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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

Dynamics and adaptive control of a dual-arm space robot with closed-loop constraints and uncertain inertial parameters

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Acta Mechanica Sinica 2014年第1期30卷 112-124页

作者： ying-hong jia Quan Hu shi-jie xu School of Astronautics Beihang University

A dynamics-based adaptive control approach is proposed for a planar dual-arm space robot in the presence of closed-loop constraints and uncertain inertial parameters of the payload. The controller is capable of controlling the po- sition and attitude of both the satellite base and the payload grasped by the manipulator end effectors. The equations of motion in reduced-order form for the constrained system are derived by incorporating the constraint equations in terms of accelerations into Kane＇s equations of the unconstrained system. Model analysis shows that the resulting equations perfectly meet the requirement of adaptive controller design. Consequently, by using an indirect approach, an adaptive control scheme is proposed to accomplish position/attitude trajectory tracking control with the uncertain parameters be- ing estimated on-line. The actuator redundancy due to the closed-loop constraints is utilized to minimize a weighted norm of the joint torques. Global asymptotic stability is proven by using Lyapunov＇s method, and simulation results are also presented to demonstrate the effectiveness of the proposed approach.

关键词： Space robot Dynamics. Adaptive control Closed-loop constraint Parameter uncertainty - Kane's equation

Dynamics of a spacecraft with large flexible appendage constrained by multi-strut passive damper

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Acta Mechanica Sinica 2013年第2期29卷 294-308页

作者： ying-hong jia shi-jie xu Quan Hu School of Astronautics Beihang University

This paper is concerned with the dynamics of a spacecraft with multi-strut passive damper for large flexible *** damper platform is connected to the spacecraft by a spheric hinge,multiple damping struts and a rigid *** damping struts provide damping forces while the rigid strut produces a motion constraint of the multibody *** exact nonlinear dynamical equations in reducedorder form are firstly derived by using Kane＇s equation in matrix *** on the assumptions of small velocity and small displacement,the nonlinear equations are reduced to a set of linear second-order differential equations in terms of independent generalized displacements with constant stiffness matrix and damping matrix related to the damping strut *** simulation results demonstrate the damping effectiveness of the damper for both the motion of the spacecraft and the vibration of the flexible appendage,and verify the accuracy of the linear equations against the exact nonlinear ones.

关键词： Dynamics·Motion constraints·Multi-strut passive damper·Kane's equation

Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua Li Yong Peng Wei Dou Cailing xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-jia Hao xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu ying xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Controllability of an underactuated spacecraft with one thruster under disturbance

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Acta Mechanica Sinica 2012年第3期28卷 838-847页

作者： Dong-Xia Wang ying-hong jia Lei Jin Hai-Chao Gui shi-jie xu Department of Guidance Navigation and ControlSchool of AstronauticsBeihang University100191 BeijingChina

For an underactuated spacecraft using only one thruster, the attitude controllability with respect to the or- bit frame is studied in the presence of periodical oscillation disturbance, which provides a preconditional guide on de- signing control law for underactuated attitude control sys- tem. Firstly, attitude dynamic model was established for an underactuated spacecraft, and attitude motion was described using the special orthogonal group （SO （3））. Secondly, Liou- ville theorem was used to confirm that the flow generated by the drift vector of the underactuated attitude control system is volume-preserving. Furthermore, according to Poincar6＇s re- currence theorem, we draw conclusions that this drift field is weakly positively poisson stable （WPPS）. Thirdly, the suffi- cient and necessary condition of controllability was obtained on the basis of lie algebra rank condition （LARC）. Finally, the controllable conditions were analyzed and simulated in different cases of inertia matrix with the installed position of thruster.

关键词： Underactuated spacecraft Periodical oscilla-tion disturbance. Controllability. Weakly positively poissonstable ~ Lie algebra

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma jia Liu Xiang Xia Ning xu Wen Sun jianjun Du jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Context-Based Moving Object Trajectory Uncertainty Reduction and Ranking in Road Network

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Journal of Computer Science & Technology 2016年第1期31卷 167-184页

作者： jian Dai Zhi-ming Ding jia-jie xu School of Computer Science Beijing University of Technology Beijing 100124 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Software Chinese Academy of Sciences Beijing 100190 China School of Computer Science and Technology Soochow University Suzhou 215000 China

To support a large amount of GPS data generated from various moving objects, the back-end servers usually store low-sampling-rate trajectories. Therefore, no precise position information can be obtained directly from the back-end servers and uncertainty is an inherent characteristic of the spatio-temporal data. How to deal with the uncertainty thus becomes a basic and challenging problem. A lot of researches have been rigidly conducted on the uncertainty of a moving object itself and isolated from the context where it is derived. However, we discover that the uncertainty of moving objects can be efficiently reduced and effectively ranked using the context-aware information. In this paper, we focus on context- aware information and propose an integrated framework, Context-Based Uncertainty Reduction and Ranking （CURR）, to reduce and rank the uncertainty of trajectories. Specifically, given two consecutive samplings, we aim to infer and rank the possible trajectories in accordance with the information extracted from context. Since some context-aware information can be used to reduce the uncertainty while some context-aware information can be used to rank the uncertainty, to leverage them accordingly, CURR naturally consists of two stages： reduction stage and ranking stage which complement each other. We also implement a prototype system to validate the effectiveness of our solution. Extensive experiments are conducted and the evaluation results demonstrate the efficiency and high accuracy of CURR.

关键词： moving object trajectory uncertainty reduction road network context-aware information