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Re-evaluating the necessity of routine laboratory monitoring during isotretinoin therapy for acne

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World Journal of Clinical Cases 2024年第28期12卷 6237-6240页

作者： Yun-Xia Zhu liang Wu Sheng-Cai Zhu Xiu-Ping Wang Deng Zhang Yan-Ping Tan Xiao-liang Ouyang chun-ming li Department of Dermatology The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Dermatology Jiangxi Provincial Maternal and Child Health HospitalNanchang 330000Jiangxi ProvinceChina Department of Plastic Surgery The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

In this letter,we discuss the topic of necessity of routine laboratory monitoring during isotretinoin treatment for *** to Park and colleagues,it is advisable to monitor the levels of triglycerides,alanine aminotransferase,and aspartate aminotransferase every 5 to 6 ***,the levels of total cholesterol and low-density lipoprotein should be checked within the first two months of *** is a commonly prescribed agent mainly used to treat *** its high effectiveness,it necessitates regular monitoring of laboratory parameters due to its side effect ***,there remains a lack of consensus on the appropriate frequency for monitoring these parameters during treatment with *** letter will provide insight into this complex and controversial *** on existing literature,we concluded that the incidence of changes in lipid and liver aminotransferase levels during isotretinoin treatment for acne was low and likely clinically *** generally healthy people,we recommend testing lipid and liver profiles once at baseline and a second time at the peak ***,frequent testing might still be beneficial in certain populations of patients.

关键词： Acne Isotretinoin Laboratory monitoring liver function Blood lipids

Angular disturbance prediction for countermeasure launcher in active protection system of moving armored vehicle based on an ensemble learning method

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Defence Technology（防务技术） 2023年第3期21卷 207-218页

作者： chun-ming li Guang-hui Wang Hai-ping Song Xu-feng Huang Qi Zhou China North Vehicle Research Institute Beijing100072China School of Aerospace Engineering Huazhong Univerisity of Science and TechnologyWuhan430074China

The active protection system(APS),usually installed on the turret of armored vehicles,can significantly improve the vehicles’survivability on the battlefield by launching countermeasure munitions to actively intercept incoming ***,uncertainty over the launch angle of the countermeasure is increased due to angular disturbances when the off-road armored vehicle is moving over rough ***,accurate and comprehensive angular disturbance prediction is essential to the real-time monitoring of the countermeasure launch *** this paper,a deep ensemble learning(DEL)-based approach is proposed to predict the angular disturbances of the countermeasure launcher in the APS based on previous time-series *** view of the intricate temporal attribute of angular disturbance prediction,the sampling information of historical time series measured by an inertial navigation device is adopted as the input of the developed DEL ***,the recursive multi-step(RMS)prediction strategy and multi-output(MO)prediction strategy are combined with the DEL model to perform the final angular disturbance prediction for the countermeasure launcher in the APS of a moving armored *** proposed DEL model is validated by using the different datasets from real *** results reveal that this approach can be used to accurately predict angular disturbances,with the maximum absolute error of each DOF less than 0.1°.

关键词： prediction disturbance moving

Preparation and characterization O-lauroyl chitosan/poly (L-lactic acid) blend membranes by solution-casting approach

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Chinese Chemical Letters 2007年第2期18卷 213-216页

作者： Yao Zu liao Mei Hua Xin ming chun li Sheng Su College of Materials Science and Engineering Huaqiao University Quanzhou 362021 China

O-Lauroyl chitosan/poly(l-lactide) (OCS/PLLA) blend membranes with different compositions were prepared by solution-casting approach using chloroform as common solvent. The experimental results of FT-IR, DSC and WAXD indicated that inter-association hydrogen-bond interactions existed between OCS and PLLA in the blend membranes. And SEM observation confirmed that the blend membranes with suitable compositions were compatible.

关键词： Hydrogen bond Chitosan PLLA Compatibility

Efficient C_(2)-Symmetric Chiral Schiff Bases for Lanthanide-catalyzed Asymmetric Hydrogenation of Acetophenone

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Chinese Chemical Letters 2006年第10期17卷 1297-1300页

作者： Peng Fei YAN Wen Bin SUN Guang ming li chun Hong NIE Zheng Yu YUE School of Chemistry and Materials Science Heilongjiang University Harbin 150080

An array of C2-symmetric chiral Schiff bases of substituted salicylaldehyde （1R, 2R）-1, 2-cyclohexanediamine and （R）-（＋）-2, 2＇-diamino-1, 1＇-binaphthalene, incorporated with lanthanide complexes, have been applied as catalysts for asymmetric hydrogenation of acetophenone for the first time. Highly enantioselective product with 90% enantiomeric excess （e.e.） was obtained when the catalyst, hybridized by the bulky electron-donating 3, 5-di-tert-butyl substituted Schiff base （2） and SmCl3.4THF, was employed.

关键词： Chiral Schiff base lanthanide (HI) complexes asymmetric hydrogenation acetophenone 2-propanol.

Phase modulation of bcc-structured Fe35Mn25Al15Cr10Ni15 high-entropy alloy by interstitial carbon

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Journal of Iron and Steel Research International 2018年第8期25卷 877-882页

作者： Cong-hui Hu Jian-lei Zhang Yun-hu Zhang Ke Han chun-ming li Chang-jiang Song Qi-jie Zhai State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced Ferrometallurgy and School of Materials Science and Engineering Shanghai University Shanghai 200444 China National High Magnetic Field Laboratory Florida State University Tallahassee FL 32310 USA

High-entropy alloys （HEAs） usually contain more than five alloying elements. The ductility of a body-centered cubic （bcc）- type HEA typically is lower than that of their face-centered cubic （fcc） counterpart. And low ductility restricts engineering applications of the bcc-structured HEAs. In engineering materials, improvement in ductility usually results in deduction of mechanical strength. A method to improve both mechanical strength and ductility in a bcc-structured HEA was proposed by adding interstitial carbon. Experimental results showed that replacement of 5 at.% Cr with 5 at.% C in a bcc-structured Fe35Mn25Al15Cr10Ni15 HEA resulted in an increase in fcc phase from 0.3 to 93.7 vol.%. Strength and ductility increased at the same time. The transition of bcc-structure to fcc-structure along with a remaining small amount of bcc phase improved mechanical properties. This work indicates that interstitial carbon can be employed to modulate the fraction of constituent phases in a bcc-structured HEA to enhance engineering mechanical properties.

关键词： High-entropy alloy Interstitial carbon Constituent phase Phase modulation Mechanical property

Cloning and molecular characterization of△^(12)-fatty acid desaturase gene from Mortierella isabellina

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World Journal of Gastroenterology 2006年第21期12卷 3373-3379页

作者： ming-chun li Hang li Dong-Sheng Wei Lai-Jun Xing Department of Microbiology The College of Life Science Nankai University Tianjin 30071 China

AIM： To clone △^12 -fatty acid desaturase gene of Mortierella isabellina and to functionally characterize this gene in vitro and in ***： Reverse transcriptional polymerase chain reaction （RT-PCR） was used to clone the open reading frame of △^12-fatty acid desaturase gene （D12D） of Mortierella isabellina. Plasmids pEMICL12 and pYMICL12 were constructed with it. pEMICL12 was transformed into Escherichia coli（***） strain BL21 using CaCl2 method for expression after induction with IPTG. pTMICL12 was transformed into Saccharomyces cerevisiae strain IN- VSc1 using lithium acetate method for expression under the induction of galactose. Northern blotting method was used to investigate the effect of temperature on the transcriptional level of this gene in *** strain IN- ***： Recombinant plasmids pEMICL12 and pTMICL12 were successfully constructed and transformed into E. coli and *** separately with appropriate method. After induction with IPTG and galactose, it was found that expression of △^12-fatty acid desaturase genes in *** and S. cerevisiae under appropriate conditions led to the production of active △^12-fatty acid desaturase, which could convert 17.876% and 17.604% of oleic acid respectively to linoleic acid by GC-MS detection in vitro and in ***： Cloning and expression of *** D12D gene in *** and *** is successfully completed.

关键词： Mortierella isabellina △^12-fatty acid desaturase In vitro expression

Construction of a Metallacyclopentadiene Ring through the Attack of Carbanions to M≡C Bond Followed by C—H Activation

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Chinese Journal of Chemistry 2024年第3期42卷 235-242页

作者： chun Tang Shengjie Zhang Zhengyu Lu Qian li ming Luo Dafa Chen Haiping Xia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringCollaborative Innovation Center of Chemistry for Energy MaterialsXiamen UniversityXiamenFujian361005 China Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis Department of ChemistrySouthern University of Science and TechnologyShenzhenGuangdong518055 China

Metallacyclopentadienes are important metallacycles and regarded as intermediates in many reactions,therefore,new methods to achieve them are *** this study,a formal[3+2]method,through the reactions of an osmapentalyne with benzyl carbanions,was *** reactions underwent a nucleophilic attack of carbanions to the Os≡C bond,followed by C—H activation to form the five-membered osmacyclopentadiene *** of the reactions were carried out at room temperature,the substituents on the aromatic rings of benzyl carbanions are diverse,and the resulting products contain an Os—H bond,representing a novel type of 10C-carbolong *** work provides a new convenient route to construct metallacyclopentadienes,which is expected to further promote the development of such a type of substances.

关键词： Metallacyclopentadiene Carbolong chemistry Osmium C–H activation Nucleophilic addition

Elastic three-dimensional phononic topological insulators with Dirac hierarchy

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 54-62页

作者： Shao-Yong Huo Qiu-Shuang Yang Jiu-Jiu Chen Hong-Kang li Long-Chao Yao Fu-chun He chun-ming Fu College of Mechanical Engineering University of South ChinaHengyang 421001China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

Three-dimensional(3D)phononic topological insulators(TIs)featuring two-dimensional(2D)surface states and one-dimensional(1D)hinge states have opened up a new route for multi-dimensional robust wave transport,providing unprecedented methods for integrated acoustic sensors and energy harvesting ***,aiming at the elastic 3D phononic TI with gapless surface states and hinge states,the realization of elastic 3D phononic TIs with gapless surface states and hinge states is a significant challenge due to the complicated multi-mode polarization of elastic waves in 3D *** this study,we demonstrate an elastic 3D phononic TI with a Dirac hierarchy by elaborately operating the corresponding spatial symmetries of the chiral honeycomb ***,a 3D double Dirac cone of elastic wave can be achieved by doubling the lattice along the outof-plane direction to fold two iso-frequency Weyl *** topological phase transitions and 2D gapless two-fold Dirac surface states of elastic wave are realized by breaking the half-lattice spatial translation ***,based on the Brillouin zone folding along the in-plane direction,the 2D gapless two-fold surface Dirac cones are folded into four-fold surface Dirac ***,by inducing the relative radius of adjacent holes to break the in-plane spatial inversion symmetry,the fourfold surface Dirac cones are gapped and associated with a surface state inversion,in which the gapless 1D hinge Dirac dispersion is *** research offers a route for engineering the hierarchies of TIs in 3D elastic wave systems and provides new possibilities for designing 3D ultrasonic devices with unconventional functions.

关键词： Dirac topological hierarchy

Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis

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Journal of Geriatric Cardiology 2022年第12期19卷 937-948页

作者： Zhi-Qing WANG Bo XU chun-ming li Chang-Dong GUAN Yue CHANG li-Hua XIE Su ZHANG Jia-Yue HUANG Patrick W Serruys William Wijns liang-Long CHEN Sheng-Xian TU Department of Cardiology Fujian Heart Medical CenterFujian Institute of Coronary Heart DiseaseFujian Medical University Union HospitalFujianChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Cardiology National Clinical Research Center for Cardiovascular DiseasesFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The Lambe Institute for Translational Medicine and Curam University of GalwayGalwayIreland

BACKGROUND Intermediate coronary lesions(ICLs)are highly prevalent but ported mixed *** strain has been associated with plaque vulnerability,yet its role in predicting lesion progression is largely *** purpose of this study was to determine the predictive value of angiography-derived radial wall strain(RWS)for progression of untreated non-culprit *** Post-hoc analysis was conducted in a study cohort including 603 consecutive patients with 808 ICLs identified at index procedure with angiographic follow-up of up to two *** analysis was performed on selected angiographic frames with minimal foreshortening and vessel *** progression was defined as≥20%increase in percent diameter *** Lesion progression occurred in 49 ICLs(6.1%)with a median follow-up period of 16.8 *** RWS(RWSmax),frequently located at the proximal and throat plaque regions,distinguished progressive ICLs from silent *** largest area under the curve value of 0.75(95%CI:0.67–0.82,P12.6%.According to this threshold,178 ICLs were classified as having a high strain *** to a high strain amplitude with RWS_(max)>12.6%was independently associated with an increased risk of lesion progression(adjusted HR=6.82,95%CI:3.67–12.66,P<0.001).CONCLUSIONS Assessment of RWS from coronary angiography is feasible and provides independent prognostic value in patients with untreated ICLs.

关键词： coronary stenosis strain