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Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing wang Lin Guo Pan-Pan Ma Xiao-Long Ye ming-Lin Pan bo Hang Jian-Hua Mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

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Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-ming Xue Song Feng Yong-Hao Chen Han Yi Min Xiao Pin-Jing Cheng Xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao Hao-Qiang wang Bao-Qian Li Ji-Rong Zhao Lei-Xun Tang Wen Luo bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,In,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline

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Effects of Colloid Transport on Permeability of Water-bearing Media in Subsurface Environment

Effects of Colloid Transport on Permeability of Water-bearin...

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第十届全国渗流力学学术会议暨2009渗流力学及应用国际论坛

作者： LI Hai ming,wang bo Water & Soil Environment Pollution Control Laboratory,Tianjin University of Science &Technology, Tianjin 300457,China

A sets of sand column experiments were conducted to investigate the transport and deposition of colloids in water-saturated porous media,and the mechanism of the permeability reduced by transport and deposition of colloids are *** research results show that the breakthrough curves of colloid transport in water-bearing media presented as three stages:"not-yet-breakthrough","breakthrough in process","stable-breakthrough",however,there were no completely breakthrough. The concentration of colloid had great influence on the permeability of water-bearing media,and the effect of low concentration was relatively *** deposition of colloids was the main reason for the permeability loss of the porous media.

关键词： Colloid transport and deposition water-bearing media permeability

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Searching for new players in regulating axon outgrowth in Caenorhabditiselegans

Searching for new players in regulating axon outgrowth in Ca...

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2012全国发育生物学大会

作者： Jia-ming wang,bo Zhang,Song Song,Mei Ding Institute of genetics and developmental biology,Chinese Academy of Sciences,Beijing,100101

The nervous system development is a highly complex,but precisely controlled biological *** the formation of neural network,the axon of individual neuron needs to be guided to proper site and connect with its target cell. The proper axon outgrowth is regulated by guidance *** kinds of guidance cues have been identified in the past decades:Netrins,Slits,Semaphorins and ***,how a fairly limited number of guidance cues pattern the complex nervous system is less *** used *** neurons as a model to study axon *** previous studies in our lab have demonstrated that a conserved Wnt pathway plays an important role in RME A-P axon outgrowth.A Ror family kinase CAM-1,previously considered as Wnts inhibitor,functions as a main receptor for Wnt signal during this *** does CAM-1 facilitate Wnt signaling? Are there any other guidance factors cooperate with CAM-1 to guide axon outgrowth? In order to answer above questions,we performedan yeast two-hybrid screen using CAM-1 intracellular domain as a bait and indentified several putative CAM-1 binding *** functional analysis will be reported at the meeting. Conclusions:CAM-l functions as the Wnt receptor to regulate RME A-P axon outgrowth.

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SnO_(2)/metal organic complex composite derived from low-temperature activated metal organic complex for advanced lithium storage

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Rare Metals 2024年第7期43卷 3032-3043页

作者： Gui-Long Liu Zi-Han Zhao Jin-Ke Shen Zi-bo Zhao Nai-Teng Wu Dong-Lei Guo Wei-Wei Yuan Yong Liu Ye-Hua Su Xian-ming Liu Luoyang Key Laboratory of Green Energy Materials College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Inner Mongolia Shijie Chemical Co. Ltd.Alxa League 737300

Sn-based metal organic complexes with coordination bonds,multi-active sites,and high theoretical capacity have attracted much attention as promising anodes for lithium ion ***,the low electrical conductivity and huge volume changes restricted their electrochemical stability and practical ***,Snbased anode with superior electrochemical performance,including a high reversible capacity of 1050.1 mAh·g^(-1)at 2 A·g^(-1)and a stable capacity of 1105.5 mAh·g^(-1)after 500 cycles at 1 A·g^(-1),was fabricated via a low-temperature calcination strategy from Sn metal organic *** low-temperature calcination process regulates Sn-O bond and prevents the agglomeration of SnO_(2),generating highly dispersed SnO_(2) decorated metal organic complexes and providing sufficient active sites for ion *** situ characterizations expound that the undecomposed Sn-based metal organic complexes could be transformed into SnO_(2) during lithiation and delithiation,which enhances the electrical conductivity and induces a strong pseudo-capacitive behavior,accelerating the electrochemical kinetics;the multiple solid electrolyte interface with inflexible LiF and flexible ROCO_(2)Li buffers the volume variation of the electrode,resulting in its high electrochemical *** work provides a simple strategy for preparing excellent Sn-based anodes from metal organic complexes and reveals the lithium storage mechanism of the prepared Snbased anode.

关键词： Metal organic complex Lithium ion battery Electrochemical activation Low-temperature activation Partial decomposition

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IGBT断态下瞬时开通机理与模型预测研究

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武汉理工大学学报 2009年第23期31卷 130-133页

作者：唐勇陈明汪波海军工程大学电力电子研究所武汉430033

针对IGBT断态下由外加dv/dt引起的瞬时开通现象,基于IGBT的工作机理与物理模型进行分析并建立预测模型,并且实现了模型所需参数的准确提取。并针对某型器件采用该模型进行仿真计算,计算结果与实验测量值具有较好的一致性,证明了该模型... 详细信息

针对IGBT断态下由外加dv/dt引起的瞬时开通现象,基于IGBT的工作机理与物理模型进行分析并建立预测模型,并且实现了模型所需参数的准确提取。并针对某型器件采用该模型进行仿真计算,计算结果与实验测量值具有较好的一致性,证明了该模型方法的准确性。该模型对于指导IGBT的工程应用具有实际价值。

关键词： IGBT dv/dt 瞬时开通模型

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芳香耐热含能化合物合成研究进展

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含能材料 2017年第10期25卷 873-880页

作者：张俊林周静毕福强霍欢胡怀明王伯周西安近代化学研究所陕西西安710065 西北大学化学与材料科学学院陕西西安710127

芳环体系稳定性高,耐热含能化合物骨架多为芳环结构。根据环系不同对芳香耐热含能化合物进行分类,对单环、并环和偶联多芳环三类含能化合物的合成及性能进行综述。在全面总结近年来单环、并环和偶联多芳环三类不同结构的芳香耐热含能化... 详细信息

芳环体系稳定性高,耐热含能化合物骨架多为芳环结构。根据环系不同对芳香耐热含能化合物进行分类,对单环、并环和偶联多芳环三类含能化合物的合成及性能进行综述。在全面总结近年来单环、并环和偶联多芳环三类不同结构的芳香耐热含能化合物合成研究的基础上重点介绍了部分耐热性能突出的共轭型含能化合物的合成,同时讨论了分子结构与热稳定性之间的构效关联,并对芳香耐热含能化合物的研究前景进行了展望。

关键词：合成共轭偶联氢键稳定化耐热

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AICAR-based exercise mimetic alleviates aging-induced memory impairment through activating AMPK and improving mitochondrial quality control

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Food Science and Human Wellness 2024年

作者： bo Liao Yuan-Yuan Qin Shan-Yao Pan Gui-Ping wang Zhi Jiang Bin Li Yao wang Yu-Long wang ming-Chao Zhou Yong Zhang Gang Liu Zheng-Hong Qin Xue-Feng Xi Li Luo Department of Pharmacology and Laboratory of Aging and Nervous Diseases (SZS0703) Jiangsu Key Laboratory of Translational Research and Therapy for NeuroPsycho-Diseases， Soochow University School of Pharmaceutical Science College of Physical Education， Henan University School of Physical Education and Sports Science， Soochow University Department of Pharmacy， Suzhou Hospital of Traditional Chinese Medicine Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine Laboratory Animal Center， Medical College of Soochow University Center Lab of Ninth People's Hospital of Suzhou Department of Rehabilitation Medicine， Nan‘ao People's Hospital of Dapeng New District Rehabilitation Department， The First Affiliated Hospital of Shenzhen University， Shenzhen Second People's Hospital Tianjin Key Lab of Exercise Physiology and Sports Medicine， Tianjin University of Sport Department of Rehabilitation Medicine， Nanfang Hospital， Southern Medical University

Growing evidence suggests that exercise can provide neuroprotection by improving mitochondrial quality control (MQC) on the aged brain. Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) signaling responsiveness declines with aging. However， whether AMPK plays a role in the exercise-mediated improvement of memory and MQC in the aged hippocampus remains to be established. AICAR (5-Aminoimidazole 4-carboxamide ribonucleoside)， a pharmacological agonist of AMPK， has been proposed to be an exercise mimetic recently. However， it has not been clarified whether AICAR could mimic the effects of exercise on the aged hippocampus through improvement of MQC. In this study， AICAR (AMPK agonist) and Compound C (AMPK inhibitor) were used to investigate if AMPK plays a key role in exercise-induced improvement of MQC and if AICAR could act as an exercise mimetic through improvement of MQC in aged hippocampus. both exercise and AICAR improved the memory of aged mice and increased AMPK phosphorylation in the aged hippocampus. Exercise， but not AICAR， improved mitochondrial respiratory function in the aged hippocampus and increased the Microtubule associated protein 1 light chain 3 (LC3) II/LC3 I ratio and the protein expression of LC3 II and Autophagy Related Protein 7 (ATG7) in the lysate of whole hippocampal tissue. both exercise and AICAR increased the ratio of LC3 II/LC3 I and the protein expression of LC3 II in the mitochondrial fractions of the hippocampus. Regarding mitochondrial dynamics， neither exercise training nor AICAR changed the protein level of Mitofusin2 (Mfn2). Exercise， but not AICAR， increased the protein level of Dynamin-related protein 1 (Drp1). Furthermore， both exercise training and AICAR increased the protein level of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)， a modulator of mitochondrial biogenesis. Compound C abolished the exercise-induced effects on memory in aged mice (Fig. 1)， AMPK phosphorylation， autophagy， mitop

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Construction and validation of a neovascular glaucoma nomogram in patients with diabetic retinopathy after pars plana vitrectomy

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World Journal of Diabetes 2024年第4期15卷 654-663页

作者： Yi Shi Yan-Xin Zhang ming-Fei Jiao Xin-Jun Ren bo-Jie Hu Ai-Hua Liu Xiao-Rong Li Surgical Retina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Glaucoma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Ocular Trauma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected *** the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical *** To develop a visual risk profile model to explore factors influencing DR after *** We retrospectively selected 151 patients with DR undergoing *** patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after *** risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction *** After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram *** area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,*** AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,*** A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction *** study can help formulate relevant preventive and treatment measures.

关键词： Diabetic retinopathy Retinopathy Neovascular Glaucoma Risk factors Nomogram

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Hairpin RNA targeting multiple viral genes confers strong resistance to rice black-streaked dwarf virus

Hairpin RNA targeting multiple viral genes confers strong re...

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江苏省遗传学会2016年学术年会

作者：杨杰 Weigong Zhong Fangquan wang Wenqi Li Jinyan Zhu Fangjun Fan Jun wang ming-bo wang Qing Liu Qian-Hao Zhu Tong Zhou Ying Lan Yijun Zhou Institute of Food Crops Jiangsu Academy of Agricultural Sciences/Nanjing Branch of Chinese National Center for Rice Improvement/Jiangsu High Quality Rice R&D Center Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou University CSIRO Agriculture Institute of Plant Protection Jiangsu Academy of Agricultural Sciences

Rice black-streaked dwarf virus（RBSDV） belongs to the genus Fijivirus in the family of Reoviridae and causes severe yield loss in rice producing areas in *** silencing,as a natural defense mechanism against plant viruses,has been successfully exploited for engineering virus resistance in plants including *** this study,we generated transgenic rice lines harboring an hairpin RNA（hpRNA） construct targeting four RBSDV genes S1,S2,S6 and S10,encoding the RNA-dependent RNA polymerase,the putative core protein,the RNA silencing suppressor and the outer capsid protein,*** field nursery and artificial inoculation assays of three generations of the transgenic lines showed that they had strong resistance to RBSDV *** RBSDV resistance in the segregating transgenic populations correlated perfectly with the presence of the hpRNA ***,the hpRNA transgene was expressed in the highly resistant transgenic lines,giving rise to abundant levels of 21-24 nt small interfering RNA（siRNA）.Small RNA deep sequencing analysis of the RBSDV-resistant transgenic lines detected siRNAs from all four viral gene sequences in the hpRNA transgene,indicating that the whole chimeric fusion sequence can be efficiently processed by Dicer into *** together,our results suggest that long hpRNA targeting multiple viral genes can be used to generate stable and durable virus resistance in rice as well as other plant species.

关键词： RBSDV hpRNA RNAi multiple viral genes strong resistance

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