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Intravitreal injection of resveratrol inhibits laser-induced murine choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 886-892页

作者： hui-ming zhang Xiao-Hua Li mingjiazi Chen Jing Luo Department of Dermatology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Key Laboratory of Medical Epigenomics Changsha 410011Hunan ProvinceChina Department of Pathology and Ophthalmology Keck School of Medicine at University of Southern CaliforniaLos AngelesCalifornia 90033USA Henan Provincial People's Hospital/Henan Eye Hospital Henan Eye InstituteHenan Key Laboratory of Ophthalmology and Vision Science/Department of OphthalmologyPeople’s Hospital ofZhcngzliou University/Department of OphthalmologyPeople's Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina 5Department of Ophthalmologythe Second Xiangya I IospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM:To determine the effects of intravitreal resveratrol(RSV)on murine laser-induced choroidal neovascularization(CNV).METHODS:The toxicity of RSV to choroidal endothelial cell(CEC)was measured using thiazolyl blue tetrazolium bromide(M一)*** of RSV on choroidal endothelial cell(CEC)migration were evaluated with a modified Boyden chamber assay,while tube formation was evaluated in a 2-D gel *** was induced by laser photocoagulation in *** effects of intravitreal injection of RSV on CNV development were evaluated by fluorescein angiography(FA),confocal analysis of isolectin B4 labeled choroidal flat mounts,and histologic examination of CNV *** was used to analyze the expression and phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2).RESULTS:No significant cell toxicity was observed in CEC if the concentration of RSV was less than 200 pmol/L(P>0.05).RSV inhibited vascular endothelial growth factor(VEGF)-induced CEC migration(P<0.05)and tube formation(P<0.05)***,intravitrealinjectionof RSV significantly inhibited laser induced CNV formation in *** FA leakage,CNV volume and CNV area analysis revealed that there were 41%,45%,and 58%reduction in RSV-treated eyes(1.691±0.1032,178163±78623μm^3 and 6508±619.0μm^2,respectively)compared with those in control(2.724±0.08447,379676±98382μm3and16576±2646μm^2,respectively;P<0.05).Phospho-VEGFR2expression was much weaker in the sections of CNV lesions in RSV injected mice compared with that in control(P<0.05).CONCLUSION:Intravitreal injection of RSV exerts an inhibitory effect on CNV,which may through suppressing endothelial cell migration,tube formation and VEGFR2 phosphorylation.

关键词： resveratrol intravitreal injection choroidal neovascularization vascular endothelial growth factor receptor 2 tube formation murine

Estimation of OCDD degradation rate in soil

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Journal of Environmental Sciences 2005年第6期17卷 981-983页

作者： ZHAO Xing-ru ZHENG ming-hui zhang Bing QIAN Yong XU Xiao-bai State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of ScienceBeijing 100085 China

The current concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans （PCDD/Fs） were determined in soils contaminated with Chinese technical product sodium pentachlorophenate （ Na- PCP）. The estimated half-life of octachlorodioxin （OCDD） was about 14 years in contaminated soils based on the local historical record and mass balance calculation during the past 43 years（ 1960-2003）. The isomer profiles remained the same regardless of paddy field soil or riverbank soil. The results indicated that the congenerspecific information was efficient in estimating the PCDD/Fs fate in contaminated soils.

关键词： OCDD degradation rate Na-PCP

Interaction of hispidin with pepsin:Multi-spectroscopic analyses and docking simulation

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Food and Health 2024年第1期6卷 21-27页

作者： Wen-Qiang Wang Si-Hua Fan Xin-Huai Zhao Li Wang ming-hui zhang Qiang zhang Xue-Jun Gao College of Biology and Food Engineering Guangdong University of Petrochemical TechnologyMaoming525000China College of Animal Science Yangtze UniversityJingzhou 434023China

Hispidin is a pyranone compound found in edible and medicinal mushrooms of the Phellinus and Inonotus *** investigation used fluorescence spectroscopy,UV absorption spectroscopy,and molecular docking to examine the interaction of hispidin with *** Stern-Volmer method was used to perform the fluorescence quenching measurements at different temperatures(298 K,303 K,and 310 K).According to the findings,hispidin induced a static quenching mechanism in pepsin that resulted in the creation of a hispidin-pepsin complex with binding constants(Ka)ranging from 9.56×10^(4) to 3.45×10^(5) L mol^(-1).The positive values ofΔH(84.6 kJ mol-1)andΔS(337.9 J mol^(-1) K^(-1))demonstrated that hydrophobic forces contributed to forming the hispidin-pepsin *** findings of UV-vis absorption,synchronous fluorescence,and 3D fluorescence spectraspectra demonstrated that hispidin altered the conformation and microenvironment of *** to the analysis of molecular docking,hispidin got into the pepsin's active *** research clarifies the molecular mechanisms by which hispidin binds to pepsin and helps understand its possible biological activity in vivo.

关键词： hispidin pepsin spectroscopy molecular docking

Analysis of spudcan-footprint interaction in a single soil with nonlinear FEM

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Petroleum Science 2015年第1期12卷 148-156页

作者： Dong-Feng Mao ming-hui zhang Yang Yu Meng-Lan Duan Jun Zhao College of Mechanical and Transportation Engineering China University of Petroleum

The footprints that remain on the seabed after offshore jack-up platforms completed operations and moved out provide a significant risk for any futurej ack-up installation at that site. Detrimental horizontal and/or rotational loads will be induced on the base cone of the jack-up platform leg （spudcan） in the preloading process where only vertical loads are normally expected. However, there are no specific guidelines on design of spudcan re-installation very close to or partially overlapping existing footprints. This paper presents a rational design approach for assessing spudcan-footprint interaction and the failure process of foundation in a single layer based on nonlinear finite element method. The rela- tionship between the distance between the spudcan and the footprint and the horizontal sliding force has been obtained. Comparisons of simulation and experimental results show that the model in this paper can deal well with the combined problems of sliding friction contact, fluid-solid coupling, and convergence difficulty. The analytical results may be useful to jack-up installation workovers close to existing footprints.

关键词： Jack-up Existing footprint Spudcan-footprint interaction Numerical simulation Nonlinearity

VISCOSITY EFFECTS ON THE BEHAVIOR OF A RISING BUBBLE

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Journal of Hydrodynamics 2010年第1期22卷 81-89页

作者： WANG Han zhang Zhen-yu YANG Yong-ming zhang hui-sheng Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Department of Mathematics Shanghai University of Finance and Economics Shanghai 200433 China

In the incompressible fluid flow regime, without taking consideration of surface tension effects, the viscosity effects on the behavior of an initially spherical buoyancy-driven bubble rising in an infinite and initially stationary liquid are investigated numerically by the Volume Of Fluid （VOF） method. The ratio of the gas density to the liquid density is taken as 0.001, and the gas viscosity to the liquid viscosity is 0.01, which is close to the case of an air bubble rising in water. It is found by numerical experiments that there exist two critical Reynolds numbers Re1 and Re2 , which are in between 30 and 50 and in between 10 and 20, respectively. As Re 〉 Re1 the bubble will have the transition to toroidal form, and the toroidal bubble will break down into two toroidal bubbles. In this case viscosity will damp the development of the liquid jet and delay the formation of the toroidal bubble. As Re〈Re1 the transition will not happen. As Re2 〈 Re 〈 Re1, the bubble will split from its rim into a toroidal bubble and a spherical cap-like bubble, and as Re〈Re2 the splitting will not occur and the bubble can finally reach a stationary shape. With the decrease of the Reynolds number, the stationary shape changes from spherical-cap bubble with skirt to dimpled peach-like bubble. Before the bubble reaches its stationary shape the vortex structure in the flow field varies with time. The vortex structure corresponding to bubble stationary shape varies with the Reynolds number. It is also found that there exists another critical Reynolds number Re^＊ which is in between Re1 and Re2 , and as Re 〈 Re^＊, after the bubble rises in an accelerating manner for a moment, it will rise with an almost constant speed, and the speed increases with increasing Reynolds number. As Re 〉 Re^＊, it will not rise with a constant speed. The mechanism of the above phenomena has been analyzed theoretically and numerically.

关键词： rising bubble viscosity effects buoyancy force Volume Of Fluid (VOF) method

SURFACE TENSION EFFECTS ON THE BEHAVIOR OF TWO RISING BUBBLES

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Journal of Hydrodynamics 2011年第2期23卷 135-144页

作者： WANG Han zhang Zhen-yu YANG Yong-ming zhang hui-sheng State Nuclear Power Technology Corporation Research and Development Centre SNPTRD Beijing 100190 China Department of Mathematics Shanghai University of Finance and Economics Shanghai 200433 China Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China

In the inviscid and incompressible fluid flow regime, surface tension effects on the behavior of two initially spherical bubbles with same size rising axisymmetrically in an infinite and initially stationary liquid are investigated numerically with the VOF method. The numerical experiments are performed for two bubbles with two different bubble distances. The ratio of gas density to liquid density is 0.001, which is close to the case of air bubbles rising in water. In the case of Dis = 2.5, where Dis is defined as the ratio of the distance between the bubble centroids to the radius of the bubble, it is found from numerical experiments that there exist four critical Weber numbers We1 , We2 , We3 and We4 , which are in between 10 and 100, 3 and 4, 1.5 and 1.8, and 0.2 and 0.3, respectively. In the case of Dis = 2.3, similar phenomena also appear but the corresponding four critical Weber numbers are lower than those in the case of Dis = 2.5. The mechanism of the above phenomena is analyzed theoretically and numerically.

关键词： two bubbles buoyancy surface tension VOF method

Crystalline-amorphous M@MN_x(M=Co,Fe,Ni)encapsulated in nitrogen-doped carbon for enhanced efficient and durable hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1547-1556页

作者： Yang Yang Xiao-Chuan Duan Shao-hui Guo Xian-ming zhang College of Materials Science and Engineering College of ChemistryKey Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyYuci030600China

Developing earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is important for the sustainable energy ***,efficient and stable heterocatalysts consisting of crystalline-amorphous M@MN_(x)(M=Co,Fe,Ni)encapsulated in N-doped carbon layers supported with N-doped graphene sheets(denoted as M@MN_(x)@NC-NG)are synthesized by facile hydrothermal reaction and nitridation *** the nitriding process,metal ions in M(tzbc)_2(H_(2)O)_4(tzbc=4-(1H-1,2,4-triazol-1-yl)benzoic acid)complexes are reduced to crystalline M cores,accompanied by the formation of amorphous MN_(x)shells;the tzbc ligands are insitu carbonized to form outermost N-doped carbon(NC)layers that connect with inner MN_(x)via M-N-C motifs inherited from the complex precursors and inhibit the transition of MN_(x)from amorphous to crystalline *** Co@CoN_(x)@NC-NG catalyst exhibits excellent HER activity with small overpotentials of 45 and 64 mV at a cathode current density of 10 mA·cm^(-2)and low Tafel slopes of 40 and 85 mV·dec^(-1)in 0.5 mol·L^(-1)H_(2)SO_4 and1.0 mol·L^(-1)KOH electrolytes,*** Co@CoN_(x)@NC-NG retains 97%of the initial overpotential after 100,000 s in both acidic and alkaline *** outstanding HER performance originates from the crystalline-amorphous Co@CoN_(x)that redistributes electrons around the heterointerfaces,facilitating the conversion process of H^(+)/H_(2)O to hydrogen and thereby promoting HER *** outermost NC layers serve as the armor of Co@CoN_(x),and graphene nanosheets act as carriers of egg-like Co@CoN_(x)@NC and conduction paths for electron shuttles,ensuring stable and continuous electrocatalytic hydrogen production.

关键词： Hydrogen evolution reaction Electrocatalysts Iron group metals Heterojunction Crystalline-amorphous structure

Centrifuge modeling of unreinforced and multi-row stabilizing piles reinforced landslides subjected to reservoir water level fluctuation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1600-1614页

作者： Chenyang zhang Yueping Yin hui Yan Sainan Zhu ming zhang Luqi Wang Department of Civil Engineering The University of Hong KongHong KongChina China Institute of Geo-environment Monitoring BeijingChina Chongqing 107 Municipal Construction Engineering Co. Ltd.ChongqingChina Faculty of Engineering China University of GeosciencesWuhanChina School of Civil Engineering Chongqing UniversityChongqingChina

With the construction of the Three Gorges Reservoir dam,frequent reservoir landslide events have been *** recent years,multi-row stabilizing piles(MRSPs)have been used to stabilize massive reservoir landslides in *** this study,two centrifuge model tests were carried out to study the unreinforced and MRSP-reinforced slopes subjected to reservoir water level(RWL)operation,using the Taping landslide as a *** results indicate that the RWL rising can provide lateral support within the submerged zone and then produce the inward seepage force,eventually strengthening the slope ***,a rapid RWL drawdown may induce outward seepage forces and a sudden debuttressing effect,consequently reducing the effective soil normal stress and triggering partial pre-failure within the RWL fluctuation ***,partial deformation and subsequent soil structure damage generate excess pore water pressures,ultimately leading to the overall failure of the reservoir *** study also reveals that a rapid increase in the downslope driving force due to RWL drawdown significantly intensifies the lateral earth pressures exerted on the ***,the MRSPs possess a considerable reinforcement effect on the reservoir landslide,transforming the overall failure into a partial deformation and failure situated above and in front of the *** mechanical transfer behavior observed in the MRSPs demonstrates a progressive alteration in relation to RWL *** the RWL rises,the mechanical states among MRSPs exhibit a growing *** shear force transfer factor(*** ratio of shear forces on pile of the n th row to that of the first row)increases significantly with the RWL *** indicates that the mechanical states among MRSPs tend toward an enhanced *** insights gained from this study contribute to a more comprehensive understanding of the failure mechanisms of reservoir landslides and the mechanical behavior of M

关键词： Reservoir landslide Failure mechanism Multi-row stabilizing piles Mechanical behavior

Value-added anticancer reactivity of sub-5 nm Ag-drug nanoparticles derived from organosilver (Ⅰ) MOF

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Science China Chemistry 2019年第3期62卷 347-354页

作者： Chao-Yu Song Jia-Yuan zhang Yuan Qiu Hai-Ping Jin hui-ming zhang Shuang Liu Hong Liu Hong-Bin Qiu Guang-Gang Gao School of Basic Medicine Jiamusi University School of Materials Science and Engineering University of Jinan School of Public Health Jiamusi University

A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag_(18)(CF_3COO)_(18)(H_2O)_2}{Ag_4(erlotinib)_4}]_n·7nCH_3OH·3nH_2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC_(50) values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC_(50) value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.

关键词： erlotinib silver nanocluster targeting A549 cell supramolecular