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First spectroscopic study of HFRC plasma

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Plasma Science and Technology 2024年第8期26卷 18-24页

作者：毛安程芝峰饶波杨菁珉张明 International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic TechnologyWuhan 430074People’s Republic of China School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

An advanced spectral diagnostic system was developed to measure the electron temperature(T_(e)),electron density(N_(e)),and ion temperature(T_(i))of the Huazhong University of Science and Technology field-reversed configuration *** system consists of an optic fiber spectrometer with a wide spectral band and a 670 mm focal length high throughout Czerny-Turner monochromator equipped with both a 3600 g mm^(-1)grating and a 2400 g mm^(-1)grating to measure the line *** these components is an electronmultiplying charge-coupled device camera to capture spectral *** relative intensity of the optical fiber spectrometer was calibrated using a standard luminance source,and the wavelength calibration of the spectrometer was accomplished using a Hg/Ar *** diagnostic setup was configured to measure electron density based on the Stark effect of H_γ(n=5→n=2;434.04 nm).Doppler broadening of an OⅢ(2s^(2)2p(^(2)P^(0))3p→2s^(2)2p(^(2)P^(0))3s;375.988 nm)emission line was measured and analyzed to obtain the ion temperature,and electron temperatures were estimated from the relative strength of H_(β)(n=4→n=2;486.14 nm)(D_(β))and H_(γ)(D_(γ))spectral lines when the electron density was obtained from Stark effect *** initial experimental results indicate that the highest electron temperature of the formation region was approximately 8 eV,the electron density of the colliding-and-merging region was approaching 10^(20)m^(-3),and the ion temperature reached about 40 eV.

关键词： Stark effect Doppler effect ion temperature electron density electron temperature

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Meta-analysis of factors influencing anterior knee pain after total knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 180-191页

作者： Hui Feng ming-Li Feng Jing-bo Cheng Xiang Zhang Hai-Cheng Tao Department of Orthopaedic Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Total knee arthroplasty(TKA)is a mature procedure recommended for correcting knee osteoarthritis deformity,relieving pain,and restoring normal *** TKA is a successful and cost-effective procedure,patient dissatisfaction is as high as 50%.Knee pain after TKA is a significant cause of patient dissatisfaction;the most common location for residual pain is the anterior *** 4%and 40%of patients have anterior knee pain(AKP).AIM To investigate the effect of various TKA procedures on postoperative *** We searched PubMed,EMBASE,and Cochrane from January 2000 to September *** controlled trials with one intervention in the experimental group and no corresponding intervention(or other interventions)in the control group were *** researchers independently read the title and abstract of the studies,preliminarily screened the articles,and read the full text in detail according to the selection *** were resolved by consultation with a third *** relevant data from the included studies were extracted and analyzed using Review Manager 5.4 *** There were 25 randomized controlled trials;13 were comparative studies with or without patellar *** meta-analysis showed no significant difference between the experimental and control groups(P=0.61).Six studies were comparative studies of circumpatellar denervation vs non-denervation,divided into three subgroups for *** two-subgroup meta-analysis showed no significant difference between the experimental and the control groups(P=0.31,P=0.50).One subgroup meta-analysis showed a significant difference between the experimental and control groups(P=0.001).Two studies compared fixed-bearing TKA and mobile-bearing TKA;the results meta-analysis showed no significant difference between the experimental and control groups(P=0.630).Two studies compared lateral retinacular release vs non-release;the meta-analysis showed a signi

关键词： Total knee arthroplasty Anterior knee pain Knee osteoarthritis Interventions Meta-analysis

MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-bo cao Zhi-Yan Sun Sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

Recent progress on fabrication, spectroscopy properties, and device applications in Sn-doped CdS micro-nano structures

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Journal of Semiconductors 2024年第9期45卷 7-27页

作者： bo cao Ye Tian Huan Fei Wen Hao Guo Xiaoyu Wu Liangjie Li Zhenrong Zhang Lai Liu Qiang Zhu Jun Tang Jun Liu State Key Laboratory of Dynamic Measurement Technology School of Semiconductors and PhysicsNorth University of ChinaTaiyuan 030051China Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement North University of ChinaTaiyuan 030051China School of Instrument Science and Technology Xi'an Jiaotong UniversityXi'an 710049China

One-dimensional semiconductor materials possess excellent photoelectric properties and potential for the construction of integrated nanodevices. Among them, Sn-doped CdS has different micro-nano structures, including nanoribbons,nanowires, comb-like structures, and superlattices, with rich optical microcavity modes, excellent optical properties, and a wide range of application fields. This article reviews the research progress of various micrometer structures of Sn-doped CdS, systematically elaborates the effects of different growth conditions on the preparation of Sn-doped CdS micro-nano structures, as well as the spectral characteristics of these structures and their potential applications in certain fields. With the continuous progress of nanotechnology, it is expected that Sn-doped CdS micro-nano structures will achieve more breakthroughs in the field of optoelectronics and form cross-integration with other fields, jointly promoting scientific, technological, and social development.

关键词： Sn-doped CdS micro-nano structure superlattices optical microcavity

Crosstalk among Oxidative Stress,Autophagy,and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells:A Mixed Computational and Experimental Study

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Current Medical Science 2024年第3期44卷 578-588页

作者： Yi-miao LUO Shu-sen LIU ming ZHAO Wei WEI Jiu-xiu YAO Jia-hui SUN Yu cao Hao LI Department of Geriatrics Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan)Beijing100901China Department of Integration of Chinese and Western Medicine Peking University Health Science CenterBeijing100191China School of Pharmacy Harbin University of CommerceHarbin150028China Xiyuan Hospital China Academy of Chinese Medical ScienceBeijing100901China Wangjing Hospital China Academy of Chinese Medical ScienceBeijing100102China

Objective Brain microvascular endothelial cells (BMECs) were found to shift from their usually inactive state to an active state in ischemic stroke (IS) and cause neuronal damage. Ginsenoside Rb1 (GRb1),a component derived from medicinal plants,is known for its pharmacological benefits in IS,but its protective effects on BMECs have yet to be explored. This study aimed to investigate the potential protective effects of GRb1 on BMECs. Methods An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to mimic ischemia-reperfusion (I/R) injury. Bulk RNA-sequencing data were analyzed by using the Human Autophagy Database and various bioinformatic tools,including gene set enrichment analysis (GSEA),Gene Ontology (GO) classification and enrichment analysis,Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis,protein-protein interaction network analysis,and molecular docking. Experimental validation was also performed to ensure the reliability of our findings. Results Rb1 had a protective effect on BMECs subjected to OGD/R injury. Specifically,GRb1 was found to modulate the interplay between oxidative stress,apoptosis,and autophagy in BMECs. Key targets such as sequestosome 1 (SQSTM1/p62),autophagy related 5 (ATG5),and hypoxia-inducible factor 1-alpha (HIF-1α) were identified,highlighting their potential roles in mediating the protective effects of GRb1 against IS-induced damage. Conclusion GRbl protects BMECs against OGD/R injury by influencing oxidative stress,apoptosis,and autophagy. The identification of SQSTM1/p62,ATG5,and HIF-1α as promising targets further supports the potential of GRb1 as a therapeutic agent for IS,providing a foundation for future research into its mechanisms and applications in IS treatment.

关键词： ischemic stroke ginsenoside Rb1 brain microvascular endothelial cells oxidative stress autophagy apoptosis bioinformatic analysis

bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 646-652页

作者： Xuan Liu ming Liu Meng Ji bo Ma Yu-Cen Hou Xin-Yue Yao Qiao-Chu Cheng Li Chen Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an 710000Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment epithelial cell line(ARPE-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)*** cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell *** EMT-related indexes and BMP-6 protein levels were detected by Western ***,a BMP-6 overexpression plasmid was constructed and RPE cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression *** EMT-related indexes and extracellular regulated protein kinases(ERK)protein levels were ***:Compared with the control group,the migration of RPE cells in the TGF-β_(2) group was significantly ***-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of E-cadherin and BMP-6(P<0.05)in ***,the migration of RPE cells in the BMP-6 siRNA group was also significantly ***-6 siRNA increased the protein expression levels ofα-SMA,fibronectin and vimentin but significantly decreased the protein expression levels of E-cadherin(P<0.05).Overexpression of BMP-6 inhibited the migration of RPE cells induced by TGF-β_(2) and prevented TGF-β_(2) from affecting EMT-related biomarkers(P<0.05).CONCLUSION:BMP-6 prevents the EMT in RPE cells induced by TGF-β_(2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.

关键词： bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration

Prospect of ultrahigh-resolution fast neutron absorption spectroscopy based on a laser plasma electron accelerator

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High Power Laser Science and Engineering 2024年第1期12卷 108-115页

作者： Wen-Zhao Wang Jie Feng Xiao-Peng Zhang Yao-Jun Li Wei-Jun Zhou Wen-Chao Yan Guo-Qiang Zhang Chang-bo Fu Li-ming Chen Key Laboratory of Laser Plasma(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghaiChina Institute of High Energy Physics Chinese Academy of SciencesBeijingChina Shanghai Advanced Research Institute Chinese Academy of SciencesShanghaiChina Key Laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghaiChina

Fast neutron absorption spectroscopy is widely used in the study of nuclear structure and element analysis. However,due to the traditional neutron source pulse duration being of the order of nanoseconds, it is difficult to obtain a high-resolution absorption spectrum. Thus, we present a method of ultrahigh energy-resolution absorption spectroscopy via a high repetition rate, picosecond duration pulsed neutron source driven by a terawatt laser. The technology of single neutron count is used, which results in easily distinguishing the width of approximately 20 keV at 2 MeV and an asymmetric shape of the neutron absorption peak. The absorption spectroscopy based on a laser neutron source has one order of magnitude higher energy-resolution power than the state-of-the-art traditional neutron sources, which could be of benefit for precisely measuring nuclear structure data.

关键词： fast neutron absorption spectroscopy laser plasma accelerator photo-nuclear neutrons single neutron count

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Intermediate phase-assisted growth of CsPbBr_(3) for high performance of carbon-based perovskite solar cells

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Rare Metals 2024年第5期43卷 2222-2229页

作者： bo-Yan Liu He-ming Yang Yu-Dong Zuo Zhi-Hao Tao Jun-Chun Li Ya-Jing Chang Guo-Qing Tong Yang Jiang School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037China

CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against *** high energy barrier of phase transition from lead bromide(PbBr_(2))to CsPbBr_(3)perovskite and low solubility of perovskite in organic solvent impede the further improvement of device performance in terms of CsPbBr_(3)solar ***,an intermediate phase-assisted growth of CsPbBr_(3)perovskite was proposed by introducing tetraphenylphosphonium bromide(TPPB)as *** TPPB is expected to react with PbBr_(2)in organic solvent to form an intermediate phase of[***]-PbBr_(2),which not only effectively improves the crystallinity of PbBr2 crystals,but also greatly reduces the phase transition energy barrier,leading to uniform and compact CsPbBr_(3)perovskite films with large grain size and high *** combination with carbon electrode,the CsPbBr_(3)solar cells yield a champion device performance of 9.57%in comparison of pristine CsPbBr_(3)solar cells showing a low efficiency of 8.17%.Furthermore,the intermediate phaseassisted growth of CsPbBr_(3)-based solar cells displays an outstanding storage over720 h.

关键词： CsPbBr_(3) Perovskite solar cells Carbon electrode Hole transport layer free Intermediate phase

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International standard of Traditional Chinese Medicine Techniques: Traditional Chinese Medicine guidelines for acute primary headache(2022)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 839-850页

作者： YAO Yuning cao Kegang ZHANG Genming LIU Jianping CHEN Wei cao Junling YANG Wenming YAN Yongmei GENG Chang JU Yi ZHAO Dexi QU Miao LI Xiaoli SUN Li HAN Zhenyun HE Liyun CUI Fangyuan FU Caihong ZHOU bo LIAO Shuqin Department of Neurology Dongzhimen Hospital of Beijing University of Chinese Medicine Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine Encephalopathy center First Affiliated Hospital of Anhui University of Chinese Medicine Department of Neurology Affiliated Hospital of Shaanxi University of Chinese Medicine Department of Neurology Beijing Changping District Hospital of Traditional Chinese Medicine Neurology center Beijing Tiantan HospitalCapital Medical University Department of Neurology Affiliated Hospital of Changchun University of Chinese Medicine Department of Neurology Xuanwu HospitalCapital Medical University Department of Neurology Beijing University of Chinese Medicine Third Affiliated Hospital Department of Geriatrics Jilin Academy of Traditional Chinese Medicine Department of Neurology Shenzhen Hospital of Beijing University of Chinese Medicine Institute of Basic Research in Clinical Medicine China Academy Of Chinese Medical Sciences Department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital Department of Neurology Xiyuan Hospital of China Academy of Chinese Medical Sciences

OBJECTIVE: To summarize the evidence from Traditional Chinese Medicine(TCM) practice in the treatment of acute primary headache and provide clinical practice guidance. METHODS: The guidelines were developed in accordance with the World Health Organization guideline development manual. After the establishment of steering committee, panel and the registration and protocol formulation, the evidence on TCM for acute primary headache from published guidelines, clinical evidence, and expert experience and consensus were collected. The grading of recommendations assessment, development and evaluation method was used to grade the evidence and make the recommendations. RESULTS: Based on the available evidence, the guidelines recommended three TCM herbal decoctions, six Chinese patent medicines, and two kinds of external application of Chinese herbal medicines. Diagnostic recommendations based on the expert experience and consensus were also included in the guidelines. CONCLUSION: TCM diagnosis and treatment of decoction, Chinese patent medicine and external application for treating acute primary headache were recommended. We hope these guidelines will be helpful in standardize the TCM acute treatment of primary headache.

关键词： acute primary headache medicine, Chinese traditional practice guideline