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Enhancing betavoltaic nuclear battery performance with 3D P^(+)PNN^(+)multi-groove structure via carrier evolution

Nuclear Science and Techniques 2023年第12期34卷 1-16页

作者： Hou‑Jun He yun‑Cheng Han Xiao‑yu Wang yu‑min Liu jia‑Chen Zhang Lei Ren ming‑Jie Zheng Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China School of Nuclear Technology and Chemistry and Biology Hubei University of Science and TechnologyXianning 437100China

Betavoltaic nuclear batteries offer a promising alternative energy source that harnesses the power of beta particles emitted by *** satisfy the power demands of microelectromechanical systems(MEMS),3D structures have been proposed as a potential ***,this paper introduces a novel 3D^(63)Ni–SiC-based P^(+)PNN^(+)structure with a multi-groove design,avoiding the need for PN junctions on the inner surface,and thus reducing leakage current and power *** Carlo simulations were performed considering the fully coupled physical model to extend the electron–hole pair generation rate to a 3D structure,enabling the efficient design and development of betavoltaic batteries with complex 3D *** a result,the proposed model produces the significantly higher maximum output power density of 19.74μW/cm^(2) and corresponding short-circuit current,open-circuit voltage,and conversion efficiency of 8.57μA/cm^(2),2.45 V,and4.58%,respectively,compared with conventional planar *** analysis of the carrier transport and collection characteristics using the COMSOL Multiphysics code,we provide deep insights regarding power increase,and elucidate the discrepancies between the ideal and simulated performances of betavoltaic *** work offers a promising approach for the design and optimization of high-output betavoltaic nuclear batteries with a unique 3D design,and serves as a valuable reference for future device fabrication.

关键词： Betavoltaic nuclear battery High-output power density Three-dimensional structure Carrier drift–diffusion Carrier recombination Carrier collection efficiency

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Octopaminergic neurons function in appetitive but not aversive olfactory learning and memory in Bactrocera dorsalis

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Insect Science 2022年第6期29卷 1747-1760页

作者： Jin-Xin yu Qian Xiang jia-Bao Qu Yan-min Hui Tao Lin Xin-Nian Zeng jia-Li Liu Guangdong Engineering Research Center for Insect Behavior Regulation College of Plant ProtectionSouth China Agricultural UniversityGuangzhouGuangdongChina College of Life Sciences Department of Biological ScienceShangrao Normal UniversityShangraoJiangxiChina

The biogenic amine octopamine(OA,invertebrate counterpart of nora-drenaline)plays critical roles in the regulation of olfactory ***,OA has been thought to mediate appetitive but not aversive learning in honeybees,fruit flies(Drosophila),and ***,this viewpoint has recently been challenged because OA activity through aβ-adrenergic-like receptor drives both appetitive and aversive ***,we explored the roles of OA neurons in olfactory learning and memory retrieval in Bactrocera *** trained flies to associate an orange odor with a sucrose reward or to associate methyl eugenol,a male lure,with N,N-diethyl-3-methyl benzoyl amide(DEET)*** then treated flies with OA receptor antagonists before appetitive or aversive conditioning and a memory retention *** of OA receptor antagonist mianserin or epinastine into the abdomen of flies led to impaired of appetitive learning and memory retention with a sucrose reward,while aversive learning and memory reten-tion with DEET punishment remained *** results suggest that the OA signaling participates in appetitive but not aversive learning and memory retrieval in *** through OA receptors.

关键词： appetitive aversive Bactrocera dorsalis learning and memory octopamine

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan yu-ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Fire-needle acupuncture for upper limb spastic paralysis after stroke:Study protocol for a randomized controlled trial

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Journal of Integrative Medicine 2019年第3期17卷 167-172页

作者： Xin-yu yue Zhuo-qi Feng Xi-yi yu jia-min Hu Xiao-Jing He Shi Shu School of Traditional Chinese Medicine Naval Medical University Beijing He's SanTong Acupuncture and Fire-needle Moxibustion Clinic Basic Medical School Shanghai University of Traditional Chinese Medicine

Background: Fire-needle acupuncture, an important kind of acupuncture therapy, has been clinically used to treat upper limb spastic paralysis(ULSP) after stroke. Clinical experience has indicated that fire-needle acupuncture treatment takes less time, requires fewer visits, and has more rapid results and fewer side effects compared to chemical medicine alternatives. This study will evaluate the effects of fire-needle acupuncture for ULSP in the context of standardized clinical research and provide high-quality data to inform clinical procedures and future study ***/Design: A randomized controlled trial will be carried out to evaluate the effects of fire-needle acupuncture therapy in patients with ULSP from stroke. ULSP patients(n = 120) will be recruited at Changhai Hospital in Shanghai, China. Patients will be randomly divided into three groups, including fire-needle acupuncture group(FAG), filiform-needle acupuncture group(FFAG) and rehabilitation treatment group(RTG). During the 3-week treatment, the FAG will be treated every two days, while FFAG and RTG will be treated 5 d in a row and then rest for 2 d. The Simplified Fugl-Meyer Motor Function Scale and Modified Ashworth Scale will be used as the primary outcome measures. Statistical analysis will be conducted by an independent ***: Through this study, the utility of fire-needle acupuncture in treating ULSP after stroke will be tested, and some specific claims of fire-needle acupuncture therapy will be evaluated, such as relieving spasm and muscular tension, improving activities of daily living, rapidity of response and less frequency of treatment compared with other treatments.

关键词： Fire-needle acupuncture Upper limb spastic paralysis Stroke Randomized controlled trial Study protocol

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环状RNA CHACR调控压力超负荷诱导心肌肥大和氧化应激损伤

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中国组织工程研究 2025年第25期29卷 5362-5373页

作者：王霜韩瑜袁敏曹济民孙腾山西医科大学细胞生理学教育部重点实验室山西省细胞生理学重点实验室山西医科大学基础医学院生理学系山西省太原市030001

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方... 详细信息

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方法:①心脏原位注射环状RNA CHACR过表达慢病毒1周后进行横向主动脉缩窄手术诱导小鼠心肌肥大。术后8周,计算心脏质量/胫骨长比值和肺质量/胫骨长比值,测量心肌细胞表面积,检测肥大标志基因表达水平和心肌纤维化程度,评估心功能。②H9c2心肌细胞给予环状RNA CHACR过表达慢病毒处理72 h,然后加入1μmol/L血管紧张素Ⅱ处理24 h诱导心肌细胞肥大。通过检测心肌细胞表面积、肥大标志基因表达水平、蛋白质/DNA比值评估细胞肥大情况,通过检测活性氧水平和线粒体膜电位评估氧化应激损伤情况。结果与结论:①在体内和体外心肌肥大模型中,环状RNA CHACR的表达水平均显著降低(P<0.01);②过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心肌肥大表型,主要表现为心脏体积减小、心脏质量/胫骨长比值显著降低(P<0.05),肺质量/胫骨长比值显著降低(P<0.05),心肌细胞表面积显著减小(P<0.05),以及心肌肥大相关标志基因心房利钠肽(P<0.05)、脑钠肽(P<0.05)表达水平降低;③过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心脏纤维化,表现为纤维化面积减小(P<0.01)和纤维化标志基因Acta1的表达水平降低(P<0.05);④过表达环状RNA CHACR显著改善了小鼠心功能,主要表现为射血分数(P<0.05)和短轴缩短率(P<0.01)显著升高;(5)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的心肌细胞肥大,主要表现为心肌细胞表面积显著减小(P<0.05),心房利钠肽(P<0.05)和脑钠肽(P<0.05)表达水平显著下调,以及蛋白质/DNA比值显著减小(P<0.05);(6)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的活性氧水平升高(P<0.001)和线粒体膜电位降低(P<0.05)。结果表明,环状RNA CHACR在体内和体外心肌肥大模型中表达水平显著降低,过表达环状RNA CHACR显著抑制心肌肥大,减轻心肌纤维化,改善心功能,并且显著减轻了血管紧张素Ⅱ诱导的心肌细胞氧化应激损伤。

关键词：心肌肥大环状RNA CHACR 血管紧张素Ⅱ 横向主动脉缩窄手术氧化应激损伤

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Nonsolvent-induced phase separation-derived TiO_(2) nanotube arrays/porous Ti electrode as high-energy-density anode for lithium-ion batteries

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Rare Metals 2021年第2期40卷 393-399页

作者： Zhi-jia Zhang Jun Zhao Zhi-Jun Qiao jia-min Wang Shi-Hao Sun Wen-Xing Fu Xi-yuan Zhang Zhen-Yang yu yu-Hai Dou jian-Li Kang Ding yuan yue-Zhan Feng jian-min Ma State Key Laboratory of Separation Membrane and Membrane Processes Tianjin Municipal Key Laboratory of Advanced Fibers and Energy StorageSchool of Materials Science and EngineeringSchool of Mechanical EngineeringTiangong UniversityTianjin300387China Centre for Clean Environment and Energy Gold Coast CampusGriffith UniversityGold Coast4222Australia Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou450002China Key Laboratory for Micro-/Nano-Optoelectronic Devices Ministry of EducationSchool of Physics and ElectronicsHunan UniversityChangsha410022China

TiO_(2) nanotube arrays,growing on three-dimensional(3 D)porous Ti membrane,were synthesized using a facile nonsolvent-induced phase separation and anodization *** length of those three-dimensional nanotube arrays could be tuned by prolonging the anodizing *** the anodizing time is 8 h,the three-dimensional TiO_(2) nanotube arrays/porous Ti electrode exhibits well cycling stability and ultra-high specific capacity,which is used in lithium-ion batteries,attributed to the high utilization rate of the substrate and the high growth intensity of the active ***-dimensional TiO_(2) nano tube arrays/porous Ti electrode,at 100μA·cm^(-2) with 8 h anodizing time,shows a typical discharge plateau at 1.78 V and exhibits the specific capacity with 2126.7μAh·cm^(-2),The novel nanotube arrays@3 D porous architecture effectively shortens the electron/ion transmission path,which could pave way for optimizing the design of highperformance anode materials for next-generation energy storage system.

关键词： TiO2 nanotube arrays Nonsolvent-induced phase separation Anodization Anode Lithium-ion battery

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Research on the phase space of three-and four-body final states processes

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Chinese Physics C 2022年第8期46卷 7-22页

作者： Kang yu De-min Li jia-Jun Wu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Analytical formulae for the phase space factors and three-momenta of three-and four-body final states are derived for all sets of independent kinematic variables containing invariant mass *** formulae will help experimental physicists to perform data *** an example,we show how to use these formulae to distinguish the different mechanisms of the e+p→e+J/ψ+p process when searching the signals of P_(c) states in the energy region of the Electron-Ion collider at China(EicC).

关键词： phase space four-body final states kinematics

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Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

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Chinese Journal of Polymer Science 2022年第9期40卷 1120-1128页

作者： Mei-yu jiang jia-Sheng Wu Wei-min Liu Hao-Hui Ren Xin Wang Peng-Fei Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials and Cityu-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer ***-targeted sonodynamic therapy(SDT)can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven ***,we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting,which constituted a nano sonosensitizer(T-cRGD NPs)for fluorescence imaging-guided sonodynamic therapy.A comparable sonosensitizer(T-PEG NPs)without the targeting unit was also prepared for illustration of therapeutic *** to the role of peptide targeting,T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in *** imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.

关键词： Sonodynamic therapy Glioma Cyclic peptide Target enrichment Deep penetration

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Some Sufficient Conditions for Convergent Multivariate Subdivision Schemes with Nonnegative Finite Masks

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Acta Mathematica Sinica,English Series 2012年第7期28卷 1411-1420页

作者： min WU jia Li ZHOU Department of Mathematics Zhejiang University of Science and Technology Department of Mathematics Zhejiang University of Technology

It is well known that the convergence of multivariate subdivision schemes with finite masks can be characterized via joint spectral radius. For nonnegative masks, we will present in this paper some computable simply s... 详细信息

关键词： Cascade algorithm dilation equation joint spectral radius mask subdivision scheme

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Two Efficient Parameterized Boundaries for Vee's Asian Option Pricing PDE

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 643-652页

作者： Bai-min yu School of International Trade and Economics University of International Business and Economics

In this paper, we derive two general parameterized boundaries of finite difference scheme for VeSe~＇s PDE which is used to price both fixed and floating strike Asian options. Using these two boundaries, we can deal with all kinds of situations, especially, some extreme cases, like overhigh volatility, very small volatility, etc, under which the Asian option is usually mispriced in many existing numerical methods. Numerical results show that our boundaries are pretty efficient.

关键词： Asian option Vecer's PDE finite difference parameterized boundaries sensitivity

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