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Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong June Choi Joo Hye Sim Younmin Shin Seung-Joon oh Ji-Hyang Gu Hyun Ju Ha Dong Hwi Jeon Eun-Jung Lee min-seok oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

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Congruent Feature Selection Method to Improve the Efficacy of Machine Learning-Based Classification in Medical Image Processing

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 357-384页

作者： Mohd Anjum Naoufel Kraiem Hong min Ashit Kumar Dutta Yousef Ibrahim Daradkeh Department of Computer Engineering Aligarh Muslim UniversityAligarh202002India College of Computer Science King Khalid UniversityAbha61413Saudi Arabia School of Computing Gachon UniversitySeongnam13120Republic of Korea Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Saudi Arabia Department of Computer Engineering and Information College of Engineering in Wadi AlddawasirPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia

Machine learning(ML)is increasingly applied for medical image processing with appropriate learning *** applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify specific flaws/diseases for *** primary concern of ML applications is the precise selection of flexible image features for pattern detection and region *** of the extracted image features are irrelevant and lead to an increase in computation ***,this article uses an analytical learning paradigm to design a Congruent Feature Selection Method to select the most relevant image *** process trains the learning paradigm using similarity and correlation-based features over different textural intensities and pixel *** similarity between the pixels over the various distribution patterns with high indexes is recommended for disease ***,the correlation based on intensity and distribution is analyzed to improve the feature selection ***,the more congruent pixels are sorted in the descending order of the selection,which identifies better regions than the ***,the learning paradigm is trained using intensity and region-based similarity to maximize the chances of ***,the probability of feature selection,regardless of the textures and medical image patterns,is *** process enhances the performance of ML applications for different medical image *** proposed method improves the accuracy,precision,and training rate by 13.19%,10.69%,and 11.06%,respectively,compared to other models for the selected *** mean error and selection time is also reduced by 12.56%and 13.56%,respectively,compared to the same models and dataset.

关键词： Computer vision feature selection machine learning region detection texture analysis image classification medical images

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C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong Gong min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(Pminently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

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The temporal and spatial variability of the Yellow Sea Cold Water Mass in the southeastern Yellow Sea, 2009–2011

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Acta Oceanologica Sinica 2013年第9期32卷 1-10页

作者： oh Kyung-Hee LEE seok SONG Kyu-min LIE Heung-Jae KIM Young-Taeg Marine Environment and Conservation Research Division Korea Institute of Ocean Science and Technology Ocean Research Division Korea Hydrographic and Oceanographic Administration

The Yellow Sea Cold Water Mass （YSCWM） is one of the important water mass in the Yellow Sea （YS）. It is distributed in the lower layer in the Yellow Sea central trough with the temperature less than 10℃ and the salinity lower than 33.0. To understand the variability of the YSCWM, the hydrographic data obtained in April and August during 2009-2011 are analyzed in the southeastern Yellow Sea. In August 2011, relatively warm and saline water compared with that in 2009 and 2010 was detected in the lower layer in the Yellow Sea central area. Although the typhoon passed before the cruise, the salinity in the Yellow Sea central trough is much higher than the previous season. It means that the saline event cannot be explained by the typhoon but only by the intrusion of saline water during the previous winter. In April 2011, actually, warm and saline water （T 〉 10~C, S 〉34） was observed in the deepest water depth of the southeastern area of the Yellow Sea. The wind data show that the northerly wind in 2011 winter is stronger than in 2009 and 2010 winter season. The strong northerly wind can trigger the intrusion of warm and saline Yellow Sea Warm Current. Therefore, it is proposed that the strong northerly wind in winter season leads to the intrusion of the Yellow Sea Warm Current into the Yellow Sea central trough and influenced a variability of the YSCWM in summer.

关键词： Yellow Sea Cold Water Mass interannual variation saline event atmosphere variability Yellow Sea

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Prospect of developing Nd-Fe-B-type magnet with high electrical resistivity

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Rare Metals 2020年第1期39卷 2-12页

作者： Hae-Woong Kwon min-seok Kang Department of Materials Science and Engineering Pukyong National UniversityBusan48547Republic of Korea

Nd-Fe-B-type magnet is exclusively used as a rotor magnet in the traction motor of hybrid electric vehicle(HEV)and electric vehicle(EV),but its overly high operating temperature is a lingering problem attached to the *** major cause of the high operating temperature is eddy current,which is readily generated in the highly conductive metallic magnet under alternating magnetic field from stator *** this article,temperature rise in the Nd-Fe-B-type magnet with varying electrical resistivity under alternating magnetic field is discussed with the intention of highlighting the importance of enhancing the electrical resistivity for reducing the operating temperature of the Nd-Fe-B-type rotor *** rise in the Nd-Fe-B-type magnet(dielectric salt-added die-upset magnet)with high electrical resistivity is noticeably lower compared to the magnet(commercial sintered rotor magnet)with lower electrical resistivity,substantiating the theory that enhancing the electrical resistivity in the rotor magnet is fairly effective for suppressing the over-rise of its operating temperature during ***-upset process is revealed to be particularly pertinent for the fabrication of highly dense salt-added magnet with high electrical resistivity.

关键词： Rare-earth magnet Nd-Fe-B-type magnet Rotor magnet Operating temperature Eddy current Electrical resistivity

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Assessments of the effects of various fracture surface morphology on single fracture flow: A review

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International Journal of mining Science and Technology 2023年第1期33卷 1-29页

作者： min Gao Chengguo Zhang Joung oh School of minerals and Energy Resources Engineering University of New South WalesSydney NSW 2052Australia

Natural rock joint permeability deviates from the classic fluid flow governing equations due to the inher-ent fracture surface roughness(i.e.,contact points,spatial correlation,matching,varying aperture,iso-lated voids,infilling material,tortuosity and channellings)and engineering disturbance such as *** improve the accuracy of fracture permeability evaluation,many efforts have been made in analytical,experimental,and numerical *** study reviews the modified mathematical gov-erning equations of fluid flow and classifies them based on different influencing factors,such as friction factor,aperture,tortuosity,inertia,and various in situ stress *** experimental and simulation techniques for the coupled normal-and shear-stress flow problems were assessed,and their advantages and disadvantages were also ***,different surface roughness descriptions and their impacts on mechanical and hydraulic behaviours were discussed,followed by the potential research directions for fracture flow problems.

关键词： Surface roughness Single fracture Nonlinear flow Coupled hydromechanical(HM)behaviours

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen Qiu-Wan Wei Yi-Ren Tian Yun-Zhi Ling min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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Extraction of intersecting palm-vein and palmprint features for cancellable identity verification

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 69-86页

作者： Jaekwon Lee Beom-seok oh Kar-Ann Toh School of Electrical and Electronic Engineering Yonsei UniversitySeoulRepublic of Korea Department of Applied Artificial Intelligence Seoul National University of Science and TechnologySeoulRepublic of Korea

A novel method based on the cross-modality intersecting features of the palm-vein and the palmprint is proposed for identity *** on the unique geometrical relationship between the two biometric modalities,the cross-modality intersecting points provides a stable set of features for identity *** facilitate flexibility in template changes,a template transformation is *** maintaining non-invertibility,the template transformation allows transformation sizes beyond that offered by the con-ventional *** experiments using three public palm databases are conducted to verify the effectiveness the proposed system for identity recognition.

关键词： biometrics hand vein recognition hand-based biometrics multi-biometrics palmprint recognition

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Elucidating Ion Transport Phenomena in Sulfide/Polymer Composite Electrolytes for Practical Solid-State Batteries

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Nano-Micro Letters 2023年第10期15卷 416-432页

作者： Kyeong‑seok oh Ji Eun Lee Yong‑Hyeok Lee Yi‑Su Jeong Imanuel Kristanto Hong‑seok min Sang‑Mo Kim Young Jun Hong Sang Kyu Kwak Sang‑Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei‑roSeodaemun‑guSeoul 03722Republic of Korea Department of Chemical and Biological Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST‑gilEonyang‑eupUlju‑gunUlsan 44919Republic of Korea Hyundai Motor Company 150Hyundaiyeonguso‑roNamyang‑eupHwaseong‑siGyeonggi‑do 18280Republic of Korea

Despite the enormous interest in inorganic/polymer composite solid-state electrolytes(CSEs)for solid-state batteries(SSBs),the underlying ion transport phenomena in CSEs have not yet been ***,we address this issue by formulating a mechanistic understanding of bi-percolating ion channels formation and ion conduction across inorganic-polymer electrolyte interfaces in CSEs.A model CSE is composed of argyrodite-type Li_6PS_5Cl(LPSCl)and gel polymer electrolyte(GPE,including Li~+-glyme complex as an ion-conducting medium).The percolation threshold of the LPSCl phase in the CSE strongly depends on the elasticity of the GPE ***,manipulating the solvation/desolvation behavior of the Li~+-glyme complex in the GPE facilitates ion conduction across the LPSCl-GPE *** resulting scalable CSE(area=8×6(cm×cm),thickness~40μm)can be assembled with a high-mass-loading LiNi_(0.7)Co_(0.15)Mn_(0.15)O_(2)cathode(areal-mass-loading=39 mg cm~(-2))and a graphite anode(negative(N)/positive(P)capacity ratio=1.1)in order to fabricate an SSB full cell with bi-cell *** this constrained cell condition,the SSB full cell exhibits high volumetric energy density(480 Wh L_(cell)~(-1))and stable cyclability at 25℃,far exceeding the values reported by previous CSE-based SSBs.

关键词： Solid-state batteries Composite solid-state electrolytes Ion transport phenomena Bi-percolating ion channels Interfacial resistance

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