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HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： Qing-Zhi Hu Zhen-Rui Cao Wei-Xiong Zheng min-jie zhao Jun-Hua Gong Cong Chen Zhong-Jun Wu Rui Tao Department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(LT).The underlying mechanism primarily involves overactivation of the immune *** shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein ***:An IRI model was established by performing LT on Sprague-Dawley rats,and HSP110 was silenced using ***-eosin staining,TUNEL,immunohistochemistry,ELISA and liver enzyme analysis were performed to assess IRI following *** blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular ***:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following LT(P<0.05).However,when rats were injected with siRNAHSP110,IRI subsequent to LT was notably reduced(P<0.05).Additionally,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(P<0.05).Silencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(P<0.05).Conclusions:HSP110 in the liver promotes IRI after LT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer *** HSP110 to prevent IRI after LT may represent a promising new approach for the treatment of LT-associated IRI.

关键词： Ischemia-reperfusion injury Liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

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QoS-Aware Computation Offloading in LEO Satellite Edge Computing for IoT:A Game-Theoretical Approach

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Chinese Journal of Electronics 2024年第4期33卷 875-885页

作者： Ying CHEN Jintao HU jie zhao Geyong min School of Computer Science Beijing Information Science and Technology University University of Exeter

Low earth orbit(LEO) satellite edge computing can overcome communication difficulties in harsh environments, which lack the support of terrestrial communication infrastructure. It is an indispensable option for achieving worldwide wireless communication coverage in the future. To improve the quality-of-service(QoS) for Internet-of-things(IoT) devices, we combine LEO satellite edge computing and ground communication systems to provide network services for IoT devices in harsh environments. We study the QoS-aware computation offloading(QCO) problem for IoT devices in LEO satellite edge computing. Then we investigate the computation offloading strategy for IoT devices that can minimize the total QoS cost of all devices while satisfying multiple constraints, such as the computing resource constraint, delay constraint, and energy consumption constraint. We formulate the QoSaware computation offloading problem as a game model named QCO game based on the non-cooperative competition game among IoT devices. We analyze the finite improvement property of the QCO game and prove that there is a Nash equilibrium for the QCO game. We propose a distributed QoS-aware computation offloading(DQCO) algorithm for the QCO game. Experimental results show that the DQCO algorithm can effectively reduce the total QoS cost of IoT devices.

关键词： Satellites Costs Computational modeling Low earth orbit satellites Quality of service Games Nash equilibrium

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Low Surface Brightness Galaxies Selected by Different Model Fitting

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Research in Astronomy and Astrophysics 2024年第1期24卷 223-236页

作者： Bing-Qing Zhang Hong Wu Wei Du Pin-Song zhao min He Feng-jie Lei Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We present a study of low surface brightness galaxies(LSBGs) selected by fitting the images for all the galaxies inα.40 SDSS DR7 sample with two kinds of single-component models and two kinds of two-component models(disk+bulge):single exponential,single sersic,exponential+deVaucular(exp+deV),and exponential+sérsic(exp+ser).Under the criteria of the B band disk central surface brightness μ_(0,disk)(B)≥22.5 mag arcsec^(-2) and the axis ratio b/a> 0.3,we selected four none-edge-on LSBG samples from each of the models which contain 1105,1038,207,and 75 galaxies,*** are 756 galaxies in common between LSBGs selected by exponential and sersic models,corresponding to 68.42% of LSBGs selected by the exponential model and 72.83% of LSBGs selected by the sersic model,the rest of the discrepancy is due to the difference in obtaining μ_(0) between the exponential and sersic *** on the fitting,in the range of 0.5≤n≤1.5,the relation of μ_(0) from two models can be written as μ_(0,sérsic)-μ_(0,exp)=-1.34(n-1).The LSBGs selected by disk+bulge models(LSBG_(2)comps) are more massive than LSBGs selected by single-component models(LSBG_1comp),and also show a larger disk *** the bulges in the majority of our LSBG_(2)comps are not prominent,more than 60% of our LSBG_(2)comps will not be selected if we adopt a single-component model *** also identified 31 giant low surface brightness galaxies(gLSBGs) from LSBG_(2)*** are located at the same region in the color-magnitude diagram as other *** we compared different criteria of gLSBGs selection,we find that for gas-rich LSBGs,M_(*)> 10^(10)M_⊙ is the best to distinguish between gLSBGs and normal LSBGs with bulge.

关键词： catalogs galaxies:spiral galaxies:bulges methods:data analysis methods:statistical

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Biological factors driving colorectal cancer metastasis

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-Xing An zhao-Jin Yu Chen Fu min-jie Wei Long-Hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at *** Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial *** median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 *** is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor *** patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological *** genomic and nongenomic events can induce subclone diversity,which leads to cancer and *** the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular ***,cancer cells presenting neoantigens can be recognized and eliminated by the immune *** this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle *** remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains *** review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

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Modified constitutive models for Inconel 718 considering current density and temperature in electrically assisted forming process

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Chinese Journal of Aeronautics 2024年第2期37卷 524-540页

作者： Xuan CUI Rui zhao min WAN School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Jiangxi 330000China

Electrically Assisted Forming(EAF)technology has obvious advantages in material *** develop an effective constitutive model considering electrical effects,room temperature and electrically assisted quasi-static uniaxial tensile tests were conducted using ultrathin nickelbased superalloy plates with a thickness of 0.25 *** research focused on the two most widely recognized effects:the Joule thermal and the electric athermal *** mechanism of current action can be divided into two scenarios:one considering the Joule thermal effect only,and the other considering both effects *** basic constitutive models,namely the Modified-Hollomon model and the Johnson-Cook(J-C)model,were selected to be optimized through the classification of two different situations,and four optimized constitutive models were *** was found that the J-C model with simultaneous consideration of the Joule thermal effect and electric athermal effect had the best prediction effect by comparing the results of these four ***,the accuracy of the optimization model was verified by finite element simulation of the electrically assisted stretching optimization *** results show that the constitutive model can effectively predict the temperature effect caused by the Joule heat effect and the athermal effect of current on the material.

关键词： Joule heating Elastoplasticity Plastic deformation Superalloys Constitutive models

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Universal method for designing periodic orbits by homotopy classes in the elliptic restricted three-body problem

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Astrodynamics 2024年第1期8卷 175-188页

作者： Yue Zheng min zhao School of Electronic Engineering Xi’an Aeronautical InstituteXi’an710077China School of Aircraft Engineering Xi’an Aeronautical InstituteXi’an710077China School of Astronautics Northwestern Polytechnical UniversityXi’an710072China

The current methods for designing periodic orbits in the elliptic restricted three-body problem(ERTBP)have the disadvantages of targeting limited orbits and ergodic searches and considering only symmetric orbits.A universal method for designing periodic orbits is proposed in this ***,the homotopy classes of orbits are structured based on their topological ***,a dynamic model based on homotopy classes,ranging from the circular restricted three-body problem(CRTBP)to the ERTBP,can be built using the homotopy ***,a multi-and a single-period orbit were selected based on the resonance ***,the corresponding orbit in the ERTBP was computed by modifying the initial condition of the orbit in the *** method,without an ergodic search,can extend to any orbit,including an asymmetric orbit in the CRTBP,to the ERTBP model,and the two orbits are of the same homotopy *** of the Earth–Moon ERTBP are presented to verify the efficiency of this method.

关键词： periodic orbit elliptic restricted three-body problem(ERTBP) topology homotopy circular restricted three-body problem(CRTBP)

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Application of ultrasonic fatigue technology in very-high-cycle fatigue testing of aviation gas turbine engine blade materials:A review

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Science China(Technological Sciences) 2024年第5期67卷 1317-1363页

作者： zhao JiuCheng WAN jie ZHANG ShiZhong YAN ChuLiang zhao HongWei Key Laboratory of CNC Equipment Reliability ministry of Education Jilin UniversityChangchun 130025China School of Mechanical&Aerospace Engineering Jilin UniversityChangchun 130025China Chongqing Research Institute of Jilin University Chongqing401120China School of Aeronautic Science and Engineering Beihang UniversityBeijing 102206China

The need for very-high-cycle fatigue(VHCF)testing up to 1010cycles of aviation gas turbine engine blade materials under combined mechanical loads and complex environments has encouraged the development of VHCF testing instrumentation and *** article begins with a comprehensive review of the existing available techniques that enable VHCF *** advances in ultrasonic fatigue testing(UFT)techniques are highlighted,containing their new capabilities and methods for single load,multiaxial load,variable amplitude fatigue,and combined cycle *** techniques for conducting UFT in high-temperature,humid environments,and corrosive environments are *** developments in mechanical loading and environmental building techniques provide the possibility of laboratory construction for real service conditions of blade *** techniques that can be used for in situ monitoring of VHCF damage are *** issues in the UFT field are presented,and countermeasures are ***,the existing problems and future trends in the field are briefly described.

关键词： aviation gas turbine engine blade materials ultrasonic fatigue very-high-cycle fatigue high-temperature complex stress in situ testing

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Relativistic configuration-interaction density functional theory:Nonaxial effects on nuclear ββ decay

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Science Bulletin 2024年第13期69卷 2017-2020页

作者： Yakun Wang Pengwei zhao jie Meng State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

Nuclear ββ decay is a second-order weak process in which an even-even nucleus decays to its neighboring even-even nucleus by turning two neutrons to two protons while emitting two electrons.A nucleus undergoes such ... 详细信息

关键词： decay neighboring interaction

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Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-Chun Zhu Wei-Wei Peng jie Wang Hong-Wei zhao Ai-Guo Li min Chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

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Quaternion-Based Adaptive Trajectory Tracking Control of a Rotor-Missile with Unknown Parameters Identification

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Defence Technology（防务技术） 2024年第1期31卷 375-386页

作者： jie zhao Zhongjiao Shi Yuchen Wang Wei Wang Beijing Institute of Technology Beijing 100081China

This paper investigates the adaptive trajectory tracking control problem and the unknown parameter identification problem of a class of rotor-missiles with parametric system ***,considering the uncertainty of structural and aerodynamic parameters,the six-degree-of-freedom(6Do F) nonlinear equations describing the position and attitude dynamics of the rotor-missile are established,respectively,in the inertial and body-fixed reference ***,a hierarchical adaptive trajectory tracking controller that can guarantee closed-loop stability is proposed according to the cascade characteristics of the 6Do F ***,a memory-augmented update rule of unknown parameters is proposed by integrating all historical data of the regression *** long as the finitely excited condition is satisfied,the precise identification of unknown parameters can be ***,the validity of the proposed trajectory tracking controller and the parameter identification method is proved through Lyapunov stability theory and numerical simulations.

关键词： Rotor-missile Adaptive control Parameter identification Quaternion control

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