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Immune formulation-assisted conventional therapy on anti-infective effectness of multidrug-resistant Mycobacterium tuberculosis infection mice

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 288-292页

作者： Xiu-Li Yuan Qiang Wen Ming-de Ni Li-Kun Wang Internal Medicine department No.3 Eastern Medical District of Linyi People's Hospital Infection department.Eastern Medical District of Linyi People's Hospital

Objective:To study the effect of immune formulation-assisted conventional therapy on antiinfective ability of multidrug-resistant Mycobacterium tuberculous infection ***:BALB/c mice were used as experimental animals,multidrug-resistant Mycobacterium tuberculosis infection models were built,randomly divided into model group,moxifloxacin group,thymopentin group and combined treatment group and given corresponding drug intervention,and then colony numbers in the spleen and lung,T lymphocyte subset contents and programmed death-1(PD-1) expression levels in peripheral blood were ***:Colony numbers in lung and spleen of moxifloxacin group and thymopentin group were significantly lower than those of model group and colony numbers in lung and spleen of combined treatment group were significantly lower than those of moxifloxacin group and thymopentin group:contents of CD3^+CD4^+T cells,Thl and Thl7 in peripheral blood of moxifloxacin group and thymopentin group were higher than dtose of model group,and contents of CD3^+CD8^+T ***2 and Treg were lower than those of model group;contents of CD3^+CD4^+T *** 1 and Th 17 in peripheral blood of combined treatment group were higher than those of moxifloxacin group and thymopentin group,and contents of CD3^+CD8^+T ***2 and Treg were lower than those of moxifloxacin group and thymopentin group:PD-I expression levels on T lymphocyte,B lymphocyte and monocyte surface in peripheral blood of moxifloxacin group and thymopentin group were lower than those of model group,and PD-I expression levels on T lymphocyte.B lymphocyte and monocyte surface in peripheral blood of combined treatment group were lower than those of moxifloxacin group and thymopentin ***:Immune formulation thymopentin can enhance the anti-infective ability of multidrug-resistant Mycobacterium tuberculosis infection mice,decrease bacterial load in lung and spleen,and enhance immune function.

关键词： Mycobacterium tuberculosis Multidrug resistance Thymopentin Immune function

On-line least squares support vector machine algorithm in gas prediction

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Mining Science and Technology 2009年第2期19卷 194-198页

作者： ZHAO Xiao-hu WANG Gang ZHAO Ke-ke TAN de-jian School of Information ＆ Electronic Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Traditional coal mine safety prediction methods are off-line and do not have dynamic prediction *** Support Vector Machine(SVM) is a new machine learning algorithm that has excellent *** least squares support vector machine(LS-SVM) algorithm is an improved algorithm of *** the common LS-SVM algorithm,used directly in safety predictions,has some *** have first studied gas prediction problems and the basic theory of *** these problems,we have investigated the affect of the time factor about safety prediction and present an on-line prediction algorithm,based on ***,given our observed data,we used the on-line algorithm to predict gas emissions and used other related algorithm to compare its *** simulation results have verified the validity of the new algorithm.

关键词： LS-SVM gas on-line learning prediction

Gastroenterology training in Latin America

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World Journal of Gastroenterology 2011年第18期17卷 2283-2287页

作者： Henry Cohen Roque Saenz Luiz E de Almeida Troncon Maribel Lizarzabal Carolina Olano Gastroenterology Clinic Montevideo Medical School University del desarrollo University of So Paulo Ribeiro Preto. Rua Bernardino Campos Rua Bernardino Campos 1000 Ribeirao Preto SP 14015-130 Brazil University del Zulia

Latin America is characterized by ethnic, geographical, cultural, and economic diversity; therefore, training in gastroenterology in the region must be considered in this context. The continent’s medical education is characterized by a lack of standards and the volume of research continues to be relatively small. There is a multiplicity of events in general gastroenterology and in sub-disciplines, both at regional and local levels, which ensure that many colleagues have access to information. Medical education programs must be based on a clinical vision and be considered in close contact with the patients. The programs should be properly supervised, appropriately defined, and evaluated on a regular basis. The disparity between the patients’ needs, the scarce resources available, and the pressures exerted by the health systems on doctors are frequent cited by those complaining of poor professionalism. Teaching development can play a critical role in ensuring the quality of teaching and learning in universities. Continuing professional development programs activities must be planned on the basis of the doctors’ needs, with clearly defined objectives and using proper learning methodologies designed for adults. They must be evaluated and accredited by a competent body, so that they may become the basis of a professional regulatory system. The specialty has made progress in the last decades, offering doctors various possibilities for professional development. The world gastroenterology organization has contributed to the speciality through three distinctive, but closely inter-related, programs: Training Centers, Train-the-Trainers, and Global Guidelines, in which Latin America is deeply involved.

关键词： Training Gastroenterology Latin America

A review of the～1600 Ma sedimentation,volcanism,and tectono-thermal events in the Singhbhum craton,Eastern India

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Geoscience Frontiers 2013年第3期4卷 277-287页

作者： Priyanka Chatterjee Shuvabrata de Marinah Ranaivoson Rajat Mazumder Makoto Arima department of Geology University of Calcutta35 B.C.RoadKolkata 700019India Geological Studies Unit Indian Statistical Institute203 B.T.RoadKolkata 700108India Graduate School of Environment and Information Science Yokohama National University79-7TokiwadaiHodogaya Yokohama 240-8501Japan School of Biology Earth and Environmental SciencesUniversity of New South WalesKensingtonSydney NSW 2052Australia

The Palaeoproterozoic-Mesoproterozoic transition （ -1600 Ma） is a significant event in the Earth history as a global thermal perturbation affected the pre-1600 Ma landmasses. Like other cratonic blocks of the world, lithospheric thinning, sedimentation, magmatism, metamorphism and crustal melting/anatexis are associated with this significant geological event in the Singhbhum cratonic province of India. This paper is a review of sedimentological, magmatic and tectono-thermal events in the Singhbhum craton at 1600 Ma. The Palaeo-Mesoproterozoic sedimentation and volcanism in the Singhbhum craton took place in a terrestrial intracontinental rift setting. The available geochronological data are indicative of late Palaeoproterozoic to Neoproterozoic tectono-thermal events in the Chhotanagpur Granite Gneissic Complex （CGGC）, an east-west trending arcuate belt of granite gneisses, migmatites and metasedi- mentary rocks. A detailed multidisciplinary geo-scientific investigation of the Dalma volcanic belt and the area to its north （Chandil Formation） and further north in CGGC will enable us to constrain the extant surface processes and crust-mantle interactions, the collision events between the North and South Indian cratonic blocks, and the position of India in the Columbia supercontinent.

关键词： Late Palaeoproterozoic Mesoproterozoic Sedimentation Volcanism Geochronology Singhhhum

Patch isolation and shape predict plant functional diversity in a naturally fragmented forest

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Journal of Plant Ecology 2018年第1期11卷 136-146页

作者： Amaranta Arellano-Rivas J.Arturo de-Nova Miguel A.Munguía-Rosas Instituto de Investigación de Zonas desérticas Universidad Autónoma de San Luís PotosíSan Luis Potosí78377México Laboratorio de Ecología Terrestre Departamento de Ecología HumanaCentro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV)Mérida 97310México Facultad de Agronomía Universidad Autónoma de San Luís PotosíSan Luis Potosí78321México

Aims It is known that taxonomic diversity can be predicted by the spatial configuration of the habitat,in particular by its area and degree of ***,taxonomic diversity is a poor predictor of ecosystem *** functional diversity is strongly linked to the func-tionality and stability of ecosystems,little is known about how changes in the spatial configuration of the habitat affect functional *** this study,we evaluated whether the spatial configuration of forest patches predicts the functional diversity of plants in a fragmented *** Five functional leaf traits(leaf dry matter content,leaf punch force,specific leaf area,leaf size and leaf thickness)were measured for 23 dominant plant species in 20 forest patches in a naturally fragmented forest on the yucatan ***-weighted multivariate and individual trait metrics of functional diversity were calculated and cor-related with size,degree of isolation and the shape of forest *** Findings Patch shape was negatively correlated with multivariate and individ-ual trait(leaf dry matter content and leaf size)metrics of functional *** isolation measures were also negatively correlated with individual trait(leaf dry matter content,leaf punch force and leaf size)metrics of functional *** other words,greater patch shape irregularity and isolation degree impoverish plant func-tional *** is the first report of the negative effects of patch shape irregularity and isolation on the functional diversity of plant communities in a forest that has been fragmented for a long time.

关键词： forest fragmentation functional diversity habitat spatial configuration petenes yucatan

Constraints on the kinetic energy of type-Ic supernova explosion from young PSR J1906+0746 in a double neutron star candidate

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Chinese Physics B 2021年第6期30卷 721-726页

作者： Yi-Yan Yang Cheng-Min Zhang Jian-Wei Zhang de-Hua Wang School of Physics and Electronic Sciences Guizhou Education UniversityGuiyang 550018China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of Sciences(CAS)Beijing 100012China Astronomy department Beijing Normal UniversityBeijing 100875China School of Physics and Electronic Sciences Guizhou Normal UniversityGuiyang 550001China

So far among the nineteen pairs of detected double neutron star(DNS) systems, it is a usual fact that the first-born recycled pulsar is detected, however the youngest DNS system PSR J1906+0746, with the characteristic age of 113 kyr, is one of the three detected DNS as a non-recycled and second-born NS, which is believed to be formed by an electron capture or a low energy ultra-stripped iron core-collapse supernova(SN) explosion. The SN remnant around PSR J1906+0746 is too dim to be observed by optical telescopes, then its x-ray flux limit has been given by Chandra. A reference pulsar PSR J1509-5850 with the young characteristic age of 154 kyr was chosen as an object of comparison, which has an SN remnant observed by Chandra and is believed to be formed by iron core SN explosion. We impose a restriction on the maximum kinetic energy of electron-capture(EC) SN explosion that induces the formation of PSR J1906+0746. The estimated result is(4–8)×10^(50) erg(1 erg= 10-7 J), which is consistent with that of the published simulations of the EC process, i.e., a lower value than that of the conventional iron core SN explosion of(1–2)×10^(51) erg. As suggested, EC process for NS formation is pertained to the subluminous type Ic SN by the helium star with ONeMg core, thus for the first time we derived the kinetic energy of EC SN explosion of DNS, which may be reconciled with the recent observation of type Ic SN 2014 ft with kinetic energy of 2 × 10^(50) erg.

关键词： neutron star pulsar astrophysics high energy astrophysical phenomena

Physical modeling of failure process of the excavation in horizontal strata based on IR thermography

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Mining Science and Technology 2009年第6期19卷 689-698页

作者： HE Man-chao GONG Wei-li LI de-jian ZHAI Hui-ming State Key Laboratory for Geomechanics and deep Underground Engineering Beijing 100083 China School of Mechanics and Civil Engineering China University of Mining ＆ Technology Beijing 100083 China

In order to capture the mechanism of roadway instability in deep mines, a new approach of Physically Finite Elemental Slab Assemblage (PFESA) is proposed in order to construct a large-scale physical model simulating the geologically horizontal strata. We carried out physical modeling on the deformation and failure processes of roadways subjected to a plane loading scheme. Our laboratory tests were based on work which incorporated infrared (IR) detection, IR radiation temperature (IRT) statistics, image feature extraction and 2D Fourier transformation, from resulting thermographies. The IRT characterizes the mechanical responses from the roadway after loading with two stages, i.e., IRT evolving at higher levels corresponded to shallow mining (≤500 m) during which the roadway deformed gradually (referred to as the "steady deformation stage"); IRT evolving in a quasi-cyclical manner with multiple peaks corresponded to deep mining (800–2600 m), in which the failure mode for the roadway are dominated by breakage and collapse (called the "unsteady deformation stage"). The IR images and 2D Fourier spectra illustrate detailed information in terms of initiation, nucleation and coalescence of the damage to rock masses and the eventual failure of roadways subject to external loading.

关键词： roadway stratified rock mass deep mining physical modeling IR thermography

Evaluation of antiparasitic,anticancer,antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 32-39页

作者： Dioxelis Lopez Lilia Cherigo Alejandro de Sedas Carmenza Spadafora Sergio Martinez-Luis Centro de Biodiversidad y descubrimiento de Drogas Instituto de Investigaciones Cientificas y Servicios de Alta Tecnologia (INDICASAT AIP) department of Biotechnology Acharya Nagarjuna University departamento de Química Orgánica Facultad de Ciencias Exactas y Tecnología Universidad de Panamá Centro de Biología Celular y Molecular de Enfermedades Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP)

Objective: To investigate 33 organic extracts of mangrove plants for: antiparasitic, anticancer, and antibacterial activities, as well as their ability to inhibit the activity of the α-glucosidase enzyme. Methods: Leaves from all different plant mangrove species located in five mangrove zones of the Pacific coast of Panama were collected according to standard procedures. Qualitative phytochemical analysis of the organic extracts was performed by thin layer chromatography. The antiparasitic activity against Plasmodium falciparum, Trypanosoma cruzi and Leishmania donovani, toxicity against Artemia salina, anticancer activity in MCF-7 cell line, and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa of all organic extract were investigated according protocols stablished in our institution. Finally, the ability to inhibit the enzymatic activity of α-glucosidase was evaluated by monitoring the hydrolysis of p-nitrophenyl α-Dglucopyranoside. Results: Thirty-three different samples belonging to nine different species of vascular plants with seeds of true mangroves were collected. Triterpenoids, phenolics, and tannins were the main groups of compounds found in the sampled mangroves. Saponins, quinones, and coumarins were found in less than 50%of the samples. Laguncularia racemosa showed moderate activity against Plasmodium falciparum. None of the extracts presented anticancer activity. Rhizophora mangle exhibited potent activity against Staphylococcus aureus and Bacillus subtilis [(90.41 ±7.33)% and(96.02±6.14)% of inhibition]; Avicennia germinans and Conocarpus erectus had activity against Escherichia coli[(71.17±6.15)% and(60.60±5. 13)% of inhibition,respectively]. About 60% of the mangroves showed α-glucosidase inhibitory activity. In particular, extracts from Laguncularia racemosa, Pelliciera rhizophorae, Conocarpus erectus, Mora oleifera, and Tabebuia palustris species showed α-glucosidase inhibitory pot

关键词： Mangrove plants Anticancer activity Antibacterial activity Antiparasitic activity Alpha-glucosidase inhibition

Bowland Shale well placement strategy-Part 2:Fracture simulations using a 3D geomechanical model and implications for stratigraphic and spatial horizontal well locations

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Energy Geoscience 2022年第3期3卷 235-254页

作者： Iain de Jonge-Anderson Jingsheng Ma Xiaoyang Wu Dorrik Stow David Griffiths Institute of GeoEnergy Engineering(IGE) School of EnergyGeoscienceInfrastructure&SocietyHeriot-Watt UniversityEdinburghEH144ASUK British Geological Survey The Lyell CentreResearch Avenue SouthEdinburghEH144APUK Penrhyn Exploration UK

Hydraulic fracture modelling is a key component of a shale reservoir well placement strategy as it provides an indication of the typical lengths and heights of stimulated fractures and of the changes to the stress environment in which these are ***,spatial and stratigraphic variations in the stress and geomechanical properties of shales make accurate modelling a challenging *** the UK Bowland Shale,stacked horizontal wells targeting multiple stratigraphic intervals could be used to avoid large offset faults in a geologically complex ***,it is not known how these intervals may respond to hydraulic fracturing and predicting the height and length of hydraulic fractures is necessary in order to assess the likelihood of vertical fracture interference across landing zones or propagation towards major *** the case of the former,intervals of high effective stress may be key to containing fractures within their desired *** a planar hydraulic fracture simulator,and a 3D geomechanical model incorporating dipping stratigraphy,the issue of predicting hydraulic fracture geometry in the Bowland Shale was assessed through a series of modelling exercises using well Preese Hall-1 and horizontal *** pre-defined landing zones were targeted,narrow and long transverse fractures around 1 km from the well were *** the simulation design mimicked perforation clusters placed at 12 m intervals along horizontal pseudo-wells,the effects of stress shadowing were acute and resulted in irregular fracture ***,high effective stress intervals performed efficiently as barriers to vertical hydraulic fracture propagation,reinforcing the feasibility of using stacked production for the Bowland *** modelling results were then used to discuss the possible placement of horizontal wells in a mapped,100 km2 region around well Preese Hall-1,where up to 13 sites could be positioned,with a horizontal well length of aroun

关键词： Bowland Shale Hydraulic fracturing Geomechanics Fracture simulation Well placement