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Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)

Zoological Research 2024年第3期45卷 451-463页

作者： Bin Hu jia-min wang Qing-Xun Zhang Jing Xu Ya-Nan Xing Bo wang Shu-Yi Han Hong-Xuan He CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing Milu Ecological Research Center Beijing 102600China Beijing Capital International Airport Co. Ltd.Beijing 101300China

The gut microbiota significantly influences host physiology and provides essential ecosystem *** diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to specific dietary *** carrion crow(Corvus corone),an urban facultative scavenger bird,hosts an abundance of pathogens due to its scavenging *** this,carrion crows infrequently exhibit illness,a phenomenon related to their unique physiological *** present,however,the role of the gut microbiota remains incompletely *** this study,we performed a comparative analysis using 16S rRNA amplicon sequencing technology to assess colonic content in carrion crows and 16 other bird species with different diets in Beijing,*** findings revealed that the dominant gut microbiota in carrion crows was primarily composed of Proteobacteria(75.51%)and Firmicutes(22.37%).Significant differences were observed in the relative abundance of Enterococcus faecalis among groups,highlighting its potential as a biomarker of facultative scavenging behavior in carrion ***,*** isolated from carrion crows was transplanted into model mice to explore the protective effects of this bacterial community against Salmonella enterica *** showed that *** down-regulated the expression of pro-inflammatory cytokines tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 6(IL-6),prevented *** colonization,and regulated the composition of gut microbiota in mice,thereby modulating the host’s immune regulatory ***,*** exerts immunoregulatory and anti-pathogenic functions in carrion crows engaged in scavenging behavior,offering a representative case of how the gut microbiota contributes to the protection of hosts with specialized diets.

关键词： Carrion crow Facultative scavenger Gut microbiota Enterococcus faecalis 16S rRNA sequencing

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Correlation between serum markers and transjugular intrahepatic portosystemic shunt prognosis in patients with cirrhotic ascites

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 481-490页

作者： Xiao-Gang Hu Xiao-Xian Yang Jun Lu Gang Li jian-Ji Dai jia-min wang Yi Deng Rui Feng Department of Interventional Radiology The Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000Zhejiang ProvinceChina Medical College Jinhua PolytechnicJinhua 321017Zhejiang ProvinceChina Department of Interventional Medicine Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse *** transjugular intrahepatic portosystemic shunt(TIPS)is an efficacious intervention,but there is a lack of reliable tools for postoperative pro-gnosis *** utilized clinical biochemical markers,such as the serum albumin concentration(Alb),sodium(Na+)concentration,and serum creatinine(Scr),have limited predictive ***,the quest for novel,specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance.A retrospective analysis was conducted on 75 patients with liver cirrhosis and refractory ascites who underwent TIPS at our institution from August 2019 to August *** patients were followed up regularly for two years,and the death toll was meticulously *** patients were allocated into a survival group(n=45 patients)or a deceased group(n=30 patients)based on their prognosis *** clinical data of the two groups were collected,and Child-Pugh scores and MELD scores were calculated for *** correlation analysis was carried out to evaluate the correlation of prognosis with Child-Pugh grade,MELD score,and Cys C ***,a multiple-factor analysis utilizing the Cox proportional hazard model was used to identify independent risk factors affecting the post-TIPS prognosis of patients with liver cirrhosis and refractory *** receiver operating characteristic curve(ROC)ascertained the predictive value of the Cys C concen-tration,Child-Pugh grade,and MELD score for the prognosis of liver cirrhosis with refractory ascites in post-TIPS *** During a 2-year follow-up period,among 75 patients with liver cirrhosis and refractory ascites who underwent TIPS treatment,30 patients(40.00%)passed *** deceased cohort exhibited heightened aspartate aminotrans-ferase,alanine aminotransferase,total b

关键词： Liver cirrhosis Refractory ascites Transjugular intrahepatic portosystemic shunt Cystatin C

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Efficacy of transjugular intrahepatic portosystemic shunts in treating cirrhotic esophageal-gastric variceal bleeding

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 471-480页

作者： Xiao-Gang Hu jian-Ji Dai Jun Lu Gang Li jia-min wang Yi Deng Rui Feng Kai-Ping Lu Department of Interventional Radiology The Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000Zhejiang ProvinceChina Department of Interventional Medicine Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Department of Vascular Surgery Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Esophageal-gastric variceal bleeding(EGVB)represents a severe complication among patients with cirrhosis and often culminates in fatal ***-tional therapy,a rapidly developing treatment modality over the past few years,has found widespread application in clinical practice due to its minimally inva-sive ***,whether transjugular intrahepatic portosystemic shunt(TIPS)treatment has an impact on patient prognosis remains *** A retrospective study was conducted on ninety-two patients presenting with cirrhotic EGVB who were admitted to our hospital between September 2020 and September *** on the different modes of treatment,the patients were assigned to the study group(TIPS received,n=50)or the control group(per-cutaneous transhepatic varices embolization received,n=42).Comparative ana-lyses were performed between the two groups preoperatively and one month postoperatively for the following parameters:Varicosity status;hemodynamic parameters[portal vein flow velocity(PVV)and portal vein diameter(PVD);platelet count(PLT);red blood cell count;white blood cell count(WBC);and hepatic function[albumin(ALB),total bilirubin(TBIL),and aspartate transaminase(AST)].The Generic Quality of Life Inventory-74 was utilized to assess quality of life in the two groups,and the 1-year postoperative rebleeding and survival rates were *** Following surgical intervention,there was an improvement in the incidence of varicosity compared to the preoperative status in both ***,the study group exhibited more pronounced enhancements than did the control group(P<0.05).PVV increased,and PVD decreased compared to the preoperative values,with the study cohort achieving better outcomes(P<0.05).PLT and WBC counts were elevated postoperatively in the two groups,with the study cohort displaying higher PLT and WBC counts(P<0.05).No differences were detected between the two groups in terms of serum ALB,TBIL,or AST lev

关键词： Liver cirrhosis Esophagogastric variceal bleeding Transjugular intrahepatic portosystemic shunt Prognosis

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Is simultaneous presence of IgG4-positive plasma cells and giantcell hepatitis a coincidence in autoimmune hepatitis?A case report

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World Journal of Clinical Cases 2021年第25期9卷 7527-7534页

作者： You-Wen Tan jia-min wang Li Chen Department of Hepatology The Third Hospital of Zhenjiang Affiliated Jiangsu UniversityZhenjiang 212003Jiangsu ProvinceChina

BACKGROUND The immune-mediated invasion of IgG4-positive plasma cells in the liver is found in some autoimmune ***-cell hepatitis(GCH)is a very rare pathological feature in adults,and the clinical characteristics of the simultaneous appearance of the two pathological phenomena are not *** SUMMARY A 68-year-old woman was hospitalized with fatigue,poor appetite,and yellow urine for 20 *** function tests and immunological indexes were significantly abnormal and accompanied by elevated serum IgG4 *** pathology revealed severe inflammation of the interface between the portal tract and hepatocytes,portal area inflammation,plasma cell infiltration,formation of rosette cells,IgG4-positive plasma cells>10/high-power field,IgG4/IgG>40%,and multinucleated liver cell ***4-related autoimmune hepatitis(AIH)combined with GCH was diagnosed,and methylprednisolone was administered at 40 mg/*** weeks later,the clinical symptoms disappeared,and the liver function and immunological indicators were significantly *** was reduced at a rate of 4–8 mg per week to 8 mg/day for maintenance.A second liver biopsy 48 wk later indicated that liver inflammation and fibrosis were significantly ***4-positive plasma cells and GCH were not detected.A literature search was conducted to analyze articles reporting similar pathological *** AIH with simultaneous IgG4-positive plasma cell infiltration and GCH,liver inflammation,and fibrosis is possibly more severe than typical AIH but sensitive to corticosteroids.

关键词： IgG4 Autoimmune hepatitis Giant-cell hepatitis Case report

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TRAFFIC EMISSION TRANSPORTATION IN STREET CANYONS

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Journal of Hydrodynamics 2009年第1期21卷 108-117页

作者： XIE Xiao-min wang jia-song HUANG Zhen Key Laboratory for Power Machinery and Engineering of State Education ministry Shanghai Jiao Tong University Shanghai 200240 China

Spatial distributions of traffic-related pollutants in street canyons were investigated by field measurements and Computational Fluid Dynamics （CFD）. Two typical street canyons were selected for field monitoring, and a three-dimensional numerical model was built based on Reynolds-averaged Navier-Stokes equations equipped with the standard κ-ε turbulence models for CFD simulations. The study shows that the pollutant concentrations of vehicle emission correlate well with the traffic volume variation, wind direction and wind speed. The wind direction and speed at the roof level determine overwhellmingly the flow field and the distributions of pollutant concentrations in the street canyon. When the wind speed is equal to zero, the pollutant concentrations on the breath height of the both sides of the street canyon are almost the same. When the wind direction is perpendicular to the street, one main vortex is formed with a shape depending on the building structure on both sides of the street, the pollutant is accumulated on the leeward side, and the pollutant concentrations at the breath height on the leeward side are 2 to 3 times as those at the breath height on the windward side. If the wind direction makes some angles with the street canyon, the pollutant concentration will be higher on the leeward side because one main vortex will also be formed in the vertical section of the canyon by the perpendicular component of the wind. But pollutant concentrations decrease in the canyon because pollutants are dispersed along the axis of the street. Pollutants at different heights of the vertical section decrease with height, i.e. there are concentration gradients in the vertical section, and the pollutant concentrations on the leeward side of the upstream building are much higher than those on the windward side of the downstream building.

关键词： traffic emission street canyon field measurement CFD modeling

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Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)

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动物学研究 2024年第3期 451页

作者： Bin Hu jia-min wang Qing-Xun Zhang Jing Xu Ya-Nan Xing Bo wang Shu-Yi Han Hong-Xuan He

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On the Difference Between the Skew-rank of an Oriented Graph and the Rank of Its Underlying Graph

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 129-136页

作者： jia-min Zhu Bo-jun Yuan Yi wang School of Mathematical Sciences Anhui UniversityHefei230601China School of Science Zhejiang University of Science and TechnologyHangzhou310023China

Let G be a simple graph and G~σ be the oriented graph with G as its underlying graph and orientation σ.The rank of the adjacency matrix of G is called the rank of G and is denoted by r(G).The rank of the skew-adjacency matrix of G~σ is called the skew-rank of G~σ and is denoted by sr(G~σ).Let V(G)be the vertex set and E(G) be the edge set of *** cyclomatic number of G,denoted by c(G),is equal to |E(G)|-|V(G)|+ω(G),where ω(G) is the number of the components of *** is proved for any oriented graph G~σ that-2c(G)≤sr(G~σ)-r(G)≤2c(G).In this paper,we prove that there is no oriented graph G~σwith sr(G~σ)-r(G)=2c(G)-1,and in addition,there are infinitely many oriented graphs G~σ with connected underlying graphs such that c(G)=k and sr(G~σ)-r(G)=2c(G)-l for every integers k,l satisfying 0 ≤l≤4k and l≠1.

关键词： cyclomatic number rank skew-rank

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MicroRNA-mediated Silencing of RhoC Inhibits Tumor Invasion and Increases Chemosensitivity to Paclitaxel in SKOV3 Cells in vitro

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Chemical Research in Chinese Universities 2011年第1期27卷 70-74页

作者： PAN Ying DU Zhen-wu LENG Wei-chun ZHOU jia-wen wang Ying-jian SHENG min-jia wang Jun-rong ZHANG Gui-zhen China-Japan Union Hospital of Jilin University Changchun 130031 P. R. China

RhoC is a member of the Ras-homologous family of genes which are implicated in tumorigenesis and tumor progression. Up-regulation of RhoC is associated with tumor progression in ovarian carcinoma and RhoC is significantly correlated with the invasive capability of ovarian cancer cell lines in vitro, We developed a system that blocks RhoC in the human ovarian cancer SKOV3 cells using specific MicroRNA（miRNA） interference. By transfecting SKOV3 cells with the plasmid vector to express specific MiRNA that targets human RhoC, we were able to establish a stable clone in which RhoC expression was significantly downregulated. This resulted in the decreased invasive potential of SKOV3 cells as well as increased chemosensitivity to paclitaxel. RhoC involves in invasion and chemosensitivity of SKOV3, indicating that RhoC may be a promising therapeutic target for ovarian cancer.

关键词： RhoC gene miRNA SKOV3 cell Cell invasion Paclitaxel

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Baseline hepatocyte ballooning is a risk factor for adverse events in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease

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World Journal of Hepatology 2023年第2期15卷 237-254页

作者： You-Wen Tan jia-min wang Xing-Bei Zhou Department of Hepatology The Third Hospital of Zhenjiang Affiliated Jiangsu UniversityZhenjiang 212003Jiangsu ProvinceChina

BACKGROUND Although many studies have investigated the impact of chronic hepatitis B virus(HBV)infection and nonalcoholic fatty liver disease(NAFLD)on liver disease,few have investigated the relationship between nonalcoholic steatohepatitis(NASH)defined by liver pathology and the prognosis of chronic HBV *** patients were followed up for a short *** study aimed to further explore the impact of NAFLD and the pathological changes confirmed by liver pathology in patients with chronic HBV *** To study the effect of NAFLD confirmed using liver pathology on the outcomes of long-term serious adverse events[cirrhosis,hepatocellular carcinoma(HCC),and death]in patients with chronic hepatitis B(CHB)virus *** We enrolled patients with chronic hepatitis B virus(HBV)infection who underwent liver biopsy at the Third People’s Hospital of Zhenjaing Affiliated jiangsu University between January 2005 and September *** clinical and pathological data on liver pathology and clinical data at the end of follow-up were *** score matching(PSM)was used to balance baseline parameters,Kaplan-Meier(K-M)survival analysis was used to evaluate the risk of clinical events,and Cox regression was used to analyze the risk factors of *** Overall,456 patients with chronic HBV infection were included in the study,of whom 152(33.3%)had histologically confirmed *** median follow-up time of the entire cohort was 70.5 ***-four patients developed cirrhosis,which was diagnosed using ultrasound during the follow-up period.K-M survival analysis showed that NAFLD was not significantly associated with the risk of cirrhosis(log-rank test,P>0.05).Patients with CHB with fibrosis at baseline were more prone to cirrhosis(log-rank test,P=0.046).After PSM,multivariate analysis showed that diabetes mellitus,ballooning deformation(BD),and platelet(PLT)were independent risk factors for cirrhosis diagnosed using ultrasound(P<0.05).A to

关键词： Nonalcoholic fatty liver disease Steatohepatitis Chronic hepatitis B virus infection Hepatocellular carcinoma Cirrhosis

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Association between 5α-reductase inhibitors therapy and incidence, cancer-specific mortality,and progression of prostate cancer: evidence from a meta-analysis

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Asian Journal of Andrology 2020年第5期22卷 532-538页

作者： Lian-min Luo Re-Dian Yang jia-min wang Shan-Kun Zhao Yang-Zhou Liu Zhi-Guo Zhu Qian Xiang Zhi-Gang Zhao Department of Urology and Andrology Minimally Invasive Surgery CenterGuangdong Provincial Key Laboratory of UrologyThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China.

5a-reductase inhibitors(5-ARI)are widely employed for the treatment of benign prostatic *** has been noted that 5-ARI exhibit the potential to attenuate the risk of prostate cancer,but consistent agreement has not been ***,the effect of 5-ARI on cancer-specific mortality and progression of prostate cancer remains ***,the goal of the current meta-analysis was to elucidate the impact of 5-ARI on the incidence and progression of prostate *** searched for all studies assessing the effect of 5-ARI on risk of prostate cancer in PubMed,Embase,Medline,and Cochrane Library *** relative risk(RR)and corresponding 95%confidence intervals(CIs)were accepted to evaluate the association between 5-ARI and the risk of prostate *** results implied that subjects who accepted 5-ARI compared with the placebo group experienced a distinctly weakened overall incidence of prostate cancer(RR=0.74;95%C l:0.66-0.82;P7;RR=1.19;95%Cl:0.98-1.43;P=0.069).The results also showed that 5-ARI treatment did not significantly alter prostate cancer-specific mortality(RR=1.0;95%C l:0.95-1.05;P=0.916).In addition,it was worth noting that 5-ARI treatment acted in a protective role that presented a dramatic benefit to delay the progression of low-risk tumors(RR=0.58;95%C l:0.43-0.78;P<0.001).

关键词： 5a-reductase inhibitor meta-analysis prostate cancer

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