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Modeling and analysis for material removal and surface roughness in fluid jet polishing of optical glass

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Friction 2024年第7期12卷 1548-1563页

作者： Zhongchen CAO ming WANG Haitao LIU Tian huang Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin 300072China School of Engineering The University of WarwickCoventry CV47ALUK

luid jet polishing(FJP)is a non-contact polishing technology that can fabricate free-form optical surfaces with sub-micron-level form accuracy and nano-level surface roughness,especially for hard and brittle *** surface generation model of FJP can be used to guide the determination and optimization of process parameters and is of great significance for understanding the evolution mechanism of surface ***,predictive models for the microscopic topography of polished surfaces are still *** study established a macroscopic surface profile model for predicting 3D material removal characteristics and surface texture by combining the 3D computer fluid dynamics(CFD)simulation model and single-particle erosion mechanism.A fractal theory-based erosion model has been built to calculate the material removal caused by the erosion of a single abrasive particle on the rough surface;thus,it predicts the micro-topography and surface roughness of the polished samples.A series of polishing experiments were conducted to analyze the feasibility and accuracy of the model quantitatively and study the influence mechanism of process parameters on the material removal characteristics and surface *** indicated that the models could well predict material removal and surface *** prediction accuracy of the surface roughness Ra and maximum removal depth is better than 91.6%and 90%,*** is also found that the material removal rate of FJP could reach 0.517 mm3/min,and the surface roughness convergence rate could reach 62.9%.

关键词： fluid jet polishing(FJP) computational fluid dynamics(CFD) material removal mechanism surface roughness theoretical model

Assessment of Wet Season Precipitation in the Central United States by the Regional Climate Simulation of the WRFG Member in NARCCAP and Its Relationship with Large-Scale Circulation Biases

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Advances in Atmospheric Sciences 2024年第4期41卷 619-638页

作者： Yating ZHAO ming XUE Jing JIANG Xiao-ming HU Anning huang School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Center for Analysis and Prediction of Storms and School of Meteorology The University of OklahomaNorman 73072U.S.A

Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional ***,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are *** RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of *** dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the *** in reproducing large-scale circulation and environmental conditions is another contributing *** too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great *** simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as ***,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios.

关键词： NARCCAP Central United States precipitation low-level jet large-scale environment diurnal variation

A Deep Model for Partial Multi-label Image Classification with Curriculum-based Disambiguation

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Machine Intelligence Research 2024年第4期21卷 801-814页

作者： Feng Sun ming-Kun Xie Sheng-Jun huang MIIT Key Laboratory of Pattern Analysis and Machine Intelligence College of Computer Science and TechnologyNanjing University of AeronauticsandAstronauticsNanjing211106China

In this paper,we study the partial multi-label(PML)image classification problem,where each image is annotated with a candidate label set consisting of multiple relevant labels and other noisy *** PML methods typically design a disambiguation strategy to filter out noisy labels by utilizing prior knowledge with extra assumptions,which unfortunately is unavailable in many real ***,because the objective function for disambiguation is usually elaborately designed on the whole training set,it can hardly be optimized in a deep model with stochastic gradient descent(SGD)on *** this paper,for the first time,we propose a deep model for PML to enhance the representation and discrimination *** the one hand,we propose a novel curriculum-based disambiguation strategy to progressively identify ground-truth labels by incorporating the varied difficulties of different *** the other hand,consistency regularization is introduced for model training to balance fitting identified easy labels and exploiting potential relevant *** experimental results on the commonly used benchmark datasets show that the proposed method significantlyoutperforms the SOTA methods.

关键词： Partial multi-label image classification curriculum-based disambiguation consistency regularization label difficulty candidatelabel set.

Counterion-Mediated Hydrogen Bonding Making Strong Polyelectrolytes pH-Responsive:Current Understanding and Perspectives

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Chinese Journal of Polymer Science 2024年第9期42卷 1270-1277,I0005页

作者： Yue huang Guang-Tao Mei Zan Hua Guang-ming Liu Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei230026China The Key Laboratory of Functional Molecular Solids Ministry of Educationand Department of Materials ChemistrySchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu214002China

The counterion-mediated hydrogen bonding(CMHB)is related to the hydrogen bonding between bound counterions and polyelectrolyte chains in polyelectrolyte systems,where the counterions can both electrostatically bind to the charged groups of polyelectrolyte chains and act as hydrogen bond donors or acceptors to form hydrogen bonds with the hydrogen bond sites associated with polyelectrolyte chains simultaneously.A large number of literatures illustrate that strong polyelectrolytes(SPs)are insensitive to pH,which severely limmits the applications of SPs as smart ***,our studies have demonstrated that the CMHB makes SPs *** perspective discusses the mechanism of pH responsiveness of SPs and the pH-tunable properties of SPs,based on the pH-controlled CMHB *** future research directions on the pH responsiveness of SPs are also discussed *** is anticipated that the study of the pH responsiveness of SPs not only will provide a new understanding of the fundamental properties of SPs,but also will greatly expand the applications of SPs in the field of smart materials.

关键词： Counterion binding Hydrogen bond Polyelectrolyte brush Polyelectrolyte complexation

Experimental study of face passive failure features of a shallow shield tunnel in coastal backfill sand

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 252-271页

作者： Weifeng QIAN ming huang Bingnan WANG Chaoshui XU Yanfeng HU School of Civil Engineering Fuzhou UniversityFuzhou 350108China School of Civil Environment and Mining EngineeringUniversity of AdelaideAdelaide 5005Australia China First Highway Xiamen Engineering Co. Ltd.Xiamen 361000China

Face passive failure can severely damage existing structures and underground utilities during shallow shield tunneling,especially in coastal backfill *** this work,a series of laboratory model tests were developed and conducted to investigate such failure,for tunnels located at burial depth ratios for which C/D=0.5,0.8,1,and *** pressures,the evolution of failure processes,the failure modes,and the distribution of velocity fields were examined through model tests and numerical *** support pressure in the tests first rose rapidly to the elastic limit and then gradually increased to the maximum value in all *** maximum support pressure decreased slightly in cases where C/D=0.8,1,and 1.3,but the rebound was insignificant where C/D=*** addition,the configuration of the failure mode with C/D=0.5 showed a wedge-shaped arch,which was determined by the outcropping shear *** configuration of failure modes was composed of an arch and the inverted trapezoid when C/D=0.8,1,and 1.3,in which the mode was divided into lower and upper failure zones.

关键词： tunnel face stability passive failure model test support pressure failure mode

Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

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World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-Meng huang ming-Jin Zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

Base-controlled NHC-Ru-catalyzed transfer hydrogenation andα-methylation/transfer hydrogenation of ketones using methanol

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Chinese Chemical Letters 2024年第7期35卷 276-280页

作者： ming huang Xiuju Cai Yan Liu Zhuofeng Ke School of pharmacy School of clinical pharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Materials Science&Engineering PCFM LabSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with *** simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary ***,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and *** reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

关键词： Ru complexes Methanol Ketones β-Methylated secondary alcohols Transfer hydrogenation

Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia ming Sun Hai huang Wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

Risk Assessment of Deep-Water Horizontal X-Tree Installation

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China Ocean Engineering 2024年第2期38卷 210-220页

作者： MENG Wen-bo FU Guang-ming huang Yi LIU Shu-jie huang Liang GAOYong-hai CNOOC China Limited Zhanjiang BranchZhanjiang 524057China Key Laboratory of Unconventional Oil and Gas Development Ministry of Education(China University of Petroleum(East China))Qingdao 266580China

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault ***,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was ***,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top ***,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

关键词： subsea horizontal X-tree risk assessment fuzzy fault tree modular risk evaluation model