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基于监督机器学习算法构建脓毒性休克患者死亡风险的预测模型

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中华危重病急救医学 2024年第4期36卷 345-352页

作者：谢政金晶刘东松陆圣译俞慧韩冬孙炜黄铭江南大学附属医院急诊科江苏无锡214000 江南大学附属医院神经内科江苏无锡214000

目的基于不同监督机器学习算法,构建并验证适用于脓毒性休克患者28 d死亡风险的最佳预测模型。方法从美国重症监护医学信息数据库Ⅳv2.0(MIMIC-Ⅳv2.0)中筛选出符合脓毒症3.0的脓毒性休克患者,随机抽取病例,其中70%作为训练集,30%作为... 详细信息

目的基于不同监督机器学习算法,构建并验证适用于脓毒性休克患者28 d死亡风险的最佳预测模型。方法从美国重症监护医学信息数据库Ⅳv2.0(MIMIC-Ⅳv2.0)中筛选出符合脓毒症3.0的脓毒性休克患者,随机抽取病例,其中70%作为训练集,30%作为验证集。从人口学特征及基础生命体征、入重症监护病房(ICU)24 h内血清学指标及可能影响指标的合并症、功能评分及高级生命支持3个层面提取相关预测变量。比较基于决策树分类回归树(CART)、随机森林(RF)、支持向量机(SVM)、线性回归(LR)及超级学习器〔SL,综合了CART、RF和极端梯度提升(XGBoost)〕5种主流机器学习算法构建的模型对脓毒性休克患者28 d死亡的预测效能,筛选最佳算法模型。利用LASSO回归、RF和XGBoost算法,通过取交集确定最佳预测变量,构建预测模型。采用受试者工作特征曲线(ROC曲线)验证模型的预测效能;采用校准曲线评估模型的准确性;采用决策曲线分析(DCA)验证模型的实用性。结果最终共纳入3295例脓毒性休克患者,28 d存活2164例,死亡1131例,病死率为34.32%;其中,训练集2307例(28 d死亡792例,病死率为34.33%),验证集988例(28 d死亡339例,病死率为34.31%)。基于训练集数据分别建立5种机器学习模型;在纳入3个层面的变量后,RF、SVM、LR 3种机器学习模型在验证集预测脓毒性休克患者28 d死亡的ROC曲线下面积(AUC)依次为0.823〔95%可信区间(95%CI)为0.795~0.849〕、0.823(95%CI为0.796~0.849)、0.810(95%CI为0.782~0.838),高于CART算法模型(AUC=0.750,95%CI为0.717~0.782)和SL算法模型(AUC=0.756,95%CI为0.724~0.789),故将以上3种算法模型确定为最佳算法模型。综合3个层面变量后,通过LASSO回归、RF和XGBoost算法筛选并取交集,得出16个最佳预测变量,依次为入ICU 24 h内pH最大值、白蛋白(Alb)最大值、体温最大值、血乳酸(Lac)最小值、Lac最大值、血肌酐(SCr)最大值、Ca^(2+)最大值、血红蛋白(Hb)最小值、白细胞计数(WBC)最小值、年龄、简化急性生理学评分Ⅲ(SAPSⅢ)、WBC最大值、急性生理学评分Ⅲ(APSⅢ)、Na^(+)最小值、体质量指数(BMI)及活化部分凝血活酶时间(APTT)最小值。ROC曲线分析显示,以上述16个最佳预测变量构建的Logistic回归模型为最佳预测模型,在验证集中的AUC为0.806(95%CI为0.778~0.835);校准曲线及DCA曲线显示,该模型的精准度较高,且净收益最高可达0.3,其预测效能明显优于传统以单一功能评分〔APSⅢ评分、SAPSⅢ评分、序贯器官衰竭评分(SOFA)〕建立的模型〔AUC(95%CI)分别为0.746(0.715~0.778)、0.765(0.734~0.796)、0.625(0.589~0.661)〕。结论以pH值、Alb、体温、Lac、SCr、Ca^(2+)、Hb、WBC、SAPSⅢ评分、APSⅢ评分、Na^(+)、BMI、APTT等16个最佳变量构建的Logistic回归模型为脓毒性休克患者28 d死亡风险的最佳预测模型,其效能稳定,区分度及精准度均较高。

关键词：监督机器学习脓毒性休克预测模型

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退役风电叶片PET回收处理流变性能研究

塑料科技 2024年第2期52卷 20-24页

作者：王靖陈煌黄明富黄逸舟刘洁朱光旭时代新材料科技股份有限公司湖南株洲412007

PET硬质闭孔泡沫作为夹芯材料广泛应用于风电叶片。为进一步做好退役叶片的规模化利用,实现风电叶片材料绿色可持续发展,PET材料的有效利用方面的研究日益受到关注。文章利用旋转流变仪研究了PET泡沫回收粉料(Re-fPET)的动态流变性能,Re... 详细信息

PET硬质闭孔泡沫作为夹芯材料广泛应用于风电叶片。为进一步做好退役叶片的规模化利用,实现风电叶片材料绿色可持续发展,PET材料的有效利用方面的研究日益受到关注。文章利用旋转流变仪研究了PET泡沫回收粉料(Re-fPET)的动态流变性能,Re-fPET回收料复合黏度对温度敏感,呈现明显的剪切变稀行为,在270℃以上复合黏度下降更明显。通过Cross方法外推求得零剪切黏度η0,并进一步根据Arrhenius计算黏流活化能,ΔEη0为241.29 kJ/mol,升高温度对链段间的解缠结作用明显。采用转矩流变仪研究了Re-fPET回收粉料的加工流变特性,在270℃以上,Re-fPET树脂扭矩值下降很快且达到平衡时间更短,平衡后扭矩值更小,熔体特性黏度明显下降,材料明显降解,不利于加工。

关键词：风电叶片PET泡沫黏流活化能零剪切黏度流变性能

Shaped patterns synthesis in time-modulated antenna arrays with static uniform amplitude and phase excitations

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Frontiers of Electrical and Electronic Engineering in China 2010年第2期5卷 179-184页

作者： Gang LI Shiwen YANG ming huang Zaiping NIE Department of Microwave Engineering School of Electronic EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China

Abstract A novel approach for the synthesis of shaped beam patterns in time-modulated antenna arrays(TMAAs)with static uniform amplitude and phase excitations is proposed in this paper.Based on the sideband radiation in TMAAs,shaped beam patterns can be realized by only controlling the switch-on time sequences of the TMAAs.Differential evolution(DE)algorithm is adopted to optimize the time modulation parameters to obtain the desired flat-top and cosecant-squared beams and to suppress the sidelobe levels(SLLs).Simulation results of a time-modulated linear array(TMLA)and a timemodulated semicircular array(TMSA)demonstrate the effectiveness of the proposed approach for the synthesis of shaped beam patterns from TMAAs.

关键词： antenna arrays time modulation shaped pattern differential evolution

A rare complication after radiofrequency ablation in the treatment of colorectal liver metastasis: A case report

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Journal of Interventional Medicine 2020年第4期3卷 213-215页

作者： Rong Ding Jinmei Zhou Yinshan Yang Ling Zhao Shuai Luo ming huang Minimally Invasive Interventional Medicine Third Affiliated Hospital of Kunming Medical UniversityTumor Hospital of Yunnan ProvinceKunming650118PR China

Radiofrequency ablation(RFA)is one of the safe and effective treatments of colorectal cancer with liver metastasis,which has the advantages of minimally invasive,fewer complications,short hospitalization time and repeatable operation.A special case with advanced transverse colon carcinoma was treated by RFA in our center.All the procedures were performed,which were recommended by the guideline.An intestinal perforation occurred on the second day after the RFA,then surgeon performed emergency surgery,unfortunately,anastomotic leakage occurred on the 21st day after the operation,yet after conservative medical treatment,the patient achieved remission of symptoms and discharged from the hospital.Rare complications occurred after RFA in the treatment of colorectal cancer with liver metastasis are unpredictable,which could affect the efficacy of RFA and performance status of patients.Further investigation of the mechanism of these complications is warranted urgently,which might offer more effective methods against these rare complications.

关键词： metastasis treatment after

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li ming-Sheng huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang ming huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

花生种子受低温胁迫后萌发幼苗生长及生理特性研究

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中国油料作物学报 2024年第1期46卷 102-112页

作者：刘燕孔洁袁洁刘璇黄明明郭仁波邹晓霞青岛农业大学农学院/山东省旱作农业技术重点实验室山东青岛266109 青岛农业大学实验室管理中心山东青岛266109

花生收获期易受低温胁迫,为研究低温胁迫对不同成熟度花生种子萌发、幼苗生长和叶片生理特性的影响,以青花7号花生品种为材料,以十成熟(完熟)未受低温胁迫的种子为对照(CK),研究了九成熟2℃低温胁迫(T1)、九成熟-1℃低温胁迫(T2)、十成... 详细信息

花生收获期易受低温胁迫,为研究低温胁迫对不同成熟度花生种子萌发、幼苗生长和叶片生理特性的影响,以青花7号花生品种为材料,以十成熟(完熟)未受低温胁迫的种子为对照(CK),研究了九成熟2℃低温胁迫(T1)、九成熟-1℃低温胁迫(T2)、十成熟2℃低温胁迫(T3)和十成熟-1℃低温胁迫(T4)处理下种子萌发幼苗的最大光化学效率(Fv/Fm)、干物质积累和内源激素含量变化。结果表明:与CK相比,低温处理的种子萌发后幼苗Fv/Fm受到抑制,且种子成熟度越低,受低温胁迫的影响越明显;出苗后10~18 d,T1和T2处理幼苗地上部干物质重均显著低于CK,各低温处理下幼苗地下部干物质重与CK均无明显差异,但在22~26 d均显著高于CK;各处理下GA3、ZR、IAA和ABA含量随幼苗生长的变化趋势一致,但各取样时期的内源激素含量因胁迫温度和成熟度不同表现出明显差异,在出苗后10 d,T1-T4处理下萌发幼苗的(IAA+GA3+ZR)/ABA比值较CK分别降低12.82%、25.64%、25.64%和38.46%,而出苗后26 d,较CK分别提升47.62%、42.11%、60%和46.34%;温度对GA3、ZR、ABA和(IAA+GA3+ZR)/ABA比值影响极显著,对Fv/Fm值影响显著,成熟度对GA3和ZR影响极显著;(IAA+GA3+ZR)/ABA比值与幼苗干物质积累呈较强正相关,与根冠比和Fv/Fm呈现负相关。基于本研究,建议在低温冷害多发区,花生应在充分成熟后收获,以避免低温胁迫造成种子质量下降和幼苗生长受限。

关键词：花生低温胁迫种子成熟度干物质量 Fv/Fm 内源激素

湖南省中小学足球教师专业化发展困境与应对策略

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体育科技 2024年第2期45卷 155-156,159页

作者：黄明刘鑫邹娟花衡阳师范学院体育科学学院湖南衡阳421008

中小学足球教师专业化发展对于提升校园足球开展效果和学生体质健康以及促进新时代体教融合具有十分重要的现实意义。文章以湖南省H市中小学足球教师为个案考察对象,运用访谈和参与式观察等教育人类学的研究方法,探讨了目前湖南省中小... 详细信息

中小学足球教师专业化发展对于提升校园足球开展效果和学生体质健康以及促进新时代体教融合具有十分重要的现实意义。文章以湖南省H市中小学足球教师为个案考察对象,运用访谈和参与式观察等教育人类学的研究方法,探讨了目前湖南省中小学足球教师在专业化发展过程中面临的多重困境,并分析了其背后的深层次原因。研究认为:目前湖南省中小学足球教师专业化发展存在校园足球价值观偏离、职业认同度低、缺少进修和培训机会、缺乏学习交流的组织团体等困境,其主要是由于湖南省中小学足球教师在专业发展理念上面临“功利主义”的导向、在专业发展动力上面临“保障制度”的缺失、在专业知识学习上面临“学习途径”的匮乏、在专业发展组织上面临“合作精神”的缺失等原因造成的。基于此,提出树立正确的校园足球价值观;建立完善的教师保障制度;创建多元化的教师培训体系;构建合作共赢的教师专业共同体等四条应对策略。

关键词：校园足球足球教师中小学专业化发展

A case of tiny foreign body hidden in the neck for 27 years

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Clinical Research Communications 2023年第3期6卷 7-9页

作者： ming huang Na Wang Zhi-Hua Hu Yu-Fei Zheng Shuang-Lin Qin Hubei Provincial Key Research Base for Humanities and Social Sciences Rural Education and Cultural Development Center Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China Thyroid and Breast Surgery Xianning Central HospitalXianning 437100China

Neck trauma has the characteristics of diversity,complexity,and danger.Mild injuries generally require debridement and suturing or symptomatic treatment.In severe cases,acute laryngeal obstruction,subcutaneous emphysema,severe deformation and collapse of laryngeal and tracheal cartilage,or damage to adjacent organs may occur.If not diagnosed in a timely manner or mishandled,it can endanger the patient’s life or leave sequelae.If foreign body residue is caused by head and neck trauma,a reasonable judgment should be made based on the patient’s condition and corresponding measures should be taken.Accurate localization of foreign bodies before and during surgery,as well as appropriate surgical methods,are key to ensuring successful treatment.This article reports a case of a small foreign body in the neck admitted to Xianning Central Hospital at the end of January 2023.

关键词： neck trauma foreign body metal nodule

Microwave Communication Under Weak Intensity to Quantumized Level:Recent Progress and Future Challenges

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Journal of Communications and Information Networks 2021年第1期6卷 17-31页

作者： Chen Gong Shanchi Wu Chengjie Zuo Kai Yang Shangbin Li Junyu Zhang Zhongbin Dai ming huang ming Zhao Rui Ni Zhengyuan Xu Jinkang Zhu University of Science and Technology of China Hefei 230026China Huawei Technology Shenzhen 518129China

We provide an overview of the recent progresses on the system architecture design and performance prediction for microwave signal detection under weak signal intensity regime,up to quantumized level.The technique roadmap includes two perspectives,the opto-electro-mechanical(OEM)and superconducting devices.For the former one,we first overview the concept of OEM,and then introduce the signal detection based on capacitive-opto-electro-mechanical systems and piezoopto-electro-mechanical systems.For the latter one,we first overview the concept and architecture of Josephson junction,and then introduce the signal detection based on superconducting Hanbury Brown-Twiss(HBT)experiments andΛenergy-level splitting system.Besides,we review the microwave detection based on Rydberg atom system.We believe that this overview can provide a guidance for future transmission limit,signal processing,detection device fabrication and real experiments.

关键词： microwave signal detection quantumized microwave photons opto-electro-mechanical superconducting