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A novel non-invasive model to predict high-risk varices in cirrhotic patients

Hepatobiliary Surgery and Nutrition 2024年第3期13卷 530-532页

作者： Kelvin K.c.ng Department of Surgery The Chinese University of Hong Kong Medical CentreHong KongChina

Acute variceal bleeding is one of the most common and potentially life-threatening complications in patients with liver *** is conventionally diagnosed by oesophagogastroduodenoscopy,which is invasive to patients and carries hospital *** would be more cost-effective if non-invasive tests could screen out high-risk patients who developed acute variceal bleeding requiring endoscopic *** can potentially reduce the need for invasive procedures for cirrhotic *** recent years,there have been advancements in non-invasive methods for assessing the risk of variceal *** include transient elastography(FibroScan)of the liver and spleen,platelet count,imaging modalities[ultrasound or magnetic resonance imaging(MRI)],and non-invasive liver function tests[child-Pugh score or the Model for End-Stage Liver Disease(MELD)score].The 2.15 Baveno VI consensus is developed by an international panel of experts to improve the diagnosis and management of portal hypertension and its complications,specifically focusing on variceal bleeding in patients with cirrhosis(1).The consensus emphasizes using noninvasive methods to screen out high-risk varices(HRV)requiring therapeutic *** key features of the Baveno VI criteria include a liver stiffness measurement(LSM)2. kPa and a platelet count>150,000/*** can confidently rule out *** has been proven to avoid unnecessary endoscopy up to 40%with a specificity of up to 46%(2..In recent years,spleen stiffness measurement(SSM)has been a useful tool to assess portal hypertension and to predict ***,the revised Baveno VII consensus in 2.2. recommends SSM≤40 kPa would avoid more unnecessary endoscopy in patients who fall outside Baveno VI criteria,with a missed HRV rate of<5%(3).

关键词： Non-invasive model high-risk varices cirrhosis

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Dissipationless layertronics in axion insulator MnBi2.e4

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National Science Review 2024年第6期11卷 189-196页

作者： Shuai Li ming Gong Shuguang cheng Hua Jiang X.c.Xie School of Physical Science and Technology Soochow University Institute for Advanced Study Soochow University International center for Quantum Materials School of Physics Peking University Department of Physics Northwest University Interdisciplinary center for Theoretical Physics and Information Sciences Fudan University Hefei National Laboratory

Surface electrons in axion insulators are endowed with a topological layer degree of freedom followed by exotic transport phenomena, e.g., the layer Hall effect. Here, we propose that such a layer degree of freedom can be manipulated in a dissipationless way based on the antiferromagnetic MnBi2.e4with tailored domain structure. This makes MnBi2.e4a versatile platform to exploit the ‘layertronics’ to encode, process and store information. Importantly, the layer filter, layer valve and layer reverser devices can be achieved using the layer-locked chiral domain wall modes. The dissipationless nature of the domain wall modes makes the performance of the layertronic devices superior to those in spintronics and valleytronics. Specifically, the layer reverser, a layer version of the Datta–Das transistor, also fills up the blank in designing the valley reverser in valleytronics. Our work sheds light on constructing new generation electronic devices with high performance and low-energy consumption in the framework of layertronics.

关键词： axion insulator MnBi2.e4 layertronics antiferromagnetic domain wall dissipationless transport

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challenges and opportunities for battery health estimation:Bridging laboratory research and real-world applications

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Journal of Energy chemistry 2024年第2期89卷 434-436,I0011页

作者： Te Han Jinpeng Tian c.Y.chung Yi-{2. Wei center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Department of Electrical and Electronic Engineering and Research centre for Grid Modernization The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina

Addressing climate change demands a significant shift away from fossil fuels,with sectors like electricity and transportation relying heavily on renewable *** to this transition are energy storage systems,notably lithium-ion *** time,these batteries degrade,affecting their efficiency and posing safety *** and predicting battery aging is essential,especially estimating its state of health(SOH).Various SOH estimation methods exist,from traditional model-based approaches to machine learning approaches.

关键词： Energy storage systems State of health Multi-source data Scientific AI Data-sharing mechanism

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chinese expert consensus on the clinical application of drugcoated balloon(2.(nd) Edition)

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Journal of Geriatric cardiology 2024年第2期21卷 135-152页

作者： The Expert Writing committee of the chinese Expert consensus on clinical Applications of Drug-coated Balloon(2.(nd)Edition) Jun-Bo GE Yun-Dai cHEN 不详 Zhongshan Hospital Fudan University chinese PLA General Hospital

Percutaneous coronary interventions have progressed through the era of plain balloon dilation, bare-metal stent insertion to drug-eluting stent treatment, which has significantly reduced the acute occlusion and restenosis rates of target vessels and improved patient prognosis, making drug-eluting stents the mainstream interventional treatment for coronary artery disease. In recent years, drug-coated balloons(DcBs) have become a new treatment strategy for coronary artery disease, and the drugs used in the coating and the coating technology have progressed in the past years. Without permanent implant, a DcB delivers antiproliferative drugs rapidly and uniformly into the vessel wall via the excipient during a single balloon dilation. Many evidence suggests that DcB angioplasty is an effective measure for dealing with in-stent restenosis and de novo lesions in small coronary *** more clinical studies are published, new evidence is emerging for the use of DcB angioplasty in a wide range of coronary diseases, and the indications are expanding internationally. Based on the latest research from china and elsewhere, the Expert Writing committee of the chinese Expert consensus on clinical Applications of Drug-coated Balloon has updated the previous DcB consensus after evidence-based discussions and meetings in terms of adequate preparation of in-stent restenosis lesions, expansion of the indications for coronary de novo lesions, and precise guidance of DcB treatment by intravascular imaging and functional evaluation.

关键词： balloon drugs dealing

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Progress of Lyman-alpha-based beam emission spectroscopy(Ly BES)diagnostic on the HL-2. tokamak

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Plasma Science and Technology 2024年第3期26卷 118-125页

作者：周艺轩余羿许敏柯锐聂林徐皓赵光义刘灏袁子豪肖晨雨李继全肖池阶 the HL-2. Team Southwestern Institute of Physics Chengdu 610041People's Republic of China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082People's Republic of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871People's Republic of China

An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the HL-2. *** 2.-channel edge LyBES,which is intended to measure the density fluctuation in plasma edge(from R=1960 mm to R=2.2. mm)with an improved spatial resolution of 3.3 mm,is a complement to the existing conventional beam emission spectroscopy(BES)*** this article,we introduce the progress of LyBES diagnostic,including the collection optics,the monochromator,and the detector *** reflectance of the collection mirrors is measured to be~82.at 12. nm,and the aberration geometrical radius of the collection optics is tested to be~150μm in the aimed *** linear dispersion of the LyBES monochromator is designed to be~0.09 nm mm^(-1).The bandwidth of the detector system with the 5×10^(7)V A^(-1)preamplifier gain is measured to be~2.0 kHz,and the peak-to-peak noise of the detector system is tested to be~16 *** finalized design,components development and testing of the LyBES diagnostic have been completed at present,and an overall performance of the LyBES diagnostic is to be confirmed in the next HL-2. campaign.

关键词： density fluctuation Ly BES BES vacuum ultraviolet

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mRNA vaccines:a new era in vaccine development

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Oncology Research 2024年第10期32卷 1543-1564页

作者： SHUBHRA cHANDRA JENNIFER c.WILSON DAVID GOOD ming Q.WEI School of Pharmacy&Medical Sciences Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia School of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,particularly through the development of mRNA cancer vaccines,has ushered in a new era in the field of *** article provides a concise overview of the key principles,recent advancements,and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer *** cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune *** vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens,prompting the immune system to recognize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vaccines holds immense potential for addressing the heterogeneity of cancer and tailoring treatments to individual *** breakthroughs in the development of mRNA vaccines,exemplified by the success of cOVID-19 vaccines,have accelerated their application in *** mRNA platform’s versatility allows for the rapid adaptation of vaccine candidates to various cancer types,presenting an agile and promising avenue for therapeutic *** trials of mRNA cancer vaccines have demonstrated encouraging results in terms of safety,immunogenicity,and *** candidates,such as BioNTech’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outcomes in targeting melanoma and solid tumors,*** successes underscore the potential of mRNA vaccines to elicit robust and durable anti-cancer immune *** the field holds great promise,challenges such as manufacturing complexities and cost considerations need to be addressed for widespread *** development of scalable and cost-effective manufacturing processes,along with ongoing clinical research,will be pivotal in realizing the full potential of mRNA cancer ***,mRNA cancer vaccines represent a cutting-edge therapeutic approach that holds the promise of transforming cancer treatment.

关键词： cancer immunotherapy Immune checkpoint Preventive&therapeutic vaccine Delivery system mRNA

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多措并举标本兼治有力有效做好基督教工作

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中国宗教 2024年第5期 33-34页

作者： 1.中共山东省委统战部 2.山东省民宗委中共山东省委统战部山东省民宗委

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责... 详细信息

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责任制,通过强化组织保障“小切口”,推动基层宗教事务管理“大文章”。一是压实主体责任。将宗教工作纳入各级党委重要议事日程,构建起各级党委齐抓共管的工作体制。

关键词：基督教中国化齐抓共管宗教事务管理主体责任工作责任制和谐稳定严格落实标本兼治

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Jetting-based bioprinting:process,dispense physics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei Long ng Viktor Shkolnikov Singapore centre for 3D Printing(Sc3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore HP Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning

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The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on HL-2. tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 Maarten DE BOcK Manfred von HELLERMANN Michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the HL-2. Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China college of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

charge-exchange(cX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the HL-2. tokamak. The simultaneous measurements of He II(468.57 nm), c VI(52..1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed cX intensity is obviously too high. Modeling of the active He II cX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： cXRS ion temperature plasma rotation impurity concentration

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永恒的丰碑：“大陈岛垦荒红色档案”建设侧记

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浙江档案 2024年第5期 10-11+16页

作者： 1.台州市档案馆 2.台州市椒江区档案馆台州市档案馆台州市椒江区档案馆

在台州市椒江区档案馆的特藏馆内，挂着一幅由团中央在1956年赠给温州青年志愿垦荒队的旗帜“建设伟大祖国的大陈岛”，这面旗帜承载着一件件珍贵的档案史料和一个个生动的历史场景，大陈岛激情燃烧的垦荒史、波澜壮阔的发展史，宛如画...

在台州市椒江区档案馆的特藏馆内，挂着一幅由团中央在1956年赠给温州青年志愿垦荒队的旗帜“建设伟大祖国的大陈岛”，这面旗帜承载着一件件珍贵的档案史料和一个个生动的历史场景，大陈岛激情燃烧的垦荒史、波澜壮阔的发展史，宛如画卷般展现在眼前。“大陈岛垦荒精神”是台州的城市精神，是这座城市发展生生不息的力量源泉。1956年到1960年，温州、台州两地467名青年陆续上岛支援建设，他们卷起裤管，咬紧牙关，用血和汗锻炼成了一个个生产能手，在荒岛上发展出种植业、畜牧业和海洋养殖业。一代垦荒人用青春和汗水孕育了“艰苦创业、奋发图强、无私奉献、开拓创新”

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