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Montanide ISA-720 and Naloxone in HbsAg Vaccine Formulation:Cytokine Profiling and Monitoring of Long-Lasting Humoral Immune Responses

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biomedical and Environmental Sciences 2022年第9期35卷 792-803页

作者： mina Mirzaee Setareh Haghighat bahareh Golkaran Fatemeh Asgarhalvaei Rayhaneh Mirzaee Morteza Taghizadeh Mohammad Ali Savoji behzad Esfandiari Mehdi Mahdavi Department of Microbiology Faculty of Advanced Sciences&TechnologyTehran Medical SciencesIslamic Azad University(IAUPS)TehranIran Department of biotechnology Faculty of Advanced Sciences&TechnologyPharmaceutical Sciences BranchIslamic Azad UniversityTehran-Iran(IAUPS) Department of Medical vaccine Razi Vaccine and Serum Research InstituteAgricultural ResearchEducation and Extension Organization(AREEO)KarajIran Department of Epidemiology and biostatistics Pasteur Institute of IranTehranIran Department of Laboratory Animal Science Pasteur Institute of IranKarajIran Advanced Therapy Medicinal Product(ATMP)Department Breast Cancer Research CenterMotamed Cancer InstituteAcademic Center for EducationCulture and Research(ACECR)TehranIran Recombinant Vaccine Research Center Tehran University of Medical SciencesTehranIran Department of Immunology Pasteur Institute of IranTehranIran Immunotherapy Group The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehranIran

Objective This study aimed to investigate the effects of Montanide ISA-720 and Naloxone(NLX)in Hepatitis b surface antigen(HbsAg)vaccine formulation on cytokine and long-lasting antibody *** First,the HbsAg was formulated in Montanide ISA-720 adjuvant and Naloxone at 5 and 10mg/*** experimental mice were immunized three times at a 2-week interval,and then IL-4,IL-2,TNF-α,and IFN-γcytokines;long-lasting IgG antibody responses 220 days after the last shot;and IgG1/IgG2a isotypes were assessed by *** The HbsAg-Alum group exhibited the highest IL-4 cytokine response among the experimental groups,whereas NLX in HbsAg-MON720 vaccine formulation did not affect cytokine *** addition,NLX in Alum-based vaccine suppressed IL-4 cytokine response and increased the IL-2/IL-4 cytokine ***,HbsAg-MON720 was more potent than HbsAg-Alum in the induction of antibody responses,and NLX in Alum-and MON720-based vaccines induced long-lasting antibody *** NLX in Alum-based vaccine decreased IL-4 cytokine response,increased IL-2/IL-4 cytokine ratio,and improved long-lasting humoral immune responses in both vaccine ***,the adjuvant activity of NLX in the vaccine formulation depends on the type of adjuvant and the nature of the antigen in the vaccine formulation.

关键词： HbsAg Vaccine Naloxone Montanide ISA-720 Long-lasting humoral response

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Refractive outcomes among glaucoma patients undergoing phacoemulsification cataract extraction with and without Kahook Dual blade goniotomy

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Eye and Vision 2019年第1期6卷 236-241页

作者： Erin G.Sieck Cara E.Capitena Young Rebecca S.Epstein Jeffrey R.SooHoo mina b.pantche.a Jennifer L.Patnaik Anne M.Lynch Malik Y.Kahook Leonard K.Seibold Department of Ophthalmology University of Colorado School of Medicine1675 Aurora Court F731AuroraCO 80045USA

background:Glaucoma patients undergoing phacoemulsification alone have a higher rate of refractive surprise compared to patients without *** risk is further increased with combined filtering ***,there are few and conflicting reports on the effect of combined phacoemulsification and micro-invasive glaucoma surgery(MIGS).Here,we look at refractive outcomes of glaucoma patients undergoing phacoemulsification with and without Kahook Dual blade(KDb)***:Retrospective chart review of 385 glaucomatous eyes of 281 patients,which underwent either phacoemulsification alone(n=309)or phacoemulsification with KDb goniotomy(n=76,phaco-KDb)at the University of *** main outcome was refractive surprise defined as the difference in target and postoperative refraction spherical equivalent greater than±0.5 Diopter(D).Results:Refractive surprise greater than±0.5 D occurred in 26.3%of eyes in the phaco-KDb group and 36.2%in the phacoemulsification group(p=0.11).Refractive surprise greater than±1.0 D occurred in 6.6%for the phacoKDb group and 9.7%for the phacoemulsification group(p=0.08).There was no significant difference in risk of refractive surprise when pre-operative IOP,axial length,keratometry or performance of KDb goniotomy were assessed in univariate ***:There was no difference between refractive outcomes of glaucomatous patients undergoing phacoemulsification with or without KDb goniotomy.

关键词： Kahook Dual blade goniotomy refractive surprise glaucoma cataract

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功能独立性评定量表对非痴呆性血管性认知功能障碍患者的预测价值及护理策略

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国际护理学杂志 2024年第19期43卷 3616-3621页

作者：王婧蔡春茜陈晓娜王雪薛米娜张新牛亚利天津医科大学总医院康复医学科天津300052 天津中医药大学第一附属医院针灸部天津300000 天津医科大学总医院空港医院神经外科天津300000

目的了解功能独立性评测(Function Independent Measure,FIM)量表对非痴呆型血管认知障碍患者(Vascular Cognitive Impairment No Dementia,VCIND)患者的应用价值。方法采取单中心、病例-对照研究。采用蒙特利尔认知评估量表(Montreal C... 详细信息

目的了解功能独立性评测(Function Independent Measure,FIM)量表对非痴呆型血管认知障碍患者(Vascular Cognitive Impairment No Dementia,VCIND)患者的应用价值。方法采取单中心、病例-对照研究。采用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)及简易智能精神状态检查量表(Mini-Mental State Examination,MMSE)在诊断为脑血管病患者中筛选VCIND组59例和认知正常患者45例为对照组,记录两组患者基本资料、应用FIM量表进行评定并统计分析。结果与对照组比较,VCIND组社会认知及交流能力分项目评分较差;VCIND组FIM量表总分与MMSE量表、MoCA量表评分呈正相关。结论应用FIM量表对VCIND患者评估,可早期识别VCIND患者生活质量下降的危险因素,及早采取护理干预措施,延缓VCIND患者生活质量下降速度,控制疾病进展,为预防VCIND发生提供科学依据。

关键词：非痴呆性血管性认知功能障碍社会认知交流能力

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Dietary Coleus amboinicus Lour. decreases ruminal methanogenesis and biohydrogenation, and improves meat quality and fatty acid composition in longissimus thoracis muscle of lambs

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Journal of Animal Science and biotechnology 2022年第3期13卷 816-834页

作者： Yulianri Rizki Yanza Malgorzata Szumacher-Strabel Dorota Lechniak Sylwester Ślusarczyk Pawel Kolodziejski Amlan Kumar Patra Zora Váradyová Dariusz Lisiak mina Vazirigohar Adam Cieslak Department of Animal Nutrition Faculty of Veterinary Medicine and Animal SciencePoznań University of Life Sciences60-637 PoznańPoland Department of biology Education Universitas Islam RiauJl.Kaharuddin Nasution 113Pekanbaru 28284Indonesia Department of Genetics and Animal breeding Poznań University of Life SciencesWołyńska 3360-637 PoznańPoland Department of Pharmaceutical biology and botany Wrocław Medical University50-556 WrocławPoland Department of Animal Physiology and biochemistry Faculty of Veterinary Medicine and Animal SciencePoznań University of Life Sciences60-637 PoznańPoland Department of Animal Nutrition West Bengal University of Animal and Fishery SciencesBelgachiaK.B.Sarani 37Kolkata 700037India Institute of Animal Physiology Centre of Biosciences of Slovak Academy of SciencesŠoltésovej 4-604001 KošiceSlovak Republic Department of Meat and Fat Technology Wacław Dąbrowski Institute of Agricultural and Food BiotechnologyRakowiecka 3602-532 WarszawaPoland Zist Dam Group University Incubator CenterUniversity of ZanjanZanjan 45371-38791Iran

background:Methane production and fatty acids(FA)biohydrogenation in the rumen are two main constraints in ruminant production causing environmental burden and reducing food product *** functions can be modulated by the biologically active compounds(bACs)of plant origins as shown in several studies *** in methane emission,modulation of FA composition with positive impact on the ruminant *** amboinicus Lour.(CAL)contains high concentration of polyphenols that may potentially reduce methane production and modulate ruminal biohydrogenation of unsaturated *** study aimed to investigate the effect of bAC of Coleus amboinicus Lour.(CAL)fed to growing lambs on ruminal methane production,biohydrogenation of unsaturated FA and meat *** this study,the in vitro experiment aiming at determining the most effective CAL dose for in vivo experiments was followed by two in vivo experiments in rumen-cannulated rams and growing *** 1(RUSITEC)comprised of control and three experimental diets differing in CAL content(10%,15%,and 20%of the total diet).The two in vivo experiments were conducted on six growing,rumen-cannulated lambs(Exp.2)and 16 growing lambs(Exp.3).Animals were assigned into the control(CON)and experimental(20%of CAL)*** parameters were examined in vitro(pH,ammonia and VFA concentrations,protozoa,methanogens and select bacteria populations)and in vivo(methane production,digestibility,ruminal microorganism populations,meat quality,fatty acids profiles in rumen fluid and meat,transcript expression of 5 genes in meat).Results:CAL lowered in vitro methane production by 51%.In the in vivo Exp.3,CAL decreased methane production by 20%compared with the CON group,which corresponded to reduction of total methanogen counts by up to 28%in all experiments,notably *** Exp.3,CAL increased or tended to increase populations of some rumen bacteria(Ruminococcus albus,Megasphaera elsdenii,butyrivibr

关键词： bioactive compounds biohydrogenation Meat characteristics Methane Microorganism Ruminal fermentation Sheep

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Spatiotemporal distribution and predictors of tuberculosis incidence in Morocco

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Infectious Diseases of Poverty 2018年第1期7卷 414-426页

作者： mina Sadeq Jamal Eddine bourkadi Environmental Epidemiology Unit National Institute of Hygiene.Ministry of HealthRabatMorocco University Hospital Center.Moulay Youssef Hospital RabatMorocco Faculty of Medicine and Pharmacy University Mohammed VRabatMorocco

background:Tuberculosis(Tb)is a major health problem in *** study aims at examining trends in Tb in Morocco and identifying Tb spatial clusters and Tb-associated ***:Country-level surveillance data was ***’s correlation test was used to examine trends and an exploratory spatial data analysis was conducted to assess the global and local patterns of spatial autocorrelation in Tb rates(Moran’s I and local indicator of spatial association[LISA])at the prefecture/province *** including living in a prefecture versus living in a province,annual rainfall,annual mean temperature,population density,and AIDS incidence were *** ordinary least squares regression was thus performed and both spatial dependence and heteroscedasticity were ***:A decrease in Tb incidence rate was seen between 1995 and 2014(Kendall’s tau b=−0.72;Pbetween 2005 and 2014(10 last years)was considered,Tb rate remained stable and as high as 84 per 100000 population per year(95%CI:83.7-84.3).The highest incidence rates were seen in Tanger-Assilah,Fez,Tetouen-M’diq Fnidaq,Inezgane Ait Melleoul,and *** 2005 to 2014,while Tb incidence rate was stable in Fez(P=0.500),Tetouen-M’diq Fnidaq(P=0.300),Casablanca(P=0.500),Mohammadia(P=0.146),Al Hoceima(P=0.364),and Guelmim(P=0.242),an increase in Tb incidence rate was seen in Tanger-Assilah(Kendall’s tau=0.49;P=0.023)and a decrease in Salé(Kendall’s tau b=−0,54;P=0.014)and Inezgane-Ait Melloul(Kendall’s tau b=−0,67;P=0.0023).Tb is strongly clustered in space(P-values of Moran’s Ib spatial clustering were identified(east and west).In the east,both annual rainfall(P=0.003)and AIDS(P=0.0002)exert a statistically significant effect on Tb *** the west,only the living area(prefecture versus province)was associated with Tb rate(P=0.048).Conclusions:New information on Tb incidence and Tb-related predictors

关键词： Tb Meteorological data Prefecture/province AIDS Population density Morocco

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The functional complex network approach to foster forest resilience to global changes

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Forest Ecosystems 2019年第3期6卷 194-209页

作者： Christian Messier Jürgen bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann Département des sciences naturelles and Institut des sciences de la forêt tempérée (ISFORT) Université du Québec en Outaouais(UQO)58 rue PrincipaleRiponQC J0V 1V0 Canada Centre d’étude de la forêt Université du Québec à Montréal (UQAM)Case postale 8888succursale Centre-VilleMontréalQC H3C 3P8Canada Chair of Silviculture Institute of Forest SciencesUniversity of FreiburgTennenbacherstr.479106 FreiburgGermany Swiss Federal Institute for Forest Snow and Landscape Research WSLBirmensdorfSwitzerland Department of Ecology and Evolution University of TorontoTorontoON M5S 3B2Canada Department of Ecosystems and Society Oregon State UniversityCorvallisOR 97331USA

Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved.

关键词： forest management North America Ecosystem services

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手性催化的环氧化物立体选择性开环反应

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有机化学 2006年第9期26卷 1208-1216页

作者：王磊李叶芝黄化民方唯硕吉林大学化学学院长春130023 中国医学科学院中国协和医科大学药物研究所北京100050

手性催化的环氧化物立体选择性开环反应可以用来制备多种具光学活性的化合物,因而成为有机合成中极为重要的方法之一.多种亲核试剂都已成功应用于此类反应.综述了近十年来环氧化物的立体选择性开环反应方面的一些最新研究进展.

关键词：环氧化物立体选择性开环反应动力学拆分

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Preparation and properties of a nano TiO_2/Fe_3O_4 composite superparamagnetic photocatalyst

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Rare Metals 2009年第5期28卷 423-427页

作者： LI Yuxiang ZHANG Mei GUO Min WANG Xidong School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China College of Engineering Peking University Beijing 100871 China

Nano TiO2/Fe3O4 composite particles with different molar ratios of TiO2 to Fe3O4 were prepared via sol-gel method. X-ray diffraction, transmission electron microscopy, and vibration sample magnetometry were used to characterize the TiO2/Fe3O4 particles. The photocatalytic activity of the particles was tested by degrading methyl blue solution under UV illumination （254 nm）. The results indicate that with the content of TiO2 increasing, the photocatalytic activity of the composite particles enhances, while the magnetism of the particles decreases. When the molar ratio of TiO2 to Fe3O4 is about 8, both the photocatalytic activity and magnetism of the TiO2/Fe3O4 particles are relatively high, and their photocatalytic activity remains well after repeated use.

关键词： photocatalysis superparamagnetism sol-gel method TiO2 Fe3O4

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Template-free hydrothermal synthesis of single-crystalline SnO_2 nanocauliflowers and their optical properties

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Rare Metals 2009年第5期28卷 449-453页

作者： WANG Yali GUO Min ZHANG Mei WANG Xidong School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China College of Engineering Peking University Beijing 100871 China

Large-scale single-crystalline SnO2 nanocauliflowers were successfully synthesized using a hydrothermal growth method without any template. The samples were characterized by X-ray diffraction （XRD）, field-emission scanning electron microscopy （FE-SEM）, en- ergy-dispersive X-ray spectroscopy （EDS）, transmission electron microscopy （TEM）, and selected area electron diffraction （SAED）. FE-SEM images show that the as-grown SnO2 nanocauliflowers are constructed of tetragonal prisms with a width of 500-600 nm. XRD, EDS, and SAED results indicate that the as-grown SnO2 nanocauliflowers are single crystalline with the tetragonal rutile crystalline structure. The growth mechanism of SnO2 nanocauliflowers is also preliminarily discussed on the basis of different Sn（OH） 62- concentrations, and it is found that Sn（OH） 62- concentration plays an important role in determining the shape of the prepared SnO2. Room temperature photoluminescence was further carried out on SnO2 nanocauliflowers to investigate their optical properties. An intense blue luminescence centered at a wavelength of 424 nm is observed in the as-grown SnO2 nanocauliflowers.

关键词： nanocauliflowers SnO2 hydrothermal photoluminescence

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Optimisation of benzodiazepine Immunoassay Using <i>β</i>-Glucuronidase Enzymatic Hydrolysis: A Comparison of Five Different <i>β</i>-Glucuronidase Enzymes

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Journal of biosciences and Medicines 2022年第1期10卷 7-15页

作者： Ashraf mina Leah McNeice Shanmugam banukumar Santiago Vazquez NSW Health Pathology Forensic & Analytical Science Service (FASS) Toxicology Unit Macquarie Hospital Sydney Australia Affiliated Senior Clinical Lecturer Faculty of Medicine and Health Sydney University Sydney Australia

background: Hydrolysis improves the sensitivity of drug detection for drug classes such as opiates/opioids and benzodiazepines, which are highly metabolized by glucuronidation and sulfation and should be implemented in analytical procedures to convert conjugated metabolites into the free or unbound form. This study was aimed to compare different enzymes to make an informed decision. Methods: In this study, the CEDIA benzodiazepine assay was compared with the LC-MS-MS method using 150 positive urine samples and 50 negative urine samples. The samples were analysed without adding any enzyme and then by adding different enzymes to compare their performance. Results: The Kura Escherichia coli enzyme performed better than the Roche Escherichia coli enzyme which had 20% false-positive results. Kura bG-100 enzyme performed well but Kura b-One enzyme performed better The Kura b-One enzyme had only 11.5% false-positive results. When double the volume of Kura b-One enzyme was used to test to see if it will have any impact on reducing the number of false negatives, it performed worse. Kura Turbo enzyme behaved similarly to Kura bG-100. Conclusions: The β-glucuronidase enzymes comparison allowed us to identify the Kura b-One enzyme as the enzyme of choice for our operation because it reduces the false positives from 20% to 11.5% when compared with the Roche enzyme. It also improved the detection of oxazepam. The Kura b-One enzyme has a short incubation time for hydrolysis when used with the LC-MS-MS method. As a result, we improved the overall turn-around time and reduced the number of false positives that needed confirmation.

关键词： β-Glucuronidase Enzyme CEDIA benzodiazepine 7-Amino Clonazepam 7-Amino Clonazepam

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