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Novel methylation gene panel in adjacent normal tissues predicts poor prognosis of colorectal cancer in Taiwan

World Journal of Gastroenterology 2020年第2期26卷 154-167页

作者： Chih-hsiung Hsu Cheng-Wen Hsiao Chien-An Sun Wen-Chih Wu Tsan Yang Je-ming Hu Chi-Hua Huang Yu-Chan Liao Chao-Yang Chen Fu-Huang Lin Yu-Ching Chou Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114Taiwan Teaching Office Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242Taiwan Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242Taiwan School of Public Health National Defense Medical CenterTaipei 114Taiwan Department of Surgery Suao and Yuanshan Branches of Taipei Veterans General HospitalYilan County 264Taiwan Department of Health Business Administration Meiho UniversityPingtung County 912Taiwan Adjunct Instructor School of MedicineNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND It is evident that current clinical criteria are suboptimal to accurately estimate patient *** have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer(CRC).AIM To estimate whether a methylation gene panel in different clinical stages can reflect a different *** We enrolled 120 CRC patients from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select six genes involved in carcinogenesis *** were divided into two groups based on the methylation status of the six evaluated genes,namely,the<3 aberrancy group and≥3 aberrancy *** tumor stages were divided into two subgroups(local and advanced stages)on the basis of the pathological type of the following tissues:Tumor and adjacent normal tissues(matched normal).We assessed DNA methylation in tumors and adjacent normal tissues from CRC patients and analyzed the association between DNA methylation with different cancer stages and the prognostic outcome including time to progression(TTP)and overall *** We observed a significantly increasing trend of hazard ratio as the number of hypermethylated genes increased both in normal tissue and tumor *** 5-year TTP survival curves showed a significant difference between the≥3 aberrancy group and the<3 aberrancy *** with the<3 aberrancy group,a significantly shorter TTP was observed in the≥3 aberrancy *** further analyzed the interaction between CRC prognosis and different cancer stages(local and advanced)according to the methylation status of the selected genes in both types of *** was a significantly shorter 5-year TTP for tumors at advanced stages with the promoter methylation status of selected genes than for those with local *** found an interaction between cancer stages and the promoter methylation status of selected genes in both types of *** Our data provide a significant association

关键词： DNA methylation Panel genes Clinical stage Prognosis outcome Adjacent normal tissues Colorectal cancer

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Model-Based Networked Control Systems with Multiple Packet Transmission

Model-Based Networked Control Systems with Multiple Packet T...

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第二十九届中国控制会议

作者： YANG Sheng-hsiung WU Jenq-Lang Department of Electrical Engineering National Taiwan Ocean University

ISBN: (纸本)9781424462636

This paper studies the stabilization problem for discrete-time model-based networked control systems under multiple packet *** dynamics of model-based multiple packet transmission NCSs are modeled as switched control systems.A sufficient condition for stabilization is derived by the multiple Lyapunov function *** is shown that stabilizing networked feedback laws can be obtained by solving matrix inequalities.A numerical example is proposed for verification.

关键词： Networked Control Systems Model-based Control Multiple Packet Transmission Linear Matrix Inequality.

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Features associated with progression of small pancreatic cystic lesions: A retrospective study

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World Journal of Gastroenterology 2015年第47期21卷 13309-13315页

作者： Hong-ming Tsai Chiao-hsiung Chuang Yan-Shen Shan Yi-Sheng Liu Chiung-Yu Chen Department of Radiology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University

AIM: To investigate the progression rate of small pancreatic cystic lesions and identify characteristics associated with their ***: Patients with pancreatic cystic lesions with at least 1-year of follow-up were evaluated retrospectively. We excluded patients with cysts larger than 3 cm or with features that were a concern for malignancy. In total, 135 patients were evaluated. The interval progression of the cysts was examined. Characteristics were compared between patients with and without ***: The pancreatic cysts ranged from 3 to 29 mm. The mean follow-up period was 4.5 ± 2.3 years and the mean progression rate was 1.0 ± 1.3 mm/year. Ninety patients showed interval progression and were divided into two groups; the minimal-change group(n = 41), who had cyst progression at less than 1 mm/year, and the progression group(n = 49), who had a progression rate of more than 1 mm/year. Compared with the cysts without progression, the lesions of the progression group were more frequently associated with tubular cyst, septation or a prominent pancreatic duct(P < 0.05). The odds ratio for progression was 5.318 for septation and 4.582 for tubular ***: Small pancreatic cysts progress slowly. Lesions with tubular shape, septa, or prominent pancreatic duct were more likely to progress, and required further diagnostic intervention or shorter surveillance interval.

关键词： Pancreas Cystic lesion Progression Imaging features Observation

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Factors relating to the short term effectiveness of percutaneous biliary drainage for hilar cholangiocarcinoma

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World Journal of Gastroenterology 2009年第41期15卷 5206-5210页

作者： Hong-ming Tsai Chiao-hsiung Chuang Xi-Zhang Lin Chiung-Yu Chen Departments of Radiology College of Medicine National Cheng Kung University Tainan 704 Taiwan China Departments of Internal Medicine College of Medicine National Cheng Kung University Tainan 704 Taiwan China

AIM: To identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their survival. METHODS: Seventy-four patients with hilar cholangiocarcinoma who underwent percutaneous biliary drainage were enrolled in the study. The demographic and laboratory data as well as the imaging characteristics were retrospectively analyzed to correlate with the bile output and reduction rate of serum bilirubin 1 wk after ***: Patients with more bile duct visualized on percutaneous transhepatic cholangiography or absence of multiple liver metastases on imaging studies had more bile output after biliary drainage [odds ratio (OR): 8.471, P = 0.010 and OR: 1.959, P = 0.022, respectively]. Patients with prolonged prothrombin time had a slow decrease in serum bilirubin (OR: 0.437, P = 0.005). The median survival time was not signif icantly different in patients with low or high bile output (75 d vs 125 d, P = 0.573) or in patients with slow or rapid reduction of serum bilirubin (88 d vs 94 d, P = 0.576). CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival.

关键词： Cholangiocarcinoma Percutaneous biliary drainage Treatment effectiveness

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Ultrasonography of splenic abnormalities

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World Journal of Gastroenterology 2005年第26期11卷 4061-4066页

作者： ming-Jen Chen ming-Jer Huang Wen-hsiung Chang Tsang-En Wang Horng-Yuan Wang Cheng-Hsin Chu Shee-Chan Lin Shou-Chuan Shih Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei Taiwan China Division of Hematology and Oncology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China

AIM: This report gives a comprehensive overview of ultrasonography of splenic abnormalities. Certain ultrasonic features are also discussed with pathologic ***: We review the typical ultrasonic characteristics of a wide range of splenic lesions, illustrating them with images obtained in our institution from 2000 to *** hundred and three patients (47 men, 56 women),with a mean age of 54 years (range 9-92 years), were found to have an abnormal ultrasonic pattern of ***: We describe the ultrasonic features of various splenic lesions such as accessory spleen, splenomegaly,cysts, cavernous hemangiomas, lymphomas, abscesses,metastatic tumors, splenic infarctions, hematomas, and rupture, based on traditional gray-scale and color Doppler ***: Ultrasound is a widely available, noninvasive,and useful means of diagnosing splenic abnormalities. A combination of ultrasonic characteristics and clinical data may provide an accurate diagnosis. If the US appearance alone is not enough, US may also be used to guide biopsy of suspicious lesions.

关键词： Ultrasonography Ultrasound Splenic abnormalities Spleen

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丝氨酸331是蛋白激酶C诱导血栓素α受体磷酰化和脱敏的主要部位(英文)

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Acta Pharmacologica Sinica 2002年第10期23卷 90-98页

作者：严奉祥,YAMAMOTO Shuichi,TAIHsin-hsiung,廖端芳南华大学药物药理研究所 Department of Pediatrics Saga Medical School Saga Japan College of Pharmacy University of Kentucky Lexington KY 40536-0082 USA 南华大学药物药理研究所衡阳中国 421001 衡阳中国 421001

目的:检测人类血栓素α受体（TPα）C端丝氨酸/苏氨酸残基的各种两氨酸诱变体作为PKC底物的能力,以确定被PKC磷酸化和脱敏的特异的丝氨酸/苏氨酸残基.方法:为了易于鉴定被磷酰化的细胞内区段,使用甘胱甘肽S-转移酶（GST）-细胞内区段融... 详细信息

目的:检测人类血栓素α受体（TPα）C端丝氨酸/苏氨酸残基的各种两氨酸诱变体作为PKC底物的能力,以确定被PKC磷酸化和脱敏的特异的丝氨酸/苏氨酸残基.方法:为了易于鉴定被磷酰化的细胞内区段,使用甘胱甘肽S-转移酶（GST）-细胞内区段融合蛋白作纯化的PKC底物,然后突变磷酰化蛋白的cDNA,以找出TPα被PKC磷酰化的主要部位,并将有组氨酸尾野生型或诱变型血栓素受体α稳定地转移到人类胚胎肾（HEK）293细胞,以研究该受体的磷酸化和脱敏.结果:仅C-端能充当纯化PKC底物.丝氨酸-331（mP4）被显示强的磷酰化,丝氨酸-324（mP1）则轻微磷酰化,丝氨酸-329（mP3）则微弱磷酰化,而其它丝氨酸/苏氨酸残基没被发现磷酰化.佛被醇-12-肉豆蔻酸酯-13-乙酸盐（PMA）诱导表达野生型TPα的HEK 293细胞磷酰化.然而不能显示触发表达丝氨酸331丙氨酸诱变受体的HEK 293受体磷酸化.用PMA预处理表达野生型受体的HEK 293细胞能抑制I-B0P诱导Ca2+释放,然而用PMA预处理表达诱变受体的细胞不能中止I-BOP抑制Ca2+释放.结论:丝氨酸331是TPαa磷酰化和脱敏的主要和关键部位.

关键词：血栓素受体定点诱变丝氨酸蛋白激酶C 磷酰化

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Solid-pseudopapillary tumor of the pancreas: Clinical experience and literature review

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World Journal of Gastroenterology 2005年第9期11卷 1403-1409页

作者： Hsueh-Lien Huang Shou-Chuan Shih Wen-hsiung Chang Tsang-En Wang ming-Jen Chen Yu-Jan Chan Division of Gastroenterology

AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare ***: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our ***: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant *** mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow ***: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable.

关键词： Solid-pseudopapillary tumor of the pancreas Distal pancreatectomy Pancreaticoduodenectomy

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Low-power laser irradiation promotes the proliferation and osteogenic differentiation of human periodontal ligament cells via cyclic adenosine monophosphate

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International Journal of Oral Science 2013年第2期5卷 85-91页

作者： Jyun-Yi Wu Chia-Hsin Chen Li-Yin Yeh ming-Long Yeh Chun-Chan Ting Yan-hsiung Wang Institute of Biomedical Engineering National Cheng Kung University Department of Physical Medicine and Rehabilitation Kaohsiung Medical University Hospital Department of Physical Medicine and Rehabilitation Faculty of MedicineCollege of MedicineKaohsiung Medical University Department of Physical Medicine and Rehabilitation Kaohsiung Municipal Ta-Tung Hospital Department of Oral Hygiene College of MedicineKaohsiung Medical University School of Dentistry College of Dental MedicineKaohsiung Medical University Orthopaedic Research Center College of MedicineKaohsiung Medical University

Retaining or improving periodontal ligament （PDL） function is crucial for restoring periodontal defects. The aim of this study was to evaluate the physiological effects of low-power laser irradiation （LPLI） on the proliferation and osteogenic differentiation of human PDL （hPDL） cells. Cultured hPDL cel Is were irradiated （660 nm） daily with doses of O, 1, 2 or 4 J .cm-2. Cell proliferation was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide （MTT） assay, and the effect of LPLI on osteogenic differentiation was assessed by Alizarin Red S staining and alkaline phosphatase （ALP） activity. Additionally, osteogenic marker gene expression was confirmed by real-time reverse transcription-polymerase chain reaction （RT-PCR）. Our data showed that LPLI at a dose of 2 ***-2 significantly promoted hPDL cell proliferation at days 3 and 5. In addition, LPLI at energy doses of 2 and 4 ***-2 showed potential osteogenic capacity, as it stimulated ALP activity, calcium deposition, and osteogenic gene expression. We also showed that cyclic adenosine monophosphate （cAMP） is a critical regulator of the LPLI-mediated effects on hPDL cells. This study shows that LPLI can promote the proliferation and osteogenic differentiation of hPDL cells. These results suggest the potential use of LPLI in clinical applications for periodontal tissue regeneration.

关键词： cell proliferation cyclic adenosine monophosphate human periodontal ligament cells low-power laser irradiation osteogenic differentiation

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Study on the Amperometric Glucose Biosensor Based on Tin Oxide Electrode

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稀有金属材料与工程 2006年第S3期 291-294页

作者： Jung-Chuan Chou Shen-Kan hsiung Jui-Hsiang Hsieh Graduate School of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China Institute of Electronic Engineering Chung Yuan Christian UniversityChung-LiTaiwan 320China Institute of Biomedical Engineering Chung Yuan Christian UniversityChung-LiTaiwan 320China

An amperometric glucose biosensor based on a tin oxide （SnO2） electrode has been *** SnO2electrode is prepared by depositing the SnO2thin film onto a carbon *** fabricate the SnO2amperometric glucose biosensor,the glucose oxidase and electron transfer mediator （ferrocenecarboxylic acid,FcA） are coimmobilized on the SnO2electrode using *** detection range is up to glucose concentration of 520mg/dl as the applied potential is set at 300mV. Moreover,the most merit for the SnO2electrode as the base electrode of the SnO2amperometric glucose biosensor is that it can be operated at 150mV constant applied *** interference reduction,detection range,sensitivity and linearity are improved as the SnO2thin film is deposited onto a carbon ***,due to the low cost substrate and simple fabrication characteristics,a disposable amperometric glucose biosensor based on the SnO2electrode has been realized in this study.

关键词： amperometric glucose oxidase tin oxide carbon mediator

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Effect of Ferulic Acid,a Major Ingredient of Si-Wu-Tang,and Its Derivatives on Ovarian Cancer Cell

Effect of Ferulic Acid,a Major Ingredient of Si-Wu-Tang,and ...

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第十四届全国中药和天然药物学术研讨会

作者： ming-Ching Kao Hui-Ju Yang Yueh-hsiung Kuo China Medical University National Defense Medical Center

＜正＞The Traditional Chinese formula Si-Wu-Tang（SWT）is widely used in Oriental countries for thousands of *** main effects of SWT are reducing blood stagnation and promoting the reproduction of hematopoietic *** a...

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