检索结果-南通市图书馆

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

叶片局部弯曲对跨音速轴流压气机转子性能的影响

在线全文

学校读者我要写书评

暂无评论

沈阳航空航天大学学报 2017年第1期34卷 20-25页

作者：王建明何朝锋马阳沈阳航空航天大学航空航天工程学部(院) 沈阳110136

采用数值模拟方法研究了一系列弯高和不同弯角的叶片周向弯曲造型设计对NASA Rotor37跨声速压气机转子的气动性能的影响。结果表明:动叶弯曲能够有效地提高压气机的稳定裕度和效率,且裕度的增量与弯高和弯角呈"双峰"关系。动叶的周向弯... 详细信息

采用数值模拟方法研究了一系列弯高和不同弯角的叶片周向弯曲造型设计对NASA Rotor37跨声速压气机转子的气动性能的影响。结果表明:动叶弯曲能够有效地提高压气机的稳定裕度和效率,且裕度的增量与弯高和弯角呈"双峰"关系。动叶的周向弯曲能够引起叶顶低能流体向主流区迁移,从而降低叶顶区域的流动损失,但在主流区流动损失有所增加,并且叶片通道内流体的质量流量沿叶高方向被重新分配。

关键词：压气机动叶弯曲叶片气动性能

Local magnetic moment oscillation around an Anderson impurity on graphene

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-ming Pan Wei Li Rui-Qiong ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Tat-mediated intracellular delivery of T-bet protein into THP-1 cells can induce Th1 type response

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tat-mediated intracellular delivery of T-bet protein into TH...

新型双集热管多曲面槽式空气集热器在乌鲁木齐日光温室的应用研究

中国免疫学会第五届全国代表大会暨学术会议

作者： Yang Min, Wang Shengjun, Wang Suo-ying, ma Jie, Xu Xiao-peng, mao chao-ming, ma Bing, Tong Jia, Qiu Gu-feng, Shao Qi-xiang, Ding Qing, Xu Hua-xi (Department of Immunology, School of Medical Technology, Jiangsu University, Zhenjiang 212001,China) (Department of Pediatrics, Affiliated Hospital of Jiangsu University , Zhenjiang 212001 , China)

T-bet, a Th1-specific transcription factor, can promote the production of IFN-γ. IFN-γis the principal Th1 effector cytokine and it has a crucial role in Th1 differentiation, which can drive the differentiation of naive CD4+ T cells into T-helper 1 (Th1) cells. Based on gene transfer, the safety problem and how to efficiently control the tar-

关键词： HIV-1 Tat T-bet IFN-γ Protein transduction

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

新疆农业科学 2017年第5期54卷 945-952页

作者：张明星陈超马彩雯姜理星邹平张彩虹北京工业大学建筑工程学院北京100124 新疆农业科学院农机化研究所乌鲁木齐830091

【目的】提高日光温室主动蓄热能力,使温室内热环境得到保障。【方法】提出一种新型双集热管多曲面槽式空气集热器,将此集热器与日光温室后墙结合构成主-被动式墙体体系,将此墙体体系应用于新疆日光温室,研究该集热器在日光温室中应用... 详细信息

【目的】提高日光温室主动蓄热能力,使温室内热环境得到保障。【方法】提出一种新型双集热管多曲面槽式空气集热器,将此集热器与日光温室后墙结合构成主-被动式墙体体系,将此墙体体系应用于新疆日光温室,研究该集热器在日光温室中应用的可行性及应用效果。【结果】在集热器长度为16 m、集热器单支玻璃管接收器内空气流速为2.5 m/s的条件下,集热器出口温度可达75℃,集热效率可达50%。该集热系统通过日光温室墙体主动蓄热方式,在冬季实测期间累计可为日光温室提供约为2 400 MJ的太阳能。【结论】该结果可为集热器的推广应用提供参考。

关键词：日光温室双集热管多曲面槽式空气集热器主动蓄热集热性能供热量

在线全文

学校读者我要写书评

暂无评论

减推力起飞对航空发动机性能影响

机械工程与自动化 2017年第1期 166-167页

作者：李书明商智超马晓政中国民航大学航空工程学院天津300300

介绍了飞机减推力起飞的方法,分析了减推力起飞对民用涡轮风扇发动机性能的影响。得出减推力起飞能降低发动机涡轮前温度、起飞排气温度裕度(EGTM),延长发动机在翼时间和使用维护周期,达到节约发动机维修成本的目的。

关键词：减推力起飞涡轮风扇发动机涡轮前温度起飞排气温度裕度(EGTM)

Measurement and characterization of bulk nanobubbles by nanoparticle tracking analysis method

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2022年第6期34卷 1121-1133页

作者： Xiao-tong ma ming-bo Li chao Sun Center for Combustion Energy Key Laboratory for Thermal Science and Power Engineering of Ministry of EducationDepartment of Energy and Power EngineeringTsinghua UniversityBeijing100084China

The size of the bulk nanobubbles(typically 100 nm-200 nm in diameter)is below the optical resolution of the typical microscopes,which makes it difficult to make a direct observation of them and differentiate between the nanoparticles and the *** this work,a nanoparticle tracking analysis(NTA)system is developed for tracking and sizing the bulk nanobubbles,and more broadly,the Brownian diffusing *** demonstrate the capabilities of the NTA in characterizing the nanoparticles through systematic validation of accuracy and *** particularly exhibit its unique advantages in detecting the polydisperse nanoparticle *** the nucleation and the thermodynamic stability of the bulk nanobubbles are systematically studied by the NTA *** bulk nanobubbles smaller than 600 nm in size are generated via the ultrasonication *** is shown that both the ultrasonic cavitation treatment time and amplitude,essentially,the energy input,favor the nucleation of the bulk nanobubbles with a more concentrated size distribution,a higher concentration,and a smaller hydrodynamic *** temperature dependence of the bulk nanobubbles over a wide range from 25°C to 70°C is *** is found that the nanobubble first shrinks in size significantly and then the size keeps approximately constant with the increasing temperature,showing a narrow size *** transition temperature is around 45°***,as an open system,the NTA is a potential tool in the study of the dynamic behavior of the bulk nanobubbles in situ,such as the coalescence and the collapse.

关键词： Nanoparticle tracking analysis bulk nanobubble light scattering hydrodynamic size number concentration

Velocity profile of debris flow based on quadratic rheology model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2021年第8期18卷 2120-2129页

作者： DU Cui WU Wei-ming ma chao School of Civil Engineering Henan University of Science and TechnologyLuoyang471000China Department of Civil and Environmental Engineering Clarkson UniversityNew York13699USA School of Soil and Water Conservation Beijing Forestry UniversityBeijing100083China

The quadratic rheology model considers the yield stress,viscous stress,turbulent stress and disperse stress,so it is used in this study to derive the velocity profile of debris *** quadratic model with the parabolic eddy viscosity was numerically solved,and an analytical solution was derived for the quadratic model with a constant eddy *** two solutions were compared with the Arai-Takahashi model that excluded the viscous stress and the yield *** three models were tested by using 17 experiment cases of debris flows over rigid *** results prove that the quadratic model with parabolic and constant eddy viscosities is applicable to muddy and granular flows,whereas the Arai-Takahashi model tends to overestimate the flow velocity near the water surface if a plug-like layer *** addition,the von Karman constant and the zero-velocity elevation in the three models are related to sediment *** von Karman constant decreases first and then increases as the sediment concentration *** zero-velocity elevation is below the bed surface,likely due to the invalidity of the non-slip boundary condition for the debris flows over fixed beds.

关键词： Debris flow Velocity profile Parabolic model von Karman constant