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工人脱离职业性噪声接触后的心电图分析

中华劳动卫生职业病杂志 2007年第10期25卷 600-603页

作者：林洁明江朝强张维森侯丽君 Cheng K K lam T H 广州市第十二人民医院 510620 英国伯明翰大学公共卫生与流行病学系香港大学社区医学与公共卫生学院

目的探讨工人脱离职业性噪声接触后的心电图变化。方法在进行《广州生物库队列研究》时,第一阶段收集10413名年龄在≥50岁居民的一般资料、体格检查和实验室检查结果。受检者70%为女性,50%以上年龄在60～69岁;受检者中有2120名(21.0%)... 详细信息

目的探讨工人脱离职业性噪声接触后的心电图变化。方法在进行《广州生物库队列研究》时,第一阶段收集10413名年龄在≥50岁居民的一般资料、体格检查和实验室检查结果。受检者70%为女性,50%以上年龄在60～69岁;受检者中有2120名(21.0%)曾经接触职业性噪声,但均已脱离接触且为退休或离岗者;用上海惠普有限公司制造的MAC-CS多导联心电图机进行12导联的心电图检查;噪声职业接触史通过问卷采集,心电图由2名中级以上具有诊断资格的医师进行独立诊断。结果(1)心电图异常检出率女性为82.4%,明显高于男性的79.1%;不论男性或女性,心电图异常检出率随年龄增加而上升(P=0.000),女性随文化程度增高而明显下降(P=0.000),但无论男女,脱离职业性噪声接触后,其心电图异常检出率与从未职业性噪声接触者比较,差异无统计学意义(P>0.05);(2)比较曾经有职业性噪声接触与非接触者心电图异常的分类,在校正年龄因素和文化程度后,心律失常、心电轴偏移、房或室肥厚、ST-T改变、心肌劳损、冠状动脉综合征等比较,差异无统计学意义(P>0.05)。结论脱离职业性噪声接触后的工人心电图异常检出率未见明显高于非职业性噪音接触者。

关键词：噪声脱离接触心电图

Synthesis of Open-Cage Fullerene Derivatives Containing Multiple Hydroxyl and Amino Groups on the Rim of the Orifice

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Chinese Journal of Chemistry 2023年第12期41卷 1471-1477页

作者： Xueli Liu Rui Gao Zhen Liu Jialin ming Yi Qiu Jie Su Liangbing Gan Department of Chemistry College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot Inner Mongolia 010021 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Most of the known open-cage fullerene derivatives contain carbonyl and other relatively inert groups on the rim of the *** is difficult to rationally design further reactions and attach other functional groups on to these open-cage *** the present work,two molecules of difunctional 1,4-benzenediamine have been incorporated into the rim of an open-cage C60 derivative through one amino group leaving the other amino group free for further *** difunctional 4-aminophenol reacted analogously to form an open-cage derivative with a free OH group each on the two phenyl *** amino and hydroxyl groups on the phenyl ring above the rim of the orifice showed similar reactivity as aniline and *** of the carbonyl groups on the rim of the orifice could be selectively reduced by NaBH4 and P(OEt)*** reduction reactions were reversible and the reduced products could be readily converted back to the carbonyl ***,this redox process acts as a tool to fine tune the size of the orifice for host-guest studies.

关键词： Fullerene Open-cage Molecular container Carbonyl reduction Chan-Evans-lam coupling

Phase Ⅱb trial of in vivo electroporation mediated dualplasmid hepatitis B virus DNA vaccine in chronic hepatitis B patients under lamivudine therapy

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World Journal of Gastroenterology 2017年第2期23卷 306-317页

作者： Fu-Qiang Yang Gui-Rong Rao Gui-Qiang Wang Yue-Qi Li Yao Xie Zhan-Qing Zhang Cun-Liang Deng Qing Mao Jun Li Wei Zhao Mao-Rong Wang Tao Han Shi-Jun Chen Chen Pan De-ming Tan Jia Shang ming-Xiang Zhang Yue-Xin Zhang Ji-ming Yang Guang-ming Chen Liver Disease Research Center 458~(th) Hospital of PLA Department of Infectious Diseases Peking University First Hospital Beijing 302 Hospital Ninth Clinical Department Beijing Ditan Hospital Department of Liver Diseases Public Health Center Fudan University Department of Infectious Diseases Affiliated Hospital of Luzhou Medical College PLA Institute of Infectious Diseases Southwest Hospital Third Military Medical University Jiangsu Province People’s Hospital Nanjing 2~(nd) Hospital Nanjing PLA 81 Hospital Tianjin 3~(rd) Center Hospital Jinan Infectious Disease Hospital Fuzhou Infectious Disease Hospital Xiangya Hospital Central South University Henan Provincial People’s Hospital The Sixth People’s Hospital of Shenyang The First Affiliated Hospital of Xinjiang Medical University Infectious Disease Hospital of Tianjin

AIM To assess the efficacy and safety of in vivo electroporation(EP)-mediated dual-plasmid hepatitis B virus(HBV) DNA vaccine vs placebo for sequential combination therapy with lamivudine(lam) in patients with chronic hepatitis B. METHODS Two hundred and twenty-five patients were randomized to receive either lam + vaccine(vaccine group, n = 109) or lam + placebo(control group, n = 116). lam treatment lasted 72 wk. Patients received the DNA vaccine or placebo by intramuscular injection mediated by EP at weeks 12(start of treatment with vaccine or placebo, SOT), 16, 24, and 36(end of treatment with vaccine or placebo, EOT). RESULTS In the modified intent-to-treat population, morepatients had a decrease in HBV DNA > 2 log10 IU/m L in the vaccine group at week 12 after EOT compared with the control group. A trend toward a difference in the number of patients with undetectable HBV DNA at week 28 after EOT was obtained. Adverse events were similar. In the dynamic per-protocol set, which excluded adefovir(ADV) add-on cases at each time point instantly after ADV administration due to lam antiviral failure, more patients had a decrease in HBV DNA > 2 log10 IU/mL in the vaccine group at week 12 and 28 after EOT compared with the control group. More patients with undetectable HBV DNA at week 28 after EOT in the vaccine group were also observed. Among patients with a viral load lam chemotherapy.

关键词： Chronic hepatitis B DNA vaccine In vivo electroporation lamivudine-resistant mutants Randomized placebo-controlled trial

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STYLE NOTEBOOK

明日风尚 2009年第7期 66-69页

作者： Kiki Feng Ron lam Kim Au

横跨半个世纪的时尚摄影> 01 ICP(International Center of Photography)由即日起至9月6日举办一场名为"Avedon Fashion 1944-2000"的展览,是专门针对Richard Avedon的时尚摄影作品的展览。Richard Avedon的摄影风格深受匈牙利摄影师Martin Munkacsi影响,更以独有的美式风格撼动了战后欧洲呆板的时装摄影格局。他让模特们走出摄影棚,走上街头海滩,跳跃舞动欢笑。他抓拍行动中的模特并为定格为其招牌的"Avedon Blur"。

关键词：摄影风格时尚摄影美式风格 STYLE NOTEBOOK 时尚品牌波普艺术意大利品牌波普文化

白内障晶状体上皮细胞中色素上皮细胞衍生因子的表达

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国际眼科杂志 2010年第12期10卷 2253-2255页

作者：刘静刘冰张红松金姬关明彭智培 Dennis lam 中国北京市中日友好医院眼科 100029 吉林大学第一临床医院血库中国吉林省长春市130051 中国浙江省金华市中心医院眼科 321075 复旦大学华山医院检验中心中国上海市201203 香港中文大学眼科及视觉科学系

目的:观察色素上皮细胞衍生因子(pigment epithelium-derived factor,PEDF)在人类白内障晶状体上皮细胞中的表达,以探讨PEDF在白内障发病机制中的作用。方法:白内障超声乳化手术中,实施前囊膜环形撕囊时摘取晶状体前囊连同晶状体上皮细... 详细信息

目的:观察色素上皮细胞衍生因子(pigment epithelium-derived factor,PEDF)在人类白内障晶状体上皮细胞中的表达,以探讨PEDF在白内障发病机制中的作用。方法:白内障超声乳化手术中,实施前囊膜环形撕囊时摘取晶状体前囊连同晶状体上皮细胞,采用免疫组化的方法检测PEDF和VEGF在晶状体上皮细胞中的表达。结果:老年性白内障晶状体上皮细胞虽然PEDF存在高强度表达,与VEGF相比,这种表达还是较弱。结论:老年性白内障晶状体上皮细胞存在PEDF和VEGF的表达,而且二者之间存在着一定的相互作用,由此推断PEDF和VEGF在老年性白内障的发病机制中处于重要的作用。

关键词：色素上皮细胞衍生因子晶状体上皮细胞老年性白内障白内障超声乳化免疫组化

Salt response mechanism analysis in two rice genotypes at seedling stage through proteomics

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Salt response mechanism analysis in two rice genotypes at se...

江苏省遗传学会2016年学术年会

作者： Yan Liu Baoxiang Wang Jian Li Zhaoqiang Song Baiguan Lu ming Chi Bo Yang Derong Qin Ying-Wai lam Jiaxu Li Dayong Xu Lianyungang Institute of Agricultural Sciences Jiangsu Collaborative Innovation Center for Modern Corp Production Department of Biology The University of Vermont Vermont Genetics Network Proteomics Facility The University of Vermont Department of Biochemistry Molecular BiologyEntomologyand Plant PathologyMississippi State University

Objectives:In order to explore the contrasting salt-stress responses of two rice varieties,the physiological responses and biochemical responses were investigated using proteomics and classical biochemical ***:The results showed that the seedling growth was inhibited under salt condition in the two rice varieties,such as leaves’ wilting and *** interesting phenomenon was observed that only in the tolerant variety,the fresh root weight increased dramatically after 3 days of salt stress,and the content of chlorophyll also increased dramatically which contributes to the increase of the fresh shoot weight and dry shoot weight after 7 days.A comparison of 2-DE protein profiles between the untreated control and salt-stressed roots revealed 9 differentially expressed protein *** the nine identified proteins,six of them are not well documented about their role in the salt stress *** proteins were involved in protein metabolic *** possible implication in plant adaptation to salt stress is ***:These results provide novel insights to explore salt-response proteinscorrelated with improved salt tolerance.

关键词： physiology proteomics rice salt stress

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2%

室内设计与装修 2005年第11期 60-65页

作者：林伟明

设计总部2%是一个青年休闲服品牌,其时装连锁店遍布东南亚,以及香港、台湾和大陆各省市等。本案是2%在香港的设计总公司办公室的设计及规划。其难度及趣味在于在于其使用者本质上及要求上的差异,但同时又必须共存在一个空间内。最主要... 详细信息

设计总部2%是一个青年休闲服品牌,其时装连锁店遍布东南亚,以及香港、台湾和大陆各省市等。本案是2%在香港的设计总公司办公室的设计及规划。其难度及趣味在于在于其使用者本质上及要求上的差异,但同时又必须共存在一个空间内。最主要的使用者当然是每日在办公室里工作的一群设（共6页)

关键词：设计休闲服东南亚连锁店办公室使用者香港时装

不同年龄组和不同性别间正常中央角膜厚度的差异

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国际眼科杂志 2009年第6期9卷 1101-1103页

作者：邵运良张铭志宋跃黄育强 SK Rao Dennis lam 汕头大学·香港中文大学联合汕头国际眼科中心中国广东省汕头市515041 香港中文大学眼科及视觉科学系中国香港

目的:探讨10岁以上正常人群中央角膜厚度(central corneal thickness,CCT)在不同年龄组和不同性别间的差异。方法:用角膜内皮细胞显微镜对700名1329眼CCT进行测量。研究对象根据年龄分为7组或根据性别分为2组以研究CCT的分布特点和变化... 详细信息

目的:探讨10岁以上正常人群中央角膜厚度(central corneal thickness,CCT)在不同年龄组和不同性别间的差异。方法:用角膜内皮细胞显微镜对700名1329眼CCT进行测量。研究对象根据年龄分为7组或根据性别分为2组以研究CCT的分布特点和变化规律。结果:平均CCT为537±39μm,在11～50岁的调查对象,CCT随年龄增大而显著降低(P=0.002,r=-0.192),平均每年降低约0.63μm;在>50岁的调查对象,CCT有渐增厚的趋势(P=0.332,r=0.056),平均每年增厚约0.27μm。男性CCT(540±39μm)显著大于女性CCT(535±38μm)(T-test,P=0.01)。结论:CCT在正常人群不同年龄组、不同性别间的特点表明年龄因素对CCT的影响较小,CCT在个体之间差异较大,男性CCT大于女性CCT。

关键词：角膜中央厚度性别差异眼科学

Light-up the white light emission in microscale with a superior deep-blue AIE fiber as wave-guiding source

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Aggregate

Aggregate 2024年第2期5卷 250-260页

作者： Hao Rao Zicheng Liu ming Chen Canze Zheng Liping Xu Junkai Liu Jacky W.Y.lam Baojun Li Xianguang Yang Ben Zhong Tang Institute of Nanophotonics College of Chemistry and Materials ScienceGuangdong Provincial Key Laboratory of Nanophotonic ManipulationJinan UniversityGuangzhouChina Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic MaterialsThe Hong Kong University of Science and TechnologyKowloonHong KongChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)GuangdongChina

The development of high-performance organic blue light-emitting emitters is in urgent to act as an excitation source to contribute the white light *** the other hand,the investigation on optical waveguides have been received increasing attentions because they can manipulate the light propagation accurately in the microscale to boost the optoelectronic and energy conversion *** this work,we facilely prepared a deep-blue aggregation-induced emission(AIE)dye,namely TPP-4OMe,which shows high luminescent efficiency,narrow emission band and good stability in the aggregate ***-4OMe can be fabricated as deep-blue AIE microfibers readily with definite morphology and *** on the AIE microfibers,the active waveguide to transmit deep-blue emission signals can be achieved with a very low optical loss coefficient(α)of 6.7×10^(−3)dBμm^(−1).Meanwhile,the full-visible broadband low-loss passive waveguide can be well performed with these AIE microfibers,which has never been observed in the pure organic *** interestingly,the excellent properties of AIE microfibers enable them to act as a wave-guiding excitation source,resulting in a distinct and pure white light *** present work not only provides excellent blue light-emitting materials but also bridges the waveguide to realize the efficient white light emission to accelerate the practical applications.

关键词： AIE microfiber deep-blue emission energy transfer optical waveguide white light emission