corrosion

Proliferating cell nuclear antigen clamp associated factor,a potential proto-oncogene with increased expression in malignant gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1425-1439页

作者： li-Juan liu Jian-ming liao fan Zhu State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy&Immunology Department of Medical MicrobiologySchool of MedicineWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Neurosurgery Renmin HospitalWuhan UniversityWuhan 430060Hubei ProvinceChina

Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI *** investigation into the potential molecular targets of prediction,diagnosis,prognosis,and therapy in GI cancers is urgently *** cell nuclear antigen(PCNA)clamp associated factor(PCLAF),which plays an essential role in cell proliferation,apoptosis,and cell cycle regulation by binding to PCNA,is a potential molecular target of GI cancers as it contributes to a series of malignant properties,including tumorigenesis,epithelial-mesenchymal transition,migration,and ***,PCLAF is an underlying plasma prediction target in colorectal cancer and liver *** addition to GI cancers,PCLAF is also involved in other types of cancers and autoimmune *** pivotal pathways,including the Rb/E2F pathway,NF-κB pathway,and p53-p21 cascade,are implicated in PCLAF-mediated *** also contributes to some diseases through dysregulation of the p53 pathway,WNT signal pathway,MEK/ERK pathway,and PI3K/AKT/mTOR signal *** review mainly describes in detail the role of PCLAF in physiological status and GI *** signaling pathways involved in PCLAF are also *** of the interaction of PCLAF/PCNA or the expression of PCLAF might be potential biological therapeutic strategies for GI cancers.

关键词： Proliferating cell nuclear antigen Proliferating cell nuclear antigen clamp associated factor Transcript variant Gastrointestinal cancers Signal pathway Biological therapeutic

Air/Water Stability Problems and Solutions for lithium Batteries

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Energy Material Advances 2022年第1期2022卷 165-205页

作者： ming Yang liquan Chen Hong li fan Wu Tianmu Lake Institute of Advanced Energy Storage Technologies Liyang213300 JiangsuChina Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China Yangtze River Delta Physics Research Center Liyang213300 JiangsuChina Beijing Advanced Innovation Center for Materials Genome Engineering Key Laboratory for Renewable EnergyBeijing Key Laboratory for New Energy Materials and DevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Recently,lithium-ion batteries(liBs)have faced bottlenecks in terms of energy/power density and safety issues caused by flammable *** this regard,all-solid-state batteries(ASSBs)may be one of the most promising ***,many key battery materials(such as solid electrolytes(SEs),cathodes,and anodes)are unstable to air/water,which greatly limits their production,storage,transportation,practical applications,and the development of ***,the research status on air/water stability of SEs,cathodes,and anodes is *** mechanisms for their air/water instability are revealed in *** corresponding modification methods are also proposed,with emphasis on the construction strategies of air/water stable protective layers,including ex situ coatings and in situ ***,the application of air/water-stable protective layers in ASSBs is discussed *** but not least,the advantages and disadvantages of various protective layer construction strategies are analyzed,in which their applications in practical production are prospected.

关键词： battery protective details

Geochemical Characteristics of Trace Elements in Argillans of Alfisols in Central China

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Pedosphere 2015年第3期25卷 415-427页

作者： HUANG li liU fan TAN Wen-Feng WANG ming-Kuang Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River) Ministry of AgricultureHuazhong Agricultural University Department of Agricultural Chemistry Taiwan University

The relationships between the basic properties and trace elements in soil argillans and corresponding matrix soils were studied by sampling from the B horizons of 26 Alfisols in croplands of the subtropical area in Central China. The soil elements(K, Na, Ca,Mg, Mn, Co, Cu, Cr, Cd, li, Mo, Ni, Pb, Ti, V, and Zn) were extracted by acid digestion and their contents were measured using inductively coupled plasma optical emission spectrometry(ICP-OES). The mean contents of clay and organic matter in the argillans were approximately 1.1 and 1.3 times greater than those in the matrix soils, respectively. The p H values and the contents of P2O5 and bases(K2O, Na2 O, Ca O, and Mg O) in the argillans were higher than those in the corresponding matrix soils. Cu, Cd, Ti, and V were enriched in the argillans. Correlation coefficients and factor analyses showed that Co, Cu, li, and Zn were bound with phyllosilicates and manganese oxides(Mn-oxides) in the argillans. Cr and Pb were mainly associated with iron oxides(Fe-oxides), while Ni was bound with Mn-oxides. Cd, Ti, and V were chiefly associated with phyllosilicates, but Cr and Mo were rarely enriched in the *** contrast, in the matrix soils, Co and Zn were associated with organic matter and Fe-oxides, Cr existed in phyllosilicates, and Mo was bound to Fe-oxides. Cd, Ti, and V were associated with organic matter. The results of this study suggest that clays, organic matter, and minerals in the argillans dominate the illuviation of trace elements in Alfisols. Argillans might be the active interfaces of elemental exchange and nutrient supply in cropland soils in Central China.

关键词： clay cutan organic matter phyllosilicates soil element

Cu^(2+)污染下农作物叶片特征光谱探究

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光谱学与光谱分析 2025年第1期45卷 264-271页

作者：张超吴轩杨可明齐钒宇夏天中国地质调查局发展研究中心北京100037 中国地质大学(北京)地球科学与资源学院北京100083 全国地质资料馆北京100037 中国矿业大学(北京)地球科学与测绘工程学院北京100083 中国资源卫星应用中心北京100094

为探究重金属胁迫下农作物污染响应的敏感叶型及谱段,设计了室外温室环境下的不同铜胁迫梯度玉米花盆试验。以玉米叶片为探究对象,利用仪器测定了出穂期玉米叶片的高光谱反射率数据以及叶片中重金属含量数据,为研究提供了基础数据。从... 详细信息

为探究重金属胁迫下农作物污染响应的敏感叶型及谱段,设计了室外温室环境下的不同铜胁迫梯度玉米花盆试验。以玉米叶片为探究对象,利用仪器测定了出穂期玉米叶片的高光谱反射率数据以及叶片中重金属含量数据,为研究提供了基础数据。从频率域角度,结合时频分析的方法设计了叶片光谱探测法(LSDM),获得了重金属铜胁迫下敏感叶型及谱段,为农作物重金属监测提供技术支撑。根据玉米的生长过程,从老叶(O)、中叶(M)、新叶(N)光谱350~1300 nm的全谱段和子谱段角度进行探究。(1)对铜胁迫下玉米叶片的高光谱反射率数据进行双微分(SOD)和包络线移除(CR),转换到频率域上,结合时频分析的方法进行Daubechies小波6层分解。(2)根据信号异常点、小波高值点和SODCR曲线高值点,定义玉米叶片的光谱异常参数(SAP)。异常变化反射率ACR(异常反射率与其后一个相邻波段反射率差值的绝对值);异常小波系数AWC(异常小波系数与其后一个相邻波段小波系数差值的绝对值);异常SODCR值ASV(异常点SODCR值与其后一个相邻波段SODCR值差值的绝对值)。通过光谱异常参数与玉米叶片重金属含量的相关关系,探究对铜污染响应敏感的叶型及谱段。结果表明,叶片光谱探测法LSDM能高效地对玉米叶片弱信息进行增强,并准确定位出重金属铜胁迫引起的光谱异常谱段位置,异常变化范围集中在350~800 nm内;光谱异常参数能定量地衡量玉米叶片在重金属铜胁迫下的光谱异常;在不同铜胁迫梯度下,玉米新叶(N)为敏感叶型,敏感谱段为蓝边、绿峰、黄边、红谷。该研究有望为其他谷类农作物及其冠层尺度重金属监测提供技术支撑。

关键词：重金属胁迫玉米叶片高光谱敏感叶型敏感谱段

Active site identification and engineering during the dynamic evolution of copper-based catalysts for electrocatalytic CO_(2) reduction

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Science China Chemistry 2023年第1期66卷 78-95页

作者： Bangwei Deng Xueyang Zhao Yizhao li ming Huang Shihan Zhang fan Dong Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of EnvironmentZhejiang University of TechnologyHangzhou 310014China

To date,copper-based catalysts are one of the most prominent catalysts that can electrochemically reduce CO_(2)towards highvalue fuels or chemicals,such as ethylene,ethanol,and acetic ***,the chemically active feature of Cu-based catalysts hinders the understanding of the intrinsic catalytic active sites during the initial and the operative processes of electrochemical CO_(2)reduction(CO_(2)RR).The identification and engineering of active sites during the dynamic evolution of catalysts are thereby vital to further improve the activity,selectivity,and durability of Cu-based catalysts for high-performance CO_(2)*** this regard,four triggers for the dynamic evolution of catalysts were introduced in ***,three typical active-site theories during the dynamic reconstruction of catalysts were *** addition,the strategies in catalyst design were summarized according to the latest reports of Cu-based catalysts for CO_(2)RR,including the tuning of electronic structure,controlling of the external potential,and regulation of local catalytic ***,the conclusions and perspectives were provided to inspire more investigations and studies on the intrinsic active sites during the dynamic evolution of catalysts,which could promote the optimization of the catalyst system to further improve the performance of CO_(2)RR.

关键词： active site dynamic reconstruction copper-based catalysts electrochemical CO_(2)reduction local catalytic environment

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan Yu-ming Wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle