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Study on the Amperometric Glucose Biosensor Based on Tin Oxide Electrode

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稀有金属材料与工程 2006年第A03期35卷 291-294页

作者： Cheng-Wei Liao Jung-Chuan Chou Tai-Ping Sun Shen-Kan hsiung Jui-Hsiang Hsieh Institute of Biomedical Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640 China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China

An amperometric glucose biosensor based on a tin oxide (SnO_2) electrode has been *** SnO_2 electrode is prepared by depositing the SnO_2 thin film onto a carbon *** fabricate the SnO_2 amperometric glucose biosensor,the glucose oxidase and electron transfer mediator (ferrocenecarboxylic acid,FcA) are coimmobilized on the SnO_2 electrode using *** detection range is up to glucose concentration of 520mg/dl as the applied potential is set at 300mV. Moreover,the most merit for the SnO_2 electrode as the base electrode of the SnO_2 amperometric glucose biosensor is that it can be operated at 150mV constant applied *** interference reduction,detection range,sensitivity and linearity are improved as the SnO_2 thin film is deposited onto a carbon ***,due to the low cost substrate and simple fabrication characteristics,a disposable amperometric glucose biosensor based on the SnO_2 electrode has been realized in this study.

关键词： amperometric glucose oxidase tin oxide carbon mediator

A New Cerebroside, Asperiamide A, from Marine Fungus Asperillus sp.

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有机化学 2004年第Z1期24卷 107-页

作者： OUYANG,ming-An CHEN,Bi-E KUO,Yueh-hsiung Department of Bio-engineering & Technology Huaqiao University Quanzhou 362011 Department of Bio-engineering & Technology Huaqiao University Quanzhou 362011 Department of Chemistry Taiwan University Taipei

　　Cerebrosides and ceramides[1] have been isolated from a number of marine organisms such as sea stars, sea anemones, gorgonians, sponges, tunicates, dinoflagellates, and green algae. Some cerebroside and ceramides exhibited cytotoxic, antitumor,[2,3] immunostimulatory,[4] antifungal,[5] and antiviral[6] activites. In the search for bioactive components,two water soluble constituents, asperiamide A and adenosine, were isolated from the marine fungus Asperillus sp. The current report describes the structural elucidation of a new compound, aspefiamide A (1) and a known one, adenosine (2).……

关键词： structural elucidation marine organisms water soluble new compound green algae

Seismic performance of an existing bridge with scoured caisson foundation

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 151-165页

作者： Kuo-Chun Chang Yu-Chi Sung Kuang-Yen Liu Ping-hsiung Wang Zheng-Kuan Lee Lu-Sheng Lee Witarto Department of Civil Engineering Taiwan University (NTU) Professor Department of Civil Engineering Taipei University of Technology (NTUT) Center for Research on Earthquake Engineering (NCREE) Associate Researcher Associate Technologist Technologist Department of Civil Engineering The University of Houston Ph.D Student

This paper presents in-situ seismic performance tests of a bridge before its demolition due to accumulated scouring problem. The tests were conducted on three single columns and one caisson-type foundation. The three single columns were 1.8 m in diameter,reinforced by 30-D32 longitudinal reinforcements and laterally hooped by D16 reinforcements with spacing of 20 cm. The column height is 9.54 m,10.59 m and 10.37 m for Column P2,P3,and P4,respectively. Column P2 had no exposed foundation and was subjected to pseudo-dynamic tests with peak ground acceleration of 0.32 g first,followed by one cyclic loading test. Column P3 was the benchmark specimen with exposed length of 1.2 m on its foundation. The exposed length for Column P4 was excavated to 4 m,approximately 1/3 of the foundation length,to study the effect of the scouring problem to the column performance. Both Column P3 and Column P4 were subjected to cyclic loading tests. Based on the test results,due to the large dimension of the caisson foundation and the well graded gravel soil type that provided large lateral resistance,the seismic performance among the three columns had only minor differences. Lateral push tests were also conducted on the caisson foundation at Column P5. The caisson was 12 m long and had circular cross-sections whose diameters were 5 m in the upper portion and 4 m in the lower portion. An analytical model to simulate the test results was developed in the OpenSees platform. The analytical model comprised nonlinear flexural elements as well as nonlinear soil springs. The analytical results closely followed the experimental test results. A parametric study to predict the behavior of the bridge column with different ground motions and different levels of scouring on the foundation are also discussed.

关键词： Analytical models Cyclic loads Hydraulic structures Piles Pressure vessels Reinforcement Seismic waves Seismology Soil structure interactions Soils Textile scouring Underwater foundations

High Coercivity Sr-ferrite Magnetic Thin Films Induced by Various Underlayers

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Journal of Materials Science & Technology 2000年第2期16卷 201-203页

作者： W. C. Chang, C. T.Lin and T.C. Yen (Department of Physics, Chung Cheng University, ming-hsiung, Chia-Yi, Taiwan-China) C.S.Liou and T.T.Shau (Super Electronic Ltd., Taipei, Taiwan-China) Department of Physics Chung Cheng University Ming-Hsiung Chia-Yi Taiwan Super Electronic Ltd. Taipei Taiwan

Three kinds of oxide underlayers, namely Si02, ZnO and Al2O3, were deposited prior to the sputtering of Sr-ferrite films, respectively, in order to induce the optimum grain morphology and the texture of the films. A Sr-ferrite film with an easy axis in-plane orientation was induced by SiO2 underlayer. In contrast, it prefers to be perpendicular to film plane for the cases of ZnO and Al2O3 underlayers. The optimum magnetic properties of the former film along film plane are: 4πMr=1.7 kG, iHc=5.35 kOe, and Sq=0.59, which are mainly dominated by the exchange coupling effect, determined by Wohlfarth's remanence analysis, among grains. While those for the films with an easy axis perpendicular to film plane can be as high as 4πMr=3.72 kG, iHc=6.42 kOe, and Sq=0.82, which are mainly dominated by the magnetostatic interaction among grains.

关键词： Thin High Coercivity Sr-ferrite Magnetic Thin Films Induced by Various Underlayers Sr SrO

Evaluation of Inference Adequacy in Cumulative Logistic Regression Models:An Empirical Validation of ISW-Ridge Relationships

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China Ocean Engineering 2008年第1期22卷 43-56页

作者： Cheng-Wu CHEN Hsien-Chueh Peter YANG Chen-Yuan CHEN Alex Kung-hsiung CHANG Tsung-Hao CHEN Department of Logistics Management Shu-Te University Kaohsiung 82445 China Department of Risk Management and Insurance National Knohsiung First Univershy of Scierwe and Technology Kaohsiung 811 China Department of Management Information System Yung- Ta Institute of Technology and Commerce Pingtung County 90941 China Department of Business Administration National Pingtung University of Science and Technology Pingtung China Department of Business Adrninistration MingDao University ChangHua 52345 China

Internal solitary wave propagation over a submarine ridge results in energy dissipation, in which the hydrodynamic interaction between a wave and ridge affects marine environment. This study analyzes the effects of ridge height and potential energy during wave-ridge interaction with a binary and cumulative logistic regression model. In testing the Global Null Hypothesis, all values are p 〈0.001, with three statistical methods, such as Likelihood Ratio, Score, and Wald. While comparing with two kinds of models, tests values obtained by cumulative logistic regression models are better than those by binary logistic regression models. Although this study employed cumulative logistic regression model, three probability functions p^1, p^2 and p^3, are utilized for investigating the weighted influence of factors on wave reflection. Deviance and Pearson tests are applied to cheek the goodness-of-fit of the proposed model. The analytical results demonstrated that both ridge height （X1 ） and potential energy （X2 ） significantly impact （p 〈 0. 0001 ） the amplitude-based refleeted rate; the P-values for the deviance and Pearson are all 〉 0.05 （0.2839, 0.3438, respectively）. That is, the goodness-of-fit between ridge height （ X1 ） and potential energy （X2） can further predict parameters under the scenario of the best parsimonious model. Investigation of 6 predictive powers （ R2, Max-rescaled R^2, Sorners＇ D, Gamma, Tau-a, and c, respectively） indicate that these predictive estimates of the proposed model have better predictive ability than ridge height alone, and are very similar to the interaction of ridge height and potential energy. It can be concluded that the goodness-of-fit and prediction ability of the cumulative logistic regression model are better than that of the binary logistic regression model.

关键词： binary logistic regression cumulative logistic regression model goodness-of-fit internal solitary wave amplitude-based transmission rate

Dynamic magnetic resonance imaging features of cavernous hemangioma in the manubrium:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4262-4267页

作者： Tsung-Tai Lin Hsian-He Hsu Shih-Chun Lee Yi-Jen Peng Kai-hsiung Ko Department of Radiology National Defense Medical CenterTri-Service General HospitalTaipei 114Taiwan Department of Thoracic Surgery National Defense Medical CenterTri-Service General HospitalTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Osseous hemangiomas,especially those located in the manubrium,are rare benign *** a review of the literature,only three case reports of sternal hemangioma were found.A precise diagnosis is difficult because of their nonspecific findings on computed tomography(CT)/magnetic resonance imaging(MRI).CASE SUMMARY An 88-year-old woman was suffering from a progressively enlarging mass in the *** CT images showed an osteolytic and expansile lesion with cortical *** malformation was suspected after CT-guided *** the dynamic MRI scans,the mass showed a bright signal on the T2-weighted image,peripheral nodular enhancement on the early-phase images and progressive centripetal fill-in on the delayed-phase *** hemangioma was suspected preoperatively based on the MRI features and finally confirmed by histopathologic *** This uncommon case demonstrates the possible characteristic features of manubrium cavernous hemangioma on dynamic MRI scans;knowledge about these features may prevent patients from developing catastrophic complications,such as rupture or internal hemorrhage,caused by biopsy or surgery.

关键词： Hemangioma Bone tumor Sternum Magnetic resonance imaging Osteolytic mass Case report

Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma

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Virologica Sinica 2015年第2期30卷 85-91页

作者： Yongjun Tian Jing-hsiung James Ou Department of Molecular Microbiology and Immunology University of Southern California Keck School of Medicine Los Angeles 90033 USA

Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformation of hepatocytes. HBV can also sensitize hepatocytes to oncogenic transformation by causing genetic and epigenetic changes of the host chromosomes. HBV DNA can insert into host chromosomes and recent large-scale whole-genome sequencing studies revealed recurrent HBV DNA integrations sites that may play important roles in the initiation of hepatocellular carcinogenesis. HBV can also cause epigenetic changes by altering the methylation status of cellular DNA, the post-translational modification of histones, and the expression of micro RNAs. These changes can also lead to the eventual hepatocellular transformation. These recent findings on the genetic and epigenetic alterations of the host chromosomes induced by HBV opened a new avenue for the development of novel diagnosis and treatments for HBV-induced HCC.

关键词： hepatitis B virus(HBV) hepatocellular carcinoma(HCC) genetic alterations epigenetic regulations HCC-associated micro RNAs

Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

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World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su Pin-Yu Lai Pei-Hsuan Hu Je-ming Hu Pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin Chien-An Sun Tsan Yang Chih-hsiung Hsu Hua-Ching Lin Yu-Ching Chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

Effect of Laser Welding on Properties of Dissimilar Joint of Al-Mg-Si and Al-Mn Aluminum Alloys

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Journal of Materials Science & Technology 2010年第3期26卷 276-282页

作者： C.C.Chang C.P.Chou S.N.Hsu G.Y.hsiung J.R.Chen Department of Mechanical Engineering National Chiao-Tung University National Synchrotron Radiation Research Center Department of Biomedical Engineering and Environmental Sciences National Tsing-Hua University

This study discusses the welding properties for the components of an aluminum-alloy ultra-high vacuum chamber and beam position monitor （BPM）.The welding parameters include the modes of laser output （pulsed wave and continuous wave）,welding speed,shield gas flow,welding bead structure,and focusing *** results showed that the welding defect rate of the pulsed wave type was larger than that of the continuous wave *** crack in the welding bead reduced with decreasing welding *** fusion penetration of the welding bead was higher when the focusing distance was long enough to deepen into the welding *** morphology during the experimental process revealed the proper flow of shield *** adaptability design of the welding bead structure in the preceding processes had more effect on overall welding structure and morphology.

关键词： Laser welding Aluminum alloy Ultra-high vacuum Beam position monitor (BPM)