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Circulation background of climate patterns in the past millennium: Uncertainty analysis and re-reconstruction of ENSO-like state

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Science China Earth Sciences 2016年第6期59卷 1225-1241页

作者： tan ming Key Laboratory of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences

The question of whether or not global warming has paused since more than ten years ago, namely ＂warming hia- tus＂, has attracted the attention of climate science community including the IPCC. Some authors have attributed the ＂warming hiatus＂ to the internal changes in the climate system, i.e., the recombination of ocean-atmosphere circulations. Therefore, it is necessary to propose higher requirements on reconstructing circulation background of climate change for the past millennium. However, the analyses of changes in atmospheric circulation over the last millennium as well as the conclusions of related re- gional climate patterns are so widely different and contradictory, bringing uncertainties to our understanding of regional even global climate change to a great extent. On the other hand, in the last 10 years the high-precision U/Th-dated stalagmite oxygen isotope ratio （δ^18O） sequences provided an accurate chronological frame for the paleoclimate study of the middle and late Pleistocene, in which all authors from China took the Chinese stalagmite δ^18O as the summer monsoon index without excep- tion. However, this point of view misleads the climate scientists into thinking that the stalagmite δ^18O can be as the proxy of precipitation amount. Nevertheless, it is well known that all of these records have a lot in common in the low frequency trend. However, most sequences cannot be calibrated by instrumental precipitation records, and thus the uncertainty of the climate research framework of China and even of the world has increased. Therefore, it is imperative for climatology to clarify the origin of contradiction and to reduce the uncertainty as early as possible. On the basis of analyzing the significance of stalag- mite ~180 in the monsoon regions of China, the author tries to propose a new circulation proxy in this paper： integrating the Chinese stalagmite oxygen isotope sequence to reconstruct the tropical Pacific sea surface temperature gradient, i.e., th

关键词： The past millennium ENSO Circulation background Climate pattern WPSH Stalagmite δ^18O Circulation recombination

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Local Spin Density Approximation Solution for Spinel LiV_(2)O_(4): Spin Fluctuation as a Possible Role for Heavy Fermion

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Chinese Physics Letters 2001年第11期18卷 1510-1512页

作者： tan ming-Qiu TAO Xiang-ming Department of Physics Zhejiang UniversityHangzhou 310027

We report on a self-consistent full-potential linear muffin tin orbital band-structure calculation for the heavy fermion (HF) compound LiV_(2)O_(4). It is found that a stable local spin density approximation solution for LiV_(2)O_(4) is lower in total energy than the local density approximation calculation. We speculate that the mechanism responsible for HF properties in LiV_(2)O_(4) might be of spin fluctuation type and is different from the Kondo mechanism in conventional 4f and 5f HF compounds.

关键词： calculation. compounds. approximation

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PIM-Align: A Processing-in-Memory Architecture for FM-IndexSearch Algorithm

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Journal of Computer Science & Technology 2021年第1期36卷 56-70页

作者： Xue-Qi Li Guang-ming tan Ning-Hui Sun University of Chinese Academy of Sciences Beijing 100049China

Genomic sequence alignment is the most critical and time-consuming step in genomic *** algorithms generally follow a seed-and-extend *** of the extension phase for sequence alignment has been well explored in computing-centric architectures on field-programmable gate array(FPGA),application-specific integrated circuit(ASIC),and graphics processing unit(GPU)(e.g.,the Smith-Waterman algorithm).Compared with the extension phase,the seeding phase is more critical and ***,the seeding phase is bounded by memory,i.e.,fine-grained random memory access and limited parallelism on conventional *** this paper,we argue that the processing-in-memory(PIM)concept could be a viable solution to address these *** paper describes\PIM-Align"|an application-driven near-data processing architecture for sequence *** order to achieve memory-capacity proportional performance by taking advantage of 3D-stacked dynamic random access memory(DRAM)technology,we propose a lightweight message mechanism between different memory partitions,and a specialized hardware prefetcher for memory access patterns of sequence *** evaluation shows that the proposed architecture can achieve 20x and 1820x speedup when compared with the best available ASIC implementation and the software running on 32-thread CPU,respectively.

关键词： accelerator design genomic sequence alignment near-memory computing

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Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity

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Nano Research 2022年第5期15卷 4181-4190页

作者： ming Xia Md Rejaul Hoq Pengwei Huang Wen Jiang Xi Jiang ming tan Division of Infectious Diseases Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA Department of Biological Sciences Purdue Cryo-EM FacilityPurdue UniversityIN 47907USA Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229USA

Even with implementation of current influenza vaccines,influenza still claims up to 500,000 lives worldwide annually,indicating a need for a better vaccine *** have developed a technology to generate unique S_(60)-HA1 pseudovirus nanoparticles(PVNPs)that display the receptor-binding HA1 domains of influenza *** self-assembled S_(60)-HA1 PVNP consists of a T=1 icosahedral S_(60) nanoparticle that resembles the inner shell of norovirus capsid and 60 surface-displayed HA1 antigens that are excellent vaccine *** S_(60)-HA1 PVNPs presenting HA1 antigens of H7N9 influenza virus subtypes have been produced efficiently in large *** three-dimensional(3D)structures have been solved by cryogenic electron *** PVNP-displayed HA1 antigens react with HA-specific antibody,and retain authentic sialic acid binding specificity and hemagglutinate human *** PVNPs are highly immunogenic,eliciting high titers of HA1-specific antibodies in mice and the mouse sera strongly inhibited hemagglutinations of homologous and heterologous influenza virus HA ***,the S_(60)-HA1 PVNPs may provide useful reagents to study influenza viruses and offer a potential new vaccine tactic to fight the deadly influenza disease.

关键词： S_(60)nanoparticle pseudovirus nanoparticle influenza virus influenza vaccine hemagglutinin norovirus

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Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2013年第47期19卷 8895-8901页

作者： Zhong-ming tan Bei-Cheng Sun Liver Transplantation Center of the First Affiliated Hospital Nanjing Medical University The Key Laboratory of Living Donor Liver Transplantation Ministry of Health

Chronic hepatitis B virus(HBV)infection is the key driving force of liver disease progression,resulting in the development of hepatic dysfunction,cirrhosis and hepatocellular carcinoma(HCC).The primary aim of therapy is to suppress or eliminate HBV replication to reduce the activity of hepatitis,thus reducing the risk of,or slowing the progression of,liver ***(t)ide analogues(Nucs)may result in rapid suppression of HBV replication with normalization of serum transaminases and restore liver function,thus increasing survival in patients with hepatic ***-term Nuc therapy may result in histological improvement or reversal of advanced fibrosis and reduction in disease progression,including the development of *** long-term benefits of a finite course of interferon(IFN)-αtherapy also include a sustained and cumulative response,as well as hepatitis B surface antigen seroclearance and reduction in the development of cirrhosis and/or *** IFN and newer Nucs may achieve better long-term outcomes because of improved efficacy and a low risk of drug ***,treatment outcomes are still far from *** the effects of anti-HBV treatment against HCC incidence and recurrence after hepatectomy or liver transplantation is required for further improvement of outcome.

关键词： Hepatocelluar carcinoma Antiviral therapy Carcinogenesis Recurrence Nucleos(t)ide analogues Interferon Retrospective study Clinical trial

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Water adsorption on the Be(0001) surface:from monomer to trimer adsorption

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Chinese Physics B 2012年第1期21卷 389-398页

作者： Ning Hua Tao Xiang-ming tan ming-Qiu Department of Physics Zhejiang UniversityHangzhou 310027China

In this paper, the density functional theory has been used to perform a comparative theoretical study of water monomer, dimer, trimer, and bilayer adsorptions on the Be（0001） surface. In our calculations, the adsorbed water molecules are energetically favoured adsorbed on the atop sites, and the dimer adsorption is found to be the most stable with a peak adsorption energy of - 437 meV. Further analyses have revealed that the essential bonding interaction between the water monomer and the metal substrate is the hybridization of the water 3al-like molecular orbital with the （s, P2） orbitals of the surface beryllium atoms. While in the case of the water dimer adsorption, the lbz-like orbital of the H2O molecule plays a dominant role.

关键词： Be(0001)/H2O surface adsorption energy electronic structure

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Negative Thermal Expansion and Spontaneous Magnetostriction of Nd2Fe16.5Cr0.5 Compound

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Chinese Physics Letters 2020年第1期37卷 48-50页

作者： Li-Yu HAO Tie Yang ming tan School of Physics Science and Technology Southwest UniversityChongqing 400715 College of Science Henan Agricultural UniversityZhengzhou 450002

The structural,thermal expansion,and magnetic properties of the Nc/2^16.5^0.5 compound are investigated by means of x-ray diffraction and magnetization *** Nd2^616.560.5 compound has a rhombohedral Th2Znn-type *** exists a small negative thermal expansion resulting from a spontaneous magnetostriction in the magnetic state of the^2^16.5 Cr0.5 *** average thermal expansion coefficient is-1.06×10^6/K in a temperature range 299-394 *** spontaneous magnetostrictive deformation and the Curie temperature are discussed.

关键词： structure. deformation Nd2Fe

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Precipitation of μ Phase in Nickel-based Powder Metallurgy Superalloy FGH97

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Journal of Iron and Steel Research International 2016年第8期23卷 851-856页

作者： Li-ming tan Yi-wen ZHANG Jian JIA Shou-bo HAN High Temperature Material Institute Central Iron and Steel Research Institute Beijing 100081 China Beijing Key Laboratory of Advanced High Temperature Materials Beijing 100081 China

The precipitation behavior of topological close-packed（TCP）μphase in powder metallurgy（P/M）nickelbased superalloy FGH97 was *** results showed that proper addition of solution strengthening elements,such as Co,Cr,W,Mo,improved tensile strength,while excessive addition of those elements facilitated the precipitation ofμphase,which seriously aggravated the plasticity of the P/M *** the heat-treated specimens,the relationship between critical aging time（whenμstarted to precipitate）,aging temperature,and the average electron vacancy number ofγmatrix was established.

关键词： superalloy precipitate tensile plasticity seriously Precipitation topological strengthening packed metallurgy

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Changes in rheumatoid arthritis under ultrasound before and after sinomenine injection

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World Journal of Clinical Cases 2022年第1期10卷 35-42页

作者： Yi-Min Huang Yu Zhuang Zhi-ming tan Department of Rheumatology and Immunology Huizhou Central People’s HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND Rheumatoid arthritis(RA)is a prevalent clinical autoimmune disease that is commonly treated with diclofenac and *** recent years,the application of traditional Chinese medicine in RA has received widespread attention;it promotes blood circulation,strengthens the immune system,and eliminates *** sinomenine preparation of Zhingqeng Fengtongning is studied as a possible treatment for patients with *** To explore the value of sinomenine injection into the articular cavity for the treatment of *** A total of 94 patients with RA treated from January 2019 to January 2021 were selected and divided into the study and control groups with 47 patients each using a simple random number table *** groups received conventional treatment with diclofenac sodium and methotrexate *** control group received diproxone and lidocaine by intra-articular administration while the study group received an intra-articular administration of the sinomenine preparation of Zhengqing Fengning and lidocaine.χ^(2) test was used to evaluate the therapeutic effect and synovial thickness,degree of pain through the visual analog scale(VAS),blood flow grade,arthroinflammatory indexes[rheumatoid factor(RF),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR)]before and after treatment in the two *** The total effective rate of the study group(93.62%)was higher than that of the control group(78.72%)(P0.05).After treatment,the synovial thickness and VAS score were significantly lower(P<0.05)in the study group than in the control group(2.05±0.59 mm vs 2.87±0.64 mm and 2.11±0.62 vs 2.90±0.79 scores,respectively).The rate of blood flow at grade 0 in the study group(76.60%)was higher than that in the control group(57.45%),and the rate of blood flow at grade I(10.64%)was lowe

关键词： Rheumatoid arthritis Articular injection Sinomenine Ultrasonic changes Inflammatory factors Zhengqing Fengtongning

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Calculation on phase diagrams of polyetherimide/ N,N-dimethylacetamide/H2O-BuOH casting system and their relevance to membrane performances

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Frontiers of Chemical Science and Engineering 2014年第3期8卷 312-319页

作者： ming tan Gaohong HE Yan DAI Rujie WANG Wenhua SHI State Key Laboratory of Fine Chemicals R&D Center of Membrane Science and Technology School of Chemical Engineering Dalian University of Technology Dalian 116024 China Key Laboratory of Biobased Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China

The ternary phase diagrams of polyetherimide （PEI）/N,N-dimethylacetamide （DMAc） with H2O and BuOH as non-solvent were simulated using solubility parameter and Flory-Huggins theory. The phase diagrams show that 5.5% H2O/BuOH system containing 5% BuOH and 0.5% H2O or 6.5% H2O/BuOH system containing 6.2% BuOH and 0.3% H2O is required to induce liquid- liquid demixing for 20 wt-% PEI/DMAc casting solution. Therefore, BuOH can enhance the phase separation of the PEI casting solution and hereby induce higher porosity of the membrane, and the diffusion of BuOH into the water coagulation bath causes larger pore size easily compared with DMAc. Our predictions that the membrane pure water flux first increases then decreases, and the rejection ratio of bovine serum albumin decreases with the increasing concentration of BuOH were validated by the experiments using the prepared membranes.

关键词： phase diagram solubility parameter interaction parameter ultrafiltration Flory-Huggins theory

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