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Calculations of the 3-D neutronics for CH HCSB TBM with 3×3 sub-modules

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核聚变与等离子体物理 2006年第3期26卷 170-175页

作者： ZHANG Guo-shu FENG kai-ming chen Rong-guang YUAN Tao LI Zeng-qiang Southwestern Institute of Physics Chengdu 610041

Using three dimension MCNP code and FENDL2.0 data library, neutronics calculation for a HCSB (helium cooling solid breeder ) TBM ( test blanket module ) with 3×3 sub-modules has been performed. Local tritium breeding ratio (TBR) of 0.907, total tritium generation rate of 0.0175 g· d-1, peak power density of 9.27MW· m-3 and total power deposit of 0.422MW·m-3 are obtained under neutron wall loading of 0.78MW·m-2 and duty factor of 22%.

关键词：融化覆盖中子物理 TBR 再生区

Synthesis of a new aromatic dianhydride monomer and related polyimide

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Chinese Chemical Letters 2009年第2期20卷 229-230页

作者： Yun Xia Wei ming Guang Ma Guo Hu Zhao Sheng Ying Li ming kai chen College of Chemistry and Environmental Science Lanzhou City University Lanzhou 730070 China Department of Chemistry Lanzhou University Lanzhou 730000 China

A novel aromatic dianhydride monomer, 3,3′-oxybis[（3,4-dicarboxyphenoxy）phenol] dianhydride, was successfully synthe- sized in three steps using 3,3′-oxybis（phenol） as starting material, which was reacted with 4,4′-oxydianiline （ODA） via a conventional thermal or chemical imidization method to produce a new polyimide. The resulting polyimide exhibited excellent solubility, and film-forming capability.

关键词： Polyimidc Dianhydridc Solubility

Coordinated organogel templated fabrication of silver/polypyrrole composite nanowires

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Chinese Chemical Letters 2011年第1期22卷 123-126页

作者： Bo Tian Li Li ming Tang kai chen Yu Xia Xin Jin Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084 China

A new method to fabricate metal/conducting polymer composite nanowires is presented by taking silver/polypyrrole composite nanowires as an example. A silver （D-coordinated organogel as template was prepared firstly, and redox-polymerization of pyrrole took place on the gel fiber, giving product of silver/polypyrrole nanowires. The silver/polypyrrole nanowires were characterized by multiple techniques. This strategy could be carried out in one-step procedure at room temperature, and it proves the utility of coordinated organogels in template synthesis of polymer nanostructures.

关键词： Coordinated organogel Template polymerization Polypyrrole Composite nanowires

New Hydrogen Bonded Supramolecular Hydrogels Formed through Gelating Two Isomeric Building Units Simultaneously

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Chinese Chemical Letters 2006年第10期17卷 1388-1390页

作者： Ji Wei WU Li ming TANG kai chen Liang YAN Yu Jiang WANG Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084

New hydrogen bonded supramolecular hydrogels were formed through simultaneously gelating two isomeric building units, 4-oxo-4-（2-pyridinylamino）butanoic acid （G1） and 4-oxo-4-（3-pyridinylamino）butanoic acid （G2... 详细信息

关键词： Supramolecular hydrogel hydrogen bond gelation.

KN-93,a specific inhibitor of CaMKⅡ inhibits human hepatic stellate cell proliferation in vitro

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World Journal of Gastroenterology 2007年第9期13卷 1445-1448页

作者： Ping An Jun-Yong Zhu Yan Yang Peng Lv Yi-Hao Tian ming-kai chen He-Sheng Luo Department of Gastroenterology Renmin Hospital of Wuhan University 238 Jiefang Road Wuhan 430060 Hubei Province China Educational Administration Office Renmin Hospital of Wuhan University 238 Jiefang Road Wuhan 430060 Hubei Province China Department of Obstetrics and Gynecology Hubei Xinhua Hospital 5-6 Xin Tian Men Dun Wuhan 430015 Hubei Province China Faculty of Anatomy and Embryology Wuhan University School of Modcine Wuhan 430071 Hubei Province China

AIM： To investigate the effects of KN-93, a CaMKⅡ selective inhibitor on cell proliferation and the expression of p53 or p21 protein in human hepatic stellate cells. METHODS： Human hepatic stellate cells （LX-2） were incubated with various concentrations （0-50 μmol/L） of KN-93 or its inactive derivative, KN-92. Cell proliferation was measured by CCK-8 assay, and the expression of two cell cycle regulators, p53 and p21, was determined by SDS-PAGE and Western blotting. RESULTS： KN-93 （5-50 μmol/L） decreased the proliferation of human hepatic stellate cells in a dosedependent manner from 81.76% （81.76% ± 2.58% vs 96.63% ± 2.69%, P 〈 0.05） to 27.15% （27.15% ± 2.86% vs 96.59% ± 2.44%, P 〈 0.01） after 24 h treatment. Incubation of 10 μmol/L KN-93 induced the cell growth reduction in a time-dependent manner from 78.27% at 8 h to 11.48% at 48 h. However, KN-92, an inactive derivative of KN-93, did not inhibit cell proliferation effectively. Moreover, analysis of cell cycle regulator expression revealed that KN-93 rather than KN-92 reduced the expression of p53 and p21. CONCLUSION： KN-93 has potent inhibitory effect on proliferation of LX-2 cells by modulating the expression of two special cell cycle regulators, p53 and p21.

关键词： KN-93 Human hepatic stellate cells LX-2 Cell proliferation

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生长抑素对Oddi括约肌功能的影响

世界华人消化杂志 2009年第17期17卷 1749-1752页

作者：周婷陈明锴武汉大学人民医院消化内科湖北省武汉市430060

天然生长抑素(somatostatin,SST)是一种胃肠激素及神经肽,主要分布于神经和消化系统中,具有广泛的生物学效应.消化系SST大多由胰腺和胃肠黏膜中的D细胞分泌,能抑制胃肠运动及多种激素分泌.SST调节作用由G蛋白偶联受体,即生长抑素受体(so... 详细信息

天然生长抑素(somatostatin,SST)是一种胃肠激素及神经肽,主要分布于神经和消化系统中,具有广泛的生物学效应.消化系SST大多由胰腺和胃肠黏膜中的D细胞分泌,能抑制胃肠运动及多种激素分泌.SST调节作用由G蛋白偶联受体,即生长抑素受体(somatostatin receptor,SSTR)介导.Oddi括约肌(sphincter of Oddi,SO)位于十二指肠乳头周围,是一结构和功能相对独立的器官,其运动主要受神经、激素、Cajal间质细胞的调节.SST对SO的作用尚存在争议,本文就生长抑素对SO功能的影响进行综述.

关键词：生长抑素生长抑素受体 Oddi括约肌

TCM diagnosis and treatment theory of chronic complete occlusion of coronary artery based on etiology and pathogenesis

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Journal of Hainan Medical University 2020年第21期26卷 60-64页

作者： Wen-Bin Zhang kai-ming chen Zhen Wang Yi-Tao Xue The First Clinical Medical College Shandong University of Chinese MedicineShandong250000China Cardiovascular medicine department Affiliated Hospital of Shandong University of Traditional Chinese MedicineShandong250011China

Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese *** etiology has two aspects:deficiency of blood,blood stasis,qi stagnation,and *** can be caused by deficiency or *** pathogenesis of this disease is caused by obstruction of the heart pulse,and its pathogenesis can be transformed into each *** theory of traditional Chinese medicine believes that the general rule is not ***,the treatment of coronary CTO lesions should be based on the combination of Tong and Tong *** chronic complete occlusive disease of the coronary artery can be treated through Xuanbi Tongyang,Huoxue Tongluo,and Aroma *** on the Chinese medicine's understanding of the etiology and pathogenesis of coronary CTO lesions,it provides a basis for the diagnosis and treatment of traditional Chinese medicine,solves the problems of interventional medicine in western medicine,and gives play to the unique advantages of traditional Chinese medicine for clinical diagnosis and treatment.

关键词： CTO disease TCM etiology and pathogenesis Combination of tonic and tonic Xuanbi Tongyang Huoxuetongluo Aromatic Wentong

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon chen chen Nai-Kui Liu Xiao-ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

LC-MS法评价2种盐酸非索非那定制剂的人体生物等效性

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沈阳药科大学学报 2011年第4期28卷 287-290,324页

作者：闫凯张明毕开顺陈晓辉沈阳药科大学药学院辽宁沈阳110016

目的建立LC-MS法测定人血浆中非索非那定浓度,评价盐酸非索非那定胶囊（受试制剂）与盐酸非索非那定片（参比制剂）的人体生物等效性。方法采用Kromasil C18（150 mm×4.6 mm,5μm）色谱柱;流动相：甲醇-质量分数为1%的甲酸水溶液（体... 详细信息

目的建立LC-MS法测定人血浆中非索非那定浓度,评价盐酸非索非那定胶囊（受试制剂）与盐酸非索非那定片（参比制剂）的人体生物等效性。方法采用Kromasil C18（150 mm×4.6 mm,5μm）色谱柱;流动相：甲醇-质量分数为1%的甲酸水溶液（体积比为88∶12）;离子源：大气压化学电离源,扫描方式：选择离子监测,用于定量分析的离子分别为m/z502.15（非索非那定）和m/z383.00（内标氯雷他定）。本法用于健康受试者口服盐酸非索非那定受试制剂和参比制剂的生物等效性研究。结果非索非那定质量浓度在10.0-2000.0μg.L-1内线性关系良好,方法的定量下限（LLOQ）为10.0μg.L-1。受试制剂与参比制剂的主要药物动力学参数：tmax分别为（1.9±0.2）和（1.9±0.2）h;ρmax分别为（173±77）和（183±83）μg.L-1;t1/2分别为（5.6±2.6）和（5.8±2.4）h;AUC0-t分别为（982±583）和（1081±772）μg.h.L-1,AUC0-∞分别为（1 176±738）and（1 271±998）μg.h.L-1。盐酸非索非那定胶囊的相对生物利用度为（90.8±15.3）%（n=18）。结论 2种盐酸非索非那定制剂具有生物等效性。

关键词：盐酸非索非那定药物动力学生物等效性液相色谱-质谱法