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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi Tanaka Hyung-Lok chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

Scattering Phase Correction for Semiclassical Quantization Rules in Multi-Dimensional Quantum Systems

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Communications in Theoretical Physics 2010年第2期53卷 250-256页

作者： HUANG Wen-min MOU chung-yu CHANG Cheng-Hung Department of Physics National Tsing-Hua University Hsinchu Taiwan physics Division National Center for Theoretical Sciences Hsinchu Taiwan Institute of Physics National Chiao Tung University Hsinchu Taiwan Institute of Mathematical Modeling and Scientific Computing National Chiao Tung University Hsinchu Taiwan

While the scattering phase for several one-dimensional potentials can be exactly derived, less is known in multi-dimensional quantum systems. This work provides a method to extend the one-dimensional phase knowledge to multi-dimensional quantization rules. The extension is illustrated in the example of Bogomolny＇s transfer operator method applied in two quantum wells bounded by step potentials of different heights. This generalized semiclassical method accurately determines the energy spectrum of the systems, which indicates the substantial role of the proposed phase correction. Theoretically, the result can be extended to other semiclassical methods, such as Gutzwiller trace formula, dynamical zeta functions, and semielassical Landauer Buttiker formula. In practice, this recipe enhances the applicability of semiclassical methods to multi-dimensional quantum systems bounded by general soft potentials.

关键词： Bogomolny's transfer operator semiclassical quantization rules quantum chaos

Evaluation of Pre-Emergence and Post-Emergence Herbicides for Weed Management in Miscanthus sacchariflorus and Miscanthus sinensis

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1439-1467页

作者： Bimal Kumar Ghimire Chang Yeon yu Seung Hyun Kim Ill min chung Department of Crop Science College of Sanghuh Life ScienceKonkuk UniversitySeoul05029Korea Bioherb Research Institute Kangwon National UniversityChuncheon24341Kore

Miscanthus,is a promising bioenergy crop,considered superior to other bioenergy crops because of its higher water and nutrient use efficiency,cold tolerance,and higher production of *** weeds and grass weeds,cause major problems in the Miscanthus field.A field experiment was conducted in 2018 and 2019,to assess the effects of pre-emergence(alachlor and napropamide)and post-emergence herbicides(nicosulfuron,dicamba,bentazon,and glufosinate ammonium)on broadleaf and grass weeds in *** and *** *** weed control efficiency and phytotoxicity of pre-and post-emergence herbicides were evaluated at 30 days after treatment(DAT)and compared to those of the control *** results showed wide variations in the susceptibility of the weed species to the treated *** with nicosulfuron 40 ***^(-1) provided the most effective overall weed control(with 10%visual injury),without affecting the height and biomass of neither Miscanthus species in the ***-emergence herbicides such as glufosinate ammonium 400 ***^(-1) and dicamba 482 ***^(-1) were effective and inhibited the growth and density of the majority of weeds to a 100%;however,they showed significant phytotoxicity(toxicity scale of 1-10)to both species of *** application of glufosinate ammonium caused severe injuries to the foliar region(90%visual injury)of both Miscanthus ***,*** showed a slightly higher tolerance to the herbicides nicosulfuron,bentazon and napropamide with 10%visual injury at the recommended dose than *** present study clearly showed that infestation of broadleaf and grass weeds in Miscanthus fields can cause significant damage to the growth and biomass of Miscanthus and applying pre-emergence and post-emergence herbicides effectively controls the high infestation of these weeds.

关键词： miscanthus herbicides weeds biomass chlorophyll visual injury

GC-MS analysis of volatile compounds of Perilla frutescens Britton var. Japonica accessions: morphological and seasonal variability

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Asian Pacific Journal of Tropical Medicine 2017年第7期10卷 705-714页

作者： Bimal Kumar Ghimire Ji Hye Yoo Chang Yeon yu Ill-min chung Department of Applied Life Science Konkuk University Bioherb Research Institute Kangwon National University

Objective: To investigate the composition of volatile compounds in the different accessions of Perilla frutescens(P. frutescens) collected from various habitats of China and Japan. Methods: In the present study, the essential oil from the leaves of P. frutescens cultivars from China and Japan was extracted by hydro-distillation and the chemical composition and concentration of the volatile components present in the oils were determined by gas chromatography–mass spectrometry(GC–MS) analysis. Results: Among the volatile components, the major proportion was of perilla ketone, which was followed by elemicin and beta-caryophyllene in the Chinese Perilla cultivars. The main component in the oil extracted from the Japanese accessions was myristicin, which was followed by perilla ketone and beta-caryophyllene. We could distinguish seven chemotypes, namely the perilla ketone(PK) type, perilla ketone, myristicin(PM) type, perilla ketone, unknown(PU) type, perilla ketone, beta-caryophyllene, myristicine(PB) type, perilla ketone, myristicin, unknown(PMU) type, perilla ketone, elemicine, myristicin, beta-caryophyllene(PEMB) type, and the perilla ketone, limonene, betacryophyllene, myristicin(L) type. Most of the accessions possessed higher essential oil content before the flowering time than at the flowering stage. The average plant height, leaf length, leaf width of the Chinese accessions was higher than those of the Japanese accessions. Conclusion:The results revealed that the harvest time and geographical origin caused polymorphisms in the essential oil composition and morphological traits in the Perilla accessions originating from China and Japan. Therefore, these chemotypes with desirable characters might be useful for industrial exploitation and for determining the harvest time.

关键词： Perilla frutescens Essential oil GC–MS analysis Morphological character Harvesting time

Is necrosectomy obsolete for infected necrotizing pancreatitis? Is a paradigm shift needed?

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World Journal of Gastroenterology 2014年第45期20卷 16925-16934页

作者： yu-chung Chang Department of Surgery Chung Shan Medical University Hospital College of Medicine Chung Shan Medical University

In 1886,Senn stated that removing necrotic pancreatic and peripancreatic tissue would benefit patients with severe acute *** then,necrosectomy has been a mainstay of surgical procedures for infected necrotizing pancreatitis(NP).No published report has successfully questioned the role of ***,however,increasing evidence shows good outcomes when treating walled-off necrotizing pancreatitis without a *** literature concerning NP published primarily after 2000 was reviewed;it demonstrates the feasibility of a paradigm *** majority(75%)of minimally invasive necrosectomies show higher completion rates:between 80%and 100%.Transluminal endoscopic necrosectomy has shown remarkable results when combined with percutaneous drainage or a metallic *** morbidities range from 40%to 92%.Single-digit mortality rates have been achieved with transluminal endoscopic necrosectomy,but not with video-assisted retroperitoneal necrosectomy *** procedures without necrosectomy have evolved from percutaneous drainage to transluminal endoscopic drainage with or without percutaneous endoscopic gastrostomy access for laparoscopic *** series have reached higher success rates of 79%-93%,and even 100%,using transcystic multiple drainage *** is becoming evident that transluminal endoscopic drainage treatment of walledoff NP without a necrosectomy is *** further refinement of the drainage procedures,a paradigm shift from necrosectomy to drainage is inevitable.

关键词： Delay until liquefaction Infected necrotizing pancreatitis minimally invasive treatment Transluminal endoscopic drainage/necrosectomy Walled-off pancreatic necrosis

Estimation of plasma density perturbation from dusty plasma injection by laser irradiation on tungsten target in DiPS

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Plasma Science and Technology 2020年第4期22卷 90-96页

作者： In Je KANG min-Keun BAE In Sun PARK min Ji LEE Kyu-Sun chung Department of Electrical Engineering Hanyang UniversitySeoul 133791Republic of Korea Plasma Technology Research Center National Fusion Research InstituteGunsan 54004Republic of Korea

To investigate the interaction of dusty plasma with magnetized plasmas at divertor plasma simulator,radial profiles of plasma density(ne)and electron temperature were measured in terms of plasma discharge currents and magnetic flux intensity by using a fast scanning probes system with triple *** plasma with dusts(a generation rate of 3μg s-1 and a size of 1–10μm)was produced via interactions between a high-power laser beam and a full tungsten *** ne increases,the scale of the effects of dusty plasma injection on magnetized plasmas was ***,the duration of transient fluctuation was *** numerical estimation of plasma density perturbation due to dusty plasma injection,the result was 10%at a core region of the magnetized plasma with ne of(2–5)×10^11 cm^-3 at steady state condition.

关键词： plasma density perturbation dusty plasma tungsten dust DiPS

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Ruptured hepatoblastoma with massive internal bleeding in an adult

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World Journal of Gastroenterology 2005年第39期11卷 6235-6237页

作者： Hung-Yen Ke Yee-min Jen Jyh-Cherng yu chung-Bao Hsieh Cheng-Jueng Chen Division of General Surgery Department of Surgery Department of Radio-OncologyTri-Service General HospitalNational Defense Medical CenterTaipeiTaiwanChina

Hepatoblastoma is the most common primary hepatic tumor of children. However, only a very few cases have been reported in adults. Most studies support treatment with chemotherapy followed by surgical resection. We present the first reported case of adult hepatoblastoma in Taiwan. A 52-year-old female suffered from sudden onset of abdominal pain and general weakness for *** bleeding with hemorrhagic shock was suspected and two massive lesions in both lobes of the liver with hemoperitoneum were noted from imaging *** resection of the larger left lobe tumor and radio-frequency ablation of the right smaller one were performed. The histopathology diagnosis was of a hepatoblastoma.

关键词： Adult hepatoblastoma Hepatoblastoma rupture Internal bleeding Hepatoblastoma Mixed type hepatoblastoma

The Assessment of Ocean Wave Energy Along the Coasts of Taiwan

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China Ocean Engineering 2012年第3期26卷 413-430页

作者： LIN yu-Hsien FANG ming-chung Fishing Boat & Mar.Eng.Research Center National Cheng-Kung University Dept.of Systems & Naval Mechatronic Eng. National Cheng-Kung University

The wave energy resource around the coasts of Taiwan is investigated with wave buoy data covering a 3-year period （2007-2009）. Eleven study sites within the region bounded by the 21.5^°N-25.5°N latitudes and 118°E-122°E longitudes are selected for analysis. The monthly moving-average filter is used to obtain the low-frequency trend based on the available hourly data. After quantifying the wave power and annual wave energy, the substantial resource is the result of Penghu buoy station, which is at the northeastern side of Penghu Island in the Taiwan Strait. it is investigated that the Penghu sea area is determined to be the optimal place for wave energy production according to its abundant resource of northeasterly monsoon waves, sheltering of the Taiwan Island, operation and maintenance in terms of seasonal conditions, and constructability of wave power devices.

关键词： ocean wave energy wave energy converter wave climate Taiwan Strait monsoon waves