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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin ming yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

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Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan Jie Chen Jin-Zhong Yu Fei-Peng Xu Fei-Fei Xing De-Xin Wang ming-Yan yang Feng Xing Jian Wang Yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

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Selective nano-buckling improves the performance of graphene logic transistors

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National Science Review 2024年第2期11卷 95-96页

作者： Tong yang ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

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Variational Bayesian data analysis on manifold

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Control Theory and Technology 2018年第3期16卷 212-220页

作者： yang ming Key Lab of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

In this paper, variational inference is studied on manifolds with certain metrics. To solve the problem, the analysis is first proposed for the variational Bayesian on Lie group, and then extended to the manifold that is approximated by Lie groups. Then the convergence of the proposed algorithm with respect to the manifold metric is proved in two iterative processes： variational Bayesian expectation （VB-F） step and variational Bayesian maximum （VB-M） step. Moreover, the effective of different metrics for Bayesian analysis is discussed.

关键词： Variational Bayesian Lie group data analysis

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The Center Problem and Time-Reversibility with Respect to a Quadratic Involution for a Class of Polynomial Differential Systems with Order 2 or 3

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Journal of Systems Science & Complexity 2022年第4期35卷 1608-1636页

作者： yang Jing yang ming LU Zhengyi Chengdu Institute of Computer Application Chinese Academy of SciencesChengdu610041China University of Chinese Academy of Sciences Beijing100049China School of Mathematical Sciences Sichuan Normal UniversityChengdu610068China

Most studies of the time-reversibility are limited to a linear or an affine *** this paper,the authors consider the case of a quadratic *** a polynomial differential system with a linear part in the standard form(-y,x)in R~2,by using the method of regular chains in a computer algebraic system,the computational procedure for finding the necessary and sufficient conditions of the system to be time-reversible with respect to a quadratic involution is *** the system is quadratic,the necessary and sufficient conditions can be completely obtained by this *** some cubic systems,the necessary and sufficient conditions for these systems to be time-reversible with respect to a quadratic involution are also *** conditions can guarantee the corresponding systems to have a ***,a property of a center-focus system is discovered that if the system is time-reversible with respect to a quadratic involution,then its phase diagram is symmetric about a parabola.

关键词： Center polynomial differential systems quadratic involution regular chains time-reversibility

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Research of Optical Fiber Coil Winding Model Based on Large-deformation Theory of Elasticity and Its Application

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Chinese Journal of Aeronautics 2011年第5期24卷 640-647页

作者： JIA ming yang Gongliu School of Instrumentation Science and Opto-electronics Engineering Beihang University Beijing 100191 China

Optical fiber coil winding model is used to guide proper and high precision coil winding for fiber optic gyroscope （FOG） application. Based on the large-deformation theory of elasticity, stress analysis of optical fiber free end has been made and balance equation of infinitesimal fiber is deduced, then deformation equation is derived by substituting terminal conditions. On condition that only axial tensile force exists, approximate curve equation has been built in small angle deformation scope. The comparison of tangent point longitudinal coordinate result between theory and approximation gives constant of integration, and expression with tangent point as origin of coordinate is readjusted. Analyzing the winding parameters of an example, it is clear that the horizontal distance from the highest point of wheel to fiber tangent point has millimeter order of magnitude and significant difference with fiber tension variation, and maintains invariant when wheel radius changes. The height of tension and accurate position of tangent point are defined for proper fiber guide. For application to fiber optic gyroscope, spiral-disc winding method and nonideal deformation of straddle section are analyzed, and then spiral-disc quadrupole pattern winding method has been introduced and realized by winding system. The winding results approve that the winding model is applicable.

关键词： fibers fiber optics large-deformation fiber optic gyroscope spiral-disc winding quadrupole pattern

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Integrated guidance and control design for missile with terminal impact angle constraint based on sliding mode control

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Journal of Systems Engineering and Electronics 2010年第4期21卷 623-628页

作者： Peng Wu ming yang Control and Simulation Center Harbin Institute of Technology Harbin 150001 E R. China

Aimed at the guidance requirements of some missiles which attack targets with terminal impact angle at the terminal point,a new integrated guidance and control design scheme based on variable structure control approach for missile with terminal impact angle constraint is ***,a mathematical model of an integrated guidance and control model in pitch plane is established,and then nonlinear transformation is employed to transform the mathematical model into a standard form suitable for sliding mode control method design.A sufficient condition for the existence of linear sliding surface is given in terms of linear matrix inequalities（LMIs）,based on which the corresponding reaching motion controller is also *** verify the effectiveness of the proposed integrated design scheme,the numerical simulation of missile is *** simulation results demonstrate that the proposed guidance and control law can guide missile to hit the target with desired impact angle and desired flight attitude angle simultaneously.

关键词： guidance terminal impact angle sliding mode control integrated guidance and control linear matrix inequality(LMI).

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Effects of Monovacancy on Thermal Properties of Bilayer Graphene Nanoribbons by Molecular Dynamics Simulations

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Journal of Thermal Science 2021年第6期30卷 1917-1924页

作者： yang ming ZHANG Xingli ZHANG Hang Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin 150040China Department of Mechanical Engineering University of ColoradoBoulderCO80309USA

The monovacancy defect effect on thermal conductivity of bilayer graphene nanoribbons(BGNs)was investigated using non-equilibrium molecular dynamics(NEMD)simulations in this *** results demonstrate that the presence of monovacancy defect in BGNs reduces their thermal transport properties *** major finding of this work shows that the calculated thermal conductivity reduces approximately linearly with the raise of monovacancy *** contrast to the temperature-dependent thermal conductivity in perfect BGNs,the thermal conductivity of defected BGNs first increases and then decreases with the increasing *** addition,when the difference in the monovacancy density between two layers is larger,the thermal conductivity of BGNs is *** also calculated the phonon density of states,phonon relaxation time and participation ratio to provide a deeper understanding of the simulation *** investigation confirms that the BGNs-based nano-devices could be applied in thermal management by defect engineering.

关键词： monovacancy thermal conductivity molecular dynamics graphene nanoribbons

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A modified nearly analytic discrete method and wavefield simulations in transversely isotropic media

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Science China Earth Sciences 2005年第8期48卷 1321-1328页

作者： LU ming yang Dinghui Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematical Sciences Tsinghua University Beijing 100084 China

Nearly analytic discrete method (NADM) is a higher accurate method for elastic wave equation that can suppress effectively numerical dispersion caused by discretizing the wave equation. In this paper we investigate the efficient implementation of NADM and present a refinement of the original NADM. Our theoretical analyses show that the modified NADM can improve significantly over the original one in numerous perspectives including numerical errors, storage spaces, and computational costs. Three-component synthetic VSP seismograms in 3-layered transversely isotropic (TI) media generated by the modified NADM are also reported. Theoretical analyses and numerical results show that the modified NADM can reduce storage space about 53 percent and computational costs about 30 percent compared with the original NADM. Moreover the accuracy of the modified NADM in time increases from 2-order of the original NADM to 4-order. Numerical results suggest that the modified NADM is more suitable to large-scale modeling because the modified method has little numerical dispersions even when too-coarse grids are used.

关键词： nearly analytic discrete method (NADM), elastic wave, three-component VSP seismogram, transversely isotropic(TI), seismic wave.

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In Silico Identification of Co-transcribed Core Cell Cycle Regulators and Transcription Factors in Arabidopsis

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Journal of Integrative Plant Biology 2007年第8期49卷 1253-1260页

作者： Yixing Wang ming yang Department of Botany Oklahoma State University Stillwater OK 74078 USA

Regulatory networks involving transcription factors and core cell cycle regulators are expected to play crucial roles in plant growth and development. In this report, we describe the identification of two groups of co-transcribed core cell cycle regulators and transcription factors via a two-step in silico screening. The core cell cycle regulators include TARDY ASYNCHRONOUS MEIOSIS （CYCA1;2）, CYCB1;1, CYCB2;1, CDKB1;2, and CDKB2;2 while the transcription factors include CURLY LEAF, AINTEGUMENTA, a MYB protein, two Forkhead-associated domain proteins, and a SCARECROW family protein. Promoter analysis revealed a potential web of cross- and self-regulations among the identified proteins. Because one criterion for screening for these genes is that they are predominantly transcribed in young organs but not in mature organs, these genes are likely to be particularly involved in Arabidopsis organ growth.

关键词： Arabidopsis cell cycle cyclin-dependent kinases cyclins transcription factors.

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