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World Journal of Clinical Cases 2020年第16期8卷 3458-3464页

作者： Jie-min chen Yao-Tang Zhong Chang Tu Jun Lan Department of Cardiovascular Medicine Dongguan Songshan Lake Central HospitalDongguan Institute of Cardiovascular DiseaseDongguan 523326Guangdong ProvinceChina

BACKGROUND The incidence and prevalence of atrial fibrillation are increasing each year,and this condition is one of the most common clinical *** To investigate the levels and significance of serum fibroblast growth factor 23(FGF-23)and miR-208 b in patients with atrial fibrillation and their relationship with *** From May 2018 to October 2019,240 patients with atrial fibrillation were selected as an observation group,including 134 with paroxysmal atrial fibrillation and 106 with persistent atrial fibrillation;150 patients with healthy sinus rhythm were selected as a control *** serum levels of FGF-23 and miR-208 b in the two groups were *** the observation group,cardiac parameters were determined by *** The serum levels of FGF-23 and miR-208 b in the observation group were 210.20±89.60 ng/mL and 5.30±1.22 ng/mL,which were significantly higher than the corresponding values in the control group(P0.05).The serum levels of FGF-23and miR-208 b were positively correlated with the LAD(r=0.411 and 0.382,P<0.05).In the observation group,the serum levels of FGF-23 and miR-208 b in patients with a major cardiovascular event(MACE)were 243.30±72.29 ng/mL and 6.12±1.12 ng/mL,which were significantly higher than the corresponding values in patients without a MACE(P<0.05).CONCLUSION The serum levels of FGF-23 and miR-208 b are increased in patients with atrial fibrillation and are related to the type of disease,cardiac parameters,and prognosis.

关键词： Fibroblast growth factor-23 MiR-208b Atrial fibrillation Prognosis

Intracellular and Extracellular Phosphatidylinositol 3-Phosphate Produced by Phytophthora Species Is Important for Infection

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Molecular Plant 2013年第5期6卷 1592-1604页

作者： shan Lu Linlin chen Kai Tao Nannan Sun Yuren Wu Xiaoxue Lu Yuanchao Wang Daolong Dou Department of Plant Pathology Nanjing Agricultural University Nanjing 210095 China Key Laboratory of Integrated Management of Crop Diseases and Pests (ministry of Education) Nanjing 210095 China

RxLR effectors produced by Phytophthora pathogens have been proposed to bind to phosphatidylinositol 3-phosphate （Ptdlns（3）P） to mediate their translocation into host cells and/or to increase their stability in planta. Since the levels of Ptdlns（3）P in plants are low, we examined whether Phytophthora species may produce Ptdlns（3）P to pro- mote infection. We observed that Ptdlns（3）P-specific GFP biosensors could bind to P. parasitica and P. sojae hyphae dur- ing infection of Nicotiana benthamiana leaves transiently secreting the biosensors, suggesting that the hyphae exposed Ptdlns（3）P on their plasma membrane and/or secreted Ptdlns（3）R Silencing of the phosphatidylinositol 3-kinases （PI3K） genes, treatment with LY294002, or expression of Ptdlns（3）pobinding proteins by P. sojae reduced the virulence of the pathogen on soybean, indicating that pathogen-synthesized Ptdlns（3）P was required for full virulence. Secretion of Ptdlns（3）P-binding proteins or of a PI3P-5-kinase by N. benthamiana leaves significantly increased the level of resist- ance to infection by P. parasitica and P. capsici. Together, our results support the hypothesis that Phytophthora species produce external Ptdlns（3）P to aid in infection, such as to promote entry of RxLR effectors into host cells. Our results derived from P. sojae RxLR effector Avrlb confirm that both the N-terminus and the C-terminus of this effector can bind Ptdlns（3）P.

关键词： Phytophthora sojae RxLR effectors phosphatidylinositol 3-phosphate (Ptdlns(3)P) phosphatidylinositol3-kinases (PI3Ks).

A practical guide to promote informatics-driven efficient biotopographic material development

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Bioactive Materials 2022年第2期7卷 515-528页

作者： Yuanlong Guo Jiaomei Mi chen Ye Yong Ao Mengru Shi Zhengjie shan Bingzhi Li Zetao chen Zhuofan chen Krasimir Vasilev Yin Xiao Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Research Center for Dental and Cranial Rehabilitation and Material EngineeringGuangzhou510055China Academic Unit of Science TechnologyEngineering and Mathematics(STEM)University of South AustraliaMawson LakesSA5095Australia Institute of Health and Biomedical Innovation Queensland University of TechnologyBrisbane4059Australia

Micro/nano topographic structures have shown great utility in many biomedical areas including cell therapies,tissue engineering,and implantable ***-assisted informatics methods hold great promise for the design of topographic structures with targeted properties for a specific medical *** benefit from these methods,researchers and engineers require a highly reusable“one structural parameter-one set of cell responses”***,existing confounding factors in topographic cell culture devices seriously impede the acquisition of this kind of *** carefully dissecting the confounding factors and their possible reasons for emergence,we developed corresponding guideline requirements for topographic cell culture device development to remove or control the influence of such *** on these requirements,we then suggested potential strategies to meet *** this work,we also experimentally demonstrated a topographic cell culture device with controlled confounding factors based on these guideline requirements and corresponding strategies.A“guideline for the development of topographic cell culture devices”was summarized to instruct researchers to develop topographic cell culture devices with the confounding factors removed or well *** guideline aims to promote the establishment of a highly reusable“one structural parameter-one set of cell responses”database that could facilitate the application of informatics methods,such as artificial intelligence,in the rational design of future biotopographic structures with high efficacy.

关键词： Biotopographic materials Cell culture device Confounding factor Database Informatics

One size fits all? Contract farming among broiler producers in China

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Journal of Integrative Agriculture 2018年第2期17卷 473-482页

作者： HUANG Ze-ying XU Ying ZENG Di WANG chen WANG Ji-min Institute of Agricultural Economics and Development Chinese Academy of Agricultural Sciences Centre for Global Food and Resources University of Adelaide

Contract farming has been increasingly found to benefit smallholders in developing countries, yet much less is known about its role in the poultry industry where economies of scale could be more prominent. This study aims to narrow this gap by analysing the choice of contract farming among Chinese broiler producers using a nationally representative survey. Simply cost-benefit analysis and multinomial logit regression modelling are jointly employed to explain contract farming decision making especially among small producers. In contrast to many recent studies, we find that small producers, though not passively excluded, usually opt out of contract farming due to limited profitability when large producers are coexistent. Such relationship is appropriately identified through a control function approach to correct for possible endogeneity. Therefore, contract farming may not help achieve higher welfare goals for small broiler producers who actually instead seek alternative market opportunities that better realise their comparative advantages.

关键词： contract farming broiler price multinomial logit China

Investigating the mechanisms of glyphosate resistance in goosegrass(Eleusine indica) population from South China

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Journal of Integrative Agriculture 2015年第5期14卷 909-918页

作者： ZHANG Chun FENG Li HE Ting-ting YANG Cai-hong chen Guo-qi TIAN Xing-shan Guangdong Provincial Key Laboratory of High Technology for Plant Protection Institute of Plant ProtectionGuangdong Academy of Agricultural Sciences

Glyphosate has been used worldwide for nearly 40 years,and 30 types of resistant weeds have been *** is mass-produced and widely used in China,but few studies and reports on glyphosate-resistant weeds and resistance mechanisms *** studies found a goosegrass species with high glyphosate resistance from orchards in South China and its glyphosate resistant mechanism was described in this *** cDNAof 5-enolpyruvylshikimate-3-phosphate synthase（EPSPS,EC 2.***.1.19）,the target enzyme of glyphosate,was cloned from the glyphosate-resistant and-susceptible goosegrass,respectively,and referred as EPSPS-R and *** Pro106 residue was known to be involved in the glyphosate resistance in most goosegrass ***,sequence analysis did not find the mutation at the Pro106 residue in the R biotype EPSPS amino acid *** residue 133 and 382 was mutated in the R biotype EPSPS amino acid sequence instead,but it did not affect the EPSPS-S and EPSPS-R genes sensitivities to ***-PCR and Western blot analyses suggested that EPSPS mRNA and protein are mainly present in the shoot tissues both in the R and S goosegrass *** EPSPS-R rapidly responds to the glyphosate in R-biotype goosegrass and the induced expression was detected at 12 h post glyphosate *** mRNA and protein expression of EPSPS-R increased constantly as the increasing concentration of ***,the expression of the EPSPS-S was not induced significantly by glyphosate in the S goosegrass *** of real-time PCR results showed that the copy number of the EPSPS in R-biotype goosegrass was 4.7 times higher than that in the S goosegrass *** the results implied that EPSPS gene amplification might mainly caused the glyphosate resistance of a goosegrass population collected from orchards in South China.

关键词： populations shoot residue susceptible constantly translocation instead implied confer chlorophyll

Study on acute recent stage pancreatitis

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World Journal of Gastroenterology 2014年第43期20卷 16138-16145页

作者： Ye-chen Feng min Wang Feng Zhu Ren-Yi Qin Department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

Acute pancreatitis(AP)is an inflammatory disease of the pancreas which involves the pancreas and surrounding tissue,and systemic inflammation with a characteristic systemic increase of vascular permeability and increased risk of multiple organ ***,the pathogenesis of AP is fuzzy,and the diagnosis and treatment need to be ***,increased knowledge of AP may achieve more thorough understanding of the *** use of further advanced diagnostic tools and superior treatment,potentially will help clinicians to manage AP at an appropriate ***,in view of the multi factorial disease and the complex clinical manifestations,the management of patients with AP is also remaining areas for improvement.

关键词： Acute pancreatitis Organ failure Necrosis Inflammation Management

Physiological Processes Contributing to the Difference in Grain Amino Acid Content Between Two Hybrid Rice(Oryza sativa L.)Cultivars

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 101-107页

作者： min Huang Hengdong Zhang Chunrong Zhao Guanghui chen Yingbin Zou Crop and Environment Research Center for Human Health College of AgronomyHunan Agricultural UniversityChangsha410128China.

Improving grain amino acid content of rice(Oryza sativa L.)is essential for the health of *** study was conducted to identify the physiological processes that contribute to the higher grain amino acid content in hybrid rice cultivar Lingliangyou 268 compared to Luliangyou *** results showed that total amino acid content in grains was 9%higher in Lingliangyou 268 than in Luliangyou *** was no significant difference in grain nitrogen(N)content between Lingliangyou 268 and Luliangyou 996,while ratio of amino acid to N was 6%higher in Lingliangyou 268 compared to Luliangyou 996.A total of 16 differentially expressed proteins related to amino acid metabolism(e.g.,erythronate-4-phosphate dehydrogenase domain containing protein)were identified in grains between Lingliangyou 268 and Luliangyou *** identified proteins were involved in 10 molecular *** of the 10 defined functions were related to binding(heterocyclic compound binding,nucleoside phosphate binding,nucleotide binding,organic cyclic compound binding,protein binding,and small molecule binding)and the other 4 defined functions were catalytic activity,enzyme regulator activity,hydrolase activity,and transferase *** results indicate that the higher grain amino acid content in Lingliangyou 268 compared to Luliangyou 996 is attributed to increased efficiency of converting N to amino acid that results from altered expression of proteins related to amino acid metabolism.

关键词： Amino acid content grain quality protein expression protein function hybrid rice

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帕金森病认知损害的神经影像学研究进展

中国临床神经科学 2024年第1期32卷 104-110页

作者：万晨晖张衡单爱狄张克忠南京医科大学第一附属医院神经内科南京210029

帕金森病(PD)是一种常见的中枢神经系统变性疾病,认知损害是PD常见的非运动症状之一,其机制目前尚不完全清楚。神经影像学技术可以显示疾病特异性的结构和功能特征,是研究PD认知损害发生发展机制的强大工具。文中将从神经影像技术中的... 详细信息

帕金森病(PD)是一种常见的中枢神经系统变性疾病,认知损害是PD常见的非运动症状之一,其机制目前尚不完全清楚。神经影像学技术可以显示疾病特异性的结构和功能特征,是研究PD认知损害发生发展机制的强大工具。文中将从神经影像技术中的磁共振成像和正电子发射计算机断层扫描两个方面,对近年来PD认知损害的神经影像学研究进展予以综述。

关键词：帕金森病认知损害影像学

首次及重复献血者血液检测不合格情况的多因素分析

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新疆医学 2024年第4期54卷 404-409页

作者：付薪静穆耶赛尔·艾尼娃尔张美林王瑞涛王珊周丽君陈敏乌鲁木齐市血液中心乌鲁木齐830011

目的分析初次及重复无偿献血者血液检测情况,通过对不同献血形式,检测项目以及人群分布特征的分析,为制定无偿献血招募,为无偿献血队伍纳入更多健康的血液资源提供参考依据。方法对乌鲁木齐市血液中心2017-2021年无偿献血者样本的检测... 详细信息

目的分析初次及重复无偿献血者血液检测情况,通过对不同献血形式,检测项目以及人群分布特征的分析,为制定无偿献血招募,为无偿献血队伍纳入更多健康的血液资源提供参考依据。方法对乌鲁木齐市血液中心2017-2021年无偿献血者样本的检测结果进行分析,分别从检测项目,献血形式以及人群分布特征,比较不同人群初次和重复献血的血液不合格分布情况。结果初次和重复机采血小板献血者各项目血液检验不合格率有统计学意义(P<0.05),初次和重复全血献血者不同年龄不合格率有统计学意义(P<0.001),初次和重复全血献血者和血小板献血者在不同文化程度以及不同职业的不合格率均有统计学意义(P<0.01)。结论2017-2021年乌鲁木齐市无偿献血者中,血液不合格率与献血频次以及人群的年龄,文化程度和职业分布有关。本次研究发现重复献血的高学历的年轻群体不合格率较低。应定期关注感染人群组成变化和人群感染项目流行率变化,对保障血液安全和避免血液资源浪费有重要意义。

关键词：无偿献血检验不合格率人群分布

Distribution patterns and industry planning of commonly used traditional Chinese medicinal plants in China

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Plant Diversity 2022年第3期44卷 255-261页

作者： Zhang-Jian shan Jian-Fei Ye Da-cheng Hao Pei-Gen Xiao Zhi-Duan chen An-ming Lu State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China China National Botanical Garden Beijing 100093China Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Medicinal plants are the primary material basis for disease prevention and treatment in traditional Chinese medicine(TCM).The conservation and sustainable utilization of these medicinal plants is critical for the development of the TCM ***,wild medicinal plant resources have sharply declined in recent *** ameliorate the shortage of medicinal plant resources,it is essential to explore the development potential of the TCM industry in different geographical *** this purpose,we examined the spatial distribution of commonly used medicinal plants in China,the number of Chinese medicinal material markets,and the number of TCM decoction piece ***,multispecies superimposition analysis and Thiessen polygons were used to reveal the optimal range for planting bulk medicinal plants and the ideal regions for building Chinese medicinal material markets,***,we quantitatively analyzed mismatches between the spatial distribution of commonly used medicinal plant richness,Chinese medicinal material markets,and TCM decoction piece *** found that the areas suitable for growing commonly used medicinal plants in China were mainly distributed in Hengduan Mountain,Nanling Mountain,Wuling Mountain,and Daba Mountain *** Thiessen polygon network based on Chinese medicinal material market localities showed there are currently fewer markets in southwestern,northwestern,and northeastern China than in central and southern *** decoction piece enterprises are concentrated in a few provinces,such as Hebei and *** found that the distribution of commonly used medicinal plants,Chinese medicinal material markets and TCM decoction piece enterprises are mismatched in Henan,Shaanxi,Hunan,Hubei,Zhejiang,Fujian,Chongqing,and *** recommend strengthening development of the TCM industry in Henan,Hunan,Zhejiang,Shaanxi,Hubei,Chongqing,Fujian,and Xizang;building more Chinese medicinal material markets in southw

关键词： Medicinal plant Distribution pattern Traditional Chinese medicine industry Thiessen polygon