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Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

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Bioactive Materials 2021年第9期6卷 2783-2800页

作者： Atta ur Rehman Khan Kai Huang mina shahriari khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi Zhao Jinzhong Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Department of Sports Medicine Department of OrthopedicsShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233PR China Microbiological Engineering and Industrial Biotechnology Group College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Multidisciplinary Centre for Advanced Materials of Shanghai University of Engineering Science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620PR China Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC3122Australia

Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged *** nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled ***,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive *** characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant ***,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue *** angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin􀀀6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.

关键词： Bioactive NF membrane Diabetic wound healing Antibacterial Antioxidant Anti-inflammatory Angiogenesis

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natural polymer-based bilayer adhesive skin substitute for infected burned wound healing

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Bioactive Materials 2023年第11期 177-195页

作者： mina shahriari-khalaji Mamoona Sattar Ran Cao Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Research Group of Microbiological Engineering and Medical Materials College of Biological Science and Medical EngineeringDonghua UniversityShanghai201620China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine Donghua UniversityShanghai201620China

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, and large surface area. The mortality rate in patients with infected burns is twice that of non-infected burns. Developing multifunctional skin substitutes to augment the healing rate of infected burns is vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) and oxidized alginate grafted catechol (O-AlgCat) on a hydrophobic electrospun layer, forming a bilayer skin substitute (BSS). The functional layer (FL) was fabricated by physiochemical crosslinking to ensure favorable biodegradability. The gallium-containing hydrophobic electrospun layer or backing layer (BL) could mimic the epidermis of skin, avoiding fluid penetration and offering antibacterial activity. 3D printed FL contains catechol, gallium, and biologically active platelet rich fibrin (PRF) to adhere to both tissue and BL, show antibacterial activity, encourage angiogenesis, cell growth, and migration. The fabricated bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant antibacterial activity (P ≤ 0.05), faster clot formation, and the potential to promote proliferation (P ≤ 0.05) and migration (P ≤ 0.05) of L929 cells. Furthermore, the angiogenesis was significantly higher (P ≤ 0.05) when evaluated in vivo and in ovo. The BSS-covered wounds healed faster due to low inflammation and high collagen density. Based on the obtained results, the fabricated bioactive BSS could be an effective treatment for infected burn wounds.

关键词： Infected burn wound Bioactive skin substitute Double cross-linked Anti-inflammation Tissue adhesion

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A Review of State-of-the-art Flexible Power Point Tracking Algorithms in Photovoltaic Systems for Grid Support:Classification and Application

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 1-21页

作者： mina Haghighat Mehdi Niroomand Hossein Dehghani Tafti Christopher D.Townsend Tyrone Fernando the Department of Electrical Engineering University of IsfahanIsfahanIran the Department of Electrical Electronic and Computer EngineeringUniversity of Western AustraliaCrawley WA 6009Australia

To maximize conversion efficiency,photovoltaic(PV)systems generally operate in the maximum power point tracking(MPPT)***,due to the increasing penetra tion level of PV systems,there is a need for more developed control functions in terms of frequency support services and voltage control to maintain the reliability and stability of the power ***,flexible active power control is a manda tory task for grid-connected PV systems to meet part of the grid ***,a significant number of flexible pow er point tracking(FPPT)algorithms have been introduced in the existing *** purpose of such algorithms is to real ize a cost-effective method to provide grid support functional ities while minimizing the reliance on energy storage *** paper provides a comprehensive overview of grid support functionalities that can be obtained with the FPPT control of PV systems such as frequency support and volt-var *** of these grid support functionalities necessitates PV sys tems to operate under one of the three control strategies,which can be provided with FPPT *** three control strate gies are classified as:①constant power generation control(CP GC),②power reserve control(PRC),and③power ramp rate control(PRRC).A detailed discussion on available FPPT algo rithms for each control strategy is also *** paper can serve as a comprehensive review of the state-of-the-art FPPT algorithms that can equip PV systems with various grid support functionalities.

关键词： Maximum power point tracking(MPPT) flexi ble power point tracking(FPPT) power reserve control(PRC) power ramp rate control(PRRC) low voltage ride-through(LVRT) constant power generation(CPG)

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Thermal performance of domed roof in air-conditioned spaces

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Energy and Built Environment 2024年第2期5卷 270-287页

作者： Ibrahim Reda Raouf N.AbdelMessih Mohamed Steit Ehab M.mina Mechanical Power Engineering Faculty of EngineeringAin Shams University1 El-Sarayat St.Cairo 11517Egypt Architectural Engineering Faculty of EngineeringAin Shams UniversityCairoEgypt

Due to their thermal performance,domed roofs are one of the passive solutions that affect energy consumption in *** thermal performance of domed roofs has been investigated in many naturally ventilated ***,few studies have discussed their performance in conditioned ***,this study introduces a computational comparison between domed and flat roofs to investigate their impact on thermal comfort inside a conditioned *** an earlier stage,field measurements were carried out inside a Bahraini mosque to acquire its indoor air conditions during the summer period of 2021,in addition to validating the computational *** findings of this study confirm that,under mechanical cooling conditions,the flat roof offers a lower indoor temperature than the domed roof by 0.4℃and 0.1℃for open and closed doors,***,the air velocity is lower by approximately 0.01 m/s for both door *** overall PMV values of the flat roof are also lower by 0.07 and 0.01,while the PPD values are lower by 0.20,and 0.34 for open and closed doors,*** on these small differences,it can be concluded that the thermal performance of both roofing systems behaves equally in conditioned ***,the air patterns are substantially different,the overall thermal performance is *** similarity drives building designers to rethink the thermal performance of the domed roofs in air-conditioned spaces with such a hot climate,regardless of their aesthetic and acoustical behaviour.

关键词： Thermal comfort Computational fluid dynamics(CFD) Predicted mean vote(PMV)and predicted percentage dissatisfied(PPD) Domed roof Flat roof

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Changes in sexual activity in young women during pregnancy

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Asian pacific Journal of Reproduction 2024年第5期13卷 213-218页

作者： Ghazal Mansouri mina Zakeri Fatemeh Karami Robati Leila Allahqoli Azam Dehghani Department of Obstetrics and Gynecology School of MedicineAfzalipour HospitalKerman University of Medical SciencesKermanIran Clinical Research Development Unit Afzalipour HospitalKerman University of Medical SciencesKermanIran School of Public Health Iran University of Medical Sciences(IUMS)TehranIran Gastroenterology and Hepatology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran

Objective:To conduct changes in sexual activity during pregnancy and its related factors in pregnant ***:The present descriptive cross-sectional study was conducted in 2017 on pregnant women who referred to the women's clinic of Afzalipour Hospital in the southeast of *** were included in the study through convenient *** data collection tool was a researcher-made questionnaire consisting of two parts of personal social information of the couple and questions to measure the level of sexual activity and the attitude of the subjects during pregnancy compared to before ***:201 Pregnant women were *** average age of pregnant women was(27.3±6.1)years and their average gestational age was(24.7±11.8)*** than 62%of women had decreased sexual *** was a significant relationship between the amount of changes in sexual activity and delivery time(P=0.013),abortion history(P=0.001)and premature birth history(P=0.002).Most pregnant women believed that sex during pregnancy caused damage to the fetus(67.7%).A decrease in the intensity of sexual desire was reported in 63%of pregnant *** than 60%of the subjects did not consult with doctors and midwives with regards to sexual issues(63.5%).The most common reason for not consulting was not feeling the need(32%).Most women experienced back pain during(42.8%)and after(39.8%)***:Changes in sex life during pregnancy are often caused by the lack of sexual knowledge and the increase in misconceptions among couples,which can affect the quality of *** role of education is ***,it is suggested that by including sexual counseling along with pregnancy care,wrong beliefs and information among women will be corrected.

关键词： Sexual behavior Women Pregnancy Midwifery Sex counseling Fetus

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Old Town Vibes

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China Weekly 2024年第5期 60-61页

作者： mina Yan 不详

For a taste of traditional Naxi culture as well as stunning scenery,get high on a visit to UNESCO-listed Lijiang,perched at the end of the Himalayas.

关键词： listed UNESCO culture

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Correlation between critical thinking and emotional intelligence:a national crosssectional study on operating room nursing students in Iran

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Frontiers of Nursing 2024年第1期11卷 99-104页

作者： Armin Fereidouni Esmaeil Teymoori Tayebeh Bahmani Hamid Reza Sabet Zahra Maleki mina Gharibi Department of Operating Room Technology Community Based Psychiatric Care Research CenterSchool of Nursing and MidwiferyShiraz University of Medical SciencesShirazIran Department of Operating Room Technology School of Paramedical SciencesAJA University of Medical SciencesTehranIran Department of Operating Room School of Allied Medical ScienceFasa University of Medical SciencesFasaIran Clinical Education Research Center Shiraz University of Medical SciencesShirazIran Medical Journalism Department School of Paramedical SciencesShiraz University of Medical SciencesShirazIran Department of Epidemiology Student Research CommitteeShiraz University of Medical SciencesShirazIran

Objective:According to the World Federation of Medical Education,critical thinking should be part of the training of medical and paramedical *** can improve the quality of care of patients after surgery by having or acquiring this skill in health ***,Emotional intelligence is introduced as an impor tant and effective factor on the professional performance and mental health of healthcare ***,the present study was designed and implemented to determine the relationship between emotional intelligence and critical thinking among operating room nursing students of medical sciences universities in ***:This cross-sectional study was done on 420 operating room students in 10 top medical sciences universities of Iran in *** sampling method in this research was multistage *** data collection instruments included demographic characteristics,Rickett's critical thinking,and Bradberry-Greaves'emotional intelligence *** receiving the ethics code,data collection was done for 2 *** data analysis,descriptive and inferential analyses including independent t-tests,analysis of variance,and Pearson correlation were *** collected data were analyzed by SPSS 18(IBM Corporation,Armonk,New York,United States).P-value<0.05 was considered ***:The mean age of the students participating in this study was 23.02±3.70 years,with women constituting 67.4%of *** results of data analysis indicated that the mean total score of critical thinking and emotional intelligence was 124.10±37.52 and 114.12±43.63,respectively.A direct significant correlation between critical thinking and emotional intelligence(r=0.459,P-value<0.001)and a significant relationship between gender and emotional intelligence(P-value=0.028)were ***:Based on the present study results,educational managers in the Ministry of Health are suggested to consider suitable educational programs for improving critical think

关键词： critical thinking emotional intelligence operating room students operating room nurses

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COVID-19 mortality paradox(United States vs Africa):Mass vaccination vs early treatment

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World Journal of Experimental Medicine 2024年第1期14卷 6-12页

作者： mina Thabet Kelleni Department of Pharmacology College of MedicineMinia UniversityMinya 61111Egypt

The coronavirus disease 2019(COVID-19)mortality rate in 55 African countries is almost 4.5 times lower than in the coronavirus disease 2019(COVID-19)despite Africa having over 4.2 times more *** mortality paradox is also evident when comparing Nigeria,a heavily populated,poorly vaccinated and weakly mandated country to Israel,a small,highly vaccinated and strictly mandated *** has almost 4 times lower COVID mortality than *** this Field of Vision perspective,I explain how this paradox has evolved drawing upon my academic,clinical and social *** April 2020,I’ve developed and been using the Egyptian immune-modulatory Kelleni’s protocol to manage COVID-19 patients including pediatric,geriatric,pregnant,immune-compromised and other individuals suffering from multiple ***’s unfortunate that severe acute respiratory syndrome coronavirus 2 is still evolving accompanied by more *** in Africa,we’ve been able to live without anxiety or mandates throughout the pandemic because we trust science and adopted early treatment using safe,and effective repurposed drugs that have saved the majority of COVID-19 *** article represents an African and Egyptian tale of honor.

关键词： COVID-19 Early treatment Kelleni’s Protocol Mandates Mortality Paradox SARS-CoV-2 Nucleic acid based vaccines

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Thermo-Physical Potential of Recycled Banana Fibers for Improving the Thermal and Mechanical Properties of Biosourced Gypsum-Based Materials

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Journal of Renewable Materials 2024年第4期12卷 843-867页

作者： Youssef Maaloufa Soumia Mounir Sara Ibnelhaj Fatima Zohra El Wardi Asma Souidi Yakubu Aminu Dodo Malika Atigui mina Amazal Abelhamid Khabbazi Hassan Demrati Ahmed Aharoune National School of Architecture Agadir New ComplexIbn Zohr UniversityAgadirMorocco Energy Materials and Sustainable Development(EMDD)Center for WaterNatural ResourcesEnvironment and Sustainable Development(CERNE2D)Mohammed V UniversityRabatMorocco Thermodynamics and Energetics Laboratory Faculty of ScienceIbn Zohr UniversityAgadirMorocco Architectural Engineering Department Najran UniversityNajranSaudi Arabia The Centre of Scientific and Engineering Research Najran UniversityNajranSaudi Arabia Physics Department LPMAT LaboratoryFaculty of Sciences Ain ChockHassan II UniversityCasablancaMorocco

The development of bio-sourced materials is essential to ensuring sustainable construction;it is considered a locomotive of the green ***,it is an abundant material in our country,to which very little attention is being *** work aims to valorize the waste of the trunks of banana trees to be used in ***,the physicochemical properties of the fiber,such as the percentage of crystallization and its morphology,have been determined by X-ray diffraction tests and scanning electron microscopy to confirm the potential and the impact of the mode of drying on the quality of the banana fibers,with the purpose to promote the use of this material in ***,the results obtained with the gypsum matrix allowed us to note a preponderant improvement in the composite’s thermal properties thanks to the variation of the banana fiber ***,the impact of the nature of the banana fiber distribution(either fiber mixed in matrix or fiber series model)on the flexural and compressive strengths of the composites was *** results obtained indicate that the insulation gain reaches up to 40%.It depends on the volume fraction and type of distribution of the banana ***,the thermal inertia of the composites developed,represented by thermal diffusivity and thermal effusivity,was *** indicate a gain of 40%and 25%,respectively,in terms of thermal diffusivity and thermal effusivity of the developed composites compared to plaster *** the mechanical properties,the flexural strength depends on the percentage of the volume fraction of banana fibers used,and it can reach 20%more than the flexural strength of plaster;nevertheless,there is a significant loss in terms of the compressive strength of the studied *** results obtained are confirmed by the microstructure of the fiber *** fact,the morphology of the banana fibers was improved by the drying *** reduces the amorphous area an

关键词： Biosourced materials fiber banana flexural strength mechanical properties open-air drying plaster thermal properties waste management

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Aryl hydrocarbon receptor dynamics in esophageal squamous cell carcinoma:From immune modulation to therapeutic opportunities

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World Journal of Experimental Medicine 2024年第3期14卷 48-56页

作者： mina Rahmati Hassan Moghtaderi Saeed Mohammadi Ahmed Al-Harrasi Biotechnology Research Center Pasteur Institute of IranTehran ***TehranIran Natural and Medical Sciences Research Center University of NizwaNizwa 616Ad DakhiliyahOman

Esophageal squamous cell carcinoma(ESCC)is a substantial global health *** escape mechanisms are important in ESCC progression,enabling cancer cells to escape the surveillance of the host immune *** key player in this process is the Aryl Hydrocarbon Receptor(AhR),which influences multiple cellular processes,including proliferation,differentiation,metabolism,and immune *** AhR signaling participates in ESCC development by stimulating carcinogenesis,epithelial-mesenchymal transition,and immune *** AhR signaling is a potential therapeutic approach for ESCC,with AhR ligands showing efficacy in preclinical ***,modification of AhR ligands and combination therapies present new opportunities for therapeutic *** review aims to address the knowledge gap related to the role of AhR signaling in ESCC pathogenesis and immune escape.

关键词： Esophageal squamous cell carcinoma Aryl hydrocarbon receptor Immune escape Tumor microenvironment Immunosuppression Therapeutic targeting

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