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Journal of Rare Earths 2024年第6期42卷 1020-1028,I0001页

作者： yan Lei Guangzhi Zhang Yitong Yao Gaiqin zhu Zhong Chen Jiangrong Dan Hua Liu Shuwang Duo School of Materials and Mechanical and Electrical EngineeringJiangxi Science and Technology Normal University Nanchang330013China

ZnS and ZnS:3.125%Ce^(3+)(ZSC)quantum dots(QDs)were synthesized by a low-temperature solid-phase *** crystal structure,photoluminescence(PL)properties of ZSC QDs,and their effects on the growth and kojic acid production of Aspergillus oryzae(***)were *** is found that both QDs have a cubic blend structure with the average particle size ranging of 2.75-6.14 ***^(3+)doping not only increases the band gap of ZnS QDs from 3.43 to 3.48 eV,but also increases the PL intensity by about 2.23 times,which is due to the fact that the electron carrier concentration is improved,and then the rate of radiative recombination is *** integral emission intensity,biomass,extracellular proteins yield,and kojic acid production of *** cultured with ZSC(ZnS)QDs are about 4.31(3.23),1.61(1.20),1.12(1.09),and 2.99(1.68)times higher than that of medium without QDs,respectively.

关键词： Zns Quantum dots Doping First-principles calculations Aspergllus oryzae Rare earths

Pre-mating nitenpyram exposure in male mice leads to depression-like behavior in offspring by affecting tryptophan metabolism in gut microbiota

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Journal of Environmental Sciences 2024年第3期137卷 120-130页

作者： Sen yan Wei Sun Sinuo Tian Zhiyuan Meng Jinling Diao Zhiqiang Zhou Li Li Wentao zhu Innovation Center of Pesticide Research Department of Applied ChemistryCollege of ScienceChina Agricultural UniversityBeijing 100193China College of Plant Protection/Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009China College of Plant Protection Shanxi Agricultural UniversityTaiyuan 030031China

Several studies have confirmed that the health status of the paternal affects the health of the offspring,however,it remains unknown whether paternal exposure to pesticides affect the offspring ***,we used untargeted metabolomics and 16S rRNA sequencing technology,combined with tail suspension test and RT-qPCR to explore the effects of paternal exposure to nitenpyram on the neurotoxicity of *** results found that the paternal exposure to nitenpyram led to the offspring’s depressive-like behaviors,accompanied by the reduction of tryptophan content and the disorder of microbial abundance in the gut of the ***,we determined the expression of tryptophan metabolism-related genes tryptophanase(tnaA)and tryptophan hydroxylase 1(TpH1)in gut bacteria and colonic *** found that tryptophan is metabolized to indoles rather than being absorbed into colonocytes,which coursed the reduce of tryptophan availability after nitenpyram *** conclusion,our study deepens our understanding of the intergenerational toxic effects of pesticides.

关键词： Nitenpyram Depressive-like behaviors Gut microbiota Tryptophan metabolism

A novel optical emission spectroscopy method for diagnostics of contribution of different ionization mechanisms and flux of ions in different valences in discharge channel of a Hall thruster

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Chinese Journal of Aeronautics 2024年第4期37卷 294-307页

作者： yanfei WANG Ximing zhu Renqiu ZOU Shilin yan Junwei JIA Zhongxi NING Daren YU School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Aerospace Plasma Propulsion Ministry of Industry and Information TechnologyHarbin 150001China Beijing Orient Institute of Measurement and Test Beijing 100094China Beijing Aerospace Long March Aircraft Research Institute Beijing 100076China

The mass application of Hall thrusters poses the need for a diagnostic method of ionization mechanism in the discharge channel to boost the iteration and optimization of thruster *** work presents an Optical Emission Spectroscopy (OES) method for diagnostics of the contribution of different ionization mechanisms and the flux of ions in different valences in the discharge channel of a Hall *** emission spectra in the discharge channel are analyzed by jointly utilizing a collisional-radiative model,an ionization-excitation model,and a flux-conservation *** is found that the intensities of some spectral lines can be converted into the reaction rates of collision processes,e.g.,electron-induced excitation and ionization *** latter can further be used to determine the evolutions of particle fluxes by utilizing the conservation law of *** novel method is demonstrated on a kilo-watt Hall *** evolutions of several parameters are determined using this method along the discharge channel,including the ionization rates of different mechanisms,particle fluxes,particle densities,and particle *** novel method can be further developed by being jointly utilized with spectral imaging and tomography techniques,enabling diagnostics of multi-dimensional distributions of the above-mentioned parameters in the discharge channel and near-field plume.

关键词： Hall thruster Optical emission spectroscopy Ionization mechanism Particle flux Divalent ion

Insights into the mechanism of L-malic acid on drip loss of chicken meat under commercial conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1312-1324页

作者： Haijun Sun Xue yan Lu Wang Ruimin zhu Meixia Chen Jingdong Yin Xin Zhang State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China New Hope Liuhe Co. Ltd./Key Laboratory of Feed and Livestock and Poultry Products Quality&Safety ControlMinistry of AgricultureChengduSichuan 610023China Institute of Animal Husbandry and Veterinary Medicine Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Background A deterioration in the meat quality of broilers has attracted much more attention in recent years.L-malic acid(MA)is evidenced to decrease meat drip loss in broilers,but the underlying molecular mechanisms are still ***’s also not sure whether the outputs obtained under experimental conditions can be obtained in a com-mercial ***,we investigated the effects and mechanisms of dietary MA supplementation on chicken meat drip loss at large-scale *** Results showed that the growth performance and drip loss were improved by MA *** metabolome revealed that L-2-aminoadipic acid,β-aminoisobutyric acid,eicosapentaenoic acid,and nicotinamide,as well as amino acid metabolism pathways connected to the improvements of meat quality by MA *** transcriptome analysis further indicated that the effect of MA on drip loss was also related to the proper immune response,evidenced by the enhanced B cell receptor signaling pathway,NF-κB signaling pathway,TNF signaling pathway,and IL-17 signaling *** We provided evidence that MA decreased chicken meat drip loss under commercial *** and transcriptome revealed a comprehensive understanding of the underlying ***,MA could be used as a promising dietary supplement for enhancing the water-holding capacity of chicken meat.

关键词： Drip loss Immune response L-malic acid Meat quality Metabolome Transcriptome

The changes in the annual distribution of mountain runoff during the period of 1965-2018 in Hexi Corridor,Northwest China

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Research in Cold and Arid Regions 2024年第2期16卷 73-83页

作者： yan Luo ZhiXiang Lu Qi Feng Meng zhu JinBo Zhang Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China cCollege of Resources and Environmental Sciences Gansu Agricultural UniversityLanzhouGansu 730000China

The annual distribution characteristics of river runoff in arid regions have significant implications for water resource stability and *** on the mountain runoff data from 1965 to 2018,this study examines the annual change characteristics of monthly runoff of the Shiyang River Basin,Heihe River Basin,and Shule River Basin in the Hexi Corridor,Northwest *** indexes are used and analyzed,including the coefficient of variance,the complete regulation coefficient,the concentration degree and concentration period,the magnitude of change,the skewness coefficient,and the kurtosis coefficient of the annual distribution *** results reveal the following:(1)The inhomogeneity of annual runoff distribution in the Taolai River and the rivers to the west of it,except the Shiyou River,show an increasing ***,the inhomogeneity of the rivers to the east of the Taolai River generally show a downward trend,but the coefficient of variance value is still very high.(2)In the Shiyang River Basin,the annual distribution of the concentration period is characterized by a relatively discrete ***,the Heihe River Basin exhibits a relatively concentrated pattern,and the distribution pattern of the Shule River Basin is quite ***,all concentration periods in the three basins have shifted backward after the 2000s.(3)The Shiyang River Basin exhibits disordered annual distribution curves of runoff in different *** contrast,the Heihe River Basin presents a typical‘single-peak’pattern with a prominent *** Shule River Basin has regular distribution curves,with a gradually significant‘double-peak’pattern from east to ***,there has been a slight change in runoff in the Shiyang River Basin,while the Heihe River Basin and Shule River Basin have experienced significant increases in *** annual distribution curves of runoff in the Liyuan River and the rivers to the east of it exhibit a gentle peak pattern,and th

关键词： Hexi Corridor Inland rivers Mountain runoff Annual distribution characteristics of runoff

Brain mechanism of acupuncture for children with anisometropic amblyopia: a resting functional magnetic resonance imaging study based on voxel-mirrored homotopic connectivity

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 339-347页

作者： Jue Wang Jing Jia yan Sun Chong-Bing Ma Yu-zhu Chen An-Guo Liu Xing-Ke yan College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730101Gansu ProvinceChina Department of Ophthalmology Lanzhou Purui Ophthalmology HospitalLanzhou 730050Gansu ProvinceChina

AIM:To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxelmirror homotopic connectivity(VMHC)analysis method of resting functional magnetic resonance imaging(rs-fMRI)technology based on clinical ***:Eighty children with anisometropic monocular amblyopia were randomly divided into two groups:control(40 cases,1 case of shedding)and acupuncture(40 cases,1 case of shedding)*** control group was treated with glasses,red flash,grating,and visual stimulations,with each procedure conducted for 5min per *** on routine treatment,the acupuncture group underwent acupuncture of“regulating qi and unblocking meridians to bright eyes”,Jingming(BL1),Cuanzhu(BL2),Guangming(GB37),Fengchi(GB20)acupoints were taken on both sides,with the needle kept for 30min each *** groups were treated once every other day,three times per week,for a total of *** the treatment,the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were *** the same time,nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rsfMRI before and after *** differences in the brain regions between the two groups were compared and analyzed with ***:Chi-square test showed a notable difference in the total efficiency rate between the acupuncture(94.87%)and control groups(79.49%).Regarding the P100 wave latency and amplitude,the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control ***,the VMHC values of the bilateral temporal lobe,superior temporal gyrus,and middle temporal gyrus were notably increased in the acupuncture group after ***:Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic ***

关键词： resting functional magnetic resonance imaging voxel-mirror homotopy connection anisometropic amblyopia acupuncture

Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting yang Kang Chao Xia zhu Xue-Ding Wang Sumyuet Chan yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

AKT2^(S128)/CCTα^(S315/319/323)-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 782-796页

作者： Jie Chen Lingyuan Zhang Yuheng zhu Di Zhao Jing Zhang yanmeng zhu Jingyuan Pang Yuanfan Xiao Qingnan Wu yan Wang Qimin Zhan Key Laboratory of Carcinogenesis and Translational Research(ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina Peking University International Cancer Institute Peking University100191 BeijingChina Research Unit of Molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer Institute Suzhou 215000China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518107China

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic *** study employed multi-omics,including phosphoproteomics,untargeted metabolomics and lipidomics,to demonstrate that the pAKT2 Ser128 and pCCTαSer315/319/323-positive cancer-associated fibroblasts(CAFs)substantially release phosphatidylcholines(PCs),contributing to the resistance of focal adhesion kinase(FAK)inhibitors in esophageal squamous cell carcinoma(ESCC)***,we observed extremely low levels of FAK Tyr397 expression in CAFs,potentially offering no available target for FAK inhibitors playing their anti-growth role in ***,FAK inhibitor increased the intracellular concentration of Ca2+in CAFs,promoting the formation of AKT2/CCTαcomplex,leading to phosphorylation of CCTαSer315/319/323 sites and eventually enhancing stromal PC *** activation could stimulate the intratumoral Janus kinase 2(JAK2)/Signal transducer and activator of transcription 3(STAT3)pathway,triggering resistance to FAK *** of clinical samples demonstrated that stromal pAKT2 Ser128 and pCCTαSer315/319/323 are related to the tumor malignancy and reduced patient ***-targeted lipidomics and further validation cohort quantitatively showed that plasma PCs enable to distinguish the malignant extent of ESCC *** conclusion,inhibition of stroma-derived PCs and related pathway could be possible therapeutic strategies for tumor therapy.

关键词： CAFs metabolism resistance

High photoluminescence Ag-In-Ga-S quantum dots based on ZnX_(2)-treated surface passivation

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Nano Research 2024年第8期17卷 7533-7541页

作者： Danni yan Yuhui Dong Naiwei Wei Shuai yang Hong zhu Wanzhong Gu Yousheng Zou Haibo Zeng MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics&NanomaterialsSchool of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

Quaternary Ag-In-Ga-S(AIGS)quantum dot(QD)is considered a promising,spectral-tunable,and environmentally friendly luminescent display ***,the more complex surface defect states of AIGS QDs resulting from the coexistence of multiple elements lead to a low(minescence quantum yield(PLQY).Here,we develop a novel convenient method to introduce Z-type ligands ZnX_(2)(X=Cl,Br,I)for passivating the surface defects of AIGS QDs to dramatically enhance the PLQY and stability without affecting the crystalline structure and *** show that the addition of ZnCl_(2)during the purified process of AIGS QDs leads to a 3-fold increase of PLQY(from 28.5%to 87%).Impressively,the highest PLQY is up to a recorded value of 92%,which is comparable to typical heavy metal *** dynamics studies have shown that the rapid annihilation process of excitons in treated QDs is *** also confirm that the improvement in PLQY is a result of the effective passivation of the non-coordinating atom on the QD surface by building a new bonding between sulfur dangling and Zn2+.The realization of high PLQY will further promote the application of AIGS QDs in luminescent displays.

关键词： I-III-VI quantum dots Ag-In-Ga-S surface defect passivation Z-type ligand photoluminescence quantum yield

Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model

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Journal of Pharmaceutical Analysis 2024年第4期14卷 585-600页

作者： Yuanyuan Qian Xiting Wang Lulu Cai Jiangxue Han zhu Huang Yahui Lou Bingyue Zhang yanjie Wang Xiaoning Sun yan Zhang Aisong zhu Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome Zhejiang Chinese Medical UniversityHangzhou310000China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China Zhejiang Engineering Research Center for“Preventive Treatment”Smart Health of Traditional Chinese Medicine Zhejiang Chinese Medical UniversityHangzhou310000China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou310000China Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang110032China Academy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou310000China

Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex *** characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(DeepTCM).DeepTCM has gone through multilevel model calibration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(TCM).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the ***,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease ***,we experimentally confirmed the therapeutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and *** novel multiscale model opened up a new avenue to combine“disease syndrome”and“macro micro”system modeling to facilitate translational research in CHM formulas.

关键词： Chinese herbal medicine formulas Precision medicine Mathematical modeling Systems biology Coronary heart disease Depression Ischemia-reperfusion Inflammation