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Medicinal Plant 2023年第5期14卷 32-35页

作者： Jin ZHOU Xiuli ZHOU Yu ZHOU ming mei Qiang GAO Xinguo LIU Department of Pharmacy Wuhan No.1 HospitalWuhan 430022China

[Objectives]To determine the optimal reflux extraction process conditions for Compound Coptis Ointment.[Methods]The study employed the orthogonal experimental design method and drug-sensitive disc agar diffusion method to evaluate the extraction rate,berberine hydrochloride content,and bacteriostatic ring diameter of the extract as comprehensive indices,and optimized the extraction process conditions of Compound Coptis Ointment using ethanol reflux.[Results]Based on the results of comprehensive indices,the optimal reflux extraction conditions for Compound Coptis Ointment were determined to be soaking in 1.5 times the amount of 70%ethanol for 2 h,followed by two extractions with 6 times the amount of 70%ethanol for 1 h each *** verification tests were conducted under the optimal process *** yield of the extract was 28.32%±0.53%,the content of berberine hydrochloride was 4.68%±0.45%,and the diameter of the bacteriostatic ring was(2.5±0.2)cm.[Conclusions]The extract had higher drug content and exhibited better antibacterial *** optimized extraction process is simple,stable,and reliable,and can be effectively used to optimize the extraction process of Compound Coptis Ointment.

关键词： Compound Coptis Ointment Orthogonal test Antibacterial test Extraction process

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碳化硅颗粒增强复合材料超疏水表面的制备

无机材料学报 2016年第4期31卷 383-387页

作者：包晓慧明平美毕向阳河南理工大学机械与动力工程学院焦作454000

采用电化学蚀刻方法在碳化硅颗粒增强复合材料(Si C/Al)表面构筑了微纳结构,重点分析了蚀刻电流密度和蚀刻时间等关键操作参数对所得表面微观形貌及润湿特性的影响。研究发现,较高电流密度(6 A/dm2)下刻蚀的Si C/Al复合材料表面可形成... 详细信息

采用电化学蚀刻方法在碳化硅颗粒增强复合材料(Si C/Al)表面构筑了微纳结构,重点分析了蚀刻电流密度和蚀刻时间等关键操作参数对所得表面微观形貌及润湿特性的影响。研究发现,较高电流密度(6 A/dm2)下刻蚀的Si C/Al复合材料表面可形成由微米级"粒状"结构和纳米级结构(颗粒状和波鳞状)复合而成的微–纳双层结构,且这种特殊结构不因后续刻蚀时间延长而改变;优化条件形成的Si C/Al复合材料刻蚀表面呈现出静态接触角高达160.7?、滚动角低至4?的超疏水特性。本研究结果说明Si C/Al复合材料可用于制备自清洁表面。

关键词：超疏水表面电化学蚀刻 SiC/Al复合材料微纳复合结构

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城镇化、社会经济地位与居民健康差距

中国卫生政策研究 2023年第10期16卷 17-25页

作者：程明梅余倩中南财经政法大学财政税务学院湖北武汉430073 中南财经政法大学公共管理学院湖北武汉430073

利用1991—2015年“中国健康与营养调查”数据,实证考察城镇化、社会经济地位与居民健康差距之间的关系。研究发现:(1)城镇化影响居民健康。城镇化会显著增加居民的四周患病率,与慢性病患病率和患病数量存在先降后增的关系。(2)城镇化... 详细信息

利用1991—2015年“中国健康与营养调查”数据,实证考察城镇化、社会经济地位与居民健康差距之间的关系。研究发现:(1)城镇化影响居民健康。城镇化会显著增加居民的四周患病率,与慢性病患病率和患病数量存在先降后增的关系。(2)城镇化扩大了不同社会经济地位居民之间的健康差距,城镇化对社会经济地位较低居民健康的负面影响更大。(3)机制分析表明,城镇化主要通过生活方式改变、心理压力增大以及肥胖等渠道影响居民的健康状况。因此,在推进新型城镇化和实施“健康中国”战略的背景下,应关注城镇化所带来的健康分配效应,警惕城镇化进程中可能出现的“健康陷阱”。

关键词：城镇化社会经济地位生活方式健康差距

Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： Hua-Chuan Song Hang-Cheng Zhou Ping Gu Bing Bao Quan Sun Tian-ming mei Wei Cui Kang Yao Huan-Zhang Yao Shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song Ji-Zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of *** chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of ***,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative *** mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour *** studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with *** To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for *** A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July *** and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological *** Kaplan-meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low ***<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour *** Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)*** rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

STUDIES　ON　LOW　MOLECULAR　WEIGHT　MATERIALS　CONTAINED　IN　POLY（P－PHENYLENE　SULFIDE）

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Chinese Chemical Letters 1995年第10期6卷 923+624-625,926页

作者： mei ming LUO Can Shu HOU Jie YANG Yong Rong CHEN Qi Xian WU(Institute of Materials Science and Technology,Sichuan University, Chengdu 610064)

Low molecular weight materials contained in PPS resin were obtained by extracting PPS powder exhaustively with xylene and examined by solid probe mass *** families of oligomers have been identified in the extract. Cyclopenta (p-phenylenesulfide) (Ⅰ) and Cyclohexa (p-phenylene sulfide)(Ⅱ)have been isolated from PPS by extraction and recrystallization, and characterized.

关键词：

SOLID STATE PHOTOCHEMICAL SYNTHESIS OF A NOVEL HOST COMPOUND METHYL 4-(DI-3-INDOLYL) METHYLBENZOATE AND X-RAY CRYSTAL STRUCTURE OF ITS 1:1 INCLUSION COM-PLEX WITH ACETONE

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Chinese Journal of Structural Chemistry 1992年第5期 358-361页

作者： Meng Ji-Ben Du Da-ming Wang Yong-mei Wang Hong-Gen Wang Ru-JiDepartment of Chemistry and Central Laboratory, Nankai University , Tianjin, 300071

A novel host compound methyl 4-(di-3-indolyl) methylbenzoate p-CH3OCOC6H4CH (C8H6N)2(3) was prepared by irradiation of the mixed crystals of methyl p-formylbenzoate (1) and indole (2.). The crystal structure of 1:1 inclusion complex (3’ ) formed by compound (3) and acetone has been examined by X-ray diffraction analysis. The crystal belongs to triclinic system, space group P1, with cell parameters: a = 9.902(3), b = 10. 626(2), c=12. 945(2) A , α=70. 69(2),β = 72.56(2), γ = 69. 53(2)°, V = 1177. 82(?)3, Mr = 438. 53, Z = 2, Dx = 1. 236g/ cm3, μ = 0. 75cm-1, F (000) = 464. The final R is 0. 041 for 2006 observed unique reflections. There are three main planes in one molecule of this compound, the dihedral angles between them are 62. 37°, 89. 12° and 83. 308, respectively.

关键词： COM METHYLBENZOATE AND X-RAY CRYSTAL STRUCTURE OF ITS 1 SOLID STATE PHOTOCHEMICAL SYNTHESIS OF A NOVEL HOST COMPOUND METHYL 4 DI-3-INDOLYL ITS

绿色发展理念指引下城乡双向流通冷链物流发展研究

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价格月刊 2019年第5期 67-72页

作者：赵明媚呼伦贝尔学院经济管理学院内蒙古呼伦贝尔021008

从生鲜电商零售额与生鲜电商产品规模视角探讨了城乡双向流通冷链物流市场规模,同时分析冷库整体建设情况,以此研究绿色发展理念指引下城乡双向流通冷链物流的影响因素及其相关对策。提出促进绿色冷链物流资源配置平衡性,加大冷库建设... 详细信息

从生鲜电商零售额与生鲜电商产品规模视角探讨了城乡双向流通冷链物流市场规模,同时分析冷库整体建设情况,以此研究绿色发展理念指引下城乡双向流通冷链物流的影响因素及其相关对策。提出促进绿色冷链物流资源配置平衡性,加大冷库建设补贴、丰富农村冷库功能、发展农村地区绿色冷链物流企业,加大绿色冷链物流技术研发、合理布局网点、提升冷链物流信息共享程度、积极储备绿色冷链物流复合型人才等,从而促进城乡双向流通绿色冷链物流的发展。

关键词：绿色发展理念城乡双向流通冷链物流

蛋白酶活化受体2在葡萄膜黑色素瘤中的表达及对细胞增殖和侵袭的影响

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国际眼科杂志 2018年第12期18卷 2137-2141页

作者：明媚罗文高峰鄂东医疗集团黄石市中心医院眼科中国湖北省黄石市435000 河南省眼科研究所河南省立眼科医院中国河南省郑州市450000

目的:探讨蛋白酶活化受体2(protease-activated receptor 2,PAR2)在葡萄膜黑色素瘤(uveal melanoma,UM)中的表达,以及沉默人UM细胞系M23中PAR2基因对细胞增殖和侵袭的影响。方法:选取2012-02/2017-12在我院行手术治疗且资料完整的UM患... 详细信息

目的:探讨蛋白酶活化受体2(protease-activated receptor 2,PAR2)在葡萄膜黑色素瘤(uveal melanoma,UM)中的表达,以及沉默人UM细胞系M23中PAR2基因对细胞增殖和侵袭的影响。方法:选取2012-02/2017-12在我院行手术治疗且资料完整的UM患者45例45眼,选取同期因眼部外伤行眼球摘除且葡萄膜正常的患者30例30眼,实时荧光定量PCR术检测UM和正常脉络膜组织中PAR2基因表达,培养M23细胞并分为PAR2干扰组、阴性对照序列组和空白组,实时荧光定量PCR技术检测细胞中PAR2基因表达,MTT法检测细胞增殖能力,Transwell法检测细胞迁移和侵袭能力。结果:UM组织中PAR2 mRNA相对表达量为1. 73±0. 13,正常脉络膜组织中PAR2 mRNA相对表达量为1. 06±0. 10,差异有统计学意义(t=23. 732,P <0. 01); UM组织中PAR2 mRNA相对表达量与病理学类型、巩膜浸润、视盘受累和眼外生长有关,差异有统计学意义(P<0. 05);PAR2干扰组细胞中PAR2 mRNA相对表达量低于阴性对照序列和空白组,差异有统计学意义(P<0. 05); PAR2干扰组细胞24、48、72和96h时吸光度A值低于阴性对照组和空白组,差异有统计学意义(P<0. 05); PAR2干扰组迁移细胞数和侵袭细胞数低于阴性对照序列组和空白组(P<0. 05)。结论:PAR2在UM组织中呈高表达,且与肿瘤高转移风险有关,特异性沉默M23细胞中PAR2基因表达可有效抑制细胞增殖、迁移及侵袭。

关键词：葡萄膜黑色素瘤蛋白酶活化受体2 细胞增殖细胞侵袭

THE SOLID STATE CONTROLLED CONDENSATION REACTION OF FERROCENEALDEHYDE AND INDOLE

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Chinese Chemical Letters 1992年第4期3卷 247-250页

作者： Ji Ben MENG~* Da ming DU Yong mei WANG Ru Ji WANG Hong Gen WANG Department of Chemistry and Central Laboratory, Nankai University, Tianjin, 300071

The ZnCl_2-catalyzed condensation reaction of ferrocenealdehyde and indole in the solid state gave a new product (di-3-indolyi)-methylferrocene(3). The crystal structure of product 3 was determined by X-ray diffractio... 详细信息

关键词： THE SOLID STATE CONTROLLED CONDENSATION REACTION OF FERROCENEALDEHYDE AND INDOLE

THE SYNTHESIS AND X-RAY CRYSTAL STRUCTURE STUDIES OF (DI-3-INDOL YL )M ETH YLFERROCENE

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Chinese Journal of Structural Chemistry 1993年第2期 85-88页

作者： Meng Ji-Ben Du Da-ming Wang Yong-mei Wang Hong-Gen Wang Ru-JiDep-artment of Chemistry and Central Laboratory, Nankai University , Tianjin, 300071

A novel anhydrous zinc chloride catalyzed condensation reaction of ferrocenealdehyde with indole in solid state gave the title compound (Di-3-indolyl) methylferrocene ((C8H6N)2CHC5H4FeC5H5) selectively, and its crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to triclinic system, space group P1, with cell parameters a = 9. 624(2), b = 9. 957(2), c=11. 295 (4)A,α=92. 17(2), β=92. 23(2), γ=111. 30(1)°, V=985. 4A3, Mr = 430. 33, Z = 2, Dx = 1. 44g/cm3,μ= 7. 8cm-1, F(000) = 444. The final R = 0. 056 for 3027 observed reflections.

关键词： ETH DI-3-INDOL YL M ETH YLFERROCENE THE SYNTHESIS AND X-RAY CRYSTAL STRUCTURE STUDIES OF OC