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Chinese Chemical Letters 2006年第6期17卷 787-790页

作者： Ping AI Jia Chuan LIU min ZI Zhi hua deng Zhi Hong YAN Li ming YUAN Department of Chemistry Yunnan Normal University Kunming 650092

Enantioseparation of aminoglutethimide was performed by high-speed counter-current chromatography with a two-phase system composed of ethyl acetate： methanol： water = 10： 1： 9. The lower phase contained 20 mmol/L of carboxymethly-β-cyclodextrin as chiral selector. The enantiomers were separated in 1.2 h and identified by chiral HPLC. This method was very efficient for the chiral preparative separation.

关键词： High speed countercurrent chromatography enantioseparation aminoglutethimide,carboxymethly-β-cyclodextrin.

Pretreatment serum albumin/globulin ratio as a prognostic biomarker in metastatic prostate cancer patients treated with maximal androgen blockade

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Asian Journal of Andrology 2019年第1期21卷 56-61页

作者： Ning Wang Jian-Ye Liu Xiong Li min-hua deng Zhi Long Jin Tang Kun Yao Yi-Chuan Zhang Le-Ye He Department of Urology The Third Xiangya Hospital of Central South UniversityChangsha 410013China institute of Prostate Disease of Central South University Changsha 410013China Center for Molecular Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Molecular Radiation Oncology Xiangya HospitalCentral South UniversityChangsha 410008China.

The pretreatment serum albumin/globulin ratio (AGR)has been used as a prognostic biomarker for various cancer ***, the prognostic value of the AGR for prostate cancer,especially for metastatic prostate cancer (mPCa)after maximal androgen blockade (MAB),remains *** aim of this study was to evaluate the prognostic value of the pretreatment serum AGR for mPCa treated with *** retrospective study included 214 mPCa patients receiving MAB from October 2007 to March 2017. The correlation of the AGR with survival was estimated using Kaplan-Meier analysis and Cox proportional hazards *** cutoff value of the AGR was 1.45 according to the receiver operating characteristic ***-Meier analysis demonstrated that patients with a low AGR (min levels (≥40.0 g l^-1),the serum AGR remained an independent predictor of CSS (P=0.009). The pretreatment AGR was an independent prognostic biomarker for PFS and CSS in patients with mPCa receiving *** addition,the AGR remained effective for the prediction of CSS in patients with normal albumin levels (≥40 g l^-1).However,further prospective studies are needed to confirm our conclusions.

关键词： albumin/globulin ratio maximal androgen blockade metastatic prostate cancer prognosis survival

Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-Dan Xu min-hua deng Shi-Hui Hao Jie-Wei Chen Xiao-Dan Ma Wei-Tao Zhuang Jing-hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

双波长荧光雷达探测大气生物气溶胶的性能分析

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光谱学与光谱分析 2017年第9期37卷 2804-2808页

作者：饶志敏华灯鑫何廷尧王强乐静西安理工大学机械与精密仪器工程学院陕西西安710048

生物气溶胶在大气中扩散极易传播和发生各种流行疾病,也是生物武器投放的主要形式,实现生物气溶胶实时、远距离的探测显得尤为重要。构建了一台双波长荧光雷达用于大气中生物气溶胶的预警和识别。该雷达系统采用Nd∶YAG固体激光器作为... 详细信息

生物气溶胶在大气中扩散极易传播和发生各种流行疾病,也是生物武器投放的主要形式,实现生物气溶胶实时、远距离的探测显得尤为重要。构建了一台双波长荧光雷达用于大气中生物气溶胶的预警和识别。该雷达系统采用Nd∶YAG固体激光器作为激励光源,基频1 064nm、四倍频266nm作为工作波长。基于激光诱导荧光雷达探测原理,对红外波段的弹性散射信号和紫外波段诱导的荧光信号进行数值分析。结果显示,在探测误差小于10%的情况下,距离为1.0km时,单激光脉冲测量得到白天和夜晚细菌孢子的最小探测浓度分别为15 100个颗粒·L^(-1)和8 386个颗粒·L^(-1);当脉冲数累加到10 000时,白天和夜晚的细菌孢子最小探测浓度显著改善,分别为144个颗粒·L^(-1)和77个颗粒·L^(-1)。分析结果还表明,通过红外波段确定细菌孢子云团位置后,为了提高系统对细菌孢子的探测性能,可增加紫外激光脉冲数量,延长荧光信号采集时间。

关键词：荧光雷达双波长信噪比最小探测浓度

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Synthesis and Opto-electronic Properties of Europium and Terbium Complexes with Pyridine or Bipyridine Linked Oligothiophene Ligand

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Synthesis and Opto-electronic Properties of Europium and Ter...

Modeling of flow and temperature distribution in electroslag remelting withdrawal process for fabricating large-scale slab ingots

中国化学会第四届有机化学学术会议

作者： LIU,Ping PAN, Wan-Zhang ZHANG, Ya-min HU, Jian-hua deng, Wen-Ji (Research Institute of Materials Science, South China University of Technology, Guangzhou 510640) (Department of Applied Physics, South China University of Technology, Guangzhou 510640)

Rare earth complexes as fluorescent dyes have attracted attention not only for academic interest but also for their potential application, such as electroluminescence devices, photoluminescence devices and laser systems. Pyridine and bipyridine are very popular complexing agents. Transition metal complexes based on pyridine or bipyridine ligand, for example, rhodium-bipyridine complex and ruthenium-bipyridine complex, have been investigated extensively.

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Journal of Iron and Steel Research International 2017年第6期24卷 569-578页

作者： Wan-ming Li Zhou-hua Jiang Xi-min Zang Xin deng School of Material and Metallurgy University of Science and Technology Liaoning School of Metallurgy Northeastern University

Currently, the market demands for large-scale and high-quality slab ingots are increasing significantly. A novel electroslag remelting withdrawal （ESRW） process with two series-connected electrodes and a T- shaped mould was developed to produce large-scale and high-quality slab ingots. It is very difficult to ob- tain large slab ingots with good surface quality and high width-to-thickness ratio. And it is not efficient for improving the quality of slab ingots by using trial-and-error-based approaches because the ESRW mecha- nisms are very complex. Thus, a three-dimensional mathematical model was developed to determine the relationship between process parameters and physical phenomena during the ESRW process. The relation- ship between the temperature field of the ESRW process and the surface quality of slab ingots was estab- lished. A good agreement between the simulated and measured temperature fields of slab ingots was ob- tained. The results indicate that the maximum values of current density, electromagnetic force and Joule heat all occur at the electrode-slag interface between the two electrodes. It can be found that the flow is turbulent and the temperature distribution is uniform in the slag pool with the influences of buoyancy and electromagnetic force. The wrinkles in the narrow faces of slab ingots are caused by the relatively lower in- put power. Increasing the electrode width and reducing the curvature can significantly improve the surface quality of slab ingots.

关键词： Electroslag remeltingwithdrawal processLarge-scale slabSurface qualityWrinkleFlowTemperature field

脂质转移蛋白SiLTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SiLTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SiLTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SiLTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SiLTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SiLTP1 盐胁迫谷子耐盐响应

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Electroslag Remelting Withdrawing Technology for Offshore Jack-up Platform Rack Steel Manufacturing Process

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Journal of Iron and Steel Research International 2016年第4期23卷 297-304页

作者： Xi-min ZANG Tian-yu QIU Wan-ming LI Xin deng Zhou-hua JIANG hua SONG School of Material and Metallurgy University of Science and Technology Liaoning School of Metallurgy Northeastern University School of Mechanical Engineering and Automation University of Science and Technology Liaoning

Offshore jack up platform rack steel must exhibit high strength and toughness as well as excellent welding properties. A high-quality large ingot is a prerequisite for obtaining a high-performance rough part. The electroslag remelting withdrawing （ESRW） technology using a T-shaped mold and bifilar mode was introduced to replace casting technology. Numerical simulation of the ESRW process was performed to determine the distribution of the temperature and velocity fields and to determine the optimum process for producing rack steels. Several A514Q slab ingots with dimensions of 0.32 m×1.40 m × 4.00 m were produced using ESRW technology in an industrial plant. The industrial test indicated that slab ingots produced by the ESRW method exhibited uniform chemical compositions and compact macrostructures. A 115.4 mm thick plate was produced from the rough ingot after 11 roiling passes. Samples were obtained from different positions in the steel plate to test the mechanical performance and examine the microstructure, and the results revealed that the properties of the steel plate satisfied ASTM standards. The ESRW process improved the tensile strength and toughness of the slab ingot, enabling significant improvements in the anisotropy and low temperature toughness, which are critical for the development of rack steel for offshore platforms.

关键词： electroslag remelting withdrawing rack steel mechanical performance low temperature toughness

Infinitely Many Solutions to a Class of p-Laplace Equations

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 770-779页

作者： Yi-hua deng College of Mathematics and Statistics Hengyang Normal University

In this paper, we study a class of p-Laplace equations. Using variational methods, we prove that there are two solutions and one of these solutions is nonnegative. Using recurrence method, we prove that there are infi... 详细信息

关键词： p-Laplace equation variational methods infinitely many solutions nonnegative solution