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Angiopoietin-1 Promote the Integrity of Neovascularization in the Subcutaneous Matrigel of Type 1 Diabetic Rats

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Angiopoietin-1 Promote the Integrity of Neovascularization i...

福建大田银场矿区银多金属矿床地质特征与成因探讨

贵州省医学会肾脏病学分会暨血液净化分会学术年会

作者： ShaoBin LI HeQin Zou minmin gong YuQin Chen XiaoYong Yan LiMei Yu YiBin Yang Key Laboratory of Cell Engineering of Guizhou Province The Affiliated Hospital of Zunyi Medical College Department of Nephrology & Rheumatology Affiliated Hospital of Zunyi Medical College

Objective:Diabetic microangiopathy is one of the complications of *** study was to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel-angiogenesis model,established in type 1 diabetic ***’.Construction and identification of Ang-1 adenoviral *** rat model was established by STZ,divided into four group:Control group,Diabetes group,Blank vector group and Ang-1 treatment *** Matrigel was inserted subcutaneously into the abdominal cavity of rats at 8 weeks,the treatment group was injected with Ang-1 adenovirus vector via tail vein,the rats were sacrificed at 10 *** of Matrigel were observed with transmission electron *** endothelial cell and pericyte and Immunohistochemistry cell tight junctions protein(JG12,a-SMA,Desmin,Z0-1,Occludin,VE-cadherin,and Connexin40).RT-PCR was used to determine protein expression of neovascular in ***’.Ang-1 treatment of diabetic rat subcutaneous Matrigel visible angiogenesis and increased the capillaries *** electron microscopy showed that the structure of Matrigel in Ang-1 group was intact and enhanced the barrier function of blood *** basement membrane is complete in the neovascularization and pericyte coverage has ***,the integrity of vascular improved,the cell tight junctions protein was up-regulated in Ang-1 treatment ***:Ang-1 could alleviate the neovascular leakage,promote the integrity of neovascularization in the Subcutaneous Matrigel of diabetic rats.

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福建地质 2014年第4期33卷 286-292页

作者：龚敏敏福建省第二地质勘探大队永安366000

大田银场矿区银多金属矿产于燕山早期第三阶段第一次侵入的二长花岗岩体中,受燕山早期北东东向断裂构造控制,矿体呈脉状、透镜状产出,区内矽卡岩化发育地段是矿体富集部位,矽卡岩化与印支-燕山期推覆构造关系密切,属于中-低温热液充填-... 详细信息

大田银场矿区银多金属矿产于燕山早期第三阶段第一次侵入的二长花岗岩体中,受燕山早期北东东向断裂构造控制,矿体呈脉状、透镜状产出,区内矽卡岩化发育地段是矿体富集部位,矽卡岩化与印支-燕山期推覆构造关系密切,属于中-低温热液充填-交代型银多金属矿床。

关键词：银多金属矿床地质特征成因探讨大田银场

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陶瓷工艺品在现代家居装饰中的应用探析

江苏陶瓷 2019年第1期52卷 4-7页

作者：龚敏敏无锡工艺职业技术学院宜兴214206

随着社会的不断进步,人们的生活水平有了质的飞跃,因此,如今的人们生活已经不再局限于能够满足衣食住行上的需求,而对于家居的设计也已经上升到了审美和视觉享受的阶段上,所以,现代家居的装饰带给人们美的享受。陶瓷工艺品属于艺术品的... 详细信息

随着社会的不断进步,人们的生活水平有了质的飞跃,因此,如今的人们生活已经不再局限于能够满足衣食住行上的需求,而对于家居的设计也已经上升到了审美和视觉享受的阶段上,所以,现代家居的装饰带给人们美的享受。陶瓷工艺品属于艺术品的一种,有较高的艺术欣赏价值,能够让人们在观看后达到赏心悦目的程度,在点缀人们家居环境的同时点缀着人们的心情,让人们陶醉在家居美景之中。本文将对陶瓷工艺品在现代家居装饰中的应用进行分析。

关键词：陶瓷工艺品现代家居装饰

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病例分析法在重症医学教学中的应用研究

中国继续医学教育 2016年第34期8卷 21-22页

作者：宫敏敏遵义医学院附属医院重症医学科贵州遵义563000

病例分析法是一种新式的教学方法,它是以学生为主体、以病例为基础。通过病例分析,实现理论与实践相结合,培养学生临床思维能力和观察能力,提高学生的学习的兴趣和学习的积极性及,进而提高教学质量。本文就重症医学教学中病例分析法的... 详细信息

病例分析法是一种新式的教学方法,它是以学生为主体、以病例为基础。通过病例分析,实现理论与实践相结合,培养学生临床思维能力和观察能力,提高学生的学习的兴趣和学习的积极性及,进而提高教学质量。本文就重症医学教学中病例分析法的应用、实施并结合自己多年教学体会,分析了病例分析教学法在重症医学教学中的作用及注意事项,以期激发学生的学习兴趣及学习潜力,提高教学质量与效率。

关键词：病例分析法重症医学教学应用

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重症监护病房急性肾损伤相关危险因素及预后

中国卫生标准管理 2017年第16期8卷 28-30页

作者：宫敏敏宫静遵义医学院附属医院重症医学科贵州遵义563000 遵义医学院附属医院血液净化室贵州遵义563000

目的分析重症监护病房患者出现急性肾损伤(Acute kidney injury,AKI)的危险因素及预后。方法回顾性分析我院2013年4月—2014年6月重症监护室220例AKI的临床资料,使用logistic回归分析对相关危险因素进行分析。根据患者第28天生存状况分... 详细信息

目的分析重症监护病房患者出现急性肾损伤(Acute kidney injury,AKI)的危险因素及预后。方法回顾性分析我院2013年4月—2014年6月重症监护室220例AKI的临床资料,使用logistic回归分析对相关危险因素进行分析。根据患者第28天生存状况分为生存组(184例)和死亡组(36例)。结果 AKI患者的年龄、脓毒血症、MODS、APACHEII评分为AKI患者肾功能未恢复的危险因素。结论重症监护病房中AKI发生率高,脓毒血症为主要病因。

关键词：重症监护病房急性肾损伤预后

持续静脉-静脉血液滤过联合血液灌流抢救故意注射过量甘精胰岛素患者一例

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中华内分泌代谢杂志 2016年第7期32卷 611-612页

作者：陈文博宫敏敏高飞傅小云遵义医学院附属医院重症医学科 563099

甘精胰岛素是一类长效的类似人类的重组胰岛素，过量注射甘精胰岛素会导致有症状的低血糖以及潜在的严重并发症。目前自行注射胰岛素是糖尿病患者常用的控制血糖的方式，而故意注射超量胰岛素常可导致脑损伤、严重电解质紊乱及循环衰竭... 详细信息

甘精胰岛素是一类长效的类似人类的重组胰岛素，过量注射甘精胰岛素会导致有症状的低血糖以及潜在的严重并发症。目前自行注射胰岛素是糖尿病患者常用的控制血糖的方式，而故意注射超量胰岛素常可导致脑损伤、严重电解质紊乱及循环衰竭。2015年8月，本科收治1例故意皮下注射过量甘精胰岛素及超量口服降糖药物及安眠药物患者，现将诊治过程及治疗体会报告如下。

关键词：甘精胰岛素持续静脉-静脉血液滤过注射胰岛素患者血液灌流严重电解质紊乱抢救口服降糖药物

Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China Life Sciences 2025年第1期68卷 176-188页

作者： Zhiyi Wang Mengxue gong Yuanyuan Fang Huijuan Yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University Department of Endocrinology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University

The human microbiota-associated(HMA) mice model, especially the germ-free(GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice. Mice with similar microbiota structure to the donor exhibited better phenotypic reproducibility. The characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice, and individuals with a higher proportion of stochastic processes showed more severe disorders. Microbes enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism, and microbiota functional features related to T1D were better reproduced in these mice. This indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized mice. Our findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes

A Microarray Based Strategy for High Throughput Discovery of Potent and Selecitve SH2 Domains Binders

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A Microarray Based Strategy for High Throughput Discovery of...

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

第十一届全国化学生物学学术会议

作者： Liuxing Xie Mengchu Li Xuan Wang Jianbin Wang Xiangqian Wei Wei Wang Menghua Xia minmin gong Jiashu Liu Jieman Chen Sijia Tan Fen Yang Qicai Xiao Liqian Gao School of Pharmaceutical Science（Shenzhen） Sun Yat-Sen University

Signal transduction plays a vital role in cellular functions. It is well known that reversible tyrosine phosphorylation is also an early step in the transduction of many types of signals in multicellular organisms. Phosphorylated signaling proteins on tyrosine residues are usually specifically recognized by Src Homology 2（SH2） domain modular proteins. Since SH2 domain modular proteins are so important for the signal transduction inside the cells/human, mapping the SH2 domain binding specificity will help us predict/control the signaling state of the cell, thus facilitating us for human disease treatment caused by the aberrant signaling. A novel systematic phosphopeptide microarray platform with 144 members was developed to efficiently high throughput identification of some potent and selective binders for SH2 domain proteins, which were then validated by the lysates proteomes pull down and antibody detection on the microarray.

关键词： GRB2 Microarray PPI High Throughput

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels