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Enhanced graph-based fault diagnostic system for nuclear power plants

Nuclear Science and Techniques 2019年第12期30卷 8-21页

作者： Yong-Kuo Liu Xin Ai Abiodun Ayodeji Mao-Pu Wu min-jun peng Hong Xia Wei-Feng Yu State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen 518172GuangdongChina Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin Engineering UniversityHarbin 150001China Lianyungang JARI Deepsoft Technology Co. Ltd.Lianyungang 222002China

Scheduled maintenance and condition-based online monitoring are among the focal points of recent research to enhance nuclear plant *** of the most effective ways to monitor plant conditions is by implementing a full-scope,plant-wide fault diagnostic ***,most of the proposed diagnostic techniques are perceived as unreliable by operators because they lack an explanation module,their implementation is complex,and their decision/inference path is *** formalism has been considered for fault diagnosis because of its clear decision and inference modules,and its ability to display the complex causal relationships between plant variables and reveal the propagation path used for fault localization in complex ***,in a graphbased approach,decision-making is slow because of rule *** this paper,we present an enhanced signed directed graph that utilizes qualitative trend evaluation and a granular computing algorithm to improve the decision speed and increase the resolution of the graphical *** integrate the attribute reduction capability of granular computing with the causal/fault propagation reasoning capability of the signed directed graph and comprehensive rules in a decision table to diagnose faults in a nuclear power *** trend analysis is used to solve the problems of fault diagnostic threshold selection and signed directed graph node state *** similarity reasoning and detection ability of the granular computing algorithm ensure a compact decision table and improve the decision *** performance of the proposed enhanced system was evaluated on selected faults of the Chinese Fuqing 2 nuclear *** proposed method offers improved diagnostic speed and efficient data *** addition,the result shows a considerable reduction in false positives,indicating that the method provides a reliable diagnostic system to support further intervention by operators.

关键词： Nuclear power plants Fault diagnosis Signed directed graph Decision table Granular computing

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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang min Yi Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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A Nonlinear Control Allocation Framework for Complex Decentralized Cooperation Control System

A Nonlinear Control Allocation Framework for Complex Decentr...

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2009中国控制与决策会议

作者： Weirong Liu,min Wu,jun peng and Guojun Wang 1.School of Information Science and Engineering,Central South University,Changsha 410083,China Beijing 100080

＜正＞Control allocation problem is the key of cooperation control systems and has attracted a lot of attention of researchers. This paper proposes a nonlinear control allocation framework to provide a common optimal solution for decentralized cooperation control *** decomposing the control allocation problem into static optimal problem and dynamic stabilizing/tracking problem,an effective way to design the allocation controller and feedback control law is given in the *** allocation controller is designed to realize some control strategy and the feedback control law provides asymptotic stability for the entire ***,they are implemented decentralizedly and can adapt to complex nonlinear control allocation *** it is easy to apply and is very suitable for various complex decentralized control applications such as multiple robots cooperation,network congestion control,supply and demand equilibrium control of free market and so *** addition,it seems to be a promise method to solve large-scale optimal control problems.

关键词： Nonlinear control Decentralized control Optimization Cooperation control

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FEM analysis for the standing wave acoustic reactor with high energy efficiency

FEM analysis for the standing wave acoustic reactor with hig...

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2011年全国压电和声波理论及器件应用研讨会

作者： Jin-juan ZHOU Han-min peng jun-hui HU~* State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics,Nanjing 210016,CHINA

Conventional ultrasonic reactors use the standing wave field to generate the acoustic cavitation *** the standing wave field,the amplitude of sound pressure changes with field position periodically,and the cavitation effect may be too strong at the antinodes of sound pressure and too weak at the nodes of sound pressure. Theoretically this causes a low acoustic energy utilization *** propose the methods for increasing the acoustic energy utilization rate in ultrasonic reactors,we have proposed an index NUI,which describes the non-uniformity of acoustic *** method for decreasing ultrasonic reactors’ NUI is explored in this paper,by using the finite element calculation of sound *** the FEM model,the size of the rectangular box for simulation was 187.8×65×78 mm,and it was full with *** end face in the length direction of the rectangular box was used as the sound radiation surface,and the other face paralleled with it was utilized as the reflective *** working frequency was set as 20 kHz and the vibration velocity was assumed as 0.1 m/s in the sound radiation surface;the commercial software COMSOL MULTIPHYSICS was adopted to the finite element calculation. Through the calculation of NUI index and the average sound pressure in the sound field,the method for improving the ultrasound field energy utilization ratio is *** results indicate that the free boundary between sound field and air would increase NUI index and reduce the sound field energy utilization ***,if setting a rigid thin plate at this boundary,the sound field energy utilization rate would be improved effectively.

关键词： Ultrasonic reactor Sound field non-uniformity index NUI

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang min Zhou Luying peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui peng Sheng-Ke Tu min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-min Zhang Ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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5-脂氧合酶及其相关产物与心脑血管损伤的研究进展

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中国药理学通报 2025年第1期41卷 13-18页

作者：黄林露彭军中南大学湘雅药学院药理学系湖南长沙410013

5-脂氧合酶(5-lipoxygenase,5-LOX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LOX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密... 详细信息

5-脂氧合酶(5-lipoxygenase,5-LOX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LOX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密切相关。靶向抑制5-LOX及其相关产物级联反应中的酶和受体能够对心脑血管损伤起到保护作用,表明5-LOX及其相关产物可能是治疗心脑血管疾病潜在的靶点。已有的相关抑制剂包括5-LOX/5-LOX激活蛋白抑制剂、白三烯A4水解酶/白三烯C4合成酶抑制剂、白三烯受体拮抗剂,这些抑制剂通过不同的机制减轻炎症,抑制促炎介质白三烯的产生,促进抗炎脂质介质的形成,在心肌缺血/再灌注损伤和动脉粥样硬化的治疗中显示出了潜在的价值。该文综述了5-LOX及其相关产物在心脑血管疾病中的作用,同时总结了相关抑制剂在心脑血管应用中的研究进展。

关键词： 5-脂氧合酶心肌缺血/再灌注心肌梗死缺血性脑损伤动脉粥样硬化 5-脂氧合酶抑制剂

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Application of Adaptive Fuzzy Spiking Neural P Systems in Fault Diagnosis of Power Systems

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Chinese Journal of Electronics 2014年第1期23卷 87-92页

作者： TU min WANG jun peng Hong SHI peng School of Electrical and Information Engineering Xihua University Center for Radio Administration and Technology Development Xihua University Department of Computing and Mathematical Sciences University of Glamorgan PontypriddCF37 1DL UK School of Engineering and Science Victoria University MelbourneVic 8001 Australia

Adaptive fuzzy spiking neural P systems(AFSN P systems) are a novel kind of computing models with parallel computing and learning ability. Based on our existing works, AFSN P systems are applied to deal with the fault diagnosis problems of power systems and the uncertainty of action messages about protective relays and breakers, and a new fault diagnosis model of power systems is proposed with simple reasoning process and fast speed with parallel processing capabilities. The effectiveness of the fault diagnosis model is verified by some examples of fault diagnosis. Furthermore, the learning ability of AFSN P systems can be applied to adjust the weights in the fault diagnosis model automatically.

关键词： Membrane computing Spiking neural P systems Fault diagnosis Power systems

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