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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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双壁波纹钢管混凝土构件短柱轴压力学性能

哈尔滨工业大学学报 2025年第1期57卷 56-64页

作者：路博崔燕方勇王玉银李豪哈尔滨工业大学土木工程学院哈尔滨150090 结构工程灾变与控制教育部重点实验室(哈尔滨工业大学) 哈尔滨150090 深圳市市政设计研究院有限公司广东深圳518029

为改善空心钢筋混凝土柱(HRC)的使用与受力性能,提出一种双壁波纹钢管混凝土(CFDCST)构件。本文共进行了4个大尺寸双壁波纹钢管混凝土短柱与2个空心钢筋混凝土短柱的轴压试验,关键试验参数为试件类型与波纹钢管类型。分析构件的破坏模式... 详细信息

为改善空心钢筋混凝土柱(HRC)的使用与受力性能,提出一种双壁波纹钢管混凝土(CFDCST)构件。本文共进行了4个大尺寸双壁波纹钢管混凝土短柱与2个空心钢筋混凝土短柱的轴压试验,关键试验参数为试件类型与波纹钢管类型。分析构件的破坏模式,对比不同参数下构件的承载力、峰值应变、延性系数等关键力学指标,获得荷载-波纹钢管应变关系曲线以揭示试件的约束机理并验证外波纹钢管类型的影响。试验结果表明:外波纹钢管可为夹层混凝土提供约束作用,且螺旋角越小,外波纹钢管的约束作用越强;内波纹钢管则主要为夹层混凝土内壁提供有效支撑,以保持截面的完整性。名义约束效应系数与空心率相近时,由于咬口滑移影响,大螺旋角双壁波纹钢管混凝土比小螺旋角双壁波纹钢管混凝土的峰值应力、峰值应变与延性系数分别降低15.5%、21.8%与16.7%。在总用钢量相近的情况下,小螺旋角双壁波纹钢管混凝土柱的承载力、峰值应变与延性系数分别比空心钢筋混凝土柱提高10.6%、36.2%与50.0%。基于试验结果,检验了3种典型承载力公式的适用性,并提出了相应设计建议。

关键词：组合结构空心钢筋混凝土波纹钢管双壁构件约束机理

boosting charge extraction and efficiency of inverted perovskite solar cells through coordinating group modification at the buffer layer/cathode interface

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Nano Research 2025年第1期18卷 415-423页

作者： Zhiqing Liang Ziqiu Ren Ziyu Wang Nan yan Ling Li bo Zhang yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In inverted perovskite solar cells (PSCs),effective modification of the interface between the metalcathode and electron transport layer (ETL) is crucial forachieving high performance and stability. Herein, sulfonatedbathocuproine, commonly known as disodium bathocuproinedisulfonate (BCDS), was employed as a cathode buffer layerto address the interfacial issues at the [6,6]-phenyl-C61-butyricacid methyl ester (PCBM)/Ag interface. BCDS possesses theability to form coordinate bonds with Ag electrodes. Theutilization of the BCDS buffer layer enhanced the chargeextraction capability at the cathode interface whilesimultaneously achieving interfacial defect passivation,improving interfacial contact and increasing the built-in electricfield. Consequently, a power conversion efficiency (PCE) of25.06% was achieved. Furthermore, owing to the excellent filmforminguniformity of BCDS on PCBM, the stability of thedevice was also improved. After storage in dry air for morethan 2000 h, the device maintained 96% of its initial efficiency. This work underscores the remarkable potential of tailoringcoordination groups to enhance charge extraction efficiency at the ETL-cathode interface, unveiling a promising newfrontier in buffer layer development and performance optimization strategies for PSCs.

关键词： perovskite solar cells buffer layer bathocuproine disulfonate coordination group modification electron transport layer(ETL)-cathode interface

Effects of rainfall on the weekday traffic flow in major cities of the Beijing-Tianjin-Hebei region, China, in 2021

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Advances in Climate Change Research 2022年第6期13卷 858-867页

作者： ming-ming XIONG Zhen-Yu HAN bo LU Jun GUO Shu XU yan-Juan yanG He HUANG Tianjin Climate Center Tianjin Meteorological ServiceTianjin 300074China National Climate Center China Meteorological AdministrationBeijing 100081China Tianjin Meteorological Observatory Tianjin Meteorological ServiceTianjin 300074China

Rainfall can bring uncertainties to the traffic flow and influence the normal function of urban transportation *** impact of precipitation on the urban traffic flow,especially the different impacts among cities and areas within a city,is worth ***,we analysed the impact of precipitation on the traffic flow in the urban areas of the Beijing-Tianjin-Hebei region by comparing the traffic flow in non-precipitation and rainy weather with different hourly precipitation intensities in *** increase in the travel time index(TTI)is chosen to represent the influence of precipitation on the transportation *** results show that the maximum of the average TTI increases on the city scale under various rainfall intensities by 3.3%,6.6%and 10.8%in Beijing,Tianjin and Shijiazhuang,*** general,the increase in the TTI contributed by precipitation is the greatest at morning and afternoon peak hours,and the traffic congestion degree increases with the rainfall ***,in the morning peak,afternoon peak and midday hours in Beijing and Tianjin,the influences of the weak rainfall intensity on the traffic flow are generally great,whereas the traffic congestion degree caused by heavy precipitation is relatively ***,in morning peak hours,the congestion reduction reaches approximately 2%,which may be related to the spatial difference in the impacts of precipitation on the traffic flow and the changes in people's travel intention under different rainfall *** findings can help better understand the relationship between rainfall and urban traffic flow characteristics and also potentially contribute to the development of impact-oriented climate predictions.

关键词： Rainfall intensity Urban traffic flow Beijing-Tianjin-Hebei region Auto Navi map road condition data

D2ANet:Difference-aware attention network for multi-level change detection from satellite imagery

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Computational Visual Media 2023年第3期9卷 563-579页

作者： Jie Mei Yi-bo Zheng ming-ming Cheng TMCC CSNankai UniversityTianjin 300350China State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China

Recognizing dynamic variations on the ground,especially changes caused by various natural disasters,is critical for assessing the severity of the damage and directing the disaster ***,current workflows for disaster assessment usually require human analysts to observe and identify damaged buildings,which is labor-intensive and unsuitable for large-scale disaster *** this paper,we propose a difference-aware attention network(D2ANet)for simultaneous building localization and multi-level change detection from the dual-temporal satellite *** the differences in different channels in the features of pre-and post-disaster images,we develop a dual-temporal aggregation module using paired features to excite change-sensitive channels of the features and learn the global change *** the nature of building damage caused by disasters is diverse in complex environments,we design a difference-attention module to exploit local correlations among the multi-level changes,which improves the ability to identify damage on different *** experiments on the large-scale building damage assessment dataset xBD demonstrate that our approach provides new state-of-the-art *** code is publicly available at https://***/mj129/D2ANet.

关键词： change detection building localization sate-llite imagery dual-temporal aggregation difference attention

Excitation-dependent organic persistent luminescence

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Science China Chemistry 2020年第4期63卷 423-425页

作者： bo Zhou Dongpeng yan Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Organic persistent luminescence(OPL),which maintains obvious photoemission for a period of time after ceasing the external irradiation,has attracted wide attentions in many fields,such as biological imagings,sensors,photodynamic therapies,and molecular *** date,the long excitation-state lifetime and the high photoluminescent quantum yield under ambient conditions have been regarded as the intrinsic parameters for evaluating the OPL performance.

关键词： luminescence lifetime excitation

Electrocatalytic water splitting at nitrogen-doped carbon layers-encapsulated nickel cobalt selenide

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Journal of Energy Chemistry 2019年第7期28卷 161-170页

作者： Chuanlai Jiao Xiangjie bo ming Zhou Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province Key Laboratory of Polyoxometalate Science of Ministry of EducationNational & Local United Engineering Laboratory for Power Batteries Department of Chemistry Northeast Normal University

Generally,the catalytic overpotentials of hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)are unavoidable because of the low charge *** this work,two strategies of alloying of Co with Ni and enclosing of electrocatalysts with carbonaceous materials were both used to accelerate the catalytic efficiency of cobalt selenide for water *** nitrogen-doped carbon(NC)layer improves the reaction kinetics by efficient charge *** alloying of metal into composited electrocatalysts can modify the electronic properties of host materials,thereby tuning the adsorption behavior of intermediate and improving the electrocatalytic *** expected,Nyquist plots reveal that the charge-transfer resistance(Rct)of nickel cobalt selenide encapsulated into nitrogen-doped carbon layer(CoNiSe/NC-3,Co:Ni=1:1)are just 5 and 9 for HER and OER,respectively,which are much lower than those of CoSe/NC-1(Co:Ni=1:0)(81 and 138)and CoNiSe/NC-3 without NC(CoNiSe-3)(54 and 25).With the high charge transfer and porous structure,CoNiSe/NC-3 shows good performance for both HER and *** current density reaches 10 m A cm-2,only 100 and 270 mV overpotentials are required for HER and OER,*** the potential of 1.65 V,full water splitting also can be catalyzed by Co Ni Se/NC-3 with current density of 20 m A cm-2,suggesting that CoNiSe/NC-3 could be used as replacement for noble metal electrocatalysts.

关键词： Nickel cobalt selenide Nitrogen-doped carbon layer Water splitting Hydrogen evolution reaction Oxygen evolution reaction

Tailoring the Properties of Diels-Alder Reaction Crosslinked High-performance Thermosets by Different Bismaleimides

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Chinese Journal of Polymer Science 2020年第3期38卷 268-277,I0007页

作者： Kai-Ju Luo Li-bo Huang yan Wang Jun-Rong Yu Jing Zhu Zu-ming Hu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and EngineeringDonghua University

A series of Diels-Alder reaction cross-linked thermosets with recyclability and healability were prepared from furan-containing aromatic polyamide and bismaleimides with different chemical *** structures of synthesized bismaleimides were confirmed by 1 H nuclear magnetic resonance(1 H-NMR)spectroscopy;their reversible cross-linking with the furanic polyamide was further detected by 1 H-NMR technique and sol-gel transition *** dynamic mechanical analysis and tensile test revealed the variable thermal and mechanical properties of thermosets cross-linked by different bismaleimides and with different molar ratios of maleimide group to furan group(Ima/fur).The tensile test also demonstrated that the better recyclability and solvent-assisted healability of thermosets cross-linked could be achieved by more flexible *** work is expected to provide valuable information for design of recyclable and healable high-performance thermosets with desired properties.

关键词： Recyclability Reparability Thermosets Diels-Alder reaction

Microscopic transduodenal excision of an ampullary adenoma:A case report and review of the literature

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World Journal of Clinical Cases 2021年第18期9卷 4844-4851页

作者： Xiang Zheng Qing-Jing Sun bo Zhou ming Jin Sheng yan Department of General Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina The Affiliated Hospital of Stomatology School of StomatologyZhejiang University School of Medicineand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Transduodenal local excision is an alternative treatment approach for benign ampullary ***,this procedure has technical difficulties,especially during reconstruction of the pancreaticobiliary *** operating microscope has been widely used by surgeons for delicate surgery due to its major advantages of magnification,illumination,and stereoscopic *** application of an operating microscope in transduodenal excision of ampullary tumors has not been *** SUMMARY A 55-year-old woman was admitted for investigation of recurrent upper abdominal *** examination and laboratory tests found no *** identified a large mass in the descending part of the *** revealed a 3.5-cm-sized villous growth over the major duodenal *** of the endoscopic biopsy indicated a villous adenoma with low-grade *** transduodenal excision of the ampullary tumor was *** final pathological diagnosis was villous-tubular adenoma with low-grade *** patient was discharged on postoperative day 12 after an uneventful *** retrograde cholangiopancreatography was performed 3 mo postoperatively and showed no bile duct or pancreatic duct strictures and no tumor *** patient is continuing follow-up at our clinic and remains *** Operating microscope-assisted transduodenal local excision is a feasible and effective option for benign ampullary tumors.

关键词： Operating microscope Transduodenal local excision Ampullary tumor Endoscopic papillectomy Pancreaticoduodenectomy Case report