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Phylotranscriptomic discordance is best explained by incomplete lineage sorting within Allium subgenus Cyathophora and thus hemiplasy accounts for interspecific trait transition

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Plant Diversity 2024年第1期46卷 28-38页

作者： Zengzhu Zhang Gang Liu minjie Li State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems College of EcologyLanzhou UniversityLanzhou 730000GansuPR China

The transition of traits between genetically related lineages is a fascinating topic that provides clues to understanding the drivers of speciation and diversification.Much can be learned about this process from phylogeny-based trait evolution.However,such inference is often plagued by genome-wide gene-tree discordance(GTD),mostly due to incomplete lineage sorting(ILS)and/or introgressive hybridization,especially when the genes underlying the traits appear discordant.Here,by collecting transcriptomes,whole chloroplast genomes(cpDNA),and population genetic datasets,we used the coalescent model to turn GTD into a source of information for ILS and employed hemiplasy to explain specific cases of apparent“phylogenetic discordance”between different morphological traits and probable species phylogeny in the Allium subg.Cyathophora.Both concatenation and coalescence methods consistently showed the same phylogenetic topology for species tree inference based on single-copy genes(SCGs),as supported by the KS distribution.However,GTD was high across the genomes of subg.Cyathophora:~27%e38.9%of the SCG trees were in conflict with the species tree.Plasmid and nuclear incongruence was also present.Our coalescent simulations indicated that such GTD was mainly a product of ILS.Our hemiplasy risk factor calculations supported that random fixation of ancient polymorphisms in different populations during successive speciation events along the subg.Cyathophora phylogeny may have caused the character transition,as well as the anomalous cpDNA tree.Our study exemplifies how phylogenetic noise can be transformed into evolutionary information for understanding character state transitions along species phylogenies.

关键词： Hemiplasy Multispecies coalescence Lineage sorting Gene tree discordance Phylotranscriptomics Allium subg.Cyathophora

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Performance analysis and multi-objective optimization based on a modified irreversible Stirling cycle

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Science China(Technological Sciences) 2024年第6期67卷 1668-1684页

作者： XU Lei YU minjie LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China

The efficiency of the actual Stirling engine is much lower than the ideal Carnot cycle efficiency.To obtain more precise efficiency for Stirling engines,this paper proposes a modified Stirling cycle with a more accurate heat transfer process in Stirling engines based on a thermodynamic function called available potential.The finite-time thermodynamic method is used to analyze the model performance under constant heat source temperature,finite temperature difference heat transfer,and incomplete regenerative processes.A new polytropic process is introduced to model the heat transfer between the working fluid and external heat sources in which only heat above ambient temperature is converted into technical work.The regenerator is divided into numerous smaller heat reservoirs with individual temperature to analyze the incomplete regenerative processes.The expressions of the output power and thermal efficiency are obtained based on the modified irreversible Stirling cycle,and the effects of irreversible losses are analyzed to evaluate the performance of the proposed model.Results indicate that the efficiency of the modified cycle is much lower than that of the ideal Stirling cycle with an isothermal process.With the increase of the average heat transfer temperature difference,there exists an optimum value for the power of the irreversible cycle.The optimum power of the model was obtained for varying thermodynamic parameters by optimizing the average heat transfer temperature difference between the hot and cold sides.To optimize the irreversible model,the multi-objective optimization analysis is carried out based on NSGA-Ⅱ,which results in an optimized output power of 40.87 kW and an optimized thermal efficiency of 44%.

关键词： stirling cycle regenerative processes isopotential processes multi-objective optimization finite time thermodynamics

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Advances in friction of aluminium alloy deep drawing

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Friction 2024年第3期12卷 396-427页

作者： Yiren GAO Hongxia LI Danyang ZHAO minjie WANG Xiaobo FAN School of Mechanical Engineering Dalian University of TechnologyDalian 116023China

Broad use of lightweight aluminium alloy parts in automobile manufacturing,aerospace,electronic communication,and rail transit is mainly formed through deep drawing process.Deep drawing friction is a key boundary condition for controlling the forming quality of aluminium alloy parts.However,due to the oxidation and adhesion tendency of aluminium alloys,the tribological situations of aluminium alloy deep drawing(AADD)system is more complicated than those of traditional deep drawing of steel sheets.Therefore,the study of AADD friction is essential for manufacturing high-performance aluminium alloy parts.Herein,aiming to provide a valuable reference for researchers in related fields,a comprehensive review of AADD friction is provided,including friction mechanism,influencing factors,friction measurement,friction model,friction simulation,and lubrication-free friction control.Finally,a brief conclusion and several current challenges were discussed.

关键词： aluminium alloy deep drawing(AADD) influencing factors friction measurement friction model friction control

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Natural polysaccharide-based smart CXCR4-targeted nano-system for magnified liver fibrosis therapy

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Chinese Chemical Letters 2024年第2期35卷 341-346页

作者： Liqiong Sun Xinping Luo Chenxi Zhou Zhanwei Zhou minjie Sun College of Horticulture Nanjing Agricultural UniversityNanjing 210095China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients State Key Laboratory of Natural MedicinesDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

Activated hepatic stellate cells(aHSCs),the main source of extracellular matrix deposition,are key targets in liver fibrosis.However,no effective drug specific to aHSCs has been clinically applied due to poor drug delivery efficiency.Herein,we designed a CXC chemokine receptor 4(CXCR4)-targeted reactive oxygen species(ROS)-responsive platform AMD-Dex-ROS-responsive-sorafenib(ARS)based on natural polysaccharide and thioctic acid frame,which can deliver anti-fibrosis drug represented by sorafenib specifically to aHSCs on account of CXCR4 over-expression on aHSCs,and smartly disassemble via ROS-responsive thioketal rupture relying on high intracellular ROS in HSCs,realized on-demand drug release and effective liver fibrosis reversion.Notably,in this platform,the CXCR4 antagonist AMD3100 not only enhanced aHSCs targeting efficiency of sorafenib but also effectively magnified the aHSCs elimination of sorafenib by blocking stroma cell derived factor-1(SDF-1)/CXCR4-induced aHSCs protection,resulting in synergistic anti-fibrosis effect.The platform provided a new approach for drug delivery system design and liver fibrosis treatment.

关键词： Nanoparticle CXCR4 antagonism ROS-responsive Hepatic stellate cells Liver fibrosis

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The Wnt-dependent and Wnt-independent functions of BCL9 in development,tumorigenesis,and immunity:Implications in therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 701-710页

作者： minjie Wu Heng Dong Chao Xu Mengqing Sun Haojin Gao Fangtian Bu Jianxiang Chen College of Pharmacy and Department of Hepatology Institute of Hepatology and Metabolic DiseasesThe Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer CentreSingapore 169610Singapore Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China

B-cell CLL/lymphoma 9(BCL9)is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types,mainly through potentiating the Wnt/β-catenin signaling.However,increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles.Herein,we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular,physiological,or pathological processes.Moreover,we also concluded that the targeted inhibitors disrupt the interaction ofβ-catenin with BCL9 reported recently.

关键词： BCL9 Development Immunity Multifaceted functions Therapeutic target Tumorigenesis

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A novel approach towards the selection of regenerators for optimal Stirling engine performance based on energy and exergy analyses

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Science China(Technological Sciences) 2024年第1期67卷 295-310页

作者： YU minjie ZHANG MingHui XU Lei CUI HaiChuan LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China

Regenerators play a vital role in enhancing the overall performance of Stirling engines.Hence,this paper performed an energy and exergy analysis to elucidate the significance of regenerator characteristics concerning system performance,contributing to the optimal regenerator’s design and selection.The relationship between regenerator structure,regenerator exergy destruction,and output power,thermal efficiency,and exergy efficiency for Stirling engines was established by integrating the thermal model of Stirling engines with a mathematical model of regenerators.In contrast to cross-flow and parallel-flow regenerators,a novel concept of inclined-flow regenerators,featuring a matrix surface inclined in the direction of gas flow,was developed to achieve higher and more balanced engine output power and energy utilization efficiency.A comprehensive investigation was conducted into the effects of matrix structure types and regenerator geometries on the performance of both regenerators and engines.The results reveal that,following structural optimization,Stirling engines equipped with the inclined-flow regenerator demonstrate a substantial 16.6%,38.3%,and 37.2%increase in power output,thermal efficiency,and exergy efficiency,respectively,compared to those equipped with cross-flow regenerators.In contrast,when compared to engines fitted with parallel-flow regenerators,they experience a 13.5%reduction in power output but achieve remarkable enhancements of 45.4%and 36.7%in thermal and exergy efficiency,respectively.This study introduces new insights into selecting regenerator structures for enhancing the output performance of Stirling engines.

关键词： Stirling engine inclined-flow regenerator adiabatic model exergy analysis

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LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

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Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen Wu Jing Wu Kai Liu minjie Jiang Fang Xie Xuehong Yin Jushan Wu Qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of ACLF.Lon protease-1(LONP1)is a novel mediator of energy and glucose metabolism.However,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains unknown.Methods:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury model.LONP1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis regulation.Liver histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ACLF.Results:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver tissues.Furthermore,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF mice.Moreover,mitochondrial morphology was improved upon overexpression of LONP1.Meanwhile,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 overexpression.Similarly,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis disorders.Conclusion:We demonstrated that gluconeogenesis dysfunc

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

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Detection of a temporal salient object benefits from visual stimulus-specific adaptation in avian midbrain inhibitory nucleus

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Integrative Zoology 2024年第2期19卷 288-306页

作者： Jiangtao WANG Xiaoping RAO Shuman HUANG Zhizhong WANG Xiaoke NIU minjie ZHU Songwei WANG Li SHI Department of Automation Zhengzhou University School of Electrical EngineeringZhengzhouChina State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanChina Department of Automation Tsinghua UniversityBeijingChina

Food and predators are the most noteworthy objects for the basic survival of wild animals,and both are often deviant in both spatial and temporal domains and quickly attract an animal’s attention.Although stimulus-specific adaptation(SSA)is considered a potential neural basis of salient sound detection in the temporal domain,related research on visual SSA is limited and its relationship with temporal saliency is uncertain.The avian nucleus isthmi pars magnocellularis(Imc),which is central to midbrain selective attention network,is an ideal site to investigate the neural correlate of visual SSA and detection of a salient object in the time domain.Here,the constant order paradigm was applied to explore the visual SSA in the Imc of pigeons.The results showed that the firing rates of Imc neurons gradually decrease with repetitions of motion in the same direction,but recover when a motion in a deviant direction is presented,implying visual SSA to the direction of a moving object.Furthermore,enhanced response for an object moving in other directions that were not presented ever in the paradigm is also observed.To verify the neural mechanism underlying these phenomena,we introduced a neural computation model involving a recoverable synaptic change with a“center-surround”pattern to reproduce the visual SSA and temporal saliency for the moving object.These results suggest that the Imc produces visual SSA to motion direction,allowing temporal salient object detection,which may facilitate the detection of the sudden appearance of a predator.

关键词： adaptation attention model pigeon saliency

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Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids

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Chinese Chemical Letters 2024年第2期35卷 366-369页

作者： Qiao Li minjie Liu Meifen Jiang Li Wan Yingtang Ning Fen-Er Chen College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

We report the photo-mediated 1,2-aryl migration of 2‑chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid scavenger.This pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly conditions.Furthermore,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.

关键词： Green chemistry Flow chemistry 2-Arylpropionic acids Photo-Favorskii reaction

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Application of Global Leadership Initiative on Malnutrition criteria in patients with liver cirrhosis

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Chinese Medical Journal 2024年第1期137卷 97-104页

作者： minjie Jiang Juan Chen Muchen Wu Jing Wu Xiaotong Xu Juan Li Can Liu Yaping Zhao Xin Hua Qinghua Meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Department of Medical Oncology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Nutrition Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:The Global Leadership Initiative on Malnutrition(GLIM)criteria were published to build a global consensus on nutritional diagnosis.Reduced muscle mass is a phenotypic criterion with strong evidence to support its inclusion in the GLIM consensus criteria.However,there is no consensus regarding how to accurately measure and define reduced muscle mass in clinical settings.This study aimed to investigate the optimal reference values of skeletal muscle mass index for diagnosing sarcopenia and GLIM-defined malnutrition,as well as the prevalence of GLIM-defined malnutrition in hospitalized cirrhotic patients.Methods:This retrospective study was conducted on 1002 adult patients with liver cirrhosis between January 1,2018,and February 28,2022,at Beijing You-An Hospital,Capital Medical University.Adult patients with a clinical diagnosis of liver cirrhosis and who underwent an abdominal computed tomography(CT)examination during hospitalization were included in the study.These patients were randomly divided into a modeling group(cohort 1,667 patients)and a validation group(cohort 2,335 patients).In cohort 1,optimal cut-off values of skeletal muscle index at the third lumbar skeletal muscle index(L3-SMI)were determined using receiver operating characteristic analyses against in-hospital mortality in different gender groups.Next,patients in cohort 2 were screened for nutritional risk using the Nutritional Risk Screening 2002(NRS-2002),and malnutrition was diagnosed by GLIM criteria.Additionally,the reference values of reduced muscle mass in GLIM criteria were derived from the L3-SMI values from cohort 1.Multivariate logistic regression analysis was used to analyze the association between GLIM-defined malnutrition and clinical outcomes.Results:The optimal cut-off values of L3-SMI were 39.50 cm 2/m 2 for male patients and 33.06 cm 2/m 2 for female patients.Based on the cut-off values,31.63%(68/215)of the male patients and 23.3%(28/120)of the female patients had CT-determined sarcopenia in cohort 2.The prevalence of GL

关键词： Malnutrition Liver cirrhosis Sarcopenia Clinical outcomes GLIM criteria

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