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Molecular mechanisms of ZD1839 (Iressa)-induced apoptosis in human leukemic U937 cells

Acta Pharmacologica Sinica 2007年第8期28卷 1205-1214页

作者： Dong-oh MOON Moon-ok kiM Jae-dong lee Yung-hyun CHOI min-ki lee Gi-young kiM Faculty of Applied Marine Science Cheju National UniversityJeju Special Self-Governing Province 690-756Republic of Korea Department of Microbiology Pusan National UniversityBusan 614-052Republic of Korea Department of Biochemistry Dongeui University College of Oriental MedicineBusan 614-052Republic of Korea Department of Internal Medicine Pusan National University College o MedicineBusan 602-739Republic of Korea

Aim:To investigate the molecular mechanisms of ZD1839-induced apoptosis inhuman leukemic U937 ***:The inhibition of human leukemic U937 cellgrowth was assessed by 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphnyl-2H-tetrazolimbromide（MTT）assays,lactate dehydrogenase（LDH）release,and cell *** expression of anti- and pro-apoptotic proteins was detected byWestern blot ***:This study demonstrated that ZD 1839 inducedapoptosis in leukemic U937 cells by the downregulation of Bcl-2,caspase activa-tion and subsequent apoptotic *** with ZD 1839 and the caspase-3 inhibitor z-DEVD-fmk blocked apoptosis,indicating that caspase-3 activation isat least partially responsible for ZD1839-induced *** ectopic expres-sion of Bcl-2 attenuated caspase-3 activation,PARP cleavage,and subsequentindicators of apoptosis,including sub-G1DNA content and LDH *** indicate that the downregulation of Bcl-2 plays a major role in the initiationof ZD1839-induced apoptosis,and that the activation of a caspase cascade isinvolved in the execution of ***,ZD 1839 treatment triggeredthe activation of p38 mitogen-activated protein kinase（MAPK）and the down-regulation of c-Jun-N-terminal kinase（JNK）,extracellular signal-regulated kinase（ERK）and phosphatidyl inositol 3-kinase（PI3K）/*** inhibition of the ERKand PI3K/Akt pathways also significantly increased cellular ***:ZD 1839 activated caspase-3 and the inhibited Bcl-2 in human leukemic U937 cellsthrough the downregulation of the ERK and PI3K/Akt pathways.

关键词： ZD1839(Iressa) apoptosis caspase-3 Bcl-2 mitogen-activated protein kinases

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Deformation prediction of porcelain-enameled steels with strain history by press forming and high-temperature behavior of coating layer

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中国有色金属学会会刊：英文版 2012年第S3期22卷 838-844页

作者： Young-ki SON Chan-Joo lee Jung-min lee Byung-min kiM School of Mechanical Engineering Pusan National University Dongnam Regional Division Korea Institute of Industrial Technology

Porcelain enamel coatings were widely applied for the protection of steel products because they offered high corrosion protection,resistance to heat and abrasion,high hardness,hygiene and ease of *** typical process to produce enameled steels is roughly divided into two stages:the first stage consists of a forming process to give the desired shape to a steel substrate,and the second stage consists of a firing process to bond enamel frits on the *** firing process requires a high temperature above 800 °C,which may lead to austenitic transformation and severe thermal deformation of the steel *** aim of this study is to develop a finite element analysis (FE analysis) technique to predict the mechanical and thermal deformations of the enameled steels during forming and any further enameling process,including *** FE analysis involves analyzing the strain history of the steel substrate,which comprises the stress and thickness distributions of the substrate and its deformed shape,and the high-temperature behavior of the enamel coating *** validity of the FE analysis is verified through the U-bending test and firing test with various numbers and positions of enamel coating layers on the *** results reveal that the FE analysis results agree well with the experimental results with 8% error.

关键词： porcelain enamel firing process finite element analysis enameled steel thermal deformation

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DICE:An Effective Query Result Cache for Distributed Storage Systems

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Journal of Computer Science & Technology 2010年第5期25卷 933-944页

作者： Jun-ki min Member, A CM Mi-Young lee School of Computer Science and Engineering Korea University of Technology and Education Byeongcheon-myeon Cheonan Chungnam 330-708 Korea Cloud Computing Research Department Electronics and Telecommunications Research Institute (ETRI) Daejeon 305-700 Korea

Due to the proliferation of Internet and Intranet,the distributed storage systems have received a lot of attention. These systems span a large number of machines and store huge amount of data for a lot of *** the distributed storage systems,a row can be directly accessed using a row *** concentrate on a problem of efficient processing of queries whose predicate is on a column but not a row *** this paper,we present a cache management technique,called DICE which maintains query results of range queries to support the next range *** accelerate the search time of the cached query results,we use modified Interval Ski *** addition,we devise a novel cache replacement policy since DICE maintains an interval rather than a data *** our cache replacement policy considers the properties of intervals,our proposed technique is more efficient than traditional buffer replacement *** experimental result demonstrates the efficiency of our proposed technique.

关键词： distributed system range query query caching Interval Skip List cache replacement

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Effects of 3D deformation and nonlinear stress–strain relationship on the Brazilian test for a transversely isotropic rock

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第12期15卷 3221-3229页

作者： Juhyi Yim Yoonsung lee Seungki Hong ki-Bok min R&D Center Hyundai Engineering and Construction75Yulgok-roJongno-guSeoulRepublic of Korea Department of Energy Systems Engineering and Research Institute of Energy and Resources Seoul National University1Gwanak-roGwanak-guSeoul08826Republic of Korea

To improve the accuracy of indirect tensile strength for a transversely isotropic rock in the Brazilian test, this study considered the three-dimensional (3D) deformation and the nonlinear stress–strain relationship. A parametric study of a numerical Brazilian test was performed for a general range of elastic constants, revealing that the 3D modeling evaluated the indirect tensile strength up to 40% higher than the plane stress modeling. For the actual Asan gneiss, the 3D model evaluated the indirect tensile strength up to 10% higher and slightly enhanced the accuracy of deformation estimation compared with the plane stress model. The nonlinearity in stress–strain curve of Asan gneiss under uniaxial compression was then considered, such that the evaluated indirect tensile strength was affected by up to 10% and its anisotropy agreed well with the physical intuition. The estimation of deformation was significantly enhanced. The further validation on the nonlinear model is expected as future research.

关键词： Anisotropy Transversely isotropy Brazilian test Indirect tensile strength Nonlinearity 3D modeling

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Electrochemical characteristics of HVOF spray coated layer with WC-27NiCr and WC-10Co4Cr for Al bronze

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中国有色金属学会会刊：英文版 2012年第S3期22卷 753-759页

作者： min-su HAN Seung-jun lee min-sung kiM Seok-ki JANG Seong-jong kiM Division of Marine Engineering Mokpo Maritime University

Among the environmentally friendly marine energies,tidal current power plants require low cost because they do not need to construct a large *** power is particularly reliable energy source because the power generation capacity is predictable regardless of weather or *** materials or stainless steel have been used as materials of blades for current power ***,their strength and welding performance generated many problems in field *** alloys with excellent cavitation resistance and corrosion resistance were applied as blade materials to improve the durability of copper *** were coated with WC-27NiCr and WC-10Co4Cr using the high velocity oxy-fuel (HVOF) *** metal spray coating technology has the advantage in terms of the selection of materials for cost effectiveness and environmental effects of corrosion because the properties of the coat layer can be controlled *** with WC-27NiCr and WC-10Co4Cr by HVOF,WC-27NiCr shows better corrosion resistance *** reason for this seems to be that corrosion resistance improves and a stable passive film forms due to the effects of Ni and Cr.

关键词： tidal power copper alloys HVOF coating corrosion resistance

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A Case Study of Mesoscale Convective Band(MCB) Development and Evolution along a Quasi-stationary Front

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Advances in Atmospheric Sciences 2014年第4期31卷 901-915页

作者： Daeun JEONG ki-Hong min Gyuwon lee Kyung-Eak kiM Climate Research Department Asia-Pacific Economic Cooperation Climate Center Center for Atmospheric Remote Sensing Kyungpook National University Department of Astronomy and Atmospheric Sciences Kyungpook National University Department of Earth Atmospheric and Planetary Sciences Purdue University

This paper presents a case study of mesoscale convective band （MCB） development along a quasi-stationary front over the Seout metropolitan *** MCB,which initiated on 1500 UTC 20 September 2010 and ended on 1400 UTC 21 September 2010,produced a total precipitation amount of 259.5 *** MCB development occurred during a period of tropopause folding in the upper level and moisture advection with a low-level *** analyses show that the evolution of the MCB can be classified into five periods：（1） the cell-forming period,when convection initiated; （2） the frontogenetic period,when the stationary front formed over the Korean peninsula; （3） the quasi-stationary period,when the convective band remained over Seoul for 3 h; （4） the mature period,when the cloud cover was largest and the precipitation rate was greater than 90 mm h-1; and （5） the dissipating period,when the MCB diminished and *** synoptic,thermodynamic,and dynamic analyses show that the MCB maintained its longevity by a tilted updraft,which headed towards a positive PV *** was concentrated under this area,where a tilted ascending southwesterly converged with a tilted ascending northeasterly,at the axis of cyclonic *** formation of the convective cell was attributed in part by tropopause folding,which enhanced the cyclonic vorticity at the surface,and by the low-level convergence of warm moist air and upperlevel *** southwesterly flow ascended in a region with high moisture content and strong relative vorticity that maintained the development of an MCB along the quasi-stationary front.

关键词： convective band quasi-stationary front potential vorticity tropopause folding heavy precipitation

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Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development

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World Journal of Gastroenterology 2013年第7期19卷 984-993页

作者： min-Yu Chung Tae Gyu Lim ki Won lee WCU Biomodulation Major Center for Food and BioconvergenceDepartment of Agricultural BiotechnologySeoul National UniversitySeoul 151-742South Korea Advanced Institutes of Convergence Technology Seoul National UniversitySuwon 443-270South Korea

Cancer is one of the leading causes of death *** used cancer treatments,including chemotherapy and radiation therapy,often have side effects and a complete cure is sometimes ***,prevention,suppression,and/or delaying the onset of the disease are *** onset of gastroenterological cancers is closely associated with an individual's ***,changing lifestyle,specifically the consumption of fruits and vegetables,can help to protect against the development of gastroenterological *** particular,naturally occurring bioactive compounds,including curcumin,resveratrol,isothiocyanates,(-)-epigallocatechin gallate and sulforaphane,are regarded as promising chemopreventive ***,regular consumption of these natural bioactive compounds found in foods can contribute to prevention,suppression,and/or delay of gastroenterological cancer *** this review,we will summarize natural phytochemicals possessing potential antioxidant and/or anti-inflammatory and anti-carcinogenic activities,which are exerted by regulating or targeting specific molecules against gastroenterological cancers,including esophageal,gastric and colon cancers.

关键词： Curcumin Resveratrol (-)-Epigallocatechin gallate Isothiocyanates Sulforaphane Gastroenterological cancers Molecular target

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Factor analysis of recent major heatwaves in East Asia

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Geoscience Frontiers 2024年第1期15卷 374-383页

作者： Arim Yoon Jeongwon kim Jooyeop lee Hyun min Sung Je-Woo Hong Seung-ki min Junhong lee Jinkyu Hong Ecosystem-Atmosphere Process Laboratory Department of Atmospheric SciencesYonsei UniversitySeoul 03722Republic of Korea National Institute of Meteorological Sciences Jeju 63568Republic of Korea Korea Adaptation Center for Climate Korea Environment InstituteSejong 30121Republic of Korea Division of Environmental Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Max Planck Institute for Meteorology Hamburg 20146Germany Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoulRepublic of Korea

Heatwaves(HWs)present a major hazard to our society and more extreme heatwaves are expected with future climatic ***,it is important to improve our understanding of the underlying processes that drive HWs,in order to boost our socioeconomic-ecological *** this study,we quantified the influences of key driving factors(large-scale atmospheric circulation,soil moisture,and sea surface temperature)and their synergies on recent heatwaves in East *** conducted a factor separation analysis for three recent HW events by constraining the key factors in the regional Weather Research and Forecasting model with their climatologies or pseudo-observations in different *** study showed distinct spatial variations in the HW-controlling factors in East *** synergistic interaction of large-scale circulation and soil moisture was the most important factors in the 2013 Chinese *** the 2018 HWs in Korea and Japan,the same stagnant large-scale atmospheric circulation played a dominant role in driving the HW *** land-atmosphere coupling via soil moisture,its interaction with circulation,and SST exhibited stronger influences during the Korean HW than the Japanese *** analysis also revealed temporal variations in the factors driving Korean and Chinese HWs due to typhoon passage and other multiple processes over heterogeneous surfaces(i.e.,topographically induced Foehn winds,large-scale warm advection from the warm ocean,spatial differences in soil moisture).Our findings suggest that future heatwave-related studies should consider interactive contributions of key factors,their interplay with surface heterogeneities of complex terrain.

关键词： Heatwave East Asia Large-scale circulation Soil moisture Sea surface temperature Synergistic impacts

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Antistatic coating material consisting of poly (butylacrylate-co-styrene) core-nickel shell particle

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中国有色金属学会会刊：英文版 2009年第B9期19卷 119-123页

作者： min-Yeong JEONG Byung-Yoon AHN Sang-Koul lee Won-ki lee Nam-Ju JO Department of Polymer Science and Engineering Pusan National University Kumho Petrochemical Samsung Corning Precision Glass Division of Chemical Engineering Pukyong National University

A transparent and antistatic coating material consisting of polymer core-metal shell particle was prepared. As a polymer core, poly(butylacrylate-co-styrene)s ([P(BA-co-sty)s]) with various compositions of butylacrylate and styrene were synthesized by emulsion polymerization. And the effect of comonomer composition on the thermal property of polymer core particle was investigated. By electroless plating method, the nickel particles were formed and deposited on the surface of P(BA-co-Sty) particles to form P(BA-co-Sty) core-nickel shell composite particles. SEM observation confirms that the nickel particles with size of 15 nm are distributed on the surface of the polymer core particles. The surface resistance of P(BA-co-Sty) core-nickel shell composite is 0.8×108Ω/cm2, enough to act as antistatic coating material.

关键词：复合粒子涂层材料单体组成抗静电苯乙烯丁酯聚合物颗粒镍

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Polyaniline and multi-walled carbon nanotube composite electrode for rechargeable battery

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中国有色金属学会会刊：英文版 2012年第S3期22卷 717-721页

作者： Yu-Jeong LIM min-Young PARK Sang-Keol lee Won-ki lee Nam-Ju JO Department of Polymer Science & Engineering Pusan National University Hankook Tire Co.Ltd. Department of Polymer Engineering Pukyong National University

The multi-walled carbon nanotube was introduced into the polymer matrix (PANI) to improve the electric conductivity as well as mechanical properties of the original polymer ***/multi-walled carbon nanotube (MWCNT) composites were synthesized via ex-situ and in-situ polymerization to improve their electrical *** the DC conductivities of PANI/MWCNT according to content and diameter of MWCNT were measured by four-point *** highest electric conductivity of PANI/MWCNT composite is 20 S/cm when 0.3% (mass fraction) MWCNTs with 10 nm in diameter and 15 μm in length are added in composite.

关键词： polymer electrode electric conductivity multi-walled carbon nanotube conducting polymer

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