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A general synthetic strategy for N, P co-doped graphene supported metal-rich noble metal phosphides for hydrogen generation

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Green Energy & Environment 2024年第1期9卷 152-162页

作者： Jingwen Ma Xiang Li Guangyu Lei Jun Wang Juan Wang Jian Liu ming ke Yang Li Chunwen Sun School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing100083China State key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Lab of Advanced Nano-structures&Transfer Processes Department of Chemical EngineeringTianjin UniversityTianjin300354China PetroChina Planning and Engineering Institute Beijing100083China

The exploitation of electrocatalysts with high activity and durability for HER is desirable for future energy systems,but it is still a *** have attracted increasing attentions,but the preparation process often needs toxic regents or dangerous reaction ***,we develop a general green method to fabricate metal-rich NMPs anchored on NPG through pyrolyzing DNA cross-linked *** obtained Ru_(2) P-NPG exhibits an ultrasmall overpotential of 7 mV at 10 mA cm^(2) and ultralow Tafel slope of 33 mV dec^(-1) in 1.0 mol L?1 KOH,even better than that of commercial Pt/*** addition,Ru 2 P-NPG also shows low overpotentials of 29 and 78 mV in 0.5 mol L^(-1) H_(2)SO_(4) and 1.0 mol L^(-1) PBS,*** superior activity can be attributed to the ultrafine dispersion of Ru 2 P nanoparticles for more accessible sites,more defects formed for abundant active sites,the two-dimensional plane structure for accelerated electron transfer and mass transport,as well as the regulation of electron distribution of the ***,the synthetic method can also be applied to prepare other metal-rich noble metal phosphides(Pd_(3)P-NPG and Rh_(2)P-NPG),which also exhibits high activity for *** work provides an effective strategy for designing NMP-based electrocatalysts.

关键词： Noble metal phosphides Electrocatalyst Deoxyribonucleic acid Hydrogen evolution pH universal

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Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

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National Science Review 2024年第1期11卷 161-173页

作者： Feng Xue Fei Li ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang mingzhai Sun Pak-ming Lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center Department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of Life and Health Sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences Department of Modern Life Sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

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Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1626-1646页

作者： Kai-Lin Jiang Xiang-Xiang Wang Xue-Jiao Liu Li-Kun Guo Yong-Qi Chen Qing-Ling Jia ke-ming Yang Jiang-Hong Ling Department of Gastroenterology Shuguang HospitalShanghai 200021China Department of Pathology Shuguang HospitalShanghai 200021China

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally *** To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using *** PubMed,Web of Science,and EMBASE were searched for *** trained researchers selected the studies and extracted *** 17.0 software was used for meta-analysis of the incidence of each outcome *** adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included *** plots and Egger’s test were used to detect publication *** analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging *** Eight studies with a pooled success rate of 66.6%were *** derived from women and men had success rates of 67%and 46.7%,*** from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,*** of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,*** with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,*** generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM *** Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.

关键词： Gastric cancer organoids Human-derived organoids Gastric cancer Cell lines In vitro research models

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Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies

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World Journal of Diabetes 2024年第8期15卷 1663-1671页

作者： Jing-Wen Liu Xiao Huang ming-ke Wang Ji-Shun Yang School of Pharmacy Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Naval Medical Center Naval Medical UniversityShanghai 200052China

Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased ***,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 *** worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral ***,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral *** may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive *** review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients.

关键词： Diabetes mellitus SARS-CoV-2 COVID-19 Susceptibility Prevention Treatment

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Bibliometrics analysis based on the Web of Science:Current trends and perspective of gastric organoid during 2010-2023

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World Journal of Gastroenterology 2024年第8期30卷 969-983页

作者： Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang ke-ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China Laboratory of Cancer Biology University of OxfordOxford OX37DQUnited Kingdom School of Traditional Chinese Medicine Shanghai University of Chinese MedicineShanghai 200021China Shanghai key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China

BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy *** use of gastric organoid models holds significant promise for advancing personalized medicine ***,a comprehensive bibliometric review of this burgeoning field has not yet been *** To analyze and understand the development,impact,and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection(WoSCC)*** This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023,as indexed in the *** and VOSviewer were used to depict network maps illustrating collaborations among authors,institutions and keywords related to gastric ***,co-citation,and burst analysis methodologies were applied to assess the impact and progress of *** A total of 656 relevant studies were *** majority of research was published in gastroenterology-focused ***,Yana Zavros,Hans Clevers,James M Wells,Sina Bartfeld,and Chen Zheng were the 5 most productive authors,while Hans Clevers,Huch Meritxell,Johan H van Es,Marc Van de Wetering,and Sato Toshiro were the foremost influential scientists in this *** from the University Medical Center Utrecht,Netherlands Institute for Developmental Biology(Utrecht),and University of Cincinnati(Cincinnati,OH,United States)made the most significant ***,gastric organoids are used mainly in studies investigating gastric cancer(GC),Helicobacter pylori-infective gastritis,with a focus on the mechanisms of GC,and drug screening *** key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening *** contributions from renowned academic institutions highlight this field’s dynamic growth.

关键词： Gastric organoid Gastric disease Bibliometrics analysis Gastric cancer Gastritis

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Combined prevention and treatment measures are essential to control nosocomial infections during the COVID-19 pandemic

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World Journal of Virology 2024年第2期13卷 11-18页

作者： Jing-Wen Liu Yue-Yue Li ming-ke Wang Ji-Shun Yang Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China School of Pharmacy Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

Severe acute respiratory syndrome coronavirus-2 is a highly contagious positive-sense,single-stranded RNA virus that has rapidly spread *** of December 17,2023,772838745 confirmed cases including 6988679 deaths have been reported *** virus primarily spreads through droplets,airborne transmission,and direct *** harbor a substantial number of confirmed coronavirus disease 2019(COVID-19)patients and asymptomatic carriers,accompanied by high population density and a larger susceptible *** factors serve as potential triggers for nosocomial infections,posing a threat during the COVID-19 *** infections occur to varying degrees across different countries worldwide,emphasizing the urgent need for a practical approach to prevent and control the intra-hospital spread of *** study primarily concentrated on a novel strategy combining preventive measures with treatment for combating COVID-19 nosocomial *** suggests preventive methods,such as vaccination,disinfection,and training of heathcare personnel to curb viral ***,it explored therapeutic strategies targeting cellular inflammatory factors and certain new medications for COVID-19 *** methods hold promise in rapidly and effectively preventing and controlling nosocomial infections during the COVID-19 pandemic and provide a reliable reference for adopting preventive measures in the future pandemic.

关键词： COVID-19 SARS-CoV-2 Nosocomial infection Prevention Treatment

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多层脑功能网络与单层脑功能网络的对比研究

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华中科技大学学报（自然科学版） 2024年第5期52卷 76-82页

作者：柯铭许迪王常亮刘光耀兰州理工大学计算机与通信学院甘肃兰州730050 兰州大学第二医院磁共振科甘肃兰州730050

为探究多层脑功能网络和单层脑功能网络的联系与差异,收集34位健康个体在静息状态下的功能磁共振成像数据,分别构建单层网络和多层网络模型并进行社区检测,分析两种模型的模块划分差异、网络拓扑指标间的联系及脑节点的分类情况.研究结... 详细信息

为探究多层脑功能网络和单层脑功能网络的联系与差异,收集34位健康个体在静息状态下的功能磁共振成像数据,分别构建单层网络和多层网络模型并进行社区检测,分析两种模型的模块划分差异、网络拓扑指标间的联系及脑节点的分类情况.研究结果表明:多层网络的模块数量和质量显著高于单层网络,两种模型的网络拓扑指标间存在显著相关性,多层网络将脑节点划分为21个provincial hubs,49个connector non-hubs和20个peripheral non-hubs.显示了多层网络在研究大脑动态性具有独特优势,揭示了大脑功能的模块化特征,为深入理解大脑动态性提供了重要的思路和方法.

关键词：多层网络单层网络社区检测网络拓扑指标大脑动态性

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Impact of COVID-19 pandemic on routine childhood vaccinations

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World Journal of Virology 2024年第2期13卷 1-4页

作者： Shi-Rong Lv ming-ke Wang Xue-Lu Yu Xin-Yue Li Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

Routine pediatric vaccination is one of the most effective public health inter-ventions for the control of a number of fatal ***,during the coronavirus disease 2019 pandemic,routine pediatric vaccination rates were severely affected by disruptions of health services and vaccine confidence *** and the United Nations have taken measures to re-establish routine pediatric vaccination,while additional efforts are needed to catch up and develop plans to ensure routine vaccination services for the future pandemics.

关键词： Vaccines Childhood immunizations COVID-19 SARS-CoV-2 Pandemic

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基于LES的压气机叶栅通道非定常流动结构研究

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热能动力工程 2024年第1期39卷 98-107页

作者：黄明珂周玲季路成北京理工大学宇航学院北京100081 清华大学航空发动机研究院北京100084

为了进一步理解压气机叶栅通道内的非定常流动结构,采用大涡模拟(LES)方法研究了来流附面层厚度和稠度变化对叶栅通道内涡系结构及总压损失系数的影响。研究表明:来流附面层增厚将导致端壁处流体的轴向动能降低,使得马蹄涡压力面分支更... 详细信息

为了进一步理解压气机叶栅通道内的非定常流动结构,采用大涡模拟(LES)方法研究了来流附面层厚度和稠度变化对叶栅通道内涡系结构及总压损失系数的影响。研究表明:来流附面层增厚将导致端壁处流体的轴向动能降低,使得马蹄涡压力面分支更早地流向相邻叶片吸力面;来流附面层越厚,通道涡在叶栅尾缘沿展向抬升的高度越高,角区分离的范围也越大;叶栅的总压损失随附面层增厚而增加,附面层损失增加显著,二次流损失有所增大;稠度较低时叶栅吸力面表面存在分离,会对通道涡及角区分离产生影响;稠度增大,横向压力梯度减小,叶栅流道的速度分布更均匀,通道涡的强度和尺度减小,角区分离的范围减小;稠度增大使叶表不再分离时,总压损失显著降低,但稠度继续增大会使气流与叶片表面的摩擦损失增加。

关键词：压气机叶栅大涡模拟附面层厚度稠度角区分离

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Urgent call for attention to diabetes-associated hospital infections

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World Journal of Diabetes 2024年第8期15卷 1683-1691页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Qing-Qing Pan ming-ke Wang Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

In this editorial,we discuss the recent article by Zhao et al published in the World Journal of Diabetes,which highlights the importance of recognizing the risk indicators associated with diabetes mellitus(DM).Given the severe implications of healthcare-associated infections(HAIs)in hospitalized individuals-such as heightened mortality rates,prolonged hospitalizations,and increased costs-we focus on elucidating the connection between DM and nosocomial *** patients are susceptible to pathogenic bacterial invasion and subsequent infection,with some already harboring co-infections upon ***,DM is an important risk factor for nosocomial urinary tract infections and surgical site infections,which may indirectly affect the occurrence of nosocomial bloodstream infections,especially in patients with DM with poor glycemic *** evidence regarding the impact of DM on healthcare-associated pneumonias remains inconclusive,attention to this potential association is *** patients with DM should prioritize meticulous blood glucose management,adherence to standard operating procedures,hand hygiene practices,environmental disinfection,and rational use of drugs during *** studies are imperative to explore the main risk factors of HAIs in patients with DM,enabling the development of preventative measures and mitigating the occurrence of HAIs in these patients.

关键词： Diabetes mellitus Healthcare-associated infections Nosocomial urinary tract infections Surgical site infections Nosocomial bloodstream infections

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