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基于微生物转移网络的疾病检测算法

青岛大学学报（自然科学版） 2024年第1期37卷 27-31,38页

作者：孙洪杰吴舜尧青岛大学计算机科学技术学院青岛266071

针对疾病检测方法中忽略微生物潜在关联问题,提出一种基于微生物转移网络的新型图神经网络算法(SAGE-O-N)用于疾病检测。算法利用微生物测序信息的相似性特征构建微生物转移网络,使用图结构数据挖掘算法发掘相似性与表型关联。实验结果... 详细信息

针对疾病检测方法中忽略微生物潜在关联问题,提出一种基于微生物转移网络的新型图神经网络算法(SAGE-O-N)用于疾病检测。算法利用微生物测序信息的相似性特征构建微生物转移网络,使用图结构数据挖掘算法发掘相似性与表型关联。实验结果表明,与传统机器学习方法相比,SAGE-O-N在单种疾病上的受试者工作特征曲线面积(Area Under Curve,AUC)提高了约2%,在并发症数据集中AUC提高约4%。

关键词：图神经网络疾病检测人体菌群微生物转移网络

Ecological functions of uncultured microorganisms in the cobaltrich ferromanganese crust of a seamount in the central Pacific are elucidated by fosmid sequencing

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Acta Oceanologica Sinica 2015年第4期34卷 92-113页

作者： HUO Yingyi CHENG Hong Anton F.Post WANG Chunsheng JIANG Xiawei PAN jie wu min XU Xuewei Laboratory of Marine Ecosystem and Biogeochemistry Second Institute of Oceanography State Oceanic Administration State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography College of Life Sciences Zhejiang University The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution Marine Biology Laboratory State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University

Cobalt-rich ferromanganese is an important seafloor mineral and is abundantly present in the seamount crusts. Such crusts form potential hotspots for biogeochemical activity and microbial diversity, yet our understanding of their microbial communities is lacking. In this study, a cultivation-independent approach was used to recover genomic information and derive ecological functions of the microbes in a sediment sample collected from the cobalt-rich ferromanganese crust of a seamount region in the central Pacific. A total of 78 distinct clones were obtained by fosmid library screening with a 16S rRNA based PCR method. Proteobacteria and MGI Thaumarch-aeota dominated the bacterial and archaeal 16S rRNA gene sequence results in the microbial community. Nine fosmid clones were sequenced and annotated. Numerous genes encoding proteins involved in metabolic functions and heavy metal resistance were identified, suggesting alternative metabolic pathways and stress responses that are essential for microbial survival in the cobalt-rich ferromanganese crust. In addition, genes that participate in the synthesis of organic acids and exoploymers were discovered. Reconstruction of the metabolic pathways revealed that the nitrogen cycle is an important biogeochemical process in the cobalt-rich ferromanganese crust. In addition, horizontal gene transfer （HGT） events have been observed, and most of them came from bacteria, with some occurring in archaea and plants. Clone W4-93a, belonging to MGI Thaumarch-aeota, contained a region of gene synteny. Comparative analyses suggested that a high frequency of HGT events as well as genomic divergence play important roles in the microbial adaption to the deep-sea environment.

关键词： seamount cobalt-rich ferromanganese crust metagenome horizontal gene transfer

Ecological Networks of Allometric Growth,Feeding Behavior and Gut Microbiota in Chinese Alligator Hatchlings

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Asian Herpetological Research 2024年第2期15卷 104-114页

作者： Ke SUN Wengang LI Guangwei FAN Liuyang YANG Huabin ZHANG Yilin SHU Yongkang ZHOU Genjun TU Song ZHANG Pingsi YI Maliha AYUB Xiaobing wu Tao PAN College of Life Sciences Anhui Normal UniversityWuhu 241000AnhuiChina The Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin Wuhu 241000AnhuiChina School of Wetland Yancheng Teachers UniversityYancheng 224007JiangsuChina National Long-term Scientific Research Base for Chinese Alligator Artificial Breeding and Protection in Anhui Anhui Research Center for Chinese Alligator ReproductionXuancheng 242034AnhuiChina

Chinese alligator hatchlings in captivity are fragile and have a high mortality rate within first *** body mass gain of reptile animals is closely related to their feeding behavior and gut *** study analyzed the intrinsic factors influencing the allometric growth of Chinese alligator hatchlings based on their body mass gain,feeding behavior,and gut *** information would enhance the health management of Chinese alligator *** was a significant correlation between the total distance moved,the average number of conspecifics nearby,and body mass *** alligator hatchlings with a greater growth rate showed greater activity and more independent behavior during feeding than those with a lower growth ***,after feeding started,some functions of the gut microbiota showed significant relationships with growth rate and feeding *** alligator hatchlings with a greater growth rate showed greater levels of heme biosynthesis than those with a lower growth rate,and feeding activity was inhibited by long-chain fatty acid *** results elucidate the relationships between health,feeding behavior,and the gut microbiota of Chinese alligator *** the intrinsic factors of their health and feeding behavior can improve the health management of Chinese alligator hatchlings in captivity for conservation.

关键词： allometric growth behavior Chinese alligator hatchlings gut microbiota

Irrigation regimes modulate non-structural carbohydrate remobilization and improve grain filling in rice(Oryza sativa L.)by regulating starch metabolism

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Journal of Integrative Agriculture 2024年第5期23卷 1507-1522页

作者： Yuguang Zang Gaozhao wu Qiangqiang Li Yiwen Xu mingming Xue Xingyu Chen Haiyan Wei Weiyang Zhang Hao Zhang Lijun Liu Zhiqin Wang Junfei Gu Jianchang Yang Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology/Agricultural College YangzhouUniversityYangzhou225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009China

Recently developed ‘super’ rice cultivars with greater yield potentials often suffer from the problem of poor grain filling, especially in inferior spikelets. Here, we studied the activities of enzymes related to starch metabolism in rice stems and grains, and the microstructures related to carbohydrate accumulation and transportation to investigate the effects of different water regimes on grain filling. Two ‘super’ rice cultivars were grown under two irrigation regimes of well-watered(WW) and alternate wetting and moderate soil drying(AWMD). Compared with the WW treatment,the activities of ADP glucose pyrophosphorylase(AGPase), starch synthase(StSase) and starch branching enzyme(SBE), and the accumulation of non-structural carbohydrates(NSCs) in the stems before heading were significantly improved, and more starch granules were stored in the stems in the AWMD treatment. After heading, the activities of α-amylase, β-amylase, sucrose phosphate synthase(SPS) and sucrose synthase in the synthetic direction(SSs)were increased in the stems to promote the remobilization of NSCs for grain filling under AWMD. During grain filling, the enzymatic activities of sucrose synthase in the cleavage direction(SSc), AGPase, StSase and SBE in the inferior spikelets were increased, which promoted grain filling, especially for the inferior spikelets under ***, there were no significant differences in vascular microstructures. The grain yield and grain weight could be improved by 13.1 and 7.5%, respectively, by optimizing of the irrigation regime. We concluded that the low activities of key enzymes in carbon metabolism is the key limitation for the poor grain filling, as opposed to the vascular microstructures, and AWMD can increase the amount of NSC accumulation in the stems before heading, improve the utilization rate of NSCs after heading, and increase the grain filling, especially in the inferior spikelets, by altering the activities of key enzymes in carbon metabolism.

关键词： rice(Oryza sativa L.) non-structural carbohydrates(NsCs) enzymatic activity grain illing starch granules vascular bundle

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-ming Cui Yi-ming Zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun Zhu jie Zhang Zhuang-Zhuang Shi ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-Ling Hu Na Jia Yu-Wei Gao wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

铜陵特色文化资源挖掘利用的研究——以铜陵市图书馆“铜文化”专题数据库建设为例

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滁州职业技术学院学报 2024年第1期23卷 21-26页

作者：李明吴杰潘宏亮铜陵职业技术学院安徽铜陵244061 铜陵市图书馆安徽铜陵244061

铜文化作为铜陵特色文化,有着极高的文化价值和经济价值。为进一步挖掘、整合与利用铜文化资源,强化其在公共文化服务体系中的地位和作用,促进铜文化事业和产业发展,铜陵市图书馆着力打造“铜文化”专题数据库。文章介绍了数据库建设概... 详细信息

铜文化作为铜陵特色文化,有着极高的文化价值和经济价值。为进一步挖掘、整合与利用铜文化资源,强化其在公共文化服务体系中的地位和作用,促进铜文化事业和产业发展,铜陵市图书馆着力打造“铜文化”专题数据库。文章介绍了数据库建设概况与意义,梳理了数据库资源收集方式与主要内容,总结了数据库建设工作中遇到的问题并提出了四点举措建议,以期数据库建设工作顺利推进并实现预期目标。

关键词：特色文化铜陵市图书馆铜文化数据库

Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression

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World Journal of Psychiatry 2024年第6期14卷 848-856页

作者： Yi Wang Qun Lu Ittipalanukul Penpat Juan wu Dilinuer Abulikemu Fei-Cui Zeng Jia-Ying Huang Zhi-Hai Hu Department of Acupuncture and Moxibustion Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Laboratory Medicine Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Postgraduate Student Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Radiology Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of General Practice Shanghai University of Traditional Chinese Medicine Affiliated Shuguang HospitalShanghai 200120China General Practice of Traditional Chinese Medicine North Bund Street Community Health Service CenterShanghai 200080China General Practice of Traditional Chinese Medicine Shanghai Hongkou District Jiaxing Road Community Health Service CenterShanghai 200082China

BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health *** hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is *** present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently *** To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate *** This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June *** were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were *** before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were *** The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent group

关键词： Depression Prick Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index

Effect of biomass addition on the surface and adsorption characterization of carbon-based adsorbents from sewage sludge

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Journal of Environmental Sciences 2013年第2期25卷 405-412页

作者： Changzi wu min Song Baosheng Jin Yimin wu Yaji Huang Key Laboratory of Energy Thermal Conversion and Control Ministry of EducationSchool of Energy and EnvironmentSoutheast University

Sewage sludge with the additive corn cob was used as prescusor to prepare sludge-based carbon adsorbents by pyrolysis method. And then, the carbonizated products were activated with potassium hydroxide. The mixing ratio of the corn cob to sewage sludge was investigated. The surface area and pore size distribution, elemental composition, surface chemistry structure and the surface physical morphology were determined and compared. The results demonstrated that the addition of corn cob into the sewage sludge sample could effectively improve the surface area （from 287 to 591 m 2 /g） and the microporosity （from 5% to 48%） of the carbon based adsorbent, thus enhancing the adsorption behavior. The sulfur dioxide adsorption capacity was measured according to breakthrough test. It was found that the sulfur dioxide adsorption capacity of the adsorbents was obviously enhanced after the addition of the corn cob. It is presumed that not only highly porous adsorbents, but also a high metallic content of these materials are required to achieve good performances.

关键词： sewage sludge activated carbon biomass SO2 adsorption porosity

技术创新对体育企业高质量发展的影响研究——基于中介效应与调节效应的双重检验

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保定学院学报 2024年第3期37卷 7-16页

作者：章杰戴园园吴铖铖池州学院体育学院安徽池州247000 池州学院商学院安徽池州247000

体育产业高质量发展需要全面贯彻新发展理念,形成创新驱动、主体活跃、结构更优的发展格局。基于体育企业2010—2021年面板数据建构固定效应模型,探究技术创新对体育企业发展质量的影响及传导路径,并进一步分析融资约束、研发费用加计... 详细信息

体育产业高质量发展需要全面贯彻新发展理念,形成创新驱动、主体活跃、结构更优的发展格局。基于体育企业2010—2021年面板数据建构固定效应模型,探究技术创新对体育企业发展质量的影响及传导路径,并进一步分析融资约束、研发费用加计扣除政策对上述关系的中介效应与调节效应。结果显示:技术创新显著提升体育企业发展质量,且该提升作用具有滞后效应;融资约束对技术创新提升体育企业发展质量具有抑制作用,研发费用加计扣除政策对技术创新提升体育企业发展质量具有促进作用。规模异质性研究发现,大规模企业技术创新对发展质量的提升作用以及融资约束中介效应强于小规模企业,但其研发费用加计扣除政策调节效应弱于小规模企业。

关键词：体育企业技术创新高质量发展融资约束研发费用加计扣除政策