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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-ming pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Effect of cold rolling and annealing on microstructure and properties of a new resource-saving duplex stainless steel Fe–19Cr–0.6Al–12Mn

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Journal of Iron and Steel Research International 2020年第12期27卷 1420-1432页

作者： ming-ming pan Xiao-ming Zhang Yong Chen Xiang-bin Su Peng Chen State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

An Fe-19Cr-0.6Al-12Mn duplex stainless steel with an optimized alloy composition of Ni replaced by Mn and Cr partially replaced by Al was developed to avoid the edge cracking, which is a common defect in the hot rolling of traditional twophase stainless steels. The newly developed duplex stainless steel could be hot-rolled in the single-phase ferrite (α) region by controlling rolling temperature and the single-phase ferrite microstructure was retained on water cooling. To obtain the two-phase stainless steel product with ferrite and austenite (γ) microstructure, cold rolling and annealing were carried out,and appropriate cold rolling reduction and annealing process parameters were determined. The significant impact of annealing on microstructure, mechanical properties and pitting resistance of the experimental steel was studied. It was observed that with the increase in cold rolling reduction, the number of γ nucleation points was dramatically increased leading to the precipitation of more γ at α grain boundaries after annealing. During annealing at 800 ℃ and with the increase in annealing time, the austenite fraction was increased with a lower rate and remained almost constant when the annealing time was greater than 4 h. With the increase in annealing temperature, the austenite fraction decreased gradually in the temperature range of 750-860 ℃. Good combination of strength, ductility and excellent pitting resistance was obtained by cold rolling to 80% reduction and annealing at 800 ℃ for 4 h. Grain refinement and the existence of Σ3 boundaries played a vital role in improving the pitting resistance of the experimental steel. With good combination of strength, ductility and corrosion resistance, the newly developed duplex stainless steel is expected to be a new resource-saving dual-phase stainless steel.

关键词： Resource-saving duplex stainless steel Edge cracking Rolling reduction Annealing Tensile property Pitting corrosion

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On water in nominally anhydrous minerals from mantle peridotites and magmatic rocks

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Science China Earth Sciences 2016年第6期59卷 1157-1172页

作者： HUI HeJiu XU YongJiang pan ming'En State Key Laboratory for Ore Deposit Research School of Earth Sciences and Engineering Nanjing University

Trace amount of water associated with the lattice defects of nominally anhydrous minerals （NAMs） can be measured using Fourier transform infrared spectroscopy （FTIR） and secondary ion mass spectrometry （SIMS）. Lots of data on water in NAMs from different lithologies, especially mantle peridotite xenoliths, have been published. The water distribution in olivine from peridotite xenoliths often displays a diffusion profile with high water concentration in the core and low at the rim, which indicates water loss via diffusion during the ascent of host magma. On the other hand, water is homogeneously distributed in pyroxene and its concentration is typically interpreted to represent a mantle value. The water concentration of magma in equilibrium with NAM can be estimated using specific partition coefficient, from which the water content of parental magma and the mantle source can be inferred. The accuracy of this method, however, depends on the selection of appropriate partition coefficient for the system. Using hydrogen isotope compositions and H2O/Ce ratios of mantle NAMs, water source regions can be traced and water heterogeneity can be mapped in the upper mantle. Water plays an important role in the stability of cratonic mantle. The water contents and vertical distribution patterns can be significantly different among different cratonic manties, which may result from different geologic activities. However, the mantle-plume interaction may not necessarily result in significant change of water content in cratonic mantle. The estimation of the water content in the upper mantle is still largely based on geochemical models due to the limitations of data on water in mantle NAMs.

关键词： Nominally anhydrous minerals Fourier transform infrared spectroscopy Craton stability Water in the upper mantle Magma ascent rate Water in magma

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Flexible scheduling model of crude oil operations under crude supply disturbance

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Science China Chemistry 2009年第3期52卷 387-400页

作者： ming pan Yu Qian XiuXi Li School of Chemical and Energy Engineering South China University of Technology Guangzhou 510640 China

Today’s changeable market and resultant disturbance of crude oil supply require agile and flexible scheduling of crude oil operation. The objective of flexible scheduling is to keep stable crude oil op-eration and satisfy production demands under the circumstances of supply disturbance. In this paper, a new mixed integer non-linear programming (MINLP) formulation is set up for crude oil scheduling firstly, and then some heuristic rules worked out by some experts are proposed to linearize bilinear terms and prefix some binary variables in the MINLP model. These rules not only reduce the complexity of the MINLP model, but also can be used to solve the scheduling problems in various conditions. In case study, the new model with heuristic rules and the best models reported in the literature are com-pared and evaluated in three benchmark examples in the normal situation, and then three abnormal situations of supply delay are considered based on the new approach. The results of case study show that the new flexible approach can handle crude oil scheduling problems efficiently in both normal and abnormal conditions.

关键词： safety of crude supply crude oil operation flexible scheduling mathematical model safety stock

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Investigation of turbulence and skin friction modification in particle-laden channel flow using lattice Boltzmann method

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Applied Mathematics and Mechanics(English Edition) 2018年第4期39卷 477-488页

作者： ming pan Qing xiang Shuai TANG Yuhong DONG Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai UniversityShanghai 200072China

Interaction between turbulence and particles is investigated in a channel flow. The fluid motion is calculated using direct numerical simulation(DNS) with a lattice Boltzmann(LB) method, and particles are tracked in a Lagrangian framework through the action of force imposed by the fluid. The particle diameter is smaller than the Kolmogorov length scale, and the point force is used to represent the feedback force of particles on the turbulence. The effects of particles on the turbulence and skin friction coefficient are examined with different particle inertias and mass loadings. Inertial particles suppress intensities of the spanwise and wall-normal components of velocity, and the Reynolds shear stress. It is also found that, relative to the reference particle-free flow,the overall mean skin-friction coefficient is reduced by particles. Changes of near wall turbulent structures such as longer and more regular streamwise low-speed streaks and less ejections and sweeps are the manifestation of drag reduction.

关键词： lattice Boltzmann(LB) equation particle channel flow turbulence modulation skin friction

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Drag reduction of turbulent channel flows over an anisotropic porous wall with reduced spanwise permeability

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Applied Mathematics and Mechanics(English Edition) 2019年第7期40卷 1041-1052页

作者： Qingxiang LI ming pan Quan ZHOU Yuhong DONG Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Shanghai 200072 China

The direct numerical simulation (DNS) is carried out for the incompressible viscous turbulent flows over an anisotropic porous wall. Effects of the anisotropic porous wall on turbulence modifications as well as on the turbulent drag reduction are investigated. The simulation is carried out at a friction Reynolds number of 180, which is based on the averaged friction velocity at the interface between the porous medium and the clear fluid domain. The depth of the porous layer ranges from 0.9 to 54 viscous units. The permeability in the spanwise direction is set to be lower than the other directions in the present simulation. The maximum drag reduction obtained is about 15.3% which occurs for a depth of 9 viscous units. The increasing of drag is addressed when the depth of the porous layer is more than 25 wall units. The thinner porous layer restricts the spanwise extension of the streamwise vortices which suppresses the bursting events near the wall. However, for the thicker porous layer, the wall-normal fluctuations are enhanced due to the weakening of the wall-blocking effect which can trigger strong turbulent structures near the wall.

关键词： direct numerical simulation (DNS) anisotropic porous medium drag reduction turbulent open channel flow

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Recent studies of Pickering emulsion system in petroleum treatment:The role of particles

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Petroleum Science 2021年第5期18卷 1551-1563页

作者： Jin-Xin Liu Heng-Jia Zhu pan Wang Jian-ming pan School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang212013China School of Agricultural Equipment Engineering Jiangsu UniversityZhenjiang212013China

Pickering emulsions stabilized by solid particles have gained much attention,which afford high stability,low toxicity,controllable rheological properties and stimuli-responsive behavior compared to the traditional emulsions emulsified by *** particles,as the core parts of the emulsion systems,play an important role in the fabrication and application of Pickering emulsion systems,making them attractive in petroleum *** this review,the influence of various particles on the stability and properties of Pickering emulsion systems as well as recent researches associated with the stimuliresponsibility of Pickering emulsion systems are ***,the design of functional particles and Pickering emulsion systems with super stabilities and controllable rheological properties are ***,some petroleum application of Pickering emulsion systems for enhanced oil recovery and spilled oil collection as well as the application as soft templates to fabricate oil-absorbing material and as three-phase microreactors that most likely for petroleum application are discussed,and the issues hindering the actual application of Pickering emulsion systems are also *** review charts a way for Pickering emulsion studies that could lead to a valid petroleum application through design of the particles served as the enhancers of Pickering emulsion stability for purpose of tailoring chemical flooding.

关键词： Pickering emulsion Enhanced oil recovery Stimuli-responsive Oil contamination removal

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Signifcant impact of cold-rolling deformation and annealing on damping capacity of Fe-Mn-Cr alloy

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Journal of Iron and Steel Research International 2020年第5期27卷 566-576页

作者： Bo Xia Xiao-ming Zhang R.D.K.Misra ming-ming pan Yu-qian Wang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX 79668USA

The infuences of cold-rolling deformation and annealing on the damping capacity of Fe-19Mn-8Cr alloy were *** was observed that the cold-rolled Fe-19Mn-8Cr alloy with a reduction of 10%showed the relatively excellent damping capacity because of the relatively moreε-martensite and lower dislocation density,and the reduction of slopes of diferent damping curves increased along with increasing the cold-rolling ***,the subsequent annealing process can further enhance the damping *** 70%cold-rolling deformation,the austenite grain would grow up with the increase in the annealing temperature,which resulted in a signifcant change in the content and morphology ofε-martensite infuencing the damping capacity of the experimental *** damping capacity was optimum when annealed at 800°C for 30 min,displaying that the size ofε-martensite has a vital infuence on the damping capacity of the experimental *** study may enrich the fundamental knowledge about how to ameliorate the damping capacity of Fe-Mn-Cr damping steels.

关键词： Damping capacity Fe-19Mn-8Cr damping alloy ε-martensite α′-martensite Cold rolling

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Phase transformation kinetics of Ti-1300 alloy during continuous heating

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Rare Metals 2015年第4期34卷 233-238页

作者： ming-pan Wan Yong-Qing Zhao Wei-Dong Zeng State Key Laboratory of Solidification Processing Northwest Polytechnical University College of Materials and Metallurgy Guizhou University Northwest Institute for Nonferrous Metal Research

Abstract The α ＋ β→β phase transformation kinetics of Ti-1300 alloy during continuous heating at different heating rates were investigated using dilatometric method. Results show that the curves of the α ＋ β→β phase transformation exhibit a typical S-shaped pattern, which indicates that the α ＋ β→β phase transformation is a nucleation-growth-controlled process. The overall activation energy of the α ＋ β→β transformation of the alloy is 797 kJ·mol^-1. The nucleation and growth mechanism of the α ＋ β→β transformation was also investigated using the non-isothermal Avrami exponent. The Avrami exponent during α ＋ β→β transformation process significantly changes with transformed volume fraction increasing, which indicates that the α ＋ β→β transformation mechanism in the Ti-1300 alloy varies at different sections.

关键词： Ti-1300 alloy Phase transformation Dilatometry Kinetics

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Electrochemically promoted N-heterocyclic carbene polymercatalyzed cycloaddition of aldehyde with isocyanide acetate

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Science China Chemistry 2022年第10期65卷 1873-1878页

作者： Chu-Hong Ou Ying-ming pan Hai-Tao Tang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China

N-heterocyclic carbene(NHC) is a potent organic small-molecule ***,its high synthetic price and frequent use in combination with excess oxidants have limited its utilization in industrial *** designed and synthesized a porous organic polymer with NHC as the core structure to solve the above *** catalytic performance of the polymer was tested in this *** polymer can successfully catalyze the cycloaddition reaction of aldehyde and ethyl isocyanoacetate under *** results showed that the polymer catalyst can be recycled and had higher catalytic activity than homogeneous *** developed catalytic system(organic electrochemistry and NHC polymer) solves the existing problems of NHC catalysis and provides a reference for the development of new green catalytic systems.

关键词： NHC catalysis electrochemistry heterogeneous catalysis cycloaddition

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