检索结果-南通市图书馆

Analytical model for predicting time-dependent lateral deformation of geosynthetics-reinforced soil walls with modular block facing

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 711-725页

作者： Luqiang ding Chengzhi Xiao Feilong Cui School of Civil and Transportation Engineering Hebei University of TechnologyTianjin300401China

To date,few models are available in the literature to consider the creep behavior of geosynthetics when predicting the lateral deformation(d)of geosynthetics-reinforced soil(GRS)retaining *** this study,a general hyperbolic creep model was first introduced to describe the long-term deformation of geosynthetics,which is a function of elapsed time and two empirical parameters a and *** conventional creep tests with three different tensile loads(Pr)were conducted on two uniaxial geogrids to determine their creep behavior,as well as the a-Pr and b-Pr *** test results show that increasing Pr accelerates the development of creep deformation for both ***,a and b respectively show exponential and negatively linear relationships with Pr,which were confirmed by abundant experimental data available in other *** on the above creep model and relationships,an accurate and reliable analytical model was then proposed for predicting the time-dependent d of GRS walls with modular block facing,which was further validated using a relevant numerical investigation from the previous *** evaluation and comparison of the proposed model with six available prediction models were *** a parametric study was carried out to evaluate the effects of wall height,vertical spacing of geogrids,unit weight and internal friction angle of backfills,and factor of safety against pullout on d at the end of construction and 5 years *** findings show that the creep effect not only promotes d but also raises the elevation of the maximum d along the wall ***,the limitations and application prospects of the proposed model were discussed and analyzed.

关键词： Geosynthetics Creep behavior Geosynthetics-reinforced soil(GRS)walls Lateral deformation Analytical model

Targeted nanostrategies eliminate pre-metastatic niche of cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5358-5373页

作者： Juan Wang Ning Zhang Xiuping ding Chengrui Fu Xiaodong Li Baosheng Li Jianxun ding Tianmeng Sun Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education Institute of ImmunologyThe First HospitalJilin University1 Xinmin StreetChangchun 130061China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical Sciences440 Jiyan RoadJinan 250117China Department of orthopaedics The Second Hospital of Shandong UniversityShandong University247 Beiyuan StreetJinan 250033China State Key Laboratory of Molecular Engineering of Polymers Fudan University220 Handan RoadShanghai 200433China

Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer *** advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical *** advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments.A series of nanostrategies have been designed to eliminate the PMN,including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines,the targeting and scavenging of myeloid-derived suppressor cells,fibroblasts,and critical extracellular matrix components,and the elimination of circulating tumor cells prior to colonization in distant *** review summarizes the underlying mechanisms of PMN formation,highlights the anti-PMN efficacy of currently reported nanostrategies,and underlines the unresolved questions.

关键词： nanoparticle controlled drug delivery pre-metastatic niche elimination metastasis suppression cancer therapy

Benchmark experiment on slab^(238)U with D-T neutrons for validation of evaluated nuclear data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第2期35卷 145-159页

作者： Yan-Yan ding Yang-Bo Nie Yue Zhang Zhi-Jie Hu Qi Zhao Huan-Yu Zhang Kuo-Zhi Xu Shi-Yu Zhang Xin-Yi Pan Chang-Lin Lan Jie Ren Xi-chao Ruan Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 62100China

A benchmark experiment on^(238)U slab samples was conducted using a deuterium-tritium neutron source at the China Institute of Atomic *** leakage neutron spectra within energy levels of 0.8-16 MeV at 60°and 120°were measured using the time-of-flight *** samples were prepared as rectangular slabs with a 30 cm square base and thicknesses of 3,6,and 9 *** leakage neutron spectra were also calculated using the MCNP-4C program based on the latest evaluated files of^(238)U evaluated neutron data from CENDL-3.2,ENDF/B-Ⅷ.0,JENDL-5.0,and *** on the comparison,the deficiencies and improvements in^(238)U evaluated nuclear data were *** results showed the following.(1)The calculated results for CENDL-3.2 significantly overestimated the measurements in the energy interval of elastic scattering at 60°and 120°.(2)The calculated results of CENDL-3.2 overestimated the measurements in the energy interval of inelastic scattering at 120°.(3)The calculated results for CENDL-3.2 significantly overestimated the measurements in the 3-8.5 MeV energy interval at 60°and 120°.(4)The calculated results with JENDL-5.0 were generally consistent with the measurement results.

关键词： Leakage neutron spectra Uranium D-T neutron source Evaluated nuclear data

Dynamic impact properties of deep sandstone under thermal-hydraulicmechanical coupling loads

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第6期21卷 2113-2129页

作者： CAO Chunhui ding Haonan ZOU Baoping School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China Zhejiang-Singapore Joint Laboratory for Urban Renewal and Future City Hangzhou 310023China

The deep rock mass within coal mines situated in a challenging environment are characterized by high ground stress,high geotemperature,high osmotic water pressure,and dynamic disturbances from mechanical *** investigate the impact of this complex mechanical environment on the dynamic characteristics of roof sandstone in self-formed roadways without coal pillars,standard specimens of deep sandstone from the 2611 upper tunnel working face of the Yongmei Company within the Henan Coal Chemical Industry Group in Henan,China were prepared,and an orthogonal test was *** a self-developed geotechnical dynamic impact mechanics test system,triaxial dynamic impact tests under thermal-hydraulicmechanical coupling conditions were conducted on deep *** results indicate that under high confining pressure,deep sandstone exhibits pronounced brittle failure at low temperatures,with peak strength gradually decreasing as temperature and osmotic water pressure ***,under low confining pressure and low temperature,the brittleness of deep sandstone weakens gradually,while ductility ***,sandstone demonstrates higher peak strength at low temperatures under high axial pressure conditions,lower peak strength at high temperatures,and greater strain under low axial pressure and high osmotic water *** in impact air pressure and osmotic water pressure have proportionally greater effects on peak stress and peak *** 50%of the input strain energy is utilized as effective energy driving the sandstone fracture *** analysis identifies the optimal combination of factors affecting the peak stress and peak strain of *** the coupling effect,intergranular and transgranular fractures occur within the *** images illustrate that the damage forms range from minor damage with multiple fissures to extensive fractures and severe *** study elucidates the varied dynamic impact me

关键词： Deep sandstone Thermal-hydraulicmechanical coupling Dynamic impact Stress-strain Failure Modes Polar analysis

Harnessing bacteria for tumor therapy:Current advances and challenges

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： Lina Guo Jinsong ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

Heat management technology for solid-state high voltage and high repetitive pulse generators:Towards better effects and reliability

在线全文

学校读者我要写书评

暂无评论

High Voltage 2024年第1期9卷 2-21页

作者： Yanan Wang Linyuan Ren Zihao Yang Saikang Shen Zichen Deng Qi Yuan Weidong ding Zhenjie ding School of Electrical Engineering Xi'an Jiaotong UniversityXi'anChina School of Electronic and Information Engineering Xi'an Jiaotong UniversityXi'anChina

Solid-state high voltage high repetitive pulse generators have a broad prospect in various *** high power and high-frequency operation of the pulse generator suffer from the massive heat dissipation problem,which limits the improvement of the output parameters and even affects the *** article focuses on heat management technology for high voltage high repetitive pulse ***,the typical circuit topology of the high repetitive pulse generators was *** the perspective of different application requirements,the demands of the heat management design were ***,the heat generation characteristics and difficulties of solid-state high voltage high repetitive pulse generators were ***,the different stateof-art cooling techniques were reviewed,and their applicability and limitations for the high voltage high repetitive generators were ***,a flow chart for heat management design was given.

关键词： pulse state high

A noval iron-capturing nanocomposites against biofilms for disrupting bacterial nutritional balance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第6期67卷 1760-1761页

作者： Jinying Lin Qihang ding Yao Sun Department of Oral Implantology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool of StomatologyJilin UniversityChangchun130021China Department of Chemistry Korea UniversitySeoul02841Korea National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan430079China

Currently,the escalating crisis of bacterial infections and antibiotic resistance poses a significant global public health challenge[1-3].This situation has driven the search for novel antimicrobial ***,a crucial micr... 详细信息

关键词： metabolism resistance balance

Dynamic motion of quadrupedal robots on challenging terrain:a kinodynamic optimization approach

在线全文

学校读者我要写书评

暂无评论

Frontiers of Mechanical Engineering 2024年第3期19卷 23-40页

作者： Qi LI Lei ding Xin LUO Engineering Research Center of Hubei Province for Clothing Information Wuhan 430200China School of Computer Science and Artificial Intelligence Wuhan Textile UniversityWuhan 430200China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

The dynamic motion of quadrupedal robots on challenging terrain generally requires elaborate spatial–temporal kinodynamic motion planning and accurate control at higher refresh rate in comparison with regular ***,conventional quadrupedal robots usually generate relatively coarse planning and employ motion replanning or reactive strategies to handle terrain *** resultant complex and computation-intensive controller may lead to nonoptimal motions or the breaking of locomotion *** this paper,a kinodynamic optimization approach is *** generate long-horizon optimal predictions of the kinematic and dynamic behavior of the quadruped robot on challenging terrain,we formulate motion planning as an optimization problem;jointly treat the foot’s locations,contact forces,and torso motions as decision variables;combine smooth motion and minimal energy consumption as the objective function;and explicitly represent feasible foothold region and friction constraints based on terrain *** track the generated motions accurately and stably,we employ a whole-body controller to compute reference position and velocity commands,which are fed forward to joint controllers of the robot’s *** verify the effectiveness of the developed approach through simulation and on a physical quadruped robot *** show that the quadruped robot can successfully traverse a 30°slope and 43% of nominal leg length high step while maintaining the rhythm of dynamic trot gait.

关键词： quadrupedal robot kinodynamic planning nonlinear optimization challenging terrain whole-body control

A human-sensitive frequency band vibration isolator for heavy-duty truck seats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1733-1748页

作者： Qingqing LIU Shenlong WANG Ge YAN Hu ding Haihua WANG Qiang SHI Xiaohong ding Huijie YU School of Mechanical Engineering University of Shanghai for Science and Technology State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of Mechnoinformatics Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering Science Shanghai University State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle Engineering Hunan University Yanfeng Adient Seating Co. Ltd. College of Mechanical and Electrical Engineering Jiaxing Nanhu University

In this study, a human-sensitive frequency band vibration isolator(HFBVI)with quasi-zero stiffness(QZS) characteristics for heavy-duty truck seats is designed to improve the comfort of heavy-duty truck drivers on uneven roads. First, the analytical expressions for the force and displacement of the HFBVI are derived with the Lagrange equation and d'Alembert's principle, and are validated through the prototype restoring force testing. Second, the harmonic balance method(HBM) is used to obtain the dynamic responses under harmonic excitation, and further the influence of pre-stretching on the dynamic characteristics and transmissibility is discussed. Finally, the experimental prototype of the HFBVI is fabricated, and vibration experiments are conducted under harmonic excitation to verify the vibration isolation performance(VIP) of the proposed vibration isolator. The experimental results indicate that the HFBVI can effectively suppress the frequency band(4–8 Hz) to which the human body is sensitive to vertical vibration. In addition, under real random road spectrum excitation, the HFBVI can achieve low-frequency vibration isolation close to 2 Hz, providing new prospects for ensuring the health of heavy-duty truck drivers.

关键词： 70L05 heavy-duty truck seat human-sensitive frequency band low-frequency vibration isolation O328 quasi-zero stiffness (QZS) real random road spectrum