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Three-dimensional label-free morphology of CD8+T cells as a sepsis biomarker

Light(Science & Applications) 2023年第12期12卷 2565-2576页

作者： mindong sung Jong Hyun Kim Hyun-Seok Min Sooyoung Jang JaeSeong Hong Bo Kyu Choi JuHye Shin Kyung Soo Chung Yu Rang Park Division of Pulmonary and Critical Care Medicine Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Tomocube Inc155 Sinseong-roShinsung-dongYuseong-guDaejeonRepublic of Korea

Sepsis is a dysregulated immune response to infection that leads to organ dysfunction and is associated with a high incidence and mortality rate.The lack of reliable biomarkers for diagnosing and prognosis of sepsis is a major challenge in its management.We aimed to investigate the potential of three-dimensional label-free CD8+T cell morphology as a biomarker for sepsis.This study included three-time points in the sepsis recovery cohort(N=8)and healthy controls(N=20).Morphological features and spatial distribution within cells were compared among the patients'statuses.We developed a deep learning model to predict the diagnosis and prognosis of sepsis using the internal cell morphology.Correlation between the morphological features and clinical indices were analysed.Cell morphological features and spatial distribution differed significantly between patients with sepsis and healthy controls and between the survival and non-survival groups.The model for predicting the diagnosis and prognosis of sepsis showed an area under the receiver operating characteristic curve of nearly 100%with only a few cells,and a strong correlation between the morphological features and clinical indices was observed.Our study highlights the potential of three-dimensional label-free CD8+T cell morphology as a promising biomarker for sepsis.This approach is rapid,requires a minimum amount of blood samples,and has the potential to provide valuable information for the early diagnosis and prognosis of sepsis.

关键词： sepsis diagnosis Morphological

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仿水蛭蠕动爬行软体机器人设计

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机器人 2024年第2期46卷 139-146页

作者：李恭新王民栋朱亚洲刘娜栾小丽刘飞江南大学物联网工程学院轻工过程先进控制教育部重点实验室江苏无锡214122 上海大学机电工程与自动化学院上海200444

为了寻求一种无损和对患者友好的肠道检查方法,提出并设计了一种仿水蛭的软体机器人。该仿水蛭软体机器人由2个以双层结构为“脚”的吸附驱动器和以自束缚多腔室为本体的伸缩驱动器组成,通过控制2个吸附驱动器的交替运动和伸缩驱动器的... 详细信息

为了寻求一种无损和对患者友好的肠道检查方法,提出并设计了一种仿水蛭的软体机器人。该仿水蛭软体机器人由2个以双层结构为“脚”的吸附驱动器和以自束缚多腔室为本体的伸缩驱动器组成,通过控制2个吸附驱动器的交替运动和伸缩驱动器的配合运动实现蠕动爬行。结合实际实验和数值仿真验证了吸附驱动器的吸附特性和伸缩驱动器的调节机理,并分别通过软体机器人在平面、斜坡和类肠道等环境的实验进一步验证了机器人的运动性能。吸附驱动器最大吸附力可达3.05N,软体机器人运动速度可达5mm/s,验证了该机器人可以在类肠道的环境中实现无损和可控的运行。这项工作有望为肠道疾病的检查和治疗应用提供无损和对患者友好的新方法。

关键词：软体机器人仿水蛭肠道检查

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MnCeTiO_(x)协同催化脱除氮氧化物与氯苯研究

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环境科学学报 2024年第3期44卷 345-353页

作者：汪振辉顾秋香杨波王刘莹雷玉杰黄琼陈敏东江苏省大气环境与装备技术协同创新中心江苏省大气环境监测与污染控制高技术研究重点实验室南京信息工程大学环境科学与工程学院南京210044

垃圾焚烧过程中会产生大量的氮氧化物(NO_(x))和含氯挥发性有机物(氯苯(CB)为代表).选择性催化还原(SCR)技术中脱硝催化剂可协同脱除氮氧化物与氯苯.而针对垃圾焚烧尾气,研究和开发可在除尘后布置的中低温(<250℃)协同脱除NO_(x)与CB的... 详细信息

垃圾焚烧过程中会产生大量的氮氧化物(NO_(x))和含氯挥发性有机物(氯苯(CB)为代表).选择性催化还原(SCR)技术中脱硝催化剂可协同脱除氮氧化物与氯苯.而针对垃圾焚烧尾气,研究和开发可在除尘后布置的中低温(<250℃)协同脱除NO_(x)与CB的催化剂对垃圾焚烧尾气污染物的控制至关重要.本文通过溶胶凝胶法制备一系列TiO_(x)掺杂的MnCeTiO_(x)催化剂,当Mn、Ce、Ti物质的量比为5∶1∶5时,5MnCe5TiO_(x)在160~220℃反应温度区间内,对NO_(x)的脱除效率≥95%,对氯苯的脱除效率≥90%.Ti的掺杂可促进MnCeO_(x)催化剂表面缺陷、表面吸附氧及微孔的生成,提高MnCeO_(x)催化剂氧化还原性能与表面活性Mn^(4+)的浓度.同时,反应机理研究表明,MnCeTiO_(x)协同脱除催化脱除NO_(x)与CB过程中,NH3与CB会产生竞争吸附;单齿复合亚硝酸、线性亚硝酸、桥接硝酸盐等是反应的主要中间体.

关键词：氮氧化物氯苯协同脱除 MnCeTiO_(x)

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前置式蒸汽冷却器管系泄漏检测研究

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电站辅机 2024年第2期45卷 27-31页

作者：樊进国邓科季敏东东方电气集团东方锅炉股份有限公司四川成都611731

前置式蒸汽冷却器是电站回热系统中的一个重要设备,位于回热系统给水流程的最后一级,它利用中压抽汽的过热度加热给水,进一步提高进入省煤器的给水温度。其壳侧为低压、高温的过热蒸汽,管侧为高压给水,管系泄漏会导致给水喷射到壳侧,高... 详细信息

前置式蒸汽冷却器是电站回热系统中的一个重要设备,位于回热系统给水流程的最后一级,它利用中压抽汽的过热度加热给水,进一步提高进入省煤器的给水温度。其壳侧为低压、高温的过热蒸汽,管侧为高压给水,管系泄漏会导致给水喷射到壳侧,高速流动的蒸汽裹挟给水水滴冲刷换热管,导致周围换热管损坏,影响设备寿命和换热能力。通过分析前置式蒸汽冷却器管系泄漏的类型和危急疏水排放类型,结合前置式蒸汽冷却器运行特点,提出了采用温差检测换热管泄漏的方法,简述了该方法的原理、组成和优点。温差检测换热管泄漏法相比常规的液位检测方法具有优势,可以低成本、快捷地检测前置蒸冷器管系泄漏。

关键词：蒸汽冷却器温差爆管管系泄漏控制

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Application of MnCeO_(x)supported on palygorskite and Al(OH)_(3)for HCHO oxidation:Catalytic performance and stability

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Journal of Rare Earths 2022年第12期40卷 1860-1869,I0002页

作者： Qiong Huang Lirui Xu Yao Xiao Jie Zhu Guofang An Peiyang Li Bo Yang mindong Chen Hong Yang Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technologies Jiangsu Key Laboratory of Atmospheric Environmental Monitoring&Pollution ControlSchool of Environmental Science&EngineeringNanjing University of Information Science&TechnologyNanjing 210044China Department of Geography and Environmental Science University of ReadingWhiteknightsReadingRG66ABUK

Indoor formaldehyde(HCHO)is an important air pollutant,while it is very difficult to reduce HCHO to low-level(e.g.<0.08 mg/m^(3)).Catalytic oxidation at ambient temperature has been increasingly recognized as one of the important methods to mitigate HCHO pollution due to its good effectiveness,stability,and recyclability.To further improve the activity of catalytic oxidation,this study develops the integrated MnCeO_(x)catalysts supported on palygorskite(Pal)and aluminium hydroxide(Al(OH)_(3)).Our results indicate that the synergistic interaction in MnCeO_(x)through the oxygen transfer mechanism from the oxygen reservoir CeO_(2)to MnOxsignificantly improves the activity.Pal,Al(OH)_(3),etc.were applied as the supports with a focus on their dispersion,microstructure,strength,and relative role.MnCeO_(x)can be anchored on the surface of Al(OH)_(3)with high dispersion.With the integrated catalyst,HCHO concentration decreases from 1.012 to 0.086 mg/m^(3)within 48 h.Higher oxidation activity of MnCeO_(x)powder may be ascribed to the amount of active components on the surface.The incorporation of ZSM-5 and activated carbon can improve the adsorption of HCHO,and all integrated catalysts exhibit stronger activities,with HCHO being degraded to the level lower than 0.08 mg/m^(3).Meantime,the samples exhibit good stability and strength(20.2 MPa)without obvious decrease over five consecutive stability experiments.

关键词： MnCeOx Integrated catalysts Catalytic oxidation HCHO Ambient temperature Rare earths

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污水厂更严格排放标准设计案例分析--以青岛市某工业园污水厂为例

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净水技术 2024年第3期43卷 174-180页

作者：陈民东邓浩王宝娟庄贵李超超青岛腾远设计事务所有限公司山东青岛266100 胶州首创博瑞水务有限公司山东胶州266300 胶州市住房和城乡建设局山东胶州266300

青岛地区很多工业企业向乡镇集中,乡镇污水处理厂同时接纳生活污水及工业废水较为普遍。该项目近期设计规模为3000 m^(3)/d,进水中约2/3为工业废水,其中含有大量难降解污染物的多元生物废水量为300 m^(3)/d,而出水标准为准Ⅳ类(除TN外)... 详细信息

青岛地区很多工业企业向乡镇集中,乡镇污水处理厂同时接纳生活污水及工业废水较为普遍。该项目近期设计规模为3000 m^(3)/d,进水中约2/3为工业废水,其中含有大量难降解污染物的多元生物废水量为300 m^(3)/d,而出水标准为准Ⅳ类(除TN外),多元生物废水采用臭氧预氧化单独处理后接入生化系统,生化段采用改良型AAO+AO工艺,TN去除全部在生物池实现,深度处理采用高效沉淀池+臭氧催化+砂滤+接触消毒工艺,项目投运后,CODCr、TN、TP去除率分别为96.38%、86.97%、98.70%,出水水质稳定达到设计标准,可为同类型污水处理厂设计提供参考。

关键词：难降解污染物改良型 AAO+AO 工艺高效沉淀池催化臭氧氧化乡镇污水处理

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Treatment of Microalgae in Ballast Water Using Hydroxyl Radical in Accordance with the D-2 Ballast Water Discharge Standard

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高电压技术 2014年第1期40卷 232-236页

作者： MENG Xiangying CHEN Cao BAI mindong SUN Jian MENG Fanpeng Institute of Marine Engineering Department of PhysicsDalian Maritime University College of Environment and Ecology Xiamen University

The effect of hydroxyl radical(·OH) on microalgae in ballast water is experimentally investigated. An ?OH plasma generator, which has a thin plate discharge Ag electrode covered by two α-Al2 O3 dielectric layers, is built. The plasma generator is filled with O2 and gaseous H2 O and is powered by a homemade power supply. ?OH radicals are generated by a series of plasma reactions and then dissolved into ballast water to kill microalgae. The maximum density of the killed microalgae is about 11 000 cells per milliliter. At this density, the microalgae are not reactivated at the 48th hour and the 120th hour in the treated ballast waters, and the content of chlorophyll in these microalgae decreases by 100%. The water quality returns to a normal level after 120 hours without secondary pollution of aquatic organisms and environment. These results show that the requirements of the D-2 ballast water discharge standard defined by the International Maritime Organization(IMO) are satisfied with the proposed treatment, and that ·OH is an ideal substance for killing microalgae during ballast water replacement of ships.

关键词：压载水处理排放标准微藻羟自由基等离子体发生器国际海事组织俄亥俄州最大密度

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Gravimetric analysis for PM_(2.5) mass concentration based on year-round monitoring at an urban site in Beijing

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Journal of Environmental Sciences 2016年第2期28卷 154-160页

作者： Yanli Wang Wen Yang Bin Han Wenjie Zhang mindong Chen Zhipeng Bai State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science & Technology

Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon（T1/T2） and Quartz（Q1/Q2） samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_（2.5）mass concentration of 102 μg/m^3. According to the calculated PM_（2.5）mass concentration, 50% of our sampling days were acceptable（PM_（2.5）〈 75 μg/m^3）, 30% had slight/medium pollution（75–150 μg/m^3）, and 7% had severe pollution（〉 250 μg/m^3）. Sampling interruption occurred frequently for the Teflon filter group（75%） in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_（2.5）combined with high relative humidity（RH） gave rise to the interruptions. The seasonal variation of PM_（2.5）was presented, with higher monthly average mass concentrations in winter（peak value in February, 422 μg/m^3）, and lower in summer（7 μg/m^3 in June）. From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_（2.5）. The case of February presented the most serious pollution, with monthly averaged PM_（2.5）of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_（2.5）in winter could be related to increased coal consumption for heating needs.

关键词： PM_（2.5） Gravimetric analysis Sampling interruption Pollution level Relative humidity（RH） Seasonal variation

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Mn-Ce-Nb-O_x/P84 catalytic filters prepared by a novel method for simultaneous removal of particulates and NO

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Journal of Rare Earths 2019年第3期37卷 273-281页

作者： Bo Yang Qiong Huang mindong Chen Yuesong Shen Shemin Zhu Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CICAEET) Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control School of Environmental Science and Engineering Nanjing University of Information Science & Technology Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) College of Materials Science and Engineering Nanjing Tech University

The Mn-Ce-Nb-O_x/P84 catalytic filter for removal of particulates and NO simultaneous was prepared by a novel method(foam coating method). The process parameters including the concentrations of PTFE emulsion, particle size of catalyst and calcination temperature for preparation of catalytic filters were analyzed. In addition, the physical properties and performance for removal of NO(NH_3-SCR) and particulates of Mn-Ce-Nb-O_x/P84 catalytic filter prepared under the optimized parameters, were also systematic studied. Results show that the process parameters had significant influences on stability and performance of catalytic filter, The Mn-Ce-Nb-O_x/P84 catalytic filter prepared by foam coating method under the optimized parameters, has satisfactory physical properties and catalytic performance for removal of NO and particulates at 140-220 ℃. The NO removal efficiency of catalytic filter can reach95.3% at 200 ℃ as the catalyst loading amount is 450 g/m^2, Moreover,the dust removal efficiency of MnGe-Nb-O_x/P84 catalytic filter reaches as high as 99.98%, and the PM2.5 removal efficiency also reaches99.98%. The anti-sulfur performance of Mn-Ce-Nb-O_x catalytic filter is also attractive, after injecting150 ppm SO_2, the NO removal efficiency still retains up to 85%. It is indicated that the foam coating method can not only make a bond of high strength between catalyst and filter, but also make the catalytic filter possessing an excellent and stable performance for removal of NO and particulates.

关键词： Foam coating method Simultaneous removal Mn-Ce-Nb-O_x/P84 catalytic filters NO Particulates Preparation method

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Data mining to effect of key alloying elements on corrosion resistance of low alloy steels in Sanya seawater environmentAlloying Elements

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Journal of Materials Science & Technology 2021年第5期64卷 222-232页

作者： Xin Wei Dongmei Fu mindong Chen Wei Wu Dequan Wu Chao Liu School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Beijing Engineering Research Center of Industrial Spectrum Imaging University of Science and Technology BeijingBeijing 100083China SINOPEC Research Institute of Safety Engineering Qingdao266100China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China

In this paper,the relationship model between seawater environment,chemical composition and corrosion potential of low alloy steel is established and the distribution of corrosion potential of low alloy steel with changes in key alloying elements is excavated.The research was carried out with the following steps:Firstly,the relationship model between corrosion potential of low alloy steel and its influencing factors was established by data dimension reduction and artificial neural network(ANN).Secondly,key alloying elements of experimental steels were selected out by Pearson correlation analysis,then the corrosion resistance element model was visualized to show the effect of key alloying elements on corrosion potential of low alloy steel.Finally,corrosion potential of low alloy steel with the change of key alloying elements was classified and visualized by classification method.The mining results can reflect the validity of the proposed mining methods to a certain extent and provide an intuitive data basis for the development of high-quality and low-cost low alloy steels.

关键词： Low alloy steel Corrosion potential Key alloying elements Corrosion-resistant alloy Artificial neural network Data-driven model

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