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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing Wu Guang Yin Fan‑Zhen Jiao zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu kang Wang Yuanhong Peng Meng Chen Lin zhong Luji Huang F U Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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用汉白玉废料制备超细轻质碳酸钙

四川大学学报（工程科学版） 2002年第6期34卷 112-115页

作者：孙蓉康明卢忠远西南科技大学四川绵阳6210021

以汉白玉废料为原料 ,利用化学方法合成超细轻质碳酸钙粉末 ,探讨了煅烧温度、碳化温度、CO2 浓度、搅拌速度对碳酸钙颗粒的粒径的影响。实验结果表明 :通过控制煅烧温度为 95 0℃、碳化温度为 5℃、CO2 浓度为6 0 %、搅拌速度为 14 0 0... 详细信息

以汉白玉废料为原料 ,利用化学方法合成超细轻质碳酸钙粉末 ,探讨了煅烧温度、碳化温度、CO2 浓度、搅拌速度对碳酸钙颗粒的粒径的影响。实验结果表明 :通过控制煅烧温度为 95 0℃、碳化温度为 5℃、CO2 浓度为6 0 %、搅拌速度为 14 0 0r/min ,可以制得超细轻质碳酸钙。

关键词：汉白玉废料制备超细碳酸钙化学方法煅烧温度碳化温度

Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-ming Mo Xu Chen Shu-Hua zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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Relative Levels of Indoor and Outdoor Particle Number Concentrations in a Residential Building in Xi’an

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基于FAERS数据库芬戈莫德在多发性硬化患者中的肿瘤风险信号挖掘

中国颗粒学会2006年年会暨海峡两岸颗粒技术研讨会

作者： Yan-ming kang, Ke zhong, Shun-cheng Lee (School of Environmental Science and Engineering, Donghua University, Shanghai 201620, China Research Centre for Environmental Technology and Management, Department of Civil and Structural Engineering, The Hong Kong Polytechnic University, Hom Hung, Kowloon, Hong Kong, China)

＜正＞The time series of indoor and outdoor particle number concentrations in a natural ventilating residential building were tested simultaneously for 7 d in Xi’an in summer. The relationships between indoor and outdoor concentrations were examined and discussed, and linear regression analysis was employed to correlate the indoor concentration levels with outdoor concentrations. The diurnal cycles of indoor and outdoor particle concentrations of different size ranges all showed positive correlations between indoor and outdoor number concentrations. The I/O ratios of number concentrations varied with the increase of particle size, the range of the I/O ratios was from 0.89 （±0.19） to 0.99 （±0.15）.

关键词： indoor and outdoor particle number concentration I/O ratio linear regression analysis

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药物流行病学杂志 2023年第9期32卷 961-968页

作者：张千颜明明赵晖邱晓燕钟明康复旦大学附属华山医院药剂科上海200040

目的评估芬戈莫德在多发性硬化患者中潜在的肿瘤风险。方法提取美国食品药品管理局不良事件报告系统(FAERS)数据库2004年第一季度至2022年第四季度数据,采用报告比值比(ROR)法和信息成分(IC)法挖掘芬戈莫德在多发性硬化患者中潜在的肿... 详细信息

目的评估芬戈莫德在多发性硬化患者中潜在的肿瘤风险。方法提取美国食品药品管理局不良事件报告系统(FAERS)数据库2004年第一季度至2022年第四季度数据,采用报告比值比(ROR)法和信息成分(IC)法挖掘芬戈莫德在多发性硬化患者中潜在的肿瘤不良事件信号。结果获得1628例与芬戈莫德治疗多发性硬化患者有关的肿瘤不良事件报告,报告例次数排名前3位的肿瘤类别依次为皮肤和黏膜恶性肿瘤(527例次)、乳腺癌(89例次)和女性生殖器官癌(43例次)。信号分析显示,报告例次数排名前6位的肿瘤依次是基底细胞癌(189例次,ROR=5.67,ROR_(025)=4.91,IC_(025)=2.23)、恶性黑色素瘤(105例次,ROR=3.29,ROR_(025)=2.71,IC_(025)=1.39)、鳞状细胞癌(62例次,ROR=2.91,ROR_(025)=2.27,IC_(025)=1.12)、乳腺浸润性导管癌(53例次,ROR=8.62,ROR_(025)=6.56,IC_(025)=2.46)、皮肤鳞状细胞癌(45例次,ROR=3.58,ROR_(025)=2.67,IC_(025)=1.31)和子宫癌(37例次,ROR=4.09,ROR_(025)=2.96,IC_(025)=1.41)。结论芬戈莫德在多发性硬化患者中有广泛的潜在肿瘤不良事件风险,理解这一现象需要进一步的临床研究来探索,并建议服用芬戈莫德的患者进行皮肤科随访。

关键词：芬戈莫德肿瘤药品不良事件多发性硬化 FAERS数据库数据挖掘药物警戒

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三种钒系催化剂表征的对比研究

天津化工 2003年第6期17卷 24-27页

作者：钱功明钟康年刘羽武汉化工学院湖北武汉430074

本文对美国Monsanto ,国产S10 1,S10 8型钒系催化剂进行了表征对比研究。XRD物相分析、IR光谱测试、BET比表面积测定和扫描电镜形貌及成分分析的结果表明 :相对于国产样品 ,Monsanto催化剂的催化性能明显较好 ,这是由于它保持着较好的... 详细信息

本文对美国Monsanto ,国产S10 1,S10 8型钒系催化剂进行了表征对比研究。XRD物相分析、IR光谱测试、BET比表面积测定和扫描电镜形貌及成分分析的结果表明 :相对于国产样品 ,Monsanto催化剂的催化性能明显较好 ,这是由于它保持着较好的载体孔结构特征 ,具有较大的比表面积 ,同时存在着均匀分散的某种特殊的钒组分活性相。这说明制备工艺参数的合理选择是决定催化剂性能的关键。

关键词：硅藻土表征钒催化剂活性

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Membrane enhanced COD degradation of pulp wastewater using Cu_2O/H_2O_2 heterogeneous Fenton process

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Chinese Journal of Chemical Engineering 2018年第9期26卷 1896-1903页

作者： Hongjia Zhou Lin kang ming Zhou Zhaoxiang zhong Weihong Xing State Key Laboratory of Materials-Oriented Chemical Engineering National Engineering Research Center for Special Separation Membrane Nanjing Tech University

Both activity and stability of the catalyst can be improved in heterogeneous Fenton reaction,in particular,with no limitation for the working p H and no production of the *** this work,a combination of catalyst Cu_2O and pore-channel-dispersed H_2O_2is proposed to treat the pulp *** degree of CODs in the wastewater was up to 77%in the ceramic membrane reactor using Cu_2O powder(2.0 g·L^(-1))and membranefeeding H_2O_2(0.8 ml·L^(-1))within 60 *** of·OH radical formation in the advanced oxidation process was analyzed with a fluorescent *** efficiency of H_2O_2was successfully enhanced by 10%with the membrane *** on,the catalyst recyclability was evaluated in a five-cycle *** concentration of copper ions being dissolved in the treated water was monitored with *** Cu_2O/H_2O_2(membrane)treatment the effluent is qualified to discharge with COD concentration lower than 15 mg·L^(-1)with regard to the national standard GB25467-2010.

关键词： Pulp wastewater Heterogeneous Fenton Membrane Cu2O Advanced oxidation