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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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science china(life sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-feng wang Xiao-ming Cui Yi-ming Zhang Zhen-Fei wang En-tao li Chang-Fa Fan Ke Song Yuan-Guo li Run-Ze Ye Fang-Xu li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi ming-Zhu Zhang liang-jing li Shi-jing Shen Song Jin Ya-wei Zhang wei-Guang Fu lin Zhao Wen-Hao wang Tie-Cheng wang you-chun wang Jia-Fu Jiang Yan-ling Hu Na Jia Yu-wei Gao Wu-chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life sciences Institute Guangxi Medical UniversityNanning 530020China college of life sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

Proteomic analysis of differential protein expression in early process of pancreatic regeneration in pancreatectomized rats

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Acta Pharmacologica Sinica 2006年第5期27卷 568-578页

作者： ming yang~(2,4) wei liu~(3,4) chun-you wang~(2,5) tao liu~2 feng zhou~2 jing tao~2 yang wang~3 ming-tao li~3 ~2department of general surgery,union hospital,tongji medical college,huazhong university of science and technology,wuhan 430022,china ~3Proteomics Laboratory,Zhongshan medical college.Sun Yat-sen university,Guangzhou 510089.china department of general surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Proteomics Laboratory Zhongshan Medical College Sun Yat-sen University Guangzhou China

Aim:A broad-range proteomic approach was applied to investigate the complex-ity of the mechanisms involved in pancreatic regeneration for identification ofnew targets of diabetes treatment and potential markers of pancreatic stem ***:A regeneration pancreatic model was induced by 90% partial pancreate-ctomy (Px) in *** in the protein expression in regenerating rat pancreason the third day after Px,as compared with rats that received sham surgery,wereanalyzed by using 2-D gel electrophoresis (2-DE),mass spectrometry (MS),andmass ***:2-DE revealed 91 spots with at least 1.5-fold in-creases in expression at 3d after pancreatectomy and 53 differentially expressedproteins that were identified by peptide mass fingerprinting (PMF).These in-cluded cell growth-related,lipid and energy metabolism-related,protein and aminoacid metabolism-related proteins,and signal transduction ***,CK8,L-plastin,hnRNP A2/B1,and AGAT are associated with embryogenesis and celldifferentiation,and may be new potential pancreatic stem cells ***:The proteome profiling technique provided a broad-based and effec-tive approach for the rapid assimilation and identification of adaptive proteinchanges during pancreas regeneration induced by *** dataclarify the global proteome during the pancreatic proliferation and differentiationprocesses,which is important for better understanding of pancreatic regenerationand for discovering of protein biomarkers for pancreatic stem cells.

关键词： partial pancreatectomy regeneration metabolism stem cell pancreas proteomics

Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib-refractory ALK-positive NSCLC from a phase II study

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Cancer Communications 2024年第4期44卷 455-468页

作者： jing Zheng tao wang Yunpeng yang Jie Huang Jifeng feng Wu Zhuang Jianhua Chen Jun Zhao wei Zhong Yanqiu Zhao Yiping Zhang Yong Song Yi Hu Zhuang Yu youling Gong Yuan Chen feng Ye Shucai Zhang Lejie Cao Yun Fan Gang Wu Yubiao Guo Chengzhi zhou Kewei Ma Jian Fang weineng feng Yunpeng liu Zhendong Zheng Gaofeng li Huijie wang Shundong Cang Ning Wu wei Song Xiaoqing liu Shijun Zhao lieming Ding Giovanni Selvaggi yang wang Shanshan Xiao Qian wang Zhilin Shen Jianya zhou Jianying zhou li Zhang department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou Repugene technology Co. LtdHangzhouZhejiangP.R.China department of medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China department of medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China department of medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03215693)demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53(TP53)*** addition,patients with concurrent TP53 mutations had shorter OS than those without con-current TP53 *** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival

Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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Food science and Human Wellness 2024年

作者： Qi-ming Yu Yan Zhu tao Jiang Ying Gao Nan ling Na wang John Shi wei-chun Pan Qi-Zhen Du Jun-feng Yin Tea Research Institute Chinese Academy of Agricultural sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture college of Food and Health sciences， Zhejiang A & F university Zhejiang Gongshang university Guelph Food Research Center， Agriculture and Agri-Food Canada college of Public Health， Guilin medical university

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-tao Zhang Jun-Zheng wang li-tao yang Qian Yue Ke-Jun Kang Yuan-jing li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo li He Sheng-ming He Jin-wei Hu Han-Xiong Huang Tu-Chen Huang Hai-tao Jia Xi Jiang S.Karmakar Hao-Bin li Jian-Min li Jin li Qian-Yun li Ren-ming-Jie li Xue-Qian li Yu-Lan li Yi-Fan liang Bin liao Fong-Kay lin Shin-Ted lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu Yu liu Yuan-Yuan liu Zhong-Zhi liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang wei-you Tang yang Tian Guang-Fu wang li wang Qing wang Yu-feng wang Yun-Xiang wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-yang Xing Rui Xu Yin Xu tao Xue Yu-Lu Yan Nan Yi chun-Xu Yu Hai-Jun Yu Jian-feng Yue ming Zeng Zhi Zeng feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao ming-Gang Zhao Ji-Fang zhou Zu-Ying zhou jing-Jun zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and department of Engineering Physics Tsinghua UniversityBeijing 100084 department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 college of Nuclear science and technology Beijing Normal UniversityBeijing 100875 college of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 department of Physics Banaras Hindu UniversityVaranasi 221005 department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the china Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Polygonatum sibiricum polysaccharides attenuated colitis via regulating gut microbiota mediated colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway

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Food science and Human Wellness 2024年

作者： Zhong-Yu Yuan Xin-Yu wang Jun wang Yuan Xu jing Chen Shu-Qi Yu Zhi-ming Chen Pei-Lu Chen Ji-Xiao Zhu wei-feng Huang Guang-Hui Xu li-tao Yi department of Chemical and Pharmaceutical Engineering， college of Chemical Engineering， Huaqiao university Xiamen Medicine Research Institute Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine， Jiangxi university of Chinese Medicine department of Gastroenterology and Hepatology， The First Affiliated hospital of Xiamen university， Xiamen university Institute of Pharmaceutical Engineering， Huaqiao university Fujian Provincial Key Laboratory of Biochemical technology， Huaqiao university

Polygonatum sibiricum has long been a popular functional food in Asia， known for its anti-inflammatory properties. However， its efficacy in alleviating colitis has yet to be investigated. This study aimed to explore the therapeutic potential of Polygonatum sibiricum polysaccharides (PSP) in dextran sulfate sodium (DSS)-induced colitis， focusing on the related pyroptosis mechanisms. Scanning electron microscopy (SEM) analysis showed that PSP possesses a smooth surface with no pore structure and a dense， lamellar structure adorned with numerous spherical entities. PSP treatment significantly reduced colitis symptoms and decreased pro-inflammatory cytokines， likely through suppression of the TLR4/NF-κB signaling pathway. Additionally， PSP attenuated NLRP3/ASC/Caspase-1/GSDMD-mediated pyroptosis and mitochondria damage in the colon， while enhanced the expression of tight junction and adherens junction proteins. Microbiota sequencing showed that PSP increased the abundance of phylum Bacteroidota and genus such as Muribaculaceae， Lactobacillus， Clostridia， and Lachnospiraceae， while decreased the phylum Proteobacteria and the genus Enterobacter， Escherichia-Shigella， and Blautia. In conclusion， this study demonstrates that PSP exerts the potential therapeutic role against colitis， which was mediated by the regulation of gut microbiota and the inhibition of colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway.

关键词：

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu Zhang Yue Huang Lu li Xing Wen Fei Zhang jing Duan Chen-wei wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-yang li Yan-Bing Xu Xiao-Hua liang Ya-Qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng yang Xiao-jing liu Min Gao Mao-Shun li Jin-zhou wang Xing zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-tao yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma Xiao-Bo li Ping wang Xin-Ying Song li-ming Song Shi-Jie Zheng Bing li Hong-Mei Zhang Yue Zhu wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-wei yang Xue-Juan yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Chinese Academy of SciencesBeijing 100049China School of Information science and technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space science college China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of science and technology Changchun 130022China Chinese Academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai li Shu-Ning Sun Xian-Bo wang Xin Zheng Yan Huang Bei-ling li Yan-Hang Gao Zhi-Ping Qian feng liu Xiao-Bo Lu Jun-Ping liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng liang Qiao Yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao chun-Yan liu wei Yuan Xue Mei jing li tao li Rong-Jiong Zheng Xin-Yi zhou Jun Zhao Zhong-Ji Meng department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure liver cirrhosis Clinical features Prognosis

Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2022)

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International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Hua Cao Ai-Jun Chen Yong Cui Dan-Qi Deng Xing-Hua Gao Yan-ling He Xiao-jing Kang Hong-Zhong Jin Cheng-Xin li feng li Heng-Jin li Wen-Jun liao Xiao-ming liu Qian-Jin Lu Yan Lu Meng Pan wei-Hua Pan Xiao-ming Shu Qing Sun Ke-Yun Tang Juan tao Yu wang Ting Xiao Fu-Ren Zhang Han-lin Zhang Dermatology Branch of the china International Exchange and Promotion Association for medical and Health Care National Clinical Research Center for Dermatologic and Immunologic Diseases department of Dermatology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China department of Dermatology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China department of Dermatology China-Japan Friendship HospitalBeijing 100029China department of Dermatology the Second Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650101China department of Dermatology the First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100020China department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China department of Dermatology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China department of Dermatology First Medical CenterPLA General HospitalBeijing 100853China department of Dermatology Hainan Hospital of PLA General HospitalSanyaHainan 572013China department of Dermatology Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518052China hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China department of Dermatology Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China department of Dermatology Shanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China department of Rheumatology China-Japan Friendship HospitalBeijing 100029China department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China department of Dermatology Union Hospital

Dermatomyositis,an idiopathic inflammatory myopathy,is characterized by distinctive skin manifestations,proximal muscle weakness,and multiple organ involvement and can be accompanied by *** provide a reference for dermatologists and clinicians in other relevant fields of clinical practice,experts from the Dermatology Branch of the china International Exchange and Promotion Association for medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice.

关键词： dermatomyositis adult diagnosis treatment clinical protocols expert consensus