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GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期68卷 145-158页

作者： Wei JU Yiyang gu Zhengyang MAO Ziyue QIAO Yifang QIN Xiao LUO Hui XIONG ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augmentations graph pooling

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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文明叙事:习近平文化思想的方法论审视

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 34-42页

作者：张明谷生秀南京大学马克思主义学院江苏南京210023

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基... 详细信息

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基因,即从中华5000多年文明的历史传承中把握中国道路的来龙去脉及其内在逻辑必然;二是以“第二个结合”为根本方法,重塑发展中华文明的使命担当,不断推动建设中华民族现代文明实现传统文明的现代新生;三是坚守文明超越理念,将新文明的建构与中国式现代化的现实实践相互关联,以中国式现代化创造人类文明新形态,打破西方以资本逻辑为核心的形而上学抽象文明观的历史困境;四是坚持文明交流互鉴,推动落实全球文明倡议,构建人类文明交往新范式。

关键词：习近平文化思想文明叙事 “走自己的路” “第二个结合” 文明交流互鉴

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氯霉素鱼肝油乳剂中氯霉素含量的测定

上海中医药大学学报 2003年第4期17卷 55-56页

作者：余敏英奚燕杨铭顾希钧郝明上海中医药大学附属龙华医院药剂科上海200032

为建立氯霉素鱼肝油乳剂中氯霉素的含量测定方法 ,采用紫外分光光度法测定其含量 ,检测波长为 2 75nm。结果显示 ,线性浓度范围为 4 97μg/ml-2 9 82 μg/ml,平均回收率为 99 48% ,RSD为 2 0 8%。本法简便、快速、准确。

关键词：氯霉素鱼肝油乳剂氯霉素含量测定紫外分光光度法

An Online Website Fingerprinting Defense Based on the Non-Targeted Adversarial Patch

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Tsinghua Science and Technology 2023年第6期28卷 1148-1159页

作者： Xiaodan gu Bingchen Song Wei Lan ming yang School of Computer Science and Engineering Southeast UniversityNanjing 211189China

Website Fingerprinting(WF)attacks can extract side channel information from encrypted traffic to form a fingerprint that identifies the victim’s destination website,even if traffic is sophisticatedly anonymized by *** offline defenses have been proposed and claimed to have achieved good ***,such work is more of a theoretical optimization study than a technology that can be applied to real-time traffic in the practical *** defenders generate optimized defense schemes only if the complete traffic traces are *** practicality and effectiveness are *** this paper,we provide an in-depth analysis of the difficulties faced in porting existing offline defenses to the online *** then the online WF defense based on the non-targeted adversarial patch is *** reduce the overhead,we use the Gradient-weighted Class Activation Mapping(Grad-CAM)algorithm to identify critical segments that have high contribution to the *** addition,we optimize the adversarial patch generation process by splitting patches and limiting the values,so that the pre-trained patches can be injected and discarded in real-time *** experiments are carried out to evaluate the effectiveness of our *** bandwidth overhead is set to 20%,the accuracies of the two state-of-the-art attacks,DF and Var-CNN,drop to 10.83%and 15.49%,***,we implement the real-time patch traffic injection based on WFPadTools framework in the online scenario,and achieve a defense accuracy of 95.50%with 12.57%time overhead.

关键词： website fingerprinting online defense adversarial patch traffic analysis

An Active De-anonymizing Attack Against Tor Web Traffic

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Tsinghua Science and Technology 2017年第6期22卷 702-713页

作者： ming yang Xiaodan gu Zhen Ling Changxin Yin Junzhou Luo School of Computer Science and Engineering Southeast University Nanjing 211189 China

Tor is pervasively used to conceal target websites that users are visiting. A de-anonymization technique against Tor, referred to as website fingerprinting attack, aims to infer the websites accessed by Tor clients by passively analyzing the patterns of encrypted traffic at the Tor client side. However, HTTP pipeline and Tor circuit multiplexing techniques can affect the accuracy of the attack by mixing the traffic that carries web objects in a single TCP connection. In this paper, we propose a novel active website fingerprinting attack by identifying and delaying the HTTP requests at the first hop Tor node. Then, we can separate the traffic that carries distinct web objects to derive a more distinguishable traffic pattern. To fulfill this goal, two algorithms based on statistical analysis and objective function optimization are proposed to construct a general packet delay scheme. We evaluate our active attack against Tor in empirical experiments and obtain the highest accuracy of 98.64%, compared with 85.95% of passive attack. We also perform experiments in the open-world scenario. When the parameter k of k-NN classifier is set to 5, then we can obtain a true positive rate of 90.96% with a false positive rate of 3.9%.

关键词： traffic analysis active website fingerprinting anonymous communication Tor

Electronic and Shallow Impurity States in Semiconductor Heterostructures Under an Applied Electric Field

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Communications in Theoretical Physics 2005年第2X期44卷 375-380页

作者： ZHOU Hai-yang gu Shi-Wei SHI Yao-ming Department of Physics Shanghai University Shanghai 200436 China Department of Applied Physics Shanghai Jiao Tong University Shanghai 200030 China

With the use of variational method to solve the effective mass equation, we have studied the electronic and shallow impurity states in semiconductor heterostructures under an applied electric field. The electron energy levels are calculated exactly and the impurity binding energies are calculated with the variational approach. It is found that the behaviors of electronic and shallow impurity states in heterostructures under an applied electric field are analogous to that of quantum wells. Our results show that with the increasing strength of electric field, the electron confinement energies increase, and the impurity binding energy increases also when the impurity is on the surface, while the impurity binding energy increases at first, to a peak value, then decreases to a value which is related to the impurity position when the impurity is away from the surface. In the absence of electric field, the result tends to the Levine's ground state energy (-1/4 effective Rydberg) when the impurity is on the surface, and the ground impurity binding energy tends to that in the bulk when the impurity is far away from the surface. The dependence of the impurity binding energy on the impurity position for different electric field is also discussed.

关键词： heterostructures electric field impurity states

Some important aspects of wind-resistant studies on long-span bridges

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Science China(Technological Sciences) 2012年第12期55卷 3334-3343页

作者： gu ming State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China

In recent years many long-span bridges have been or are being constructed in the world, especially in China. Wind loads and responses are the key factors for their structural design. This paper introduces some important achievements of wind-resistant studies of the author's research team on long-span bridges. First, new concepts and identification methods of aerodynamic derivatives and aerodynamic admittances were proposed. Then mechanical and aerodynamic control strategies and methods of wind-induced vibrations of long-span bridges were the great concerned problems, and valuable achievements were presented. Especially, great efforts which have been theoretically and experimentally made on rain-wind induced vibration of cables of cable-stayed bridges were described. Finally, some new progresses in computation wind engineering were introduced, and a new method for simulating an equilibrium boundary layer was put forward as well.

关键词： long-span bridge aerodynamic derivative and admittance flutter and buffeting control rain-wind induced vibration ofstay cable computation wind engineering equilibrium boundary layer

Recent progress on anti-Candida natural products

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Chinese Journal of Natural Medicines 2021年第8期19卷 561-579页

作者： SUN Fu-Juan LI Min gu Liang WANG ming-Ling yang ming-Hua State Key Laboratory of Natural Medicines Department of Natural Medicinal ChemistryChina Pharmaceutical UniversityNanjing 210009China

Candida is an intractable life-threatening *** infection is extremely difficult to eradicate,and thus is the major cause of morbidity and mortality in immunocompromised ***,the rapid spread of drug-resistant fungi has led to significant decreases in the therapeutic effects of clinical *** anti-Candida agents are urgently needed to solve the complicated medical *** products with intricate structures have attracted great attention of researchers who make every endeavor to discover leading compounds for antifungal *** novel mechanisms and diverse modes of action expand the variety of fungistatic agents and reduce the emergence of drug *** recent decades,considerable effort has been devoted to finding unique antifungal agents from nature and revealing their unusual mechanisms,which results in important progress on the development of new antifungals,such as the novel cell wall inhibitors YW3548 and SCY-078 which are being tested in clinical *** review will present a brief summary on the landscape of anti-Candida natural products within the last *** will also discuss in-depth the research progress on diverse natural fungistatic agents along with their novel mechanisms.

关键词： Candida Natural products Antifungal activity Mechanisms